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Conserved domains on  [gi|1767852404|gb|QFR04410|]
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DNA gyrase subunit A, partial [Bacillus subtilis]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-310 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 726.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:PRK05560   25 VIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:PRK05560  105 NFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQV 240
Cdd:PRK05560  185 GEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQV 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 241 NKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:PRK05560  264 NKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALV 333
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-310 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 726.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:PRK05560   25 VIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:PRK05560  105 NFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQV 240
Cdd:PRK05560  185 GEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQV 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 241 NKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:PRK05560  264 NKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALV 333
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-310 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 711.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:COG0188    30 VIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:COG0188   110 NFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQV 240
Cdd:COG0188   190 GEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQV 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 241 NKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:COG0188   270 NKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTSFGINMLALV 339
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-310 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 637.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:TIGR01063  21 VIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:TIGR01063 101 NFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQV 240
Cdd:TIGR01063 181 GEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQV 260

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 241 NKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:TIGR01063 261 NKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALV 330
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 3-310 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 556.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   3 VSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNF 82
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  83 GSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGE 162
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 163 IIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNK 242
Cdd:cd00187   161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767852404 243 AKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:cd00187   240 AKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFD 307
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-310 1.23e-178

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 500.55  E-value: 1.23e-178
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404    1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:smart00434  18 VINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQG 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   81 NFGSV-DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQ 159
Cdd:smart00434  98 NFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHN 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  160 LGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQ 239
Cdd:smart00434 178 LREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQ 242

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767852404  240 VNKAKLIEKIADLVRDKKIEGITDLRDES-DRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:smart00434 243 VNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALF 314
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
5-310 1.20e-177

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 497.84  E-value: 1.20e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   5 RALPDVRDGLKPVHRRILYAMNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGS 84
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  85 V-DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEI 163
Cdd:pfam00521  80 RiDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 164 IDGVLAVSENPDITIpeLMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKA 243
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTS 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767852404 244 KLIEKIADLVRDKKIEGITDLRDESDRtGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:pfam00521 234 DLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLF 299
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-310 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 726.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:PRK05560   25 VIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:PRK05560  105 NFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTsSGKERIIVTELPYQV 240
Cdd:PRK05560  185 GEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEI-KGREAIIVTEIPYQV 263

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 241 NKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:PRK05560  264 NKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINMLALV 333
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-310 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 711.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:COG0188    30 VIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDFSMRYPLVDGQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:COG0188   110 NFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAVGMATNIPPHNL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQV 240
Cdd:COG0188   190 GEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGREQIVVTEIPYQV 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 241 NKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:COG0188   270 NKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTSFGINMLALV 339
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-310 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 637.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:TIGR01063  21 VIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDFSLRYPLVDGQG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:TIGR01063 101 NFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQV 240
Cdd:TIGR01063 181 GEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGREAIIVTEIPYQV 260

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 241 NKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:TIGR01063 261 NKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALV 330
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-309 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 587.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:PRK05561   30 VIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDFSYRYPLVDGQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:PRK05561  110 NFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQIL-GRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQ 239
Cdd:PRK05561  190 REVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGEIItGRDGIRKAYETGRGSIRVRARWEIEDLAGGRWQIVITELPYQ 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767852404 240 VNKAKLIEKIADLVRDKKIEGITDLRDESDRTG-MRIVIEIR-RDANANVILNNLYKQTALQTSFGINLLAL 309
Cdd:PRK05561  270 VSKAKLIEQIAELMNAKKLPGIADVRDESDRENpVRIVIEPKsNRVDPEALMNHLFATTDLESSYRVNMNAI 341
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 3-310 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 556.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   3 VSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNF 82
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  83 GSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGE 162
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 163 IIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEqTSSGKERIIVTELPYQVNK 242
Cdd:cd00187   161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIE-DDEGRNTIEITELPYQVNK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767852404 243 AKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:cd00187   240 AKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFD 307
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-310 1.23e-178

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 500.55  E-value: 1.23e-178
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404    1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:smart00434  18 VINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDFSNNYPLLDGQG 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   81 NFGSV-DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQ 159
Cdd:smart00434  98 NFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMATNIPPHN 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  160 LGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSgirkayesgrgSITIRAKAEIEqtssGKERIIVTELPYQ 239
Cdd:smart00434 178 LREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGKIEIE----DDNTIVITELPYQ 242

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767852404  240 VNKAKLIEKIADLVRDKKIEGITDLRDES-DRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:smart00434 243 VNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALF 314
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
5-310 1.20e-177

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 497.84  E-value: 1.20e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   5 RALPDVRDGLKPVHRRILYAMNDLgMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGS 84
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  85 V-DGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEI 163
Cdd:pfam00521  80 RiDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 164 IDGVLAVSENPDITIpeLMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQtssgKERIIVTELPYQVNKA 243
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTS 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767852404 244 KLIEKIADLVRDKKIEGITDLRDESDRtGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:pfam00521 234 DLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLF 299
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 5-309 5.01e-153

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 452.64  E-value: 5.01e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   5 RALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGS 84
Cdd:PRK13979   37 RALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRMPLIDGHGNWGS 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  85 VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEII 164
Cdd:PRK13979  117 IDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPPHNLKEVI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 165 DGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAK 244
Cdd:PRK13979  197 DGTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRAKTKIEKLENGRLGIVITEFPYRRNKAK 276

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767852404 245 LIEKIADLVRDKK----IEGITDLRDESDRTGMRIVIEIRRDAN---ANVILNNLYKQTALQTSFGINLLAL 309
Cdd:PRK13979  277 LLQTISEMTADKKhskaLENISDIRDESDRNGIRAVIEFKKSADedvAEKVLKYLYKKTDLQCNISFNMVAL 348
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-310 7.26e-148

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 432.69  E-value: 7.26e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:TIGR01061  21 IIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNNWTLVEMHG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQL 160
Cdd:TIGR01061 101 NNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIAAGYATNIPPHNL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 161 GEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQV 240
Cdd:TIGR01061 181 NEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIEIEVNKNGLNQIVITEIPYET 260

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 241 NKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALV 310
Cdd:TIGR01061 261 NKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQINYNFNMVAIA 330
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-306 3.31e-133

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 395.05  E-value: 3.31e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHG 80
Cdd:TIGR01062  21 VIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSVDG-DSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQ 159
Cdd:TIGR01062 101 NWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIAVGMATDIPPHN 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 160 LGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILG-RSGIRKAYESGRGSITIRAKAEIEQTSsgkerIIVTELPY 238
Cdd:TIGR01062 181 LHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAEIIDkAEEIRKIYETGRGSFRMRARWKKEDGQ-----IVISALPH 255

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 239 QVNKAKLIEKIADLVRDKKIEGITDLRDESDRTG-MRIVIEIR-RDANANVILNNLYKQTALQTSFGINL 306
Cdd:TIGR01062 256 QISKSKVIEQIAIQMKDKKLPMISDIRDESDHENpIRVVIVPRsNRVDPDIVMEHLFATTDLEKSYRLNM 325
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 1-309 9.28e-63

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 209.56  E-value: 9.28e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLgmtSDKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMA-QDFnyrymLVDGH 79
Cdd:PRK09631   19 VIKDRAIPDVIDGLKPVQRRILHSLFEM---HDGKFHKVANVVGNTM-KYHPHGDASIYEALVNLAnKDL-----FIDKQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  80 GNFGSV-DGDSAAAMRYTEARMSKISMEIL--RDITkdtiDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIP 156
Cdd:PRK09631   90 GNFGNLfTGDPASAARYIECRLTPLAKEVLynKEIT----EYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKIL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 157 PHQLGEIIDGVLAVSENPDITIPelmevipgPDFPTAGqILGRSGirkaYESGRGSITIRAKAEIeqtsSGKERIIVTEL 236
Cdd:PRK09631  166 PHNFNEILQAVKSELLGESFALY--------PDFPTGG-IVDVSE----YADGNGKVLVRAKIET----KDEKTIVIREI 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1767852404 237 PYQVNKAKLIEKIADLVRDKKIEgITDLrdeSDRTGMRIVIEIR--RDANANVILNNLYKQTALQTSFGINLLAL 309
Cdd:PRK09631  229 PFGTTTESLIASIEKAARKGKIK-ISSI---NDYTAENVEIEIKlpRGVYASEVIEALYAYTDCEVSISVNLLVI 299
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
1-249 3.94e-56

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 194.45  E-value: 3.94e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAMNDLgmtSDKPYKKSARIVGEVIgKYHPHGDSAVYESMVRMAQdfnyRYMLVDGHG 80
Cdd:PRK12758   38 VILERAVPHIEDGLKPVQRRILHSMKEM---DDGRYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KDLLIDTQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGSV-DGDSAAAMRYTEARMSKISMEILrdITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQ 159
Cdd:PRK12758  110 NWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHN 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 160 LGEIIDGVLAVSENPDITIPelmevipgPDFPTAGqILGRSgirkAYESGR--GSITIRAKaeIEQTSsgKERIIVTELP 237
Cdd:PRK12758  188 FNELIDASIAYLKGKEFKLY--------PDFPTGG-IIDVS----NYNDGErgGRVRVRAK--IEKLD--KKTLVITEIP 250

                         250
                  ....*....|..
gi 1767852404 238 YQVNKAKLIEKI 249
Cdd:PRK12758  251 YGTTTSSLIDSI 262
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 1-299 2.48e-47

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 165.45  E-value: 2.48e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   1 VIVSRALPDVRDGLKPVHRRILYAmndLGMTSDKPYKKSARIVGEVIGkYHPHGDSAVYESMVRMAqdfNYRYmLVDGHG 80
Cdd:PRK09630   19 VILERAIPHILDGLKPVQRRLLWT---LFRMDDGKMHKVANIAGRTMA-LHPHGDAPIVEALVVLA---NKGY-LIDTQG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  81 NFGS-VDGDSAAAMRYTEARMSKISMEILrdITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQ 159
Cdd:PRK09630   91 NFGNpLTGDPHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 160 LGEIIDGVLAVSENPDITIPelmevipgPDFPTAGQILGRSgirkaYESGRGSITIRAKAEIEQTSSgkerIIVTELPYQ 239
Cdd:PRK09630  169 FCELLEAQIAILNDQPFTLL--------PDFPSGGTMDASE-----YQDGLGSITLRASIDIINDKT----LLIKEICPS 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767852404 240 VNKAKLIEKIADLVRDK--KIEGITDLRDESDrtgmRIVIEIRRDANANVILNNLYKQTALQ 299
Cdd:PRK09630  232 TTTETLIRSIENAAKRGiiKIDSIQDFSTDLP----HIEIKLPKGIYAKDLLRPLFTHTECQ 289
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 2-287 8.48e-39

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 141.73  E-value: 8.48e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   2 IVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEV--IGkYHpHGDSAVYESMVRMAQDFNYRYMLVDGH 79
Cdd:PHA02592   24 VEERAIPNLIDGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVadLG-YH-HGETSAQDAGALMANTWNNNIPLLDGQ 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  80 GNFGSVDGDSAAAMRYTEARMSkismEILRDITKDtIDYQDNYDGSERepvvMPSRF-----PNLLVNGAAGIAVGMATN 154
Cdd:PHA02592  102 GNFGSRLVQKAAAARYIFARVH----DNFRKIYKD-EDLAPVHEDPEH----IPPAFylpiiPMVLLNGVSGIATGYATN 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404 155 IPPHQLGEIIDGVLAVSENPDITIPElmevipgPDFPtagqilGRSGirKAYESGRGSITIRAKAEIeqtsSGKERIIVT 234
Cdd:PHA02592  173 ILPHSPKSVIKAVLAALNGKDITEPK-------VQFP------EFKG--EVVEIEPGSYEIRGTYEL----NGKTKLHIT 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1767852404 235 ELPYQVNKAKLIEKIADLVRDKKIEGITDLRDEsdrtGMRIVIEIRRDANANV 287
Cdd:PHA02592  234 EIPVKYDRETYVAVLDPLEEKGKIVSYDDCTED----GFRFKVTLKREENEEA 282
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 5-301 4.49e-23

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 99.78  E-value: 4.49e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404    5 RALPDVRDGLKPVHRRILYAMNDLGMTSDKpykKSARIVGEVI--GKYHpHGDSAVYESMVRMAQDF---NYRYMLVDgH 79
Cdd:PLN03128   673 RSIPSMVDGLKPSQRKVLFACFKRNLKSEI---KVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgsNNINLLTP-S 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   80 GNFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPP 157
Cdd:PLN03128   748 GQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPN 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  158 HQLGEIIDGVLAVSENPDitiPELMEvipgpdfPTAGQILGRsgIRKAYESGRGSITIRAKAEIEQTSSgkerIIVTELP 237
Cdd:PLN03128   827 YNPRDIIANIRRLLRGEE---LEPMH-------PWYRGFKGT--ITEVSTSRSGSYTVTGIIEQIGDTT----IRITELP 890

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767852404  238 YQV---NKAKLIEKIADLVRDKKIEgITDLRDESDRTGMRIVIEIRRDANANVILNNLYK----QTALQTS 301
Cdd:PLN03128   891 VRKwtqDYKEFLEALLTGTKKKEPE-IKDFKENHTDTTVHFTVTLSEEKMARALAEGLEKkfklSTTISTS 960
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 5-305 6.11e-21

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 93.19  E-value: 6.11e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404    5 RALPDVRDGLKPVHRRILYAM------NDLgmtsdkpykKSARIVGEVIGK--YHpHGDSAVYESMVRMAQDF----NYR 72
Cdd:PTZ00108   680 RSIPSLVDGLKPGQRKILFACfkrnlkNEI---------KVAQLSGYVSEHsaYH-HGEQSLQQTIVGMAQNFvgsnNIN 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   73 YMLVDGHgnFGS--VDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPVVMPSRFPNLLVNGAAGIAVG 150
Cdd:PTZ00108   750 LLYPCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLED-DGQSVEPFYYVPIIPMVLVNGAEGIGTG 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  151 MATNIPPHQLGEIIDGVLAVSENpditiPELMEVIPgpdfptagqilgrsgirkAYESGRGSITIRAKAEIEqtSSGK-- 228
Cdd:PTZ00108   827 FSTSIPNYNPLDIIDNLRRRLNG-----EEVRPLVP------------------WYRGFKGTIERNPKGKFI--SKGIye 881

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  229 ----ERIIVTELPYQV---NKAKLIEKIAdlvrDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTS 301
Cdd:PTZ00108   882 kvpdGTVEITELPIGKwteDYKEFLESET----LKEKDVIVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIEKVFKLKST 957


                   ....
gi 1767852404  302 FGIN 305
Cdd:PTZ00108   958 ISTT 961
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 5-277 2.43e-15

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 76.82  E-value: 2.43e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404    5 RALPDVRDGLKPVHRRILYAMNDLGMTSDKpykKSARIVGEV--IGKYHpHGDSAVYESMVRMAQDF---NYRYMLVDGh 79
Cdd:PLN03237   698 RSIPSMVDGLKPGQRKILFCSFKRNFVKEA---KVAQLSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsNNINLLLPN- 772

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404   80 GNFG--SVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNyDGSEREPV-VMPSrFPNLLVNGAAGIAVGMATNIP 156
Cdd:PLN03237   773 GQFGtrLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTFIP 850

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767852404  157 PHQLGEIIDGVLAVSENpditipELMEvipgPDFPTagqilgrsgirkaYESGRGSI--TIRAKAEIEQTSSGK------ 228
Cdd:PLN03237   851 NYNPRDIVANIRRLLNG------ESME----PMHPW-------------YRGFKGTIekTASKEGGCTYTITGLyeevde 907

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1767852404  229 ERIIVTELP---YQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVI 277
Cdd:PLN03237   908 TTLRITELPirrWTDDYKEFLESLKTDNNKNKDPFIKDVKAYNDDTTVHFEV 959
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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