NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1679660774|gb|QCY76983|]
View 

sensor histidine kinase [Bacillus subtilis]

Protein Classification

ATP-binding protein( domain architecture ID 10647717)

ATP-binding protein with a histidine kinase-like ATPase domain

Gene Ontology:  GO:0005524
PubMed:  10637609|10339418

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 302-404 3.29e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


:

Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 96.18  E-value: 3.29e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774  302 IINNLTANAVEAMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTE 381
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVEL 87

                           90       100
                   ....*....|....*....|....
gi 1679660774  382 LEGDITFDNQQ-RGVVFAIRLPVR 404
Cdd:smart00387  88 HGGEISVESEPgGGTTFTITLPLE 111
 
Name Accession Description Interval E-value
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 302-404 3.29e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 96.18  E-value: 3.29e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774  302 IINNLTANAVEAMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTE 381
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVEL 87

                           90       100
                   ....*....|....*....|....
gi 1679660774  382 LEGDITFDNQQ-RGVVFAIRLPVR 404
Cdd:smart00387  88 HGGEISVESEPgGGTTFTITLPLE 111
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
260-404 1.11e-23

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 100.75  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 260 SDLLQLVIRMNEKYAEAlgKQIDFycSIEGEHDEYHVFI----VLSIINNLTANAVEAMDEEGMVSLRLRkPNESMVEFQ 335
Cdd:COG0642   185 AELLEEVVELFRPLAEE--KGIEL--ELDLPDDLPTVRGdpdrLRQVLLNLLSNAIKYTPEGGTVTVSVR-REGDRVRIS 259

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 336 VEDNGPGISEKIGDIVFDPGFTSKyDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ-RGVVFAIRLPVR 404
Cdd:COG0642   260 VEDTGPGIPPEDLERIFEPFFRTD-PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPgKGTTFTVTLPLA 328
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 302-405 1.50e-17

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 77.79  E-value: 1.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRLRKPNEsmVEFQVEDNGPGISEKIGDIVFDPGFTSkyDEFGTPSTGIGLSYVKEIVTE 381
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLSEGGE--LTLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLGLSIVRKLVEL 84

                          90       100
                  ....*....|....*....|....*
gi 1679660774 382 LEGDITFDNQ-QRGVVFAIRLPVRH 405
Cdd:pfam02518  85 LGGTITVESEpGGGTTVTLTLPLAQ 109
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
305-405 1.84e-15

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 78.09  E-value: 1.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLRKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKydefgtPS-TGIGLSYVKEIVTELE 383
Cdd:PRK11360  507 NILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTK------AKgTGLGLALSQRIINAHG 580

                          90       100
                  ....*....|....*....|...
gi 1679660774 384 GDITFDNQ-QRGVVFAIRLPVRH 405
Cdd:PRK11360  581 GDIEVESEpGVGTTFTLYLPINP 603
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 299-402 3.13e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 71.16  E-value: 3.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 299 VLSIINNLTANAVEAM----DEEGMVSLRLRKPNESmVEFQVEDNGPGISEKIGDIVFDPGFTSKydefGTPSTGIGLSY 374
Cdd:cd16915     1 LITIVGNLIDNALDALaatgAPNKQVEVFLRDEGDD-LVIEVRDTGPGIAPELRDKVFERGVSTK----GQGERGIGLAL 75

                          90       100
                  ....*....|....*....|....*....
gi 1679660774 375 VKEIVTELEGDITFDNQQR-GVVFAIRLP 402
Cdd:cd16915    76 VRQSVERLGGSITVESEPGgGTTFSIRIP 104
 
Name Accession Description Interval E-value
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 302-404 3.29e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 96.18  E-value: 3.29e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774  302 IINNLTANAVEAMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTE 381
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVEL 87

                           90       100
                   ....*....|....*....|....
gi 1679660774  382 LEGDITFDNQQ-RGVVFAIRLPVR 404
Cdd:smart00387  88 HGGEISVESEPgGGTTFTITLPLE 111
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
260-404 1.11e-23

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 100.75  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 260 SDLLQLVIRMNEKYAEAlgKQIDFycSIEGEHDEYHVFI----VLSIINNLTANAVEAMDEEGMVSLRLRkPNESMVEFQ 335
Cdd:COG0642   185 AELLEEVVELFRPLAEE--KGIEL--ELDLPDDLPTVRGdpdrLRQVLLNLLSNAIKYTPEGGTVTVSVR-REGDRVRIS 259

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 336 VEDNGPGISEKIGDIVFDPGFTSKyDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ-RGVVFAIRLPVR 404
Cdd:COG0642   260 VEDTGPGIPPEDLERIFEPFFRTD-PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPgKGTTFTVTLPLA 328
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
260-404 1.34e-22

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 95.74  E-value: 1.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 260 SDLLQLVIRMNEKYAEALGKQIDFYCSIEG---EHDEYHVFIVLSiinNLTANAVEAMDEEGMVSLRLRKpNESMVEFQV 336
Cdd:COG2205    94 AELLEEAVEELRPLAEEKGIRLELDLPPELplvYADPELLEQVLA---NLLDNAIKYSPPGGTITISARR-EGDGVRISV 169

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1679660774 337 EDNGPGISEKIGDIVFDPGFTSKYDEfGTPSTGIGLSYVKEIVTELEGDITFDNQ-QRGVVFAIRLPVR 404
Cdd:COG2205   170 SDNGPGIPEEELERIFERFYRGDNSR-GEGGTGLGLAIVKRIVEAHGGTIWVESEpGGGTTFTVTLPLA 237
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 223-404 5.71e-22

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 96.84  E-value: 5.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 223 ILRLAGEIHEVKK--DNQRIF-----------AGLSKLISNESLRDYMRA-SDLLQLVIR--------------MNEKYA 274
Cdd:COG3290   176 LERLEEELEGVKElaEALRAQrhdfrnhlhtiSGLLQLGEYDEALEYIDEiSEELQELIDsllsrignpvlaalLLGKAA 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 275 EALGKQIDFYCSIEGEHDEYHV--FIVLSIINNLTANAVEAM----DEEGMVSLRLRKpNESMVEFQVEDNGPGISEKIG 348
Cdd:COG3290   256 RARERGIDLTIDIDSDLPDLPLsdTDLVTILGNLLDNAIEAVeklpEEERRVELSIRD-DGDELVIEVEDSGPGIPEELL 334

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1679660774 349 DIVFDPGFTSKYDEfgtpSTGIGLSYVKEIVTELEGDITF-DNQQRGVVFAIRLPVR 404
Cdd:COG3290   335 EKIFERGFSTKLGE----GRGLGLALVKQIVEKYGGTIEVeSEEGEGTVFTVRLPKE 387
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 217-405 8.46e-22

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 96.57  E-value: 8.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 217 VQLSGRILR--LAGEIHEVKKDNQRIFA-------GLSKLISNesLRDY-------MRASDLLQLVIRMNEKYAEAL-GK 279
Cdd:COG5000   219 IQLSAERLRrkLADKLEEDREDLERALDtiirqvdRLKRIVDE--FLDFarlpepqLEPVDLNELLREVLALYEPALkEK 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 280 QIDFYCSIEGEH-----DEYHVFIVLsiiNNLTANAVEAMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKIGDIVFDP 354
Cdd:COG5000   297 DIRLELDLDPDLpevlaDRDQLEQVL---INLLKNAIEAIEEGGEIEVSTRR-EDGRVRIEVSDNGPGIPEEVLERIFEP 372

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1679660774 355 GFTSKydEFGtpsTGIGLSYVKEIVTELEGDITFDNQQ-RGVVFAIRLPVRH 405
Cdd:COG5000   373 FFTTK--PKG---TGLGLAIVKKIVEEHGGTIELESRPgGGTTFTIRLPLAE 419
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 302-403 1.84e-21

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 94.87  E-value: 1.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDE--EGMVSLRLRKPNEsMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGtpsTGIGLSYVKEIV 379
Cdd:COG4191   260 VLLNLLINAIDAMEEgeGGRITISTRREGD-YVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKG---TGLGLSISYGIV 335

                          90       100
                  ....*....|....*....|....*
gi 1679660774 380 TELEGDITFDNQQ-RGVVFAIRLPV 403
Cdd:COG4191   336 EKHGGRIEVESEPgGGTTFTITLPL 360
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
305-405 4.18e-20

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 90.68  E-value: 4.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLR---------KPNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKydEFGtpsTGIGLSYV 375
Cdd:COG3852   251 NLVRNAAEAMPEGGTITIRTRverqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTK--EKG---TGLGLAIV 325

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1679660774 376 KEIVTELEGDITFDNQQ-RGVVFAIRLPVRH 405
Cdd:COG3852   326 QKIVEQHGGTIEVESEPgKGTTFRIYLPLEQ 356
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 302-405 1.50e-17

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 77.79  E-value: 1.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRLRKPNEsmVEFQVEDNGPGISEKIGDIVFDPGFTSkyDEFGTPSTGIGLSYVKEIVTE 381
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLSEGGE--LTLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLGLSIVRKLVEL 84

                          90       100
                  ....*....|....*....|....*
gi 1679660774 382 LEGDITFDNQ-QRGVVFAIRLPVRH 405
Cdd:pfam02518  85 LGGTITVESEpGGGTTVTLTLPLAQ 109
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
260-405 1.62e-16

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 80.75  E-value: 1.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 260 SDLLQLVIRMNEKYAEAlgKQIDFycSIEGEHDEYHVFI----VLSIINNLTANAVEAMDEEGMVSLRLRKpNESMVEFQ 335
Cdd:COG5002   243 AELLEEVVEELRPLAEE--KGIEL--ELDLPEDPLLVLGdpdrLEQVLTNLLDNAIKYTPEGGTITVSLRE-EDDQVRIS 317

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1679660774 336 VEDNGPGISEKIGDIVFDPGF-TSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ-RGVVFAIRLPVRH 405
Cdd:COG5002   318 VRDTGIGIPEEDLPRIFERFYrVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPgKGTTFTITLPLAR 389
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 274-404 1.99e-16

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 80.79  E-value: 1.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 274 AEALGKQIDFYCSIEGEH-----DEYH---VFIvlsiinNLTANAVEAMDEEGMVSLRLRKPNESMVEFQVEDNGPGISE 345
Cdd:COG5809   353 PQALLKNVQIELELEDDIpdilgDENQlkqVFI------NLLKNAIEAMPEGGNITIETKAEDDDKVVISVTDEGCGIPE 426

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 346 KIGDIVFDPGFTSKydEFGtpsTGIGLSYVKEIVTELEGDITFDNQ-QRGVVFAIRLPVR 404
Cdd:COG5809   427 ERLKKLGEPFYTTK--EKG---TGLGLMVSYKIIEEHGGKITVESEvGKGTTFSITLPIK 481
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
305-405 1.84e-15

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 78.09  E-value: 1.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLRKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKydefgtPS-TGIGLSYVKEIVTELE 383
Cdd:PRK11360  507 NILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTK------AKgTGLGLALSQRIINAHG 580

                          90       100
                  ....*....|....*....|...
gi 1679660774 384 GDITFDNQ-QRGVVFAIRLPVRH 405
Cdd:PRK11360  581 GDIEVESEpGVGTTFTLYLPINP 603
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 299-402 3.13e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 71.16  E-value: 3.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 299 VLSIINNLTANAVEAM----DEEGMVSLRLRKPNESmVEFQVEDNGPGISEKIGDIVFDPGFTSKydefGTPSTGIGLSY 374
Cdd:cd16915     1 LITIVGNLIDNALDALaatgAPNKQVEVFLRDEGDD-LVIEVRDTGPGIAPELRDKVFERGVSTK----GQGERGIGLAL 75

                          90       100
                  ....*....|....*....|....*....
gi 1679660774 375 VKEIVTELEGDITFDNQQR-GVVFAIRLP 402
Cdd:cd16915    76 VRQSVERLGGSITVESEPGgGTTFSIRIP 104
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
302-405 2.07e-13

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 72.02  E-value: 2.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRL-----RKPNE---------SMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDefgtpS 367
Cdd:PRK13837  564 VLMNLCSNAAQAMDGAGRVDISLsraklRAPKVlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAG-----G 638

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1679660774 368 TGIGLSYVKEIVTELEGDITFDNQ-QRGVVFAIRLPVRH 405
Cdd:PRK13837  639 TGLGLATVHGIVSAHAGYIDVQSTvGRGTRFDVYLPPSS 677
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-403 6.88e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 64.37  E-value: 6.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLRKPNESmVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGtpsTGIGLSYVKEIVTELEG 384
Cdd:cd16943    10 NLLVNAAQAMEGRGRITIRTWAHVDQ-VLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEG---TGLGLSLSYRIIQKHGG 85

                          90       100
                  ....*....|....*....|
gi 1679660774 385 DITFDNQQ-RGVVFAIRLPV 403
Cdd:cd16943    86 TIRVASVPgGGTRFTIILPI 105
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-402 1.14e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 63.96  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEE-GMVSLR--------LRKPNESMV-EFQVEDNGPGISEKIGDIVFDPGFTSKYDefgtpSTGIGLSY 374
Cdd:cd16918     7 NLVRNAAQALAGSgGEIILRtrtqrqvtLGHPRHRLAlRVSVIDNGPGIPPDLQDTIFYPMVSGREN-----GTGLGLAI 81

                          90       100
                  ....*....|....*....|....*...
gi 1679660774 375 VKEIVTELEGDITFDNQQRGVVFAIRLP 402
Cdd:cd16918    82 AQNIVSQHGGVIECDSQPGHTVFSVSLP 109
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-402 2.18e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 63.18  E-value: 2.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMD----EEGMVSLRLRKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDefgtpSTGIGLSYVKE 377
Cdd:cd16920     4 VLINLVRNGIEAMSeggcERRELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE-----GLGMGLSICRS 78

                          90       100
                  ....*....|....*....|....*.
gi 1679660774 378 IVTELEGDITFD-NQQRGVVFAIRLP 402
Cdd:cd16920    79 IIEAHGGRLSVEsPAGGGATFQFTLP 104
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 297-401 3.18e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 62.48  E-value: 3.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 297 FIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESmVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVK 376
Cdd:cd16945     3 FLLRQAINNLLDNAIDFSPEGGLIALQLEADTEG-IELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFVQ 81

                          90       100
                  ....*....|....*....|....*
gi 1679660774 377 EIVTELEGDITFDNQQRGVVFAIRL 401
Cdd:cd16945    82 EVAQLHGGRITLRNRPDGVLAFLTL 106
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 285-403 3.40e-12

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 67.83  E-value: 3.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 285 CSIEGEHDEYHVFIVLS------IINNLTANAVEAMDEEGMVSLRLrKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTS 358
Cdd:COG5805   376 IQIRLELLDEDPFIYCDenqikqVFINLIKNAIEAMPNGGTITIHT-EEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTT 454

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1679660774 359 KydEFGtpsTGIGLSYVKEIVTELEGDITFD-NQQRGVVFAIRLPV 403
Cdd:COG5805   455 K--EKG---TGLGLMVSYKIIENHNGTIDIDsKVGKGTTFTITLPL 495
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 292-402 3.76e-11

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 64.55  E-value: 3.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 292 DEYHVFIVLSIINNLTANAVEAMD--EEGMVSLRLRKPNESMvEFQVEDNGPGISEKIGDIVFDPGFTSKYDEfgtpsTG 369
Cdd:PRK11086  427 DEDQVHELITILGNLIENALEAVGgeEGGEISVSLHYRNGWL-HCEVSDDGPGIAPDEIDAIFDKGYSTKGSN-----RG 500

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1679660774 370 IGLSYVKEIVTELEGDITFDNQQ-RGVVFAIRLP 402
Cdd:PRK11086  501 VGLYLVKQSVENLGGSIAVESEPgVGTQFFVQIP 534
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
258-403 4.34e-11

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 64.42  E-value: 4.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 258 RASDLLQLVIRMNEKYAEALGKQIDFYCS-----IEGEHDEyhvfiVLSIINNLTANAVEAMDEEGMVSLRLRKPNESmV 332
Cdd:PRK10364  308 DLNDLINHSLQLVSQDANSREIQLRFTANdtlpeIQADPDR-----LTQVLLNLYLNAIQAIGQHGVISVTASESGAG-V 381

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1679660774 333 EFQVEDNGPGISEKIGDIVFDPGFTSKYDefgtpSTGIGLSYVKEIVTELEGDITFDNQQ-RGVVFAIRLPV 403
Cdd:PRK10364  382 KISVTDSGKGIAADQLEAIFTPYFTTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEgKGATFTLWLPV 448
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 302-403 7.59e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 58.66  E-value: 7.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEaMDEEGMVSLRLRK----PNESMVEFQVEDNGPGISEKIGDIVFDP------GFTSKYDefGtpsTGIG 371
Cdd:cd16922     4 ILLNLLGNAIK-FTEEGEVTLRVSLeeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPfsqadsSTTRKYG--G---TGLG 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1679660774 372 LSYVKEIVTELEGDITFDNQQ-RGVVFAIRLPV 403
Cdd:cd16922    78 LAISKKLVELMGGDISVESEPgQGSTFTFTLPL 110
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-382 8.60e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 58.45  E-value: 8.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKigDI--VFDPGFTSKYDEFGTPSTGIGLSYVKEIV 379
Cdd:cd16948     9 IIGQIVSNALKYSKQGGKIEIYSET-NEQGVVLSIKDFGIGIPEE--DLprVFDKGFTGENGRNFQESTGMGLYLVKKLC 85


                  ...
gi 1679660774 380 TEL 382
Cdd:cd16948    86 DKL 88
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 305-405 2.54e-10

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 62.11  E-value: 2.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLR-KPNESMVEFQVEDNGPGISEKIGDIVFDPgFT--SKYDEFgtPSTGIGLSYVKEIVTE 381
Cdd:COG4251   401 NLISNAIKYSRPGEPPRIEIGaEREGGEWVFSVRDNGIGIDPEYAEKIFEI-FQrlHSRDEY--EGTGIGLAIVKKIVER 477

                          90       100
                  ....*....|....*....|....*
gi 1679660774 382 LEGDITFDNQQ-RGVVFAIRLPVRH 405
Cdd:COG4251   478 HGGRIWVESEPgEGATFYFTLPKAP 502
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 299-401 2.67e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 57.08  E-value: 2.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 299 VLSIINNLTANAVEAMD--EEGMVSLRLRKPNESMVeFQVEDNGPGISEKIGDIVFDPGFTSKydEFGTpSTGIGLSYVK 376
Cdd:cd16976     1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLV-LVVRDNGPGIAEEHLSRVFDPFFTTK--PVGK-GTGLGLSISY 76

                          90       100
                  ....*....|....*....|....*.
gi 1679660774 377 EIVTELEGDITFDNQQR-GVVFAIRL 401
Cdd:cd16976    77 GIVEEHGGRLSVANEEGaGARFTFDL 102
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 260-404 3.79e-10

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 61.40  E-value: 3.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 260 SDLLQLVirMNEKYAEALGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESmVEFQVEDN 339
Cdd:PRK11100  332 AALLEEL--VEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQ-VALSVEDQ 408

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1679660774 340 GPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQRGVVFA-IRLPVR 404
Cdd:PRK11100  409 GPGIPDYALPRIFERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLAtLTLPRH 474
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 302-402 8.38e-09

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 52.88  E-value: 8.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRLRKPNESMVEFQVEDNGPGISEKIGDIVFD---PGFTSKYDEFGtpSTGIGLSYVKEI 378
Cdd:cd16925     8 VVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFErfrQGDGSSTRAHG--GTGLGLSIVKEF 85

                          90       100
                  ....*....|....*....|....*
gi 1679660774 379 VTELEGDITFDNQQ-RGVVFAIRLP 402
Cdd:cd16925    86 VELHGGTVTVSDAPgGGALFQVELP 110
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 260-394 1.13e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 53.40  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 260 SDLLQLVIRMNEKYAEalgKQIDFYCSIegehDEYHVFIV-----LSIINNLTANAVEAMDEEGMVSLRlrkPNESMVEF 334
Cdd:cd16954     1 PLLDSLCSALNKVYQR---KGVSISLDI----SPELRFPGerndlMELLGNLLDNACKWCLEFVEVTAR---QTDGGLHL 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 335 QVEDNGPGISEKIGDIVFDPGftSKYDEFgTPSTGIGLSYVKEIVTELEGDITFDNQQRG 394
Cdd:cd16954    71 IVDDDGPGVPESQRSKIFQRG--QRLDEQ-RPGQGLGLAIAKEIVEQYGGELSLSDSPLG 127
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 334-402 1.25e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 52.45  E-value: 1.25e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 334 FQVEDNGPGISEKIGDIVFDPgFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQRGVVFA-IRLP 402
Cdd:cd16950    33 IQVLDNGPGIAPEEVDELFQP-FYRGDNARGTSGTGLGLAIVQRISDAHGGSLTLANRAGGGLCArIELP 101
glnL PRK11073
nitrogen regulation protein NR(II);
305-404 1.54e-08

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 55.86  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEE-GMVSLRLRKPNESMV---------EFQVEDNGPGISEKIGDIVFDPGFTSKydEFGtpsTGIGLSY 374
Cdd:PRK11073  244 NIVRNALQALGPEgGTITLRTRTAFQLTLhgeryrlaaRIDIEDNGPGIPPHLQDTLFYPMVSGR--EGG---TGLGLSI 318

                          90       100       110
                  ....*....|....*....|....*....|
gi 1679660774 375 VKEIVTELEGDITFDNQQRGVVFAIRLPVR 404
Cdd:PRK11073  319 ARNLIDQHSGKIEFTSWPGHTEFSVYLPIR 348
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 305-402 4.17e-08

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 51.23  E-value: 4.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLRK--------------PNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKydEFGTpSTGI 370
Cdd:cd16919     7 NLAVNARDAMPEGGRLTIETSNqrvdadyalnyrdlIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTK--EVGK-GTGL 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1679660774 371 GLSYVKEIVTELEGDITFDNQQ-RGVVFAIRLP 402
Cdd:cd16919    84 GLSMVYGFVKQSGGHLRIYSEPgVGTTVRIYLP 116
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-402 5.70e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 50.65  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVE-AMDEEGMVSLRlRKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTS--KYDEFGTPStGIGLSYVKEI 378
Cdd:cd16953     4 VLRNLIGNAISfSPPDTGRITVS-AMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTErpANEAFGQHS-GLGLSISRQI 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1679660774 379 VtELEGDITFDN------QQRGVVFAIRLP 402
Cdd:cd16953    82 I-EAHGGISVAEnhnqpgQVIGARFTVQLP 110
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 302-406 1.96e-07

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 52.99  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVE---AMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKigdivFDPgftskydefgTPSTGIGLSYVKEI 378
Cdd:COG3920   403 ILNELVTNALKhafLSGEGGRIRVSWRR-EDGRLRLTVSDNGVGLPED-----VDP----------PARKGLGLRLIRAL 466

                          90       100
                  ....*....|....*....|....*...
gi 1679660774 379 VTELEGDITFDNQQrGVVFAIRLPVRHL 406
Cdd:COG3920   467 VRQLGGTLELDRPE-GTRVRITFPLAEL 493
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-402 7.78e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 47.53  E-value: 7.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDE----EGMVSLRLRKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKydefgTPSTGIGLSYVKE 377
Cdd:cd16944     8 VLTNILKNAAEAIEGrpsdVGEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYVTTR-----PKGTGLGLAIVKK 82

                          90       100
                  ....*....|....*....|....*.
gi 1679660774 378 IVTELEGDITFDNQQ-RGVVFAIRLP 402
Cdd:cd16944    83 IMEEHGGRISLSNREaGGACIRIILP 108
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 302-403 1.01e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 51.09  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEaMDEEGMVSLRLRKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPS--TGIGLSYVKEIV 379
Cdd:PRK11091  402 ILWNLISNAVK-FTQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtgTGIGLAVSKRLA 480

                          90       100
                  ....*....|....*....|....*
gi 1679660774 380 TELEGDITFDNQQ-RGVVFAIRLPV 403
Cdd:PRK11091  481 QAMGGDITVTSEEgKGSCFTLTIHA 505
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 298-394 1.08e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 47.07  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 298 IVLSIINNLTANAVEAMDEEGMVSLRLrKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKE 377
Cdd:cd16975     4 LLSRALINIISNACQYAPEGGTVSISI-YDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKN 82

                          90
                  ....*....|....*..
gi 1679660774 378 IVTELEGDITFDNQQRG 394
Cdd:cd16975    83 LVEKHGGSLIIENSQKG 99
envZ PRK09467
osmolarity sensor protein; Provisional
 302-403 1.08e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 50.29  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRLrkpNESMVEFQVEDNGPGISEKIGDIVFDPgFTSKYDEFGTPSTGIGLSYVKEIVTE 381
Cdd:PRK09467  335 ALANLVVNAARYGNGWIKVSSGT---EGKRAWFQVEDDGPGIPPEQLKHLFQP-FTRGDSARGSSGTGLGLAIVKRIVDQ 410

                          90       100
                  ....*....|....*....|...
gi 1679660774 382 LEGDITFDNQQRGVVFA-IRLPV 403
Cdd:PRK09467  411 HNGKVELGNSEEGGLSArAWLPL 433
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-401 1.14e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 47.02  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLRkpNESMVEFQVEDNGPGISEKIGDIVFDPGFTSkyDEFGTPSTGIGLSYVKEIVTELEG 384
Cdd:cd16940    20 NLVDNAVRYSPQGSRVEIKLS--ADDGAVIRVEDNGPGIDEEELEALFERFYRS--DGQNYGGSGLGLSIVKRIVELHGG 95

                          90
                  ....*....|....*...
gi 1679660774 385 DITF-DNQQRGVVFAIRL 401
Cdd:cd16940    96 QIFLgNAQGGGLEAWVRL 113
PRK10337 PRK10337
sensor protein QseC; Provisional
 244-394 2.19e-06

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 49.65  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 244 LSKLISNESLRDYMRAS--DLLQ-LVIRMnekYAEALGKQIDFYCSIEGEHDEY--HVFIVLSIINNLTANAVEAMDEEG 318
Cdd:PRK10337  296 LSRLDSLDNLQDVAEIPleDLLQsAVMDI---YHTAQQAGIDVRLTLNAHPVIRtgQPLLLSLLVRNLLDNAIRYSPQGS 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 319 MVSLRLrkpNESmvEFQVEDNGPGIS----EKIGDIVFDPGFTSKydefgtPSTGIGLSYVKEIVTeLEG-DITFDNQQR 393
Cdd:PRK10337  373 VVDVTL---NAR--NFTVRDNGPGVTpealARIGERFYRPPGQEA------TGSGLGLSIVRRIAK-LHGmNVSFGNAPE 440


                  .
gi 1679660774 394 G 394
Cdd:PRK10337  441 G 441
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
260-402 3.90e-06

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 49.20  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 260 SDLLQLVIRmnekyaealgKQIDFYCSIEgeHDeyhVFIVLS--------IINNLTANAVEAMDEeGMVSLRLRKpNESM 331
Cdd:PRK10841  531 ANYLPLVVK----------KRLGLYCFIE--PD---VPVALNgdpmrlqqVISNLLSNAIKFTDT-GCIVLHVRV-DGDY 593

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679660774 332 VEFQVEDNGPGISEKIGDIVFDPGF---TSKYDEFgtPSTGIGLSYVKEIVTELEGDITFDNQ-QRGVVFAIRLP 402
Cdd:PRK10841  594 LSFRVRDTGVGIPAKEVVRLFDPFFqvgTGVQRNF--QGTGLGLAICEKLINMMDGDISVDSEpGMGSQFTIRIP 666
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 268-402 7.97e-06

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 46.04  E-value: 7.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 268 RMNEKYAEALGKQIDFycSIEGEHDEYHVFIVLSIINNLT---ANAV----------EAM--DEEGMVSLRLRKPNeSMV 332
Cdd:cd16916     7 RLVRDLARELGKQVEL--VVEGEDTELDKSVLEKLADPLThllRNAVdhgieapeerLAAgkPPEGTITLRAEHQG-NQV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 333 EFQVEDNGPGI------------------------SEKIGDIVFDPGFTSKyDEFGTPS-TGIGLSYVKEIVTELEGDIT 387
Cdd:cd16916    84 VIEVSDDGRGIdrekirekaierglitadeaatlsDDEVLNLIFAPGFSTA-EQVTDVSgRGVGMDVVKRSIESLGGTIE 162

                         170
                  ....*....|....*.
gi 1679660774 388 FDNQQ-RGVVFAIRLP 402
Cdd:cd16916   163 VESEPgQGTTFTIRLP 178
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 301-404 8.54e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 44.50  E-value: 8.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 301 SIINNLTANAVEAMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKigdivFDPGFTSKY---DEFG---TPSTGIGLSY 374
Cdd:cd16952     3 SAFSNLVSNAVKYTPPSDTITVRWSQ-EESGARLSVEDTGPGIPPE-----HIPRLTERFyrvDIERcrnTGGTGLGLAI 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1679660774 375 VKEIVTELEGDITFDNQ-QRGVVFAIRLPVR 404
Cdd:cd16952    77 VKHVMSRHDARLLIASElGKGSRFTCLFPSS 107
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
238-405 1.78e-05

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 46.55  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 238 QRIFAGLSKLisnesLRDYMRASDLLQLV---IRMNEKYAEA----LGKQIDFYCSIEGEHDEYHV--FIVLSIINNLTA 308
Cdd:COG2972   276 EEMLEALSKL-----LRYSLSKGDELVTLeeeLELIKSYLEIqklrFGDRLEVEIEIDEELLDLLIpkLILQPLVENAIE 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 309 NAVEAMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKydefgtPSTGIGLSYVKEIVTELEGD--- 385
Cdd:COG2972   351 HGIEPKEGGGTIRISIRK-EGDRLVITVEDNGVGMPEEKLEKLLEELSSKG------EGRGIGLRNVRERLKLYYGEeyg 423

                         170       180
                  ....*....|....*....|.
gi 1679660774 386 -ITFDNQQRGVVFAIRLPVRH 405
Cdd:COG2972   424 lEIESEPGEGTTVTIRIPLEE 444
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 302-402 2.12e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 46.77  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEaMDEEGMVSLRLRKP---NESM-VEFQVEDNGPGISEKIGDIVFDPgF----TSKYDEFGtpSTGIGLS 373
Cdd:PRK11107  412 IITNLVGNAIK-FTESGNIDILVELRalsNTKVqLEVQIRDTGIGISERQQSQLFQA-FrqadASISRRHG--GTGLGLV 487

                          90       100       110
                  ....*....|....*....|....*....|
gi 1679660774 374 YVKEIVTELEGDITFDNQ-QRGVVFAIRLP 402
Cdd:PRK11107  488 ITQKLVNEMGGDISFHSQpNRGSTFWFHLP 517
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-401 2.19e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 43.66  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRLRKpNESMVEFQVEDNGPGISEKIGDIVFDPGFT---SKYDEFgtPSTGIGLSYVKEI 378
Cdd:cd16947    24 ILKNLISNAIKYGSDGKFLGMTLRE-DEKHVYIDIWDKGKGISETEKDHVFERLYTledSRNSAK--QGNGLGLTITKRL 100

                          90       100
                  ....*....|....*....|....
gi 1679660774 379 VTELEGDITFDNQ-QRGVVFAIRL 401
Cdd:cd16947   101 AESMGGSIYVNSKpYEKTVFTVTL 124
PRK10490 PRK10490
sensor protein KdpD; Provisional
 296-403 3.00e-05

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 46.18  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 296 VFIvlsiinNLTANAVEAMDEEGMVSLRLRKPNESmVEFQVEDNGPGISEKIGDIVFDPgFTSKYDEFGTPSTGIGLSYV 375
Cdd:PRK10490  782 VLI------NLLENAVKYAGAQAEIGIDAHVEGER-LQLDVWDNGPGIPPGQEQLIFDK-FARGNKESAIPGVGLGLAIC 853

                          90       100
                  ....*....|....*....|....*....
gi 1679660774 376 KEIVTELEGDITFDN-QQRGVVFAIRLPV 403
Cdd:PRK10490  854 RAIVEVHGGTIWAENrPEGGACFRVTLPL 882
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
336-387 5.31e-05

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 45.39  E-value: 5.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1679660774 336 VEDNGPGISEKIGDIVFDPGftSKYDEFgTPSTGIGLSYVKEIVTELEGDIT 387
Cdd:PRK10815  413 VEDDGPGIPESKRELIFDRG--QRADTL-RPGQGLGLSVAREITEQYEGKIS 461
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-403 1.45e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 40.88  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLrkpNESMVEFQVEDNGPGISEKIGDIVFDPgfTSKYDEFGTPST---GIGLSYVKEIVTE 381
Cdd:cd16939     7 NLLRNALRYAHRTVRIALLV---SGGRLTLIVEDDGPGIPAAARERVFEP--FVRLDPSRDRATggfGLGLAIVHRVALW 81

                          90       100
                  ....*....|....*....|...
gi 1679660774 382 LEGDITF-DNQQRGVVFAIRLPV 403
Cdd:cd16939    82 HGGHVECdDSELGGACFRLTWPR 104
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 269-390 1.93e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 41.02  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 269 MNEKYAEALGKQIDFYCSIegeHDEYHVFI----VLSIINNLTANAVEA----MDEEGMVSLRLRKpNESMVEFQVEDNG 340
Cdd:cd16935     6 LSEKLELAREKGIEFTIEI---DIPILLPIspldLCIIFGNLLDNAIEAcakiDKENRFIHLKIRQ-KKGFLIISIENSY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1679660774 341 PGISEKIgdivFDPGFTSKydefGTPSTGIGLSYVKEIVTELEGDITFDN 390
Cdd:cd16935    82 EGELKKK----NGLFLSTK----KDKNHGIGLKSIREIVKKYNGNLSIEY 123
PRK15347 PRK15347
two component system sensor kinase;
302-403 2.52e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 43.48  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEaMDEEGMVSLRLRKPNEsMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGtpsTGIGLSYVKEIVTE 381
Cdd:PRK15347  517 ILVNLLGNAVK-FTETGGIRLRVKRHEQ-QLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQG---TGLGLTIASSLAKM 591

                          90       100
                  ....*....|....*....|...
gi 1679660774 382 LEGDITFDNQ-QRGVVFAIRLPV 403
Cdd:PRK15347  592 MGGELTLFSTpGVGSCFSLVLPL 614
PRK13557 PRK13557
histidine kinase; Provisional
 305-375 2.88e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 43.12  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLRkpNESM----------------VEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGtpsT 368
Cdd:PRK13557  284 NVLINARDAMPEGGRVTIRTR--NVEIededlamyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKG---T 358


                  ....*..
gi 1679660774 369 GIGLSYV 375
Cdd:PRK13557  359 GLGLSMV 365
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-402 5.40e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 39.37  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRLRKPNESmVEFQVEDNGPGISEKIGDIVFDPGF---TSKYDEFGtpSTGIGLSYVKEI 378
Cdd:cd16946     8 LFVNLLENSLRYTDTGGKLRIRAAQTPQE-VRLDVEDSAPGVSDDQLARLFERFYrveSSRNRASG--GSGLGLAICHNI 84

                          90       100
                  ....*....|....*....|....*
gi 1679660774 379 VTELEGDITFDNQQR-GVVFAIRLP 402
Cdd:cd16946    85 ALAHGGTISAEHSPLgGLRLVLTLP 109
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 297-402 8.10e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 38.58  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 297 FIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESmVEFQVEDNGPGISEKIGDIVfdpGFTSKydefgtPSTGIGLSYVK 376
Cdd:cd16924     4 FTLQPLVENAIQHGLSPLTDKGVVTISALKEDNH-VMIEVEDNGRGIDPKVLNIL---GKKPK------EGNGIGLYNVH 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1679660774 377 EIVTELEGD---ITFDNQ-QRGVVFAIRLP 402
Cdd:cd16924    74 QRLILLFGEdygIHIASEpDKGTRITFTIP 103
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-402 8.15e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 38.46  E-value: 8.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRL---RKPNESMveFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGtPSTGIGLSYVKEI 378
Cdd:cd16921     4 VLTNLLGNAIKFRRPRRPPRIEVgaeDVGEEWT--FYVRDNGIGIDPEYAEKVFGIFQRLHSREEY-EGTGVGLAIVRKI 80

                          90       100
                  ....*....|....*....|....*
gi 1679660774 379 VTELEGDITFDNQQ-RGVVFAIRLP 402
Cdd:cd16921    81 IERHGGRIWLESEPgEGTTFYFTLP 105
PRK10604 PRK10604
sensor protein RstB; Provisional
 302-407 1.73e-03

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 40.36  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLRLrkpNESMVEFQVEDNGPGISEKIGDIVFDPgFTsKYDEFGTPST---GIGLSYVKEI 378
Cdd:PRK10604  323 VLDNLLNNALRYAHSRVRVSLLL---DGNQACLIVEDDGPGIPPEERERVFEP-FV-RLDPSRDRATggcGLGLAIVHSI 397

                          90       100       110
                  ....*....|....*....|....*....|
gi 1679660774 379 VTELEGDITFDNQQ-RGVVFAIRLPVRHLI 407
Cdd:PRK10604  398 ALAMGGSVNCDESElGGARFSFSWPVWHNL 427
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 302-405 2.71e-03

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 39.89  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEaMDEEGMVSLRLRKPNESMVeFQVEDNGPGISEKIGDIVFDPgFTSKYDEFGtpSTGIGLSYVKEIVTE 381
Cdd:PRK11466  565 VITNLLSNALR-FTDEGSIVLRSRTDGEQWL-VEVEDSGCGIDPAKLAEIFQP-FVQVSGKRG--GTGLGLTISSRLAQA 639

                          90       100
                  ....*....|....*....|....*
gi 1679660774 382 LEGDITFDNQ-QRGVVFAIRLPVRH 405
Cdd:PRK11466  640 MGGELSATSTpEVGSCFCLRLPLRV 664
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
274-403 3.70e-03

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 39.39  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 274 AEALGKQIDFycSIEGEHDEyhvfivL--SIINNLTA-------NAV----------EAM--DEEGMVSLRLRkPNESMV 332
Cdd:COG0643   252 ARELGKEVEL--VIEGEETE------LdrTVLERLGDplvhlvrNAVdhgietpeerLAAgkPETGTITLSAY-HEGGRV 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 333 EFQVEDNGPGIS-EKI-------G----------------DIVFDPGFtskydefgtpST----------GIGLSYVKEI 378
Cdd:COG0643   323 VIEVSDDGRGLDlEKIrakaiekGlitaeeaaalsdeellELIFAPGF----------STaeevtdlsgrGVGMDVVKTN 392

                         170       180
                  ....*....|....*....|....*.
gi 1679660774 379 VTELEGDITFDNQQ-RGVVFAIRLPV 403
Cdd:COG0643   393 IEALGGTIEIESEPgKGTTFTLRLPL 418
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 305-387 4.57e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 39.28  E-value: 4.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 305 NLTANAVEAMDEEGMVSLRLRKPNESMVEFqVEDNGPG--ISEKIgdivFDPGFTSKydEFGTpstGIGLSYVKEIVTEL 382
Cdd:COG4192   550 NLLVNALDAVATQPQISVDLLSNAENLRVA-ISDNGNGwpLVDKL----FTPFTTTK--EVGL---GLGLSICRSIMQQF 619


                  ....*
gi 1679660774 383 EGDIT 387
Cdd:COG4192   620 GGDLY 624
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
302-409 5.11e-03

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 39.33  E-value: 5.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774  302 IINNLTANAVEAMDEEGM---VSLRLRKPNESMVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPStGIGLSYVKEI 378
Cdd:PRK09959   832 VLSNLLSNALKFTTEGAVkitTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGS-GLGLMICKEL 910

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1679660774  379 VTELEGDITFDNQQR-GVVFAIRLPVrHLIQK 409
Cdd:PRK09959   911 IKNMQGDLSLESHPGiGTTFTITIPV-EISQQ 941
PRK09303 PRK09303
histidine kinase;
302-403 6.86e-03

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 38.39  E-value: 6.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 302 IINNLTANAVEAMDEEGMVSLR-LRKPNESmVEFQVEDNGPGISEKIGDIVFDPGFTSKYDEfGTPSTGIGLSYVKEIVT 380
Cdd:PRK09303  276 VLLNLLDNAIKYTPEGGTITLSmLHRTTQK-VQVSICDTGPGIPEEEQERIFEDRVRLPRDE-GTEGYGIGLSVCRRIVR 353

                          90       100
                  ....*....|....*....|....
gi 1679660774 381 ELEGDITFDNQ-QRGVVFAIRLPV 403
Cdd:PRK09303  354 VHYGQIWVDSEpGQGSCFHFTLPV 377
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
320-404 8.48e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 37.68  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679660774 320 VSLRLRKpNESMVEFQVEDNGPGisekigdivFDPGftskydefGTPSTGIGLSYVKEIVTELEGDITFDNQ-QRGVVFA 398
Cdd:COG4585   183 VTVTLEV-DDGELTLTVRDDGVG---------FDPE--------AAPGGGLGLRGMRERAEALGGTLTIGSApGGGTRVR 244


                  ....*.
gi 1679660774 399 IRLPVR 404
Cdd:COG4585   245 ATLPLA 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH