|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-453 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 588.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 2 IKRTVKNIAEMVNGTLTNPqyEQTVIHGVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRSepnPPENH 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGD--PDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRP---LPADL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 82 AVILVDDTLTALQQLAKAYLQELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEIA 161
Cdd:COG0770 76 PLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 162 VLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEQLL---QNAYSCQT 238
Cdd:COG0770 156 VLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLaalAERAKARV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 239 KTYGTGAHNDYQLQDVSQSEEGTHFTI--KGIKNTFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRL 316
Cdd:COG0770 236 LTFGLSEDADVRAEDIELDEDGTRFTLhtPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 317 ELIKTDSGLSIINDAYNASPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYGKLGA 396
Cdd:COG0770 316 EVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGGGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELAR 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1679660759 397 FIAEGALkhfeKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKDLIE 453
Cdd:COG0770 396 AIAEAAG----GERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALKE 448
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
32-451 |
0e+00 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 518.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 32 TDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRsEPNPPENHAVILVDDTLTALQQLAKAYLQELGTRVIGV 111
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDR-EVGPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 112 TGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEIAVLEMGMSAKGEIDLLSRLANPDAAVITNIG 191
Cdd:TIGR01143 80 TGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 192 ESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEQLLQNAYSCQ----TKTYGTGAhNDYQLQDVSQSEEG-THFTIK 266
Cdd:TIGR01143 160 PAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLpnrnILSFGFEG-GDFVAKDISYSALGsTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 267 GIKNTFFI--PILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLElIKTDSGLSIINDAYNASPTSMKAAIQ 344
Cdd:TIGR01143 239 APGGEFEVslPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 345 LTESLEgyGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYGKLgAFIAEGALKHFEKdrvsHYTEKKDLLQAV 424
Cdd:TIGR01143 318 ALARFP--GKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEE-AAVIYDSFGKQGK----HFADKDELLAFL 390
|
410 420
....*....|....*....|....*..
gi 1679660759 425 KENASKGDLILFKASRGMKLEEIVKDL 451
Cdd:TIGR01143 391 KTLVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
29-452 |
6.74e-117 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 364.80 E-value: 6.74e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 29 GVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRsePNPPENHAVILVDDTLTALQQLAKAYLQELGTRV 108
Cdd:PRK11929 528 AVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVER--QVADVDLPQIVVDDTRAALGRLATAWRARFSLPV 605
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 109 IGVTGSNGKTTTKDMIHAVLGT---QYRVHKTGGNFNNHIGLPLTVLAMPENTEIAVLEMGMSAKGEIDLLSRLANPDAA 185
Cdd:PRK11929 606 VAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAPTVA 685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 186 VITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDE-------------QLLQNAYSCQTKTYGTGAHNDYQLQ 252
Cdd:PRK11929 686 LVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDpytaiwaklagarRVLRFGLQPGADVYAEKIAKDISVG 765
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 253 DVSQSEEGTHfTIKGIKNtFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLELIKTDSGLSIINDAY 332
Cdd:PRK11929 766 EAGGTRCQVV-TPAGSAE-VYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDTY 843
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 333 NASPTSMKAAIQLTESLEGyGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYGKLGAFIAEGALKHfekdRVS 412
Cdd:PRK11929 844 NANPDSMRAAIDVLAELPN-GPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAARDAAAAFGAG----ARG 918
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1679660759 413 HYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKDLI 452
Cdd:PRK11929 919 VCASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
111-284 |
1.43e-53 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 177.88 E-value: 1.43e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 111 VTGSNGKTTTKDMIHAVLGTQYRVHKTGG--------NFNNHIGLPLTVLAMPE-NTEIAVLEMGMSAKGEiDLLSRLAN 181
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 182 PDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDE-------QLLQNAySCQTKTYGTGAHNDYQLQDV 254
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDpygafliAKLKKA-GVRVITYGIEGEADLRAANI 158
|
170 180 190
....*....|....*....|....*....|...
gi 1679660759 255 SQSEEGTHF---TIKGIKNTFFIPILGKHNVMN 284
Cdd:pfam08245 159 ELSSDGTSFdlfTVPGGELEIEIPLLGRHNVYN 191
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
103-435 |
4.76e-05 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 45.39 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 103 ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRV-HKTGGNFNNHIGL--------PLTVLAMPENTEIAVLEMGMSAKGEI 173
Cdd:NF033197 89 RIPKKFIEITGVKGKTTTAELLAHILSDEYVLlHTSRGTERYPEGElsnkgsitPASILNALELAEEIGIDDYGFLIFEV 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 174 DL-LSRLAnpDAAVITNIGESHMQDLGSREGIAeAKLEIINGLKEDGVLIyigdeqllqnaysCQTKTYgtGAHNDYQLQ 252
Cdd:NF033197 169 SLgGTGAG--DVGIITNILEDYPIAGGKRSASA-AKLQSLKNAKVGSINV-------------ADLGIY--INGKNKLVI 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 253 DVSQSE---EGTHFTIKGIKNTFFIP-ILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLK-VTGMrlELIKTDSGLSI 327
Cdd:NF033197 231 TVAGVEilsKYPLRFKYGNTEFEFNPlLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKgLPGR--MAVKKEGGVVI 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 328 INdayNASP-TSMKAAIQ-LTESLEGYGKKMLVLGdmlelGDL----EETFHKECGAVIS---PDKIDRVFTYGKLGAFI 398
Cdd:NF033197 309 VD---NINPgLNVKAIEYaLDDALELLGDGTLVIG-----GDFgvvcEEIDIDKLSEVLKkyrPKIDILVGVGTELGKRL 380
|
330 340 350
....*....|....*....|....*....|....*..
gi 1679660759 399 AEGALKHFEkdrVSHYTEKKDLLQAvKENASKGDLIL 435
Cdd:NF033197 381 KKYLDKLEG---YEAGTLEEGLDDA-RELTGEGNTLV 413
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-453 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 588.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 2 IKRTVKNIAEMVNGTLTNPqyEQTVIHGVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRSepnPPENH 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGD--PDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRP---LPADL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 82 AVILVDDTLTALQQLAKAYLQELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEIA 161
Cdd:COG0770 76 PLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 162 VLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEQLL---QNAYSCQT 238
Cdd:COG0770 156 VLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLaalAERAKARV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 239 KTYGTGAHNDYQLQDVSQSEEGTHFTI--KGIKNTFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRL 316
Cdd:COG0770 236 LTFGLSEDADVRAEDIELDEDGTRFTLhtPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 317 ELIKTDSGLSIINDAYNASPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYGKLGA 396
Cdd:COG0770 316 EVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGGGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELAR 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1679660759 397 FIAEGALkhfeKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKDLIE 453
Cdd:COG0770 396 AIAEAAG----GERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALKE 448
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
32-451 |
0e+00 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 518.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 32 TDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRsEPNPPENHAVILVDDTLTALQQLAKAYLQELGTRVIGV 111
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDR-EVGPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 112 TGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEIAVLEMGMSAKGEIDLLSRLANPDAAVITNIG 191
Cdd:TIGR01143 80 TGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 192 ESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEQLLQNAYSCQ----TKTYGTGAhNDYQLQDVSQSEEG-THFTIK 266
Cdd:TIGR01143 160 PAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLpnrnILSFGFEG-GDFVAKDISYSALGsTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 267 GIKNTFFI--PILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLElIKTDSGLSIINDAYNASPTSMKAAIQ 344
Cdd:TIGR01143 239 APGGEFEVslPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 345 LTESLEgyGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYGKLgAFIAEGALKHFEKdrvsHYTEKKDLLQAV 424
Cdd:TIGR01143 318 ALARFP--GKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEE-AAVIYDSFGKQGK----HFADKDELLAFL 390
|
410 420
....*....|....*....|....*..
gi 1679660759 425 KENASKGDLILFKASRGMKLEEIVKDL 451
Cdd:TIGR01143 391 KTLVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
29-452 |
6.74e-117 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 364.80 E-value: 6.74e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 29 GVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRsePNPPENHAVILVDDTLTALQQLAKAYLQELGTRV 108
Cdd:PRK11929 528 AVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVER--QVADVDLPQIVVDDTRAALGRLATAWRARFSLPV 605
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 109 IGVTGSNGKTTTKDMIHAVLGT---QYRVHKTGGNFNNHIGLPLTVLAMPENTEIAVLEMGMSAKGEIDLLSRLANPDAA 185
Cdd:PRK11929 606 VAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAPTVA 685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 186 VITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDE-------------QLLQNAYSCQTKTYGTGAHNDYQLQ 252
Cdd:PRK11929 686 LVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDpytaiwaklagarRVLRFGLQPGADVYAEKIAKDISVG 765
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 253 DVSQSEEGTHfTIKGIKNtFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLELIKTDSGLSIINDAY 332
Cdd:PRK11929 766 EAGGTRCQVV-TPAGSAE-VYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDTY 843
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 333 NASPTSMKAAIQLTESLEGyGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYGKLGAFIAEGALKHfekdRVS 412
Cdd:PRK11929 844 NANPDSMRAAIDVLAELPN-GPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAARDAAAAFGAG----ARG 918
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1679660759 413 HYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKDLI 452
Cdd:PRK11929 919 VCASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDALS 958
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-454 |
2.42e-88 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 276.53 E-value: 2.42e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 1 MIKRTVKNIAEMVNGTLtnpQYEQTVIHGVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRSEP-NPPE 79
Cdd:PRK10773 1 MISVTLSQLADILNGEL---QGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDiDLPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 80 nhavILVDDTLTALQQLAKAYLQELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTE 159
Cdd:PRK10773 78 ----LVVKDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 160 IAVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIG---DEQLLQNAYSC 236
Cdd:PRK10773 154 YAVIELGANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNAdsnDWLNWQSVIGS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 237 QTK---TYGTGAHNDYQLQDVSQSEEGTHFTIKGIKNTFFI--PILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKV 311
Cdd:PRK10773 234 KTVwrfSPNAANSVDFTATNIHVTSHGTEFTLHTPTGSVDVllPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 312 TGMRLELIKTDSGLSIINDAYNASPTSMKAAIQLTESLEGYgkKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTY 391
Cdd:PRK10773 314 VPGRLFPIQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGY--RVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSV 391
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679660759 392 GKLGAFIAEGAlkhfekDRVSHYTEKKDLLQAVKENASKGDLI--LFKASRGMKLEEIVKDLIES 454
Cdd:PRK10773 392 GKLSHAISEAS------GVGEHFADKTALIARLKALLAEHQVItiLVKGSRSAAMEEVVRALQEN 450
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
5-454 |
3.16e-76 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 254.11 E-value: 3.16e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 5 TVKNIAEMVNGTLTnpQYEQTVIHGVATDTRKLE--QHQLFIPLKGERFDGHTFVEQAFEAGV----AAVLWDRSEPNPP 78
Cdd:PRK11930 4 TLESISGILGAEGL--GDKDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVrnfvVSEEKHPEESYPD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 79 ENhaVILVDDTLTALQQLAKAYLQELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENT 158
Cdd:PRK11930 82 AN--FLKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 159 EIAVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIingLKEDGVLIYIGD-----EQLLQNA 233
Cdd:PRK11930 160 ELGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKL---FKDCDVIIYNGDnelisSCITKSN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 234 YSCQTKTYGTGAHN-DYQLQDVSQSEEGTHFTI--KGIKNTFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLK 310
Cdd:PRK11930 237 LTLKLISWSRKDPEaPLYIPFVEKKEDHTVISYtyKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 311 VTGMRLELIKTDSGLSIINDAYNASPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFT 390
Cdd:PRK11930 317 PVAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNRRSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIG 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1679660759 391 ygkLGAFIAEGALKhFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKDLIES 454
Cdd:PRK11930 397 ---IGEEISSEASK-FEGTEKEFFKTTEAFLKSFAFLKFRNELILVKGARKFEFEQITELLEQK 456
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
5-453 |
1.02e-72 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 236.98 E-value: 1.02e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 5 TVKNIAEMVNGTL--TNPQyeqtVIHGVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRSEPNP-PENH 81
Cdd:PRK14093 8 TSDAMAEAMGATRsgALPR----DVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDKfAADA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 82 AVILVDDTLTALQQLAKAYLQELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEIA 161
Cdd:PRK14093 84 PLLVVDDVLAALRDLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 162 VLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGD----EQLLQNAYSCQ 237
Cdd:PRK14093 164 VFEIGMNHAGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDnpqfDRLAASARAAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 238 TK---TYGTGAHNDYQLQDVSQSEEGT--HFTIKGIKNTFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVT 312
Cdd:PRK14093 244 IArivSFGADEKADARLLDVALHADCSavHADILGHDVTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 313 ---GMRLELIKTDSGLSIINDAYNASPTSMKAAIQL--TESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDR 387
Cdd:PRK14093 324 agrGVRHTLEVGGGEATLIDESYNANPASMAAALGVlgRAPVGPQGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDL 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1679660759 388 VFTYGKLGAFIAEgALkhfEKDRVSHYTEKKDLLQA-VKENASKGDLILFKASRGMKLEEIVKDLIE 453
Cdd:PRK14093 404 VFCCGPLMRNLWD-AL---SSGKRGGYAEDAAALESqVVAAIRAGDVIMVKGSLGSRMKTIVTALEK 466
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
111-284 |
1.43e-53 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 177.88 E-value: 1.43e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 111 VTGSNGKTTTKDMIHAVLGTQYRVHKTGG--------NFNNHIGLPLTVLAMPE-NTEIAVLEMGMSAKGEiDLLSRLAN 181
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 182 PDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDE-------QLLQNAySCQTKTYGTGAHNDYQLQDV 254
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDpygafliAKLKKA-GVRVITYGIEGEADLRAANI 158
|
170 180 190
....*....|....*....|....*....|...
gi 1679660759 255 SQSEEGTHF---TIKGIKNTFFIPILGKHNVMN 284
Cdd:pfam08245 159 ELSSDGTSFdlfTVPGGELEIEIPLLGRHNVYN 191
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
29-344 |
2.35e-43 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 158.32 E-value: 2.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 29 GVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRSEPNPPENHAVILVDDTLTALQQLAKAYL----QEL 104
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALLAAGVPVIVVPDPRAALALLAAAFYghpsQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 105 gtRVIGVTGSNGKTTTKDMIHAVL---GtqyrvHKTG--GNFNNHIG---LPlTVLAMPENTEI--------------AV 162
Cdd:COG0769 81 --KLIGVTGTNGKTTTTYLLAQILralG-----KKTGliGTVGNGIGgelIP-SSLTTPEALDLqrllaemvdagvthVV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 163 LEmgMSAKGeIDlLSRLA--NPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGV-LIYIGDE---QLLQNAySC 236
Cdd:COG0769 153 ME--VSSHA-LD-QGRVDgvRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAaVINADDPygrRLAAAA-PA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 237 QTKTYGTGAHNDYQLQDVSQSEEGTHFTIKGIKNT--FFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLK-VTG 313
Cdd:COG0769 228 RVITYGLKADADLRATDIELSADGTRFTLVTPGGEveVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKgVPG 307
|
330 340 350
....*....|....*....|....*....|.
gi 1679660759 314 mRLELIKTDSGLSIINDaYNASPTSMKAAIQ 344
Cdd:COG0769 308 -RMERVDGGQGPTVIVD-YAHTPDALENVLE 336
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
25-342 |
1.08e-29 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 120.50 E-value: 1.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 25 TVIHGVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRSEPNPPENHAVILVDDTLTALQQLAKAYLQEL 104
Cdd:TIGR01085 2 LEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVAPVPVIIVPDLRHALSSLAAAFYGHP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 105 GTR--VIGVTGSNGKTTTKDMIH----------AVLGTqyRVHKTGGNFNNHIGLPLTVlamPENTEI------------ 160
Cdd:TIGR01085 82 SKKlkVIGVTGTNGKTTTTSLIAqllrllgkktGLIGT--IGYRLGGNDLIKNPAALTT---PEALTLqstlaemveaga 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 161 --AVLEM---GMSakgeidlLSRLA--NPDAAVITNIGESHMQDLGSREGIAEAKLEIIN--GLKEDGVLIyIGDE---- 227
Cdd:TIGR01085 157 qyAVMEVsshALA-------QGRVRgvRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTelGLKRFAVIN-LDDEygaq 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 228 ---QLLQNAYSCQTKTYGTGAHNDYQLQDVSQSEEGTHFTIKGIKNTF--FIPILGKHNVMNAMAAIAAGAYFG-ITPEG 301
Cdd:TIGR01085 229 fvkRLPKDITVSAITQPADGRAQDIKITDSGYSFEGQQFTFETPAGEGhlHTPLIGRFNVYNLLAALATLLHLGgIDLED 308
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1679660759 302 AAKGLSGLK-VTGmRLELIKTDSGLSIINDaYNASPTSMKAA 342
Cdd:TIGR01085 309 IVAALEKFRgVPG-RMELVDGGQKFLVIVD-YAHTPDALEKA 348
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
25-344 |
1.87e-27 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 114.07 E-value: 1.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 25 TVIHGVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRsEPNPPENHAVILVDDTLTALQQLAKAYL--- 101
Cdd:PRK00139 13 VEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEA-DGEAGTGVPVIIVPDLRKALALLAAAFYghp 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 102 -QELgtRVIGVTGSNGKTTTKDMIH----------AVLGT-QYRVhktgGNFNNHIGL----PLTVLAMpenteIAVL-E 164
Cdd:PRK00139 92 sDKL--KLIGVTGTNGKTTTAYLLAqilrllgektALIGTlGNGI----GGELIPSGLttpdALDLQRL-----LAELvD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 165 MGM-------SAKGeIDlLSRLA--NPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVlIYIGDE---QLLQN 232
Cdd:PRK00139 161 AGVtyaamevSSHA-LD-QGRVDglKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLAAV-INADDEvgrRLLAL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 233 AyscqtKTYGTGAHN-DYQLQDVSQSEEGTHFTIKGiknTFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLK- 310
Cdd:PRK00139 238 P-----DAYAVSMAGaDLRATDVEYTDSGQTFTLVT---EVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQg 309
|
330 340 350
....*....|....*....|....*....|....*
gi 1679660759 311 VTGmRLELIKTDSGLSIIND-AYNasPTSMKAAIQ 344
Cdd:PRK00139 310 VPG-RMERVDAGQGPLVIVDyAHT--PDALEKVLE 341
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
102-436 |
1.64e-25 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 108.24 E-value: 1.64e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 102 QELGTRVIGVTGSNGKTTTKDMIHAVL---GtqYRVHkTGGNfnnhIGLP-LTVLAMPENTEIAVLEMgmsakgeIDLLS 177
Cdd:COG0771 101 RLSPAPIIAITGTNGKTTTTTLIGHILkaaG--LRVA-VGGN----IGTPlLDLLLEPEPPDVYVLELss---fqLETTP 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 178 RLAnPDAAVITNIGESHMqDL-GSREGIAEAKLEIINGLKEDGVLIY-IGDEQLLQNAYSCQTKTYGTGAH----NDYQL 251
Cdd:COG0771 171 SLR-PDVAVILNITPDHL-DRhGSMEAYAAAKARIFANQTPDDYAVLnADDPLTRALAEEAKARVVPFSLKepleGGAGL 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 252 QD---VSQSEEGTHFTIKGIKntffipILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLELIKTDSGLSII 328
Cdd:COG0771 249 EDgklVDRASGEELLPVDDLR------LPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGVRFI 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 329 ND--AYNasPTSMKAAIqltESLE--------GYGKKmlvlgdmLELGDLEETFHKecgavispdKIDRVFTYGKLGAFI 398
Cdd:COG0771 323 NDskATN--PDATLAAL---ESFDgpvvliagGLDKG-------ADFSPLAPAVAE---------RVKAVVLIGEDAEKI 381
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1679660759 399 AEgalkHFEKDRVsHYTEKKDLLQAVK---ENASKGDLILF 436
Cdd:COG0771 382 AA----ALAGAGV-PVVIVETMEEAVAaaaELARPGDVVLL 417
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
100-436 |
1.15e-24 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 105.92 E-value: 1.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 100 YLQEL--GTRVIGVTGSNGKTTTKDMIHAVLgtqyrvhktggnfnNHIGLPLTVL--AMPEN---------TEIAVLEmg 166
Cdd:COG0773 96 MLAELmrGKRSIAVAGTHGKTTTTSMLAHIL--------------EEAGLDPTFLigGILNNfgtnarlgdGDYFVAE-- 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 167 msakgeidllsrlA----------NPDAAVITNIGESHMqDL-GSREGIAEAKLEIINGLKEDGVLIYIGDEQLLQN--- 232
Cdd:COG0773 160 -------------AdesdgsflhySPDIAVVTNIEADHL-DIyGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLREllp 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 233 AYSCQTKTYGTGAHNDYQLQDVSQSEEGTHFTIKGIKN---TFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGL 309
Cdd:COG0773 226 RCGRPVITYGFSEDADYRAENIRIDGGGSTFDVLRRGEelgEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASF 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 310 KVTGMRLELIKTDSGLSIINDaYNASPTSMKAAIQlteSL-EGYGKKMLV----------LGDMLElgDLEETFhkecga 378
Cdd:COG0773 306 KGVKRRFELKGEVGGVTVIDD-YAHHPTEIAATLA---AArEKYPDRRLVavfqphrysrTRDFLD--EFAEAL------ 373
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1679660759 379 vispDKIDRVF-----------TYGKLGAFIAEgALKHFEKDrVSHYTEKKDLLQAVKENASKGDLILF 436
Cdd:COG0773 374 ----SLADEVIlldiyaarekpIPGVSSEDLAE-AIRKRGKD-VVYVPDLDELVEALAEIARPGDVVLT 436
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
108-436 |
1.93e-24 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 105.11 E-value: 1.93e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 108 VIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNfnnhIGLPLTVLAMPENTEIAVLEMGmSAKGEidlLSRLANPDAAVI 187
Cdd:TIGR01087 104 VVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLELS-SFQLE---TTESLRPEIALI 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 188 TNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDeqllqnayscqTKTYGTGAHNDYqLQDVSQSEEGTH---FT 264
Cdd:TIGR01087 176 LNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNAD-----------DPRFARLAQKSK-AQVIWFSVEKDAergLC 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 265 IKGIKNTFF-----IPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNASPTSM 339
Cdd:TIGR01087 244 IRDGGLYLKpndleGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYNDSKATNVHAT 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 340 KAAiqltesLEGYGKKM-LVLGDMLELGDLEETFHKECGAVISpdkidrVFTYGKLGAFIAEGALKHFEKdrVSHYTEKK 418
Cdd:TIGR01087 324 LAA------LSAFDNPViLIVGGDDKGADFSPLAPAAAGKVKA------VLAIGEDAAKIAPLLKEAGLS--VYLVESLE 389
|
330
....*....|....*...
gi 1679660759 419 DLLQAVKENASKGDLILF 436
Cdd:TIGR01087 390 EAVQAAREVASPGDVVLL 407
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
27-344 |
1.90e-23 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 103.63 E-value: 1.90e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 27 IHGVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDR-SEPNPPENHA-VILVDDTLTALQQLAKAYLQEL 104
Cdd:PRK11929 29 TADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAeGEDQVAAADAlVLPVADLRKALGELAARWYGRP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 105 GT--RVIGVTGSNGKTTTKDMIHAVL---GTQYRVHKT-GGNFNNH-IGLPLTVL----------AMPENTEIAVLeMGM 167
Cdd:PRK11929 109 SEqlSLVAVTGTNGKTSCAQLLAQLLtrlGKPCGSIGTlGARLDGRlIPGSLTTPdaiilhrilaRMRAAGADAVA-MEA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 168 SAKGeIDlLSRLANP--DAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEQLLQN---AYSCQTKTYG 242
Cdd:PRK11929 188 SSHG-LE-QGRLDGLriAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARllaALPRGLKVGY 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 243 TGAHN--DYQLQDVSQSEEGTHFTIKGIKN--TFFIPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLEL 318
Cdd:PRK11929 266 SPQNAgaDVQARDLRATAHGQVFTLATPDGsyQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMER 345
|
330 340
....*....|....*....|....*....
gi 1679660759 319 IK---TDSGLSIINDaYNASPTSMKAAIQ 344
Cdd:PRK11929 346 VGptaGAQGPLVVVD-YAHTPDALAKALT 373
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
27-100 |
1.33e-14 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 68.80 E-value: 1.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 27 IHGVATDTRKLEQHQLFIPLKGERFDGHTFVEQAFEAGVAAVLWDRSEPNPPENH--------AVILVDDTLTALQQLAK 98
Cdd:pfam01225 2 IHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNISPDNpeleaakvPGIPVIDRREALAELAA 81
|
..
gi 1679660759 99 AY 100
Cdd:pfam01225 82 AF 83
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
312-393 |
3.63e-12 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 61.98 E-value: 3.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 312 TGMRLELIKTDSGLSIINDaYNASPTSMKAAIQLTESLEGyGKKMLVLGDMlelGDLEETFHKECGAVISPDKiDRVFTY 391
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFP-GRLILVFGGM---GDRDAEFHALLGRLAAALA-DVVILT 74
|
..
gi 1679660759 392 GK 393
Cdd:pfam02875 75 GD 76
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
108-451 |
5.35e-12 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 67.30 E-value: 5.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 108 VIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNfnnhIGLPL--TVLAMPENTeIAVLEMgmsAKGEIDLLSRLAnPDAA 185
Cdd:PRK14106 110 IVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPLidAVEEYGEDD-IIVAEV---SSFQLETIKEFK-PKVG 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 186 VITNIGESHMQDLGSREGIAEAKLEI-INGLKED-GVL------------------IYIGDEQLLQNayscqtktyGTGA 245
Cdd:PRK14106 181 CILNITPDHLDRHKTMENYIKAKARIfENQRPSDyTVLnyddprtrslakkakarvIFFSRKSLLEE---------GVFV 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 246 HNDyqlQDVSQSEEGTHFTIKgiKNTFFIPilGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLELIKTDSGL 325
Cdd:PRK14106 252 KNG---KIVISLGGKEEEVID--IDEIFIP--GEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGV 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 326 SIINDAYNASPtsmKAAIQLTESLE--------GYGKKmlvlgdmLELGDLEETFHKecgavispdKIDRVFTYGKLGAF 397
Cdd:PRK14106 325 KFINDSKGTNP---DAAIKALEAYEtpivliagGYDKG-------SDFDEFAKAFKE---------KVKKLILLGETAQE 385
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1679660759 398 IAEGAlkhfEKDRVSHYTEKKDLLQAVK---ENASKGDLIL----------FKA--SRGMKLEEIVKDL 451
Cdd:PRK14106 386 IAEAA----RKYGFDNILFAETLEEAVKkayEIAKPGDVVLlspacaswdmFKNfeERGRLFKELVLEL 450
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
103-435 |
2.33e-10 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 62.04 E-value: 2.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 103 ELGTRVIGVTGSNGKTTTKDMIHAVLGTQ-YRVH--------------KTGGN----------------FNNHIGLP--- 148
Cdd:COG0285 37 QRKLPVIHVAGTNGKGSTAAMLESILRAAgYRVGlytsphlvrfneriRINGEpisdeelvealeevepAVEEVDAGppt 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 149 ----LTVLAM----PENTEIAVLEMGMSakGEIDllsrlA----NPDAAVITNIGESHMQDLGS-REGIAEAKLEIIngl 215
Cdd:COG0285 117 ffevTTAAAFlyfaEAPVDVAVLEVGLG--GRLD-----AtnviDPLVSVITSIGLDHTDFLGDtLEEIAREKAGII--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 216 KEdGVLIYIGDEQ------LLQNAYSCQTKTYGTGAhnDYQLQDvsqsEEGTHFTIKGIK---NTFFIPILGKHNVMNAM 286
Cdd:COG0285 187 KP-GVPVVTGDQQpealevIEERAAELGAPLYRAGR--DFSVEE----REGAVFSYQGPGgeyEDLPLPLLGAHQAENAA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 287 A-----AIAAGAYFGITPEGAAKGLSGLKVTGmRLELIKTdsGLSIIND-AYNasPTSMKAAIQLTESLEGYGKKMLVLG 360
Cdd:COG0285 260 LalaalEALRELGLPISEEAIREGLANARWPG-RLEVLSR--GPLVILDgAHN--PAGARALAETLKELFPFRKLHLVFG 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 361 --------DMLE-LGDLEETFHkecgaVISPDkIDRVFTYGKLGAFIAEgalkhfEKDRVSHYTEKKDLLQAVKENASKG 431
Cdd:COG0285 335 mladkdieGMLAaLAPLADEVI-----VTTPP-SPRALDAEELAEAARE------LGLRVEVAPDVEEALEAALELADPD 402
|
....
gi 1679660759 432 DLIL 435
Cdd:COG0285 403 DLIL 406
|
|
| folC |
TIGR01499 |
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of ... |
98-435 |
3.15e-10 |
|
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273659 [Multi-domain] Cd Length: 397 Bit Score: 61.53 E-value: 3.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 98 KAYLQELGT-----RVIGVTGSNGKTTTKDMIHAVLGTQ-YRVH-------------------------------KTGGN 140
Cdd:TIGR01499 5 KKLLEALGNpqdlyPVIHVAGTNGKGSTCAFLESILRAAgYKVGlftsphlvsfneriringepisdeelaqafeQVRPI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 141 FNNHIGLP-----LTVLAM----PENTEIAVLEMGMSakGEIDLLSrLANPDAAVITNIGESHMQDLG-SREGIAEAKLE 210
Cdd:TIGR01499 85 LESLSQQPtyfelLTLLAFlyfaQAQVDVAVLEVGLG--GRLDATN-VIEPLVSVITSIGLDHTEILGdTLEEIAWEKAG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 211 IInglKEdGVLIYIGDEQ------LLQNAYSCQTKTYGTGAHNDYQLQD-VSQSEEGTHFTIKGIKntffIPILGKHNVM 283
Cdd:TIGR01499 162 II---KE-GVPIVTGEQEpealnvLKKKAQEKGAPLFVVGRDFNYSETDeNYLSFSGANLFLEPLA----LSLLGDHQQE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 284 NAMAAIAAGAYFG-----ITPEGAAKGLSGLKVTGmRLELIKTDSGLSIINDAYNasPTSMKAAIQLTESLEGYGKKMLV 358
Cdd:TIGR01499 234 NAALALAALEVLGkqnpkLSEEAIRQGLANTIWPG-RLEILSEDNPNILLDGAHN--PHSAEALAEWFKKRFNGRPITLL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 359 LGdMLELGDLEETFhkecgAVISPDKIDRVFTYGKLG--AFIAEGALKHFEKdrvSHYTEKKDLLQAVKE--NASKGDLI 434
Cdd:TIGR01499 311 FG-ALADKDAAAML-----APLKPVVDKEVFVTPFDYprADDAADLAAFAEE---TGKSTVEDWREALEEalNASAEDDI 381
|
.
gi 1679660759 435 L 435
Cdd:TIGR01499 382 L 382
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
7-449 |
1.28e-09 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 60.05 E-value: 1.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 7 KNIAEMVNGTLTNPQYEQTVIHGVATDTRKLEQHQLFIpLKGERFDgHTFVEQAFEAGVAAVLwdrSEPNPPENHAVILV 86
Cdd:PRK14022 14 HNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFF-AKGAYFK-HKFLQNAITQGLKLYV---SEKDYEVGIPQVIV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 87 DDTLTALQQLAKAYLQ----ELGTrvIGVTGSNGKTTTKDMIHAVL-------------GTQYRVHKTGGNFNNHIGLPL 149
Cdd:PRK14022 89 PDIKKAMSLIAMEFYDnpqhKLKL--LAFTGTKGKTTAAYFAYHILkqlhkpamlstmnTTLDGETFFKSALTTPESLDL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 150 TVLaMPENTEIAVLEMGMSAKGEIDLLSRLANP--DAAVITNIGESH--------MQDLG--SREGIAEAKLEIINGLKE 217
Cdd:PRK14022 167 FKM-MAEAVDNGMTHLIMEVSSQAYLVGRVYGLtfDVGVFLNITPDHigpiehptFEDYFyhKRLLMENSKAVVVNSDMD 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 218 DGvliyigdEQLLQNAYSCQTKTYGTGAHNdyqlqDVSQSEEGTHFTIKGIKNTFFIPILGKHNVMNAMAAIAAGAYFGI 297
Cdd:PRK14022 246 HF-------SELLEQVTPQEHDFYGIDSEN-----QIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 298 TPEGAAKGLSGLKVTGmRLELIKTDSGLSIINDaYNASPTSMKAAIQLTESLEGyGKKMLVLGdmlELGDLEETFHKECG 377
Cdd:PRK14022 314 SLEDIQKGIAQTPVPG-RMEVLTQSNGAKVFID-YAHNGDSLNKLIDVVEEHQK-GKLILLLG---AAGNKGESRRPDFG 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 378 AVISP-DKIDRVFTYG--------KLGAFIAEGALKHFEK--DRvshyteKKDLLQAVKENASKGDLILFkASRGMKLEE 446
Cdd:PRK14022 388 RVANRhPYLQVILTADdpnnedpkMITQEIASHITHPVEIidDR------AEAIKHAMSITEGPGDAVII-AGKGADAYQ 460
|
...
gi 1679660759 447 IVK 449
Cdd:PRK14022 461 IVP 463
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
109-317 |
1.60e-08 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 57.13 E-value: 1.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 109 IGVTGSNGKTTTKDMIHAVLGTQYR--VHKTGG----NFNNHIGlpltvlampeNTEIAVLEMGMSaKGEIdllsRLANP 182
Cdd:PRK14573 107 ILVSGSHGKTTVSSLITAIFQEAKKdpSYAIGGlnqeGLNGYSG----------SSEYFVAEADES-DGSL----KHYTP 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 183 DAAVITNIGESHMQDL-GSREGIAEAKLEIINGLKEDGVLIYIGDEQLLQnaySC-QTKTYGTGAhnDYQLQDVSQSEEG 260
Cdd:PRK14573 172 EFSVITNIDNEHLSNFeGDRELLLASIQDFARKVQQINKCFYNGDCPRLK---GClQGHSYGFSS--SCDLHILSYYQEG 246
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1679660759 261 --THFTIKGIKNTFF---IPILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLKVTGMRLE 317
Cdd:PRK14573 247 wrSYFSAKFLGVVYQdieLNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLE 308
|
|
| PLN02913 |
PLN02913 |
dihydrofolate synthetase |
156-212 |
2.58e-05 |
|
dihydrofolate synthetase
Pssm-ID: 178501 [Multi-domain] Cd Length: 510 Bit Score: 46.35 E-value: 2.58e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1679660759 156 ENTEIAVLEMGMS-AKGEIDLL--SRLAnpdAAVITNIGESHMQDL-GSREGIAEAKLEII 212
Cdd:PLN02913 172 ENVDIAVIEAGLGgARDATNVIdsSGLA---ASVITTIGEEHLAALgGSLESIALAKSGII 229
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
103-435 |
4.76e-05 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 45.39 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 103 ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRV-HKTGGNFNNHIGL--------PLTVLAMPENTEIAVLEMGMSAKGEI 173
Cdd:NF033197 89 RIPKKFIEITGVKGKTTTAELLAHILSDEYVLlHTSRGTERYPEGElsnkgsitPASILNALELAEEIGIDDYGFLIFEV 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 174 DL-LSRLAnpDAAVITNIGESHMQDLGSREGIAeAKLEIINGLKEDGVLIyigdeqllqnaysCQTKTYgtGAHNDYQLQ 252
Cdd:NF033197 169 SLgGTGAG--DVGIITNILEDYPIAGGKRSASA-AKLQSLKNAKVGSINV-------------ADLGIY--INGKNKLVI 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 253 DVSQSE---EGTHFTIKGIKNTFFIP-ILGKHNVMNAMAAIAAGAYFGITPEGAAKGLSGLK-VTGMrlELIKTDSGLSI 327
Cdd:NF033197 231 TVAGVEilsKYPLRFKYGNTEFEFNPlLFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKgLPGR--MAVKKEGGVVI 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 328 INdayNASP-TSMKAAIQ-LTESLEGYGKKMLVLGdmlelGDL----EETFHKECGAVIS---PDKIDRVFTYGKLGAFI 398
Cdd:NF033197 309 VD---NINPgLNVKAIEYaLDDALELLGDGTLVIG-----GDFgvvcEEIDIDKLSEVLKkyrPKIDILVGVGTELGKRL 380
|
330 340 350
....*....|....*....|....*....|....*..
gi 1679660759 399 AEGALKHFEkdrVSHYTEKKDLLQAvKENASKGDLIL 435
Cdd:NF033197 381 KKYLDKLEG---YEAGTLEEGLDDA-RELTGEGNTLV 413
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
108-307 |
2.24e-03 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 40.52 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 108 VIGVTGSNGKTTTKDMI-HAVLGTQYRV--HKTGGNF--NNHI------GlPL---TVLAMPEnTEIAVLEmgmSAKGEI 173
Cdd:PRK14016 482 IVAVTGTNGKTTTTRLIaHILKLSGKRVgmTTTDGVYidGRLIdkgdctG-PKsarRVLMNPD-VEAAVLE---TARGGI 556
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660759 174 dLLSRLA--NPDAAVITNIGESH--MQDLGSREGIAEAKLEIINGLKEDGVLIY-IGDEQLLQNAYSCQTKT--YGTGAH 246
Cdd:PRK14016 557 -LREGLAydRCDVGVVTNIGEDHlgLGGINTLEDLAKVKRVVVEAVKPDGYAVLnADDPMVAAMAERCKGKVifFSMDPD 635
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1679660759 247 NDYQLQDVSQSE-----EGTHFTIKgiKNTFFIPIL----------GK--HNVMNAMAAIAAGAYFGITPEGAAKGLS 307
Cdd:PRK14016 636 NPVIAEHRAQGGravyvEGDYIVLA--EGGWEIRIIsladipltlgGKagFNIENALAAIAAAWALGIDIELIRAGLR 711
|
|
| |
