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Conserved domains on  [gi|1712560517|gb|QDT99462|]
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prenyltransferase [Gimesia aquarii]

Protein Classification

UbiA family prenyltransferase( domain architecture ID 10195487)

UbiA family prenyltransferase catalyzes the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and is involved in the synthesis of molecules that mediate electron transport, including Vitamin K and Coenzyme Q

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 7-295 5.93e-89

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


:

Pssm-ID: 260127  Cd Length: 282  Bit Score: 266.75  E-value: 5.93e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   7 YFQLMRLPAVFTAMSDILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGRISTQHAA 86
Cdd:cd13964     1 YLQLVRLPNLFTVPADVLAGAALAGGGLGPVLRLALLLLASVLLYAAGMVLNDVFDAELDARERPERPIPSGRVSRGAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  87 VLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRTILGPLAMGLCRFLNVMLGASAVAreiNLWVKPQLRIAA 166
Cdd:cd13964    81 ALGAGLLAAGVALAALVGRLSGLVALLLAAAILLYDAWLKHTPLGPLLMGLCRGLNLLLGASAAA---AGGLGPALLAAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517 167 ILGMYVVGLTWFARMEAKNSHRGHL--LGGTLVINAGLAALVWMIATYPWPrelnltMLLTALGVVVLTINRRLIQAILN 244
Cdd:cd13964   158 ALGVYIAGVTYIARGEVHGGPRRLLplALLAVLLVIGLALALAAPRGGRVL------LALLFLALFAAWVGRPLLRAYRD 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1712560517 245 PVPQNVQIAVKTMLYSYVMLNAIIVFVWtTNPQYAILTAALLIPTIVLSRW 295
Cdd:cd13964   232 PSPPNIGKAVGAGILSLIPLDAALAAAF-GGPALALLVLALLPLALLLARK 281
 
Name Accession Description Interval E-value
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 7-295 5.93e-89

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260127  Cd Length: 282  Bit Score: 266.75  E-value: 5.93e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   7 YFQLMRLPAVFTAMSDILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGRISTQHAA 86
Cdd:cd13964     1 YLQLVRLPNLFTVPADVLAGAALAGGGLGPVLRLALLLLASVLLYAAGMVLNDVFDAELDARERPERPIPSGRVSRGAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  87 VLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRTILGPLAMGLCRFLNVMLGASAVAreiNLWVKPQLRIAA 166
Cdd:cd13964    81 ALGAGLLAAGVALAALVGRLSGLVALLLAAAILLYDAWLKHTPLGPLLMGLCRGLNLLLGASAAA---AGGLGPALLAAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517 167 ILGMYVVGLTWFARMEAKNSHRGHL--LGGTLVINAGLAALVWMIATYPWPrelnltMLLTALGVVVLTINRRLIQAILN 244
Cdd:cd13964   158 ALGVYIAGVTYIARGEVHGGPRRLLplALLAVLLVIGLALALAAPRGGRVL------LALLFLALFAAWVGRPLLRAYRD 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1712560517 245 PVPQNVQIAVKTMLYSYVMLNAIIVFVWtTNPQYAILTAALLIPTIVLSRW 295
Cdd:cd13964   232 PSPPNIGKAVGAGILSLIPLDAALAAAF-GGPALALLVLALLPLALLLARK 281
prenyl_rel_EboC NF035940
UbiA-like protein EboC;
6-299 2.18e-57

UbiA-like protein EboC;


Pssm-ID: 468273  Cd Length: 292  Bit Score: 186.21  E-value: 2.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   6 AYFQLMRLPAVFTAMSDILLGY------LLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGR 79
Cdd:NF035940    1 AYLQLMRPANIVTAWADILAGFaisgflTLTWSSAPNDISLIWLLLATIGLYGGGVVFNDVFDAELDAVERPERPIPSGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  80 ISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILK-RTILGPLAMGLCRFLNVMLGASAV-AREINLW 157
Cdd:NF035940   81 VSKQAALLLGSLLLLIGILAAFQVSLLSGVIALAIALAALLYDRFGKhHAIFGPLNMGLCRGGNLLLGMSVVpEALSEYW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517 158 VkpqlrIAAILGMYVVGLTWFARMEAKNSHRGHLLGGtLVINAGLAALVWMIATYPWPrelNLTMLLTALGVVVLTINRR 237
Cdd:NF035940  161 F-----LALIPIVYIAAITMISRGEVHGGKKSTLIIA-LLLYALVIASLLGLAFLQNG---NLLIALPFVLLFAILIFPP 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1712560517 238 LIQAILNPVPQNVQIAVKTMLYSYVMLNAIIVFVWTTNPqYAILTAALLIPTIVLSRWMSVT 299
Cdd:NF035940  232 LIKAIQNPIPPNIGKAVKAGVLSLIVLNAALAAGFGGWP-YGLLVLLLLPLSLLLAKIFAVT 292
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 5-158 1.45e-15

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 74.88  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   5 LAYFQLMRLPA---VFTAMSDILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDA--EERPSRPIPSGR 79
Cdd:COG0382     1 RAYLRLLRLDRpigILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRinERKPNRPLASGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  80 ISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKR-TILGPLAMGLCRFLNVMLGASAVAREINLWV 158
Cdd:COG0382    81 ISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLFLKRfTLLGNLVLGLLFGLGILMGFAAVTGSLPLSA 160
ubiA PRK12882
prenyltransferase; Reviewed
 6-128 2.79e-14

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 71.54  E-value: 2.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   6 AYFQLMRLPAVFTAMSDILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGRISTQHA 85
Cdd:PRK12882    6 GYLELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAAVFLATGAGNAINDYFDREIDRINRPDRPIPSGAVSPRGA 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1712560517  86 AVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRT 128
Cdd:PRK12882   86 LAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAETLKGT 128
UbiA pfam01040
UbiA prenyltransferase family;
23-178 3.45e-13

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 68.02  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  23 ILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDA--EERPSRPIPSGRISTQHAAVLGGLLMLAGVGAA 100
Cdd:pfam01040   5 ALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAimPRTPNRPLPSGRISPREALIFALVLLALGLLLL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1712560517 101 QAVGKQSLIVASLLVVAILSYDSILKR-TILGPLAMGLCRFLNVMLGASAVAREINLWVkpqLRIAAILGMYVVGLTWF 178
Cdd:pfam01040  85 LLLNPLTALLGLAALLLYVLYTLRLKRrTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLA---LLLALALFLWTWAIALA 160
chlor_syn_BchG TIGR01476
bacteriochlorophyll/chlorophyll synthetase; This model describes a subfamily of a large family ...
 56-138 8.18e-07

bacteriochlorophyll/chlorophyll synthetase; This model describes a subfamily of a large family of polyprenyltransferases (pfam01040) that also includes 4-hydroxybenzoate octaprenyltransferase and protoheme IX farnesyltransferase (heme O synthase). Members of this family are found exclusively in photosynthetic organisms, including a single copy in Arabidopsis thaliana. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 130541  Cd Length: 283  Bit Score: 49.39  E-value: 8.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  56 VFNDVFDRKVDAEERPSRPIPSGRISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLL-VVAILSYDS---ILKRTI-L 130
Cdd:TIGR01476  56 SINDYFDRDVDAINEPQRPIPSGIISLREVRWNWLVLTVAGLLVALVLGNWLIVLFTVVgIVLAVIYSMppiKLKRNGwL 135


                  ....*...
gi 1712560517 131 GPLAMGLC 138
Cdd:TIGR01476 136 GPPAVGLS 143
 
Name Accession Description Interval E-value
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 7-295 5.93e-89

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260127  Cd Length: 282  Bit Score: 266.75  E-value: 5.93e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   7 YFQLMRLPAVFTAMSDILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGRISTQHAA 86
Cdd:cd13964     1 YLQLVRLPNLFTVPADVLAGAALAGGGLGPVLRLALLLLASVLLYAAGMVLNDVFDAELDARERPERPIPSGRVSRGAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  87 VLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRTILGPLAMGLCRFLNVMLGASAVAreiNLWVKPQLRIAA 166
Cdd:cd13964    81 ALGAGLLAAGVALAALVGRLSGLVALLLAAAILLYDAWLKHTPLGPLLMGLCRGLNLLLGASAAA---AGGLGPALLAAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517 167 ILGMYVVGLTWFARMEAKNSHRGHL--LGGTLVINAGLAALVWMIATYPWPrelnltMLLTALGVVVLTINRRLIQAILN 244
Cdd:cd13964   158 ALGVYIAGVTYIARGEVHGGPRRLLplALLAVLLVIGLALALAAPRGGRVL------LALLFLALFAAWVGRPLLRAYRD 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1712560517 245 PVPQNVQIAVKTMLYSYVMLNAIIVFVWtTNPQYAILTAALLIPTIVLSRW 295
Cdd:cd13964   232 PSPPNIGKAVGAGILSLIPLDAALAAAF-GGPALALLVLALLPLALLLARK 281
prenyl_rel_EboC NF035940
UbiA-like protein EboC;
6-299 2.18e-57

UbiA-like protein EboC;


Pssm-ID: 468273  Cd Length: 292  Bit Score: 186.21  E-value: 2.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   6 AYFQLMRLPAVFTAMSDILLGY------LLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGR 79
Cdd:NF035940    1 AYLQLMRPANIVTAWADILAGFaisgflTLTWSSAPNDISLIWLLLATIGLYGGGVVFNDVFDAELDAVERPERPIPSGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  80 ISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILK-RTILGPLAMGLCRFLNVMLGASAV-AREINLW 157
Cdd:NF035940   81 VSKQAALLLGSLLLLIGILAAFQVSLLSGVIALAIALAALLYDRFGKhHAIFGPLNMGLCRGGNLLLGMSVVpEALSEYW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517 158 VkpqlrIAAILGMYVVGLTWFARMEAKNSHRGHLLGGtLVINAGLAALVWMIATYPWPrelNLTMLLTALGVVVLTINRR 237
Cdd:NF035940  161 F-----LALIPIVYIAAITMISRGEVHGGKKSTLIIA-LLLYALVIASLLGLAFLQNG---NLLIALPFVLLFAILIFPP 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1712560517 238 LIQAILNPVPQNVQIAVKTMLYSYVMLNAIIVFVWTTNPqYAILTAALLIPTIVLSRWMSVT 299
Cdd:NF035940  232 LIKAIQNPIPPNIGKAVKAGVLSLIVLNAALAAGFGGWP-YGLLVLLLLPLSLLLAKIFAVT 292
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 6-150 4.78e-17

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 79.08  E-value: 4.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   6 AYFQLMRLP-AVFTAMSDILLGYLLTHNSFELPIQFALLIVASTSLYL-SGMVFNDVFDRKVDAEERPSRPIPSGRISTQ 83
Cdd:cd13961     1 AYLELIRPPnLLMAALAQYLGALFALGPLLSLNDLELLLLFLSVFLIAaAGYIINDYFDVEIDRINKPDRPIPSGRISRR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712560517  84 HAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRT-ILGPLAMGLCRFLNVMLGASAV 150
Cdd:cd13961    81 EALILSILLNALGLILAFLLSPLALLIALLNSLLLWLYSHKLKRTpLIGNLLVALLTGLPFLFGGLAA 148
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 5-158 1.45e-15

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 74.88  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   5 LAYFQLMRLPA---VFTAMSDILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDA--EERPSRPIPSGR 79
Cdd:COG0382     1 RAYLRLLRLDRpigILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRinERKPNRPLASGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  80 ISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKR-TILGPLAMGLCRFLNVMLGASAVAREINLWV 158
Cdd:COG0382    81 ISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLFLKRfTLLGNLVLGLLFGLGILMGFAAVTGSLPLSA 160
ubiA PRK12882
prenyltransferase; Reviewed
 6-128 2.79e-14

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 71.54  E-value: 2.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   6 AYFQLMRLPAVFTAMSDILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGRISTQHA 85
Cdd:PRK12882    6 GYLELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAAVFLATGAGNAINDYFDREIDRINRPDRPIPSGAVSPRGA 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1712560517  86 AVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRT 128
Cdd:PRK12882   86 LAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAETLKGT 128
ubiA PRK12884
prenyltransferase; Reviewed
 1-152 4.38e-14

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 70.76  E-value: 4.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   1 MKKWLAYFQLMRLPAVFTAMSDILLGYLLTHnSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGRI 80
Cdd:PRK12884    1 RTKMKAYLELLRPEHGLMAGIAVVLGAIIAL-GGLPLDEALLGFLTAFFASGSANALNDYFDYEVDRINRPDRPIPSGRI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1712560517  81 STQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRT-ILGPLAMGLCRFLNVMLGASAVAR 152
Cdd:PRK12884   80 SRREALLLAILLFILGLIAAYLISPLAFLVVILVSVLGILYNWKLKEYgLIGNLYVAFLTGMTFIFGGIAVGE 152
UbiA pfam01040
UbiA prenyltransferase family;
23-178 3.45e-13

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 68.02  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  23 ILLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDA--EERPSRPIPSGRISTQHAAVLGGLLMLAGVGAA 100
Cdd:pfam01040   5 ALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAimPRTPNRPLPSGRISPREALIFALVLLALGLLLL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1712560517 101 QAVGKQSLIVASLLVVAILSYDSILKR-TILGPLAMGLCRFLNVMLGASAVAREINLWVkpqLRIAAILGMYVVGLTWF 178
Cdd:pfam01040  85 LLLNPLTALLGLAALLLYVLYTLRLKRrTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLA---LLLALALFLWTWAIALA 160
PRK09573 PRK09573
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed
 6-128 4.43e-12

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed


Pssm-ID: 181963  Cd Length: 279  Bit Score: 64.98  E-value: 4.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   6 AYFQLMRLPAVFTAMSDILLGYLLTHNsFELPIQFALLIVASTSLYLS-GMVFNDVFDRKVDAEERPSRPIPSGRISTQH 84
Cdd:PRK09573    5 AYFELIRPKNCIGASIGAIIGYLIASN-FKIDLKGIILAALVVFLVCAgGNVINDIYDIEIDKINKPERPIPSGRISLKE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1712560517  85 AAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRT 128
Cdd:PRK09573   84 AKIFSITLFIVGLILSIFINIYAFLIALLNSILLYLYAKDLKKT 127
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 8-178 1.13e-11

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 63.91  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   8 FQLMRLPAVFTAMSDILLGYLLTHNSF-ELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAEERPSRPIPSGRISTQHAA 86
Cdd:cd13956     1 LRLMRPYTLLYVLAPALAGAALAGAFAgPLPALLLLALLAVFLGAGAGYALNDYTDRELDAINKPDRPLPSGRLSPRQAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  87 VLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKRT-ILGPLAMGLCRFLNVMLGASAVAREINLWvkPQLRIA 165
Cdd:cd13956    81 AFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGLKRLkLGGWGVLGYATGLALLPGLGAVAAGGLVP--LALLLA 158

                         170
                  ....*....|...
gi 1712560517 166 AILGMYVVGLTWF 178
Cdd:cd13956   159 LVFLLLGLGINLY 171
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 24-158 1.11e-10

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 60.94  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  24 LLGYLLTHNSFELPI--QFALLIVASTSLYLSGMVFNDVFDRKVDAE-ERP-SRPIPSGRISTQHAAVLGGLLMLAGVGA 99
Cdd:cd13959    17 LWGLLLAAGGLPLPLlkLLLLFLLGAFLMRSAGCTINDIADRDIDAKvPRTkNRPLASGAISVKEALLFLAVQLLLGLAL 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517 100 AQAVGKQSLIVASLLVVAILSYdSILKR-TILGPLAMGLCRFLNVMLGASAVAREINLWV 158
Cdd:cd13959    97 LLQLNPLTILLSPIALLLVLIY-PLMKRfTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPA 155
PRK07566 PRK07566
chlorophyll synthase ChlG;
52-138 5.27e-07

chlorophyll synthase ChlG;


Pssm-ID: 236052  Cd Length: 314  Bit Score: 50.31  E-value: 5.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  52 LSGM--VFNDVFDRKVDAEERPSRPIPSGRISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDS---ILK 126
Cdd:PRK07566   77 LCGTsqTLNDYFDREVDAINEPYRPIPSGAISLRWVLYLIAVLTVLGLAVAYLLGPWVFLAALLGLFLAWIYSApplRLK 156

                          90
                  ....*....|...
gi 1712560517 127 RTI-LGPLAMGLC 138
Cdd:PRK07566  157 QNGwLGNYAVGLS 169
chlor_syn_BchG TIGR01476
bacteriochlorophyll/chlorophyll synthetase; This model describes a subfamily of a large family ...
 56-138 8.18e-07

bacteriochlorophyll/chlorophyll synthetase; This model describes a subfamily of a large family of polyprenyltransferases (pfam01040) that also includes 4-hydroxybenzoate octaprenyltransferase and protoheme IX farnesyltransferase (heme O synthase). Members of this family are found exclusively in photosynthetic organisms, including a single copy in Arabidopsis thaliana. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 130541  Cd Length: 283  Bit Score: 49.39  E-value: 8.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  56 VFNDVFDRKVDAEERPSRPIPSGRISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLL-VVAILSYDS---ILKRTI-L 130
Cdd:TIGR01476  56 SINDYFDRDVDAINEPQRPIPSGIISLREVRWNWLVLTVAGLLVALVLGNWLIVLFTVVgIVLAVIYSMppiKLKRNGwL 135


                  ....*...
gi 1712560517 131 GPLAMGLC 138
Cdd:TIGR01476 136 GPPAVGLS 143
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 16-121 9.82e-07

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 48.97  E-value: 9.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  16 VFTAMSdillGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAE-ERPS-RPIPSGRISTQHAAVLGGLLM 93
Cdd:cd13957    13 LLTALA----GYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKmKRTRnRPLPSGRISPKHALIFGLVLG 88

                          90       100
                  ....*....|....*....|....*...
gi 1712560517  94 LAGVGAAQAvgKQSLIVASLLVVAILSY 121
Cdd:cd13957    89 ILGLALLAL--FVNPLTALLGLLGIFLY 114
PRK12324 PRK12324
decaprenyl-phosphate phosphoribosyltransferase;
1-126 2.82e-06

decaprenyl-phosphate phosphoribosyltransferase;


Pssm-ID: 237058  Cd Length: 295  Bit Score: 47.93  E-value: 2.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   1 MKKWLAYFQLMR----LPAVFtamsdILLGYLLTHNSFELP------IQFALLIVASTSLYLsgmvFNDVFDRKVDAE-- 68
Cdd:PRK12324    8 KNLLAGYLKLLRpkqwIKNLF-----VFAAPIFAGNLLNPGallkvlLAFVLFCLASSAVYL----VNDIRDVEADRLhp 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1712560517  69 ERPSRPIPSGRISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILK 126
Cdd:PRK12324   79 TKRNRPIASGVVSVSLAYILAVVLLVASLALAYLLSPKLALVLLVYLVLNLAYSFKLK 136
PT_UbiA_2 cd13963
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 40-130 2.10e-05

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260126  Cd Length: 278  Bit Score: 45.16  E-value: 2.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  40 FALLIVASTSLYlsgmVFNDVFDRKVDAE--ERPSRPIPSGRISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVA 117
Cdd:cd13963    39 FVAFCLAASAVY----ILNDLLDLEADRLhpTKRNRPIASGRLSIPAALALAVVLLLAGLALALLLSPAFLLVLLAYLVL 114

                          90
                  ....*....|...
gi 1712560517 118 ILSYDSILKRTIL 130
Cdd:cd13963   115 NLAYSLKLKRIPL 127
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 3-128 2.51e-05

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 45.13  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   3 KWLAYFQL-----MRLpAVFTAmsdiLLGYLLTHNSFELPIQFALLIVASTSLYLSGMVFNDVFDRKVDAE-ERPS-RPI 75
Cdd:PRK04375    9 TLKDYLALtkprvISL-NLFTA----LGGMLLAPPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKmERTKnRPL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1712560517  76 PSGRISTQHAAVLGGLLMLAGVGA-AQAVgkqSLIVASLLVVAILSYDSI----LKRT 128
Cdd:PRK04375   84 VTGRISPREALIFGLVLGVLGFLLlGLFV---NPLAAWLTLAGIFFYVVVytlwLKRR 138
PLN00012 PLN00012
chlorophyll synthetase; Provisional
 58-100 7.04e-05

chlorophyll synthetase; Provisional


Pssm-ID: 215028  Cd Length: 375  Bit Score: 43.70  E-value: 7.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1712560517  58 NDVFDRKVDAEERPSRPIPSGRISTQHAAVLGGLLMLAGVGAA 100
Cdd:PLN00012  143 NDWYDREIDAINEPYRPIPSGAISENEVITQIWVLLLGGLGLA 185
PRK12392 PRK12392
bacteriochlorophyll c synthase; Provisional
 58-121 7.16e-05

bacteriochlorophyll c synthase; Provisional


Pssm-ID: 171463  Cd Length: 331  Bit Score: 43.91  E-value: 7.16e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  58 NDVFDRKVDAEERPSRPIPSGRISTQHAA----VLGGLLMLAGVGAAQAVGKQS--LIVASLLVVAILSY 121
Cdd:PRK12392   70 NDYFDLELDRVNEPTRPIPSGRLSEKEALwnsiIVLLLAIGLGVWLGLHIGGERgmVIISSILAGLFVAY 139
PT_UbiA_chlorophyll cd13958
Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of ...
 31-295 2.13e-04

Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of chlorophyll (Chl) biosynthesis, the addition of the tetraprenyl (phytyl or geranylgeranyl) side chain. In plant chloroplast, the chlorophyll synthase is located in thylakoid membrane and has been shown to also have a regulatory or channeling function. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260121  Cd Length: 277  Bit Score: 42.22  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  31 HNSFELPIQFALLIVASTSLyLSGM--VFNDVFDRKVDAEERPSRPIPSGRISTQHAAVLGGLLMLAGVGAAQAVGkqSL 108
Cdd:cd13958    28 QWSNWDVWLLLLGMLLAGPL-LTGTsqTINDYYDREVDAINEPYRPIPSGRISEREALWNIWVLLLLSLLVALFLD--GP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517 109 IVASLLVVAIlsydsilkrtilgplamglcrFLNVMLGASAVAREINLWVKPqlriaAILGMYVVGLTWFArmeaknshr 188
Cdd:cd13958   105 WVFAAAVVGL---------------------VLAYIYSAPPLKLKQNGWWGN-----AAVGLSYEGLPWWA--------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517 189 GHLLggtlvinaglaalvwmIATYPWPRELNLTMLLTALGVVVLTIN--------RRL-IQAIlnPVPQNVQ----IAVK 255
Cdd:cd13958   150 GAAA----------------FAGLLTWESLALALLYSIGAHGIMTLNdfksiegdRQLgLRSL--PVALGVDtaawIACG 211

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1712560517 256 TMLYSYVMlnAIIVFVWTTNPQYAILTAALLIPTIVLSRW 295
Cdd:cd13958   212 VIDVPQLA--VAALLLAWGETWYAAVVGALLLAQIPLQFK 249
PRK08238 PRK08238
UbiA family prenyltransferase;
56-157 5.36e-04

UbiA family prenyltransferase;


Pssm-ID: 236195 [Multi-domain]  Cd Length: 479  Bit Score: 41.40  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  56 VFNDVFDRKVDaEERPS---RPIPSGRISTQHAAVLGGLLMLAGVGAAQAVGKQSLIVASLLVVAILSYDSILKR-TILG 131
Cdd:PRK08238  244 ILNDLLDLEAD-RAHPRkrrRPFASGALPIPFGLAAAPLLLLAGLALALALGPAFLLVLLAYLALTLAYSLRLKRkVLVD 322

                          90       100
                  ....*....|....*....|....*.
gi 1712560517 132 PLAMGLCRFLNVMLGASAVAREINLW 157
Cdd:PRK08238  323 VLTLAALYTLRIIAGAAAIGVALSFW 348
ubiA PRK12883
prenyltransferase UbiA-like protein; Reviewed
 24-152 1.88e-03

prenyltransferase UbiA-like protein; Reviewed


Pssm-ID: 171796  Cd Length: 277  Bit Score: 39.33  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  24 LLGYLLTHNSFElPIQFALLIVASTSLYLS-GMVFNDVFDRKVDAEERPSRPIPSGRISTQHAAVLGGLLMLAGVGAAQA 102
Cdd:PRK12883   23 ILGSLVALGGIP-PIKTLILIFLVVYLGCSgGNTINDYFDYEIDKINRPNRPLPRGAMSRKAALYYSLLLFAVGLALAYL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1712560517 103 VGKQSLIVASLLVVAILSYDSILK-RTILGPLAMGLCRFLNVMLGASAVAR 152
Cdd:PRK12883  102 INIEAFLFALGAYVLMFLYAWKLKpLPFIGNVVVALLTGATPIYGAIAVGR 152
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
31-157 1.97e-03

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 39.22  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517  31 HNSFELPIQFALLIVASTSLYLSG---------------------MVFNDVFDRKVDAE--ERPSRPIPSGRISTQHAAV 87
Cdd:PRK12874   19 HSIFSLPFIFIAMIVASKQKNDTGwfgfkllilgilaavsarnfaMAFNRLVDRDIDKDnpRTANRPSVDGRISVKSMVL 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1712560517  88 LGGLLMLAGVGAAQAVGKQSLIVaSLLVVAILSYDSILKR-TILGPLAMGLCRFLNVMLGASAVAREINLW 157
Cdd:PRK12874   99 FIVLNALIFIGVSYFINPLAFKL-SFPFLIVLGGYSYFKRfSSLAHLVLGLSLGLAPIAGVVAVLGEIPLW 168
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
 8-119 2.69e-03

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 38.65  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712560517   8 FQLMRLPAVFTAMSDILLGYLLT--HNSFELPIQFALLIVASTSLYLSGMVFNDVFD--RKVDAEER--PSRPIPSGRIS 81
Cdd:cd13962     1 LLAARPRTLPASLAPVLLGTALAyyLGGFFNWLLFLLALLAALLLQIGVNLANDYFDykKGTDTEPRsgPSRVLVSGLLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1712560517  82 TQHAAVLGGLLMLAGVGAAQA-VGKQSLIVASLLVVAIL 119
Cdd:cd13962    81 PRQVLRAALVLLLLAALLGLYlVALGGWLLLLLGLLGIL 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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