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Conserved domains on  [gi|1829740713|gb|QIX11793|]
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toll-like receptor 5 [Tragopan temminckii]

Protein Classification

toll-like receptor( domain architecture ID 12156291)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
693-828 2.78e-26

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.78e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713  693 MYDAYLCYSKNDfkWVQNSLLKHLDSQYFDKNkftLCFEERDFLPGEEHINNIRDAIWKSRKTICIVTRHFLKDGWCVEA 772
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829740713  773 FNFAQSRYFSDLKEVLIMVVVGSLSQYQLMKHKPIRIFLQRsQYLRWPEDYQDIDW 828
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
273-561 2.32e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 2.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 273 NNLKNPDKDTFTGLAISDLRLLDISYGFIFSLNSLIFKSLGNLEFLNLFRNKvnhiekqAFFGLENLKILNLSSNLLGEL 352
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 353 yDYTFEGLHSIMYIDLQQNHIGMISqKSFRNLVSLKKIDLRDNALKKLPSF----PHLTTAFLGDNKLMSVAHiaiaath 428
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPE------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 429 ielernWLANLgdlyvlfqvPNLQYLSLKQNRFSyceksvnaiensqliymDLGENmlqlvwerglcldvFRTLSQLQIL 508
Cdd:COG4886   200 ------PLGNL---------TNLEELDLSGNQLT-----------------DLPEP--------------LANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1829740713 509 FLNNNYLSALPQeiFSGLTSLKILNLASNLLSHLPLGVFPQSLINLNLSGNQL 561
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
120-183 1.35e-06

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829740713 120 QRLTILRLFQNNLGDsiLEERYFQDLSSLEELDLSSNQITKLHPHpLFYNLTILKAVDLKFNKI 183
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 555-669 2.65e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.15  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713  555 NLSGNQLFSPKPEVF---MTLSILDITHNKYVCDCALKSLLVWLNETNVTLAGSESdRYCVYPPALAGVP---VSLLTyD 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPllgIPLLD-S 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1829740713  629 DCDEDELQQTLRFSVFIFISVTLLMFLMSAI--VFTR--CRGICF 669
Cdd:TIGR00864   79 GCDEEYVACLKDNSSGGGAARSELVIFSAAHegLFQPeaCNAFCF 123
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
693-828 2.78e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.78e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713  693 MYDAYLCYSKNDfkWVQNSLLKHLDSQYFDKNkftLCFEERDFLPGEEHINNIRDAIWKSRKTICIVTRHFLKDGWCVEA 772
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829740713  773 FNFAQSRYFSDLKEVLIMVVVGSLSQYQLMKHKPIRIFLQRsQYLRWPEDYQDIDW 828
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 694-842 2.58e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 100.13  E-value: 2.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 694 YDAYLCYSKND-FKWVQNSLLKHLDsqyfdKNKFTLCFEERDFLPGEEHINNIRDAIWKSRKTICIVTRHFLKDGWCVEA 772
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 773 FNFAQSRYFsDLKEVLIMVVVGSLSQYQL-------MKHKPIRIFLQRSQYLRWPEDYQDID------------WFLDNL 833
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALNEVAniwhsksvsdesKFWKKI 154


                  ....*....
gi 1829740713 834 SSQILKEKK 842
Cdd:pfam01582 155 AYDISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
273-561 2.32e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 2.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 273 NNLKNPDKDTFTGLAISDLRLLDISYGFIFSLNSLIFKSLGNLEFLNLFRNKvnhiekqAFFGLENLKILNLSSNLLGEL 352
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 353 yDYTFEGLHSIMYIDLQQNHIGMISqKSFRNLVSLKKIDLRDNALKKLPSF----PHLTTAFLGDNKLMSVAHiaiaath 428
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPE------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 429 ielernWLANLgdlyvlfqvPNLQYLSLKQNRFSyceksvnaiensqliymDLGENmlqlvwerglcldvFRTLSQLQIL 508
Cdd:COG4886   200 ------PLGNL---------TNLEELDLSGNQLT-----------------DLPEP--------------LANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1829740713 509 FLNNNYLSALPQeiFSGLTSLKILNLASNLLSHLPLGVFPQSLINLNLSGNQL 561
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
503-561 2.80e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 2.80e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1829740713 503 SQLQILFLNNNYLSALPQEIFSGLTSLKILNLASNLLSHLPLGVF--PQSLINLNLSGNQL 561
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 332-579 2.30e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 2.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 332 AFFGLENLKILNLSSNLL-GELYDYTFEGLHSIMYIDLQQNHI-GMISQKSFRNLVSLkkiDLRDNALK-KLP----SFP 404
Cdd:PLN00113   88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLETL---DLSNNMLSgEIPndigSFS 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 405 HLTTAFLGDNKLmsVAHIAIAATHIElernwlanlgdlyvlfqvpNLQYLSLKQNRFS-YCEKSVNAIENSQLIYmdLGE 483
Cdd:PLN00113  165 SLKVLDLGGNVL--VGKIPNSLTNLT-------------------SLEFLTLASNQLVgQIPRELGQMKSLKWIY--LGY 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 484 NML--QLVWERGlcldvfrTLSQLQILFLNNNYLSALPQEIFSGLTSLKILNLASNLLS-HLPLGVFP-QSLINLNLSGN 559
Cdd:PLN00113  222 NNLsgEIPYEIG-------GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSlQKLISLDLSDN 294

                         250       260
                  ....*....|....*....|
gi 1829740713 560 QLFSPKPEVFMTLSILDITH 579
Cdd:PLN00113  295 SLSGEIPELVIQLQNLEILH 314
LRR_8 pfam13855
Leucine rich repeat;
120-183 1.35e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829740713 120 QRLTILRLFQNNLGDsiLEERYFQDLSSLEELDLSSNQITKLHPHpLFYNLTILKAVDLKFNKI 183
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-416 5.02e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 5.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 115 SFVGLQRLTILRLFQNNLGDSILEerYFQDLSSLEELDLSSNQITKLHPHPLfYNLTILKAVDLKFNKISNLCESNLtsf 194
Cdd:PLN00113  279 SIFSLQKLISLDLSDNSLSGEIPE--LVIQLQNLEILHLFSNNFTGKIPVAL-TSLPRLQVLQLWSNKFSGEIPKNL--- 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 195 qGKH--FSFFSLSSNTLykTDKMVWAKCP--NPFRNITF-NLLDvSENGWSTETvqyfCTAIKGTQIKYlsfhvhtmgsg 269
Cdd:PLN00113  353 -GKHnnLTVLDLSTNNL--TGEIPEGLCSsgNLFKLILFsNSLE-GEIPKSLGA----CRSLRRVRLQD----------- 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 270 fgfNNLKNPDKDTFTGLAIsdLRLLDISYG-FIFSLNSLIFKsLGNLEFLNLFRNKVNHiEKQAFFGLENLKILNLSSNL 348
Cdd:PLN00113  414 ---NSFSGELPSEFTKLPL--VYFLDISNNnLQGRINSRKWD-MPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQ 486

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829740713 349 LGELYDYTFEGLHSIMYIDLQQNHI-GMISQK--SFRNLVSLkkiDLRDNALK-KLPS----FPHLTTAFLGDNKL 416
Cdd:PLN00113  487 FSGAVPRKLGSLSELMQLKLSENKLsGEIPDElsSCKKLVSL---DLSHNQLSgQIPAsfseMPVLSQLDLSQNQL 559
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 555-669 2.65e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.15  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713  555 NLSGNQLFSPKPEVF---MTLSILDITHNKYVCDCALKSLLVWLNETNVTLAGSESdRYCVYPPALAGVP---VSLLTyD 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPllgIPLLD-S 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1829740713  629 DCDEDELQQTLRFSVFIFISVTLLMFLMSAI--VFTR--CRGICF 669
Cdd:TIGR00864   79 GCDEEYVACLKDNSSGGGAARSELVIFSAAHegLFQPeaCNAFCF 123
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 287-399 3.35e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 287 AISDLRLLDISYGFI----FSLNSLIFKSLGNLEFLNLFRNKVNHIEKQAFFG----LENLKILNLSSNLLG-----ELY 353
Cdd:cd00116   163 ANRDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTdagaaALA 242

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1829740713 354 DYTFEGLHSIMYIDLQQNHIGMISQKSF----RNLVSLKKIDLRDNALKK 399
Cdd:cd00116   243 SALLSPNISLLTLSLSCNDITDDGAKDLaevlAEKESLLELDLRGNKFGE 292
LRRCT smart00082
Leucine rich repeat C-terminal domain;
580-626 5.74e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 5.74e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1829740713  580 NKYVCDCALKSLLVWLNETNVTLagsESDRY-CVYPPALAGvPVSLLT 626
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ---DPVDLrCASPSSLRG-PLLELL 44
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
693-828 2.78e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.78e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713  693 MYDAYLCYSKNDfkWVQNSLLKHLDSQYFDKNkftLCFEERDFLPGEEHINNIRDAIWKSRKTICIVTRHFLKDGWCVEA 772
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829740713  773 FNFAQSRYFSDLKEVLIMVVVGSLSQYQLMKHKPIRIFLQRsQYLRWPEDYQDIDW 828
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 694-842 2.58e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 100.13  E-value: 2.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 694 YDAYLCYSKND-FKWVQNSLLKHLDsqyfdKNKFTLCFEERDFLPGEEHINNIRDAIWKSRKTICIVTRHFLKDGWCVEA 772
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 773 FNFAQSRYFsDLKEVLIMVVVGSLSQYQL-------MKHKPIRIFLQRSQYLRWPEDYQDID------------WFLDNL 833
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALNEVAniwhsksvsdesKFWKKI 154


                  ....*....
gi 1829740713 834 SSQILKEKK 842
Cdd:pfam01582 155 AYDISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
273-561 2.32e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 2.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 273 NNLKNPDKDTFTGLAISDLRLLDISYGFIFSLNSLIFKSLGNLEFLNLFRNKvnhiekqAFFGLENLKILNLSSNLLGEL 352
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 353 yDYTFEGLHSIMYIDLQQNHIGMISqKSFRNLVSLKKIDLRDNALKKLPSF----PHLTTAFLGDNKLMSVAHiaiaath 428
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQITDLPE------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 429 ielernWLANLgdlyvlfqvPNLQYLSLKQNRFSyceksvnaiensqliymDLGENmlqlvwerglcldvFRTLSQLQIL 508
Cdd:COG4886   200 ------PLGNL---------TNLEELDLSGNQLT-----------------DLPEP--------------LANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1829740713 509 FLNNNYLSALPQeiFSGLTSLKILNLASNLLSHLPLGVFPQSLINLNLSGNQL 561
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
503-561 2.80e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 2.80e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1829740713 503 SQLQILFLNNNYLSALPQEIFSGLTSLKILNLASNLLSHLPLGVF--PQSLINLNLSGNQL 561
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
314-373 4.18e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 4.18e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 314 NLEFLNLFRNKVNHIEKQAFFGLENLKILNLSSNLLGELYDYTFEGLHSIMYIDLQQNHI 373
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
338-397 2.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.58e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 338 NLKILNLSSNLLGELYDYTFEGLHSIMYIDLQQNHIGMISQKSFRNLVSLKKIDLRDNAL 397
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-439 4.41e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 4.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713  64 TSFPLLEDLFLLEIGTQHVFPLYIGKEAFRNLPNLRVLDLGLNNILLLDLDSFVGLQRLTILRLFQNNLgdsileeryFQ 143
Cdd:COG4886    40 LSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE---------LS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 144 DLSSLEELDLSSNQITKLhPHPLfYNLTILKAVDLKFNKISNLCE--SNLTSFQgkhfsFFSLSSNTLyktdkmvwAKCP 221
Cdd:COG4886   111 NLTNLESLDLSGNQLTDL-PEEL-ANLTNLKELDLSNNQLTDLPEplGNLTNLK-----SLDLSNNQL--------TDLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 222 NPFRNITfNL--LDVSENgwstetvqyfctaikgtQIKYLSFHvhtmgsgfgFNNLKNpdkdtftglaisdLRLLDISYG 299
Cdd:COG4886   176 EELGNLT-NLkeLDLSNN-----------------QITDLPEP---------LGNLTN-------------LEELDLSGN 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 300 FIFSLnSLIFKSLGNLEFLNLFRNKVNHIEkqAFFGLENLKILNLSSNLLGELYDytFEGLHSIMYIDLQQNHIGMISQK 379
Cdd:COG4886   216 QLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLK 290

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 380 SFRNLVSLKKIDLRDNALKKLPSFPHLTTAFLGDNKLMSVAHIAIAATHIELERNWLANL 439
Cdd:COG4886   291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR_8 pfam13855
Leucine rich repeat;
291-349 5.81e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.81e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1829740713 291 LRLLDISYGFIFSLNSLIFKSLGNLEFLNLFRNKVNHIEKQAFFGLENLKILNLSSNLL 349
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 332-579 2.30e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 2.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 332 AFFGLENLKILNLSSNLL-GELYDYTFEGLHSIMYIDLQQNHI-GMISQKSFRNLVSLkkiDLRDNALK-KLP----SFP 404
Cdd:PLN00113   88 AIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLETL---DLSNNMLSgEIPndigSFS 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 405 HLTTAFLGDNKLmsVAHIAIAATHIElernwlanlgdlyvlfqvpNLQYLSLKQNRFS-YCEKSVNAIENSQLIYmdLGE 483
Cdd:PLN00113  165 SLKVLDLGGNVL--VGKIPNSLTNLT-------------------SLEFLTLASNQLVgQIPRELGQMKSLKWIY--LGY 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 484 NML--QLVWERGlcldvfrTLSQLQILFLNNNYLSALPQEIFSGLTSLKILNLASNLLS-HLPLGVFP-QSLINLNLSGN 559
Cdd:PLN00113  222 NNLsgEIPYEIG-------GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSlQKLISLDLSDN 294

                         250       260
                  ....*....|....*....|
gi 1829740713 560 QLFSPKPEVFMTLSILDITH 579
Cdd:PLN00113  295 SLSGEIPELVIQLQNLEILH 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-599 2.30e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 2.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713  73 FLLEIGTQHVFPLYIGKEAFRNLPNLRVLDLGLNNILLLDLDSFVGLQRLTILRLFQNNLGDSILEERYFQDLSSLEELD 152
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 153 LSSNQitklhphpLFYNLTILKAVDLKFNKISNLCESnltsfqgkhfsffslssntlyktdkmvwakcpnpfrnitfnll 232
Cdd:COG4886   103 LSGNE--------ELSNLTNLESLDLSGNQLTDLPEE------------------------------------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 233 dvsengwstetvqyfctaikgtqikylsfhvhtmgsgfgFNNLKNpdkdtftglaisdLRLLDISYGFIFSLNSLIfKSL 312
Cdd:COG4886   132 ---------------------------------------LANLTN-------------LKELDLSNNQLTDLPEPL-GNL 158

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 313 GNLEFLNLFRNKVNHIEKqAFFGLENLKILNLSSNLLGELyDYTFEGLHSIMYIDLQQNHIGMISqKSFRNLVSLKKIDL 392
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDL 235

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 393 RDNALKKLPSFPHLTtaflgdnKLmsvahiaiaaTHIELERNWLANLGDlyvLFQVPNLQYLSLKQNRFSyceksvnaIE 472
Cdd:COG4886   236 SNNQLTDLPELGNLT-------NL----------EELDLSNNQLTDLPP---LANLTNLKTLDLSNNQLT--------DL 287

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 473 NSQLIYMDLGENMLQLVWERGLCLDVFRTLSQLQILFLNNNYLSALPQEIFSGLTSLKILNLASNLLSHLPLGVFPQSLI 552
Cdd:COG4886   288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1829740713 553 NLNLSGNQLFSPKPEVFMTLSILDITHNKYVCDCALKSLLVWLNETN 599
Cdd:COG4886   368 TLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 141-580 2.37e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 2.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 141 YFQDLSSLEELDLSSNQITKLHPHP-----------LFYN------------LTILKAVDLKFNKISNLCESNLTSFQGK 197
Cdd:PLN00113  183 SLTNLTSLEFLTLASNQLVGQIPRElgqmkslkwiyLGYNnlsgeipyeiggLTSLNHLDLVYNNLTGPIPSSLGNLKNL 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 198 HFSFfslssntLYKTdkmvwaKCPNPFRNITFNL-----LDVSENGWSTEtVQYFCTAIKGTQIKYLsfhvhtmgsgfgF 272
Cdd:PLN00113  263 QYLF-------LYQN------KLSGPIPPSIFSLqklisLDLSDNSLSGE-IPELVIQLQNLEILHL------------F 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 273 NNlknpdkdTFTGlaisdlrllDISYGfifslnsliFKSLGNLEFLNLFRNKVNHIEKQAFFGLENLKILNLSSN-LLGE 351
Cdd:PLN00113  317 SN-------NFTG---------KIPVA---------LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNnLTGE 371

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 352 LYDYTFEGLHSIMYIDLQQNHIGMISqKSFRNLVSLKKIDLRDNALK-KLPSfphlttaflGDNKLMSVAHIAIAAThie 430
Cdd:PLN00113  372 IPEGLCSSGNLFKLILFSNSLEGEIP-KSLGACRSLRRVRLQDNSFSgELPS---------EFTKLPLVYFLDISNN--- 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 431 lerNWLANLGDLYvlFQVPNLQYLSLKQNRFSycEKSVNAIENSQLIYMDLGENMLQLVWERGlcldvFRTLSQLQILFL 510
Cdd:PLN00113  439 ---NLQGRINSRK--WDMPSLQMLSLARNKFF--GGLPDSFGSKRLENLDLSRNQFSGAVPRK-----LGSLSELMQLKL 506

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1829740713 511 NNNYLSA-LPQEIfSGLTSLKILNLASNLLS-HLPLGV--FPqSLINLNLSGNQLFSPKPEVF---MTLSILDITHN 580
Cdd:PLN00113  507 SENKLSGeIPDEL-SSCKKLVSLDLSHNQLSgQIPASFseMP-VLSQLDLSQNQLSGEIPKNLgnvESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
120-183 1.35e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829740713 120 QRLTILRLFQNNLGDsiLEERYFQDLSSLEELDLSSNQITKLHPHpLFYNLTILKAVDLKFNKI 183
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 697-793 1.39e-06

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 48.08  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 697 YLCYSKNDFKWVQNsLLKHLDsqyfdKNKFTLCFEERDFLPGEEHINNIRDAIWKSRKTICIVTRHFLKDGWCVEAFNFA 776
Cdd:pfam13676   2 FISYAGEDRAWAEW-LADALE-----AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA 75

                          90
                  ....*....|....*..
gi 1829740713 777 QSRyfSDLKEVLIMVVV 793
Cdd:pfam13676  76 LAD--PEGRKRLIPVRL 90
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-416 5.02e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 5.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 115 SFVGLQRLTILRLFQNNLGDSILEerYFQDLSSLEELDLSSNQITKLHPHPLfYNLTILKAVDLKFNKISNLCESNLtsf 194
Cdd:PLN00113  279 SIFSLQKLISLDLSDNSLSGEIPE--LVIQLQNLEILHLFSNNFTGKIPVAL-TSLPRLQVLQLWSNKFSGEIPKNL--- 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 195 qGKH--FSFFSLSSNTLykTDKMVWAKCP--NPFRNITF-NLLDvSENGWSTETvqyfCTAIKGTQIKYlsfhvhtmgsg 269
Cdd:PLN00113  353 -GKHnnLTVLDLSTNNL--TGEIPEGLCSsgNLFKLILFsNSLE-GEIPKSLGA----CRSLRRVRLQD----------- 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 270 fgfNNLKNPDKDTFTGLAIsdLRLLDISYG-FIFSLNSLIFKsLGNLEFLNLFRNKVNHiEKQAFFGLENLKILNLSSNL 348
Cdd:PLN00113  414 ---NSFSGELPSEFTKLPL--VYFLDISNNnLQGRINSRKWD-MPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQ 486

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829740713 349 LGELYDYTFEGLHSIMYIDLQQNHI-GMISQK--SFRNLVSLkkiDLRDNALK-KLPS----FPHLTTAFLGDNKL 416
Cdd:PLN00113  487 FSGAVPRKLGSLSELMQLKLSENKLsGEIPDElsSCKKLVSL---DLSHNQLSgQIPAsfseMPVLSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
493-539 8.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 8.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1829740713 493 GLCLDVFRTLSQLQILFLNNNYLSALPQEIFSGLTSLKILNLASNLL 539
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 555-669 2.65e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.15  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713  555 NLSGNQLFSPKPEVF---MTLSILDITHNKYVCDCALKSLLVWLNETNVTLAGSESdRYCVYPPALAGVP---VSLLTyD 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPllgIPLLD-S 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1829740713  629 DCDEDELQQTLRFSVFIFISVTLLMFLMSAI--VFTR--CRGICF 669
Cdd:TIGR00864   79 GCDEEYVACLKDNSSGGGAARSELVIFSAAHegLFQPeaCNAFCF 123
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 287-399 3.35e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 287 AISDLRLLDISYGFI----FSLNSLIFKSLGNLEFLNLFRNKVNHIEKQAFFG----LENLKILNLSSNLLG-----ELY 353
Cdd:cd00116   163 ANRDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTdagaaALA 242

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1829740713 354 DYTFEGLHSIMYIDLQQNHIGMISQKSF----RNLVSLKKIDLRDNALKK 399
Cdd:cd00116   243 SALLSPNISLLTLSLSCNDITDDGAKDLaevlAEKESLLELDLRGNKFGE 292
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 318-608 1.23e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 318 LNLFRNKVNHIE-KQAFFGLENLKILNLSSNLLGELY-DYTFEGLH---SIMYIDLQQNHIGMISQ------KSFRNLVS 386
Cdd:cd00116     3 LSLKGELLKTERaTELLPKLLCLQVLRLEGNTLGEEAaKALASALRpqpSLKELCLSLNETGRIPRglqsllQGLTKGCG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 387 LKKIDLRDNALKKL--PSFPHLTTAF------LGDNKL--MSVAHIAIAathielernwlanLGDLYvlfqvPNLQYLSL 456
Cdd:cd00116    83 LQELDLSDNALGPDgcGVLESLLRSSslqelkLNNNGLgdRGLRLLAKG-------------LKDLP-----PALEKLVL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 457 KQNRFSY--CEKSVNA-IENSQLIYMDLGENMLQLVWERGLCLDvFRTLSQLQILFLNNNYL-----SALpQEIFSGLTS 528
Cdd:cd00116   145 GRNRLEGasCEALAKAlRANRDLKELNLANNGIGDAGIRALAEG-LKANCNLEVLDLNNNGLtdegaSAL-AETLASLKS 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 529 LKILNLASNLLSHLPLGVF-------PQSLINLNLSGN--------QLFSPKPEvFMTLSILDITHNKY---VCDCALKS 590
Cdd:cd00116   223 LEVLNLGDNNLTDAGAAALasallspNISLLTLSLSCNditddgakDLAEVLAE-KESLLELDLRGNKFgeeGAQLLAES 301

                         330
                  ....*....|....*...
gi 1829740713 591 LLVWLNETNVTLAGSESD 608
Cdd:cd00116   302 LLEPGNELESLWVKDDSF 319
LRR_9 pfam14580
Leucine-rich repeat;
390-459 3.75e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 42.06  E-value: 3.75e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1829740713 390 IDLRDNALKKLPSFPHLT---TAFLGDNKLMSVA----HIAIAATHIELERNWLANLGDLYVLFQVPNLQYLSLKQN 459
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRrlkTLLLNNNRICRIGeglgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRN 123
LRR_8 pfam13855
Leucine rich repeat;
362-416 5.29e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 5.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 362 SIMYIDLQQNHIGMISQKSFRNLVSLKKIDLRDNALKKLP-----SFPHLTTAFLGDNKL 416
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
146-207 5.84e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1829740713 146 SSLEELDLSSNQITKLHPHpLFYNLTILKAVDLKFNKISNLcesNLTSFQG-KHFSFFSLSSN 207
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTL---SPGAFSGlPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 281-347 1.01e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.01e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 281 DTFTGLAISD-LRLLDISYGFIFSLNSLifKSLGNLEFLNLFRNKVNHIE--KQAFFGLENLKILNLSSN 347
Cdd:cd21340   111 DPRSLAALSNsLRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 360-559 1.36e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 360 LHSIMYIDLQQNHIGMIS-QKSFRNLvslKKIDLRDNALKK---LPSFPHLTTAFLGDNKLmsvahiaiaaTHIElernw 435
Cdd:cd21340     1 LKRITHLYLNDKNITKIDnLSLCKNL---KVLYLYDNKITKienLEFLTNLTHLYLQNNQI----------EKIE----- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 436 laNLGDLyvlfqvPNLQYLSLKQNRFSycekSVNAIEN-SQLIYMDLGENMLQLvwERGLCLDVF--RTLSQ-LQILFLN 511
Cdd:cd21340    63 --NLENL------VNLKKLYLGGNRIS----VVEGLENlTNLEELHIENQRLPP--GEKLTFDPRslAALSNsLRVLNIS 128

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1829740713 512 NNYLSALpqEIFSGLTSLKILNLASNLLSHL-----PLGVFPQsLINLNLSGN 559
Cdd:cd21340   129 GNNIDSL--EPLAPLRNLEQLDASNNQISDLeelldLLSSWPS-LRELDLTGN 178
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 314-395 2.04e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 314 NLEFLNLFrNKVNHIEKQAFFGLENLKILNLSSNLLgELYDYTFEGLhSIMYIDLQQNhIGMISQKSFRNLVSLKKIDLR 393
Cdd:pfam13306  12 SLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSSLT-SIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLP 87


                  ..
gi 1829740713 394 DN 395
Cdd:pfam13306  88 SN 89
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 309-543 2.35e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 309 FKSLGNLEFLNLFRNKVNHIEkqaffGLENLKilNLSSnllgeLYdytfeglhsimyidLQQNHIGMISqksfrNLVSLK 388
Cdd:cd21340    20 LSLCKNLKVLYLYDNKITKIE-----NLEFLT--NLTH-----LY--------------LQNNQIEKIE-----NLENLV 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 389 KidlrdnaLKKLpsfphlttaFLGDNKLmsvahiaiaaTHIE-LERnwLANLGDLYVLFQ-VPNLQYLSLKQNrfsycek 466
Cdd:cd21340    69 N-------LKKL---------YLGGNRI----------SVVEgLEN--LTNLEELHIENQrLPPGEKLTFDPR------- 113

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1829740713 467 SVNAIENSqLIYMDLGENMLQlvwerglCLDVFRTLSQLQILFLNNNYLSALPQ--EIFSGLTSLKILNLASNLLSHLP 543
Cdd:cd21340   114 SLAALSNS-LRVLNISGNNID-------SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 451-580 3.69e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 3.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829740713 451 LQYLSLKQNRFSYCE-KSVNAIENSQLIYMDL-GENMlqlvweRGLCLDVFRTLSQLQILFLNNNYLSA-LPQEIFSGLT 527
Cdd:PLN00113   45 LKYLSNWNSSADVCLwQGITCNNSSRVVSIDLsGKNI------SGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSS 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1829740713 528 SLKILNLASNLLS-HLPLGVFPqSLINLNLSGNQLFSPKPE---VFMTLSILDITHN 580
Cdd:PLN00113  119 SLRYLNLSNNNFTgSIPRGSIP-NLETLDLSNNMLSGEIPNdigSFSSLKVLDLGGN 174
LRRCT smart00082
Leucine rich repeat C-terminal domain;
580-626 5.74e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 5.74e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1829740713  580 NKYVCDCALKSLLVWLNETNVTLagsESDRY-CVYPPALAGvPVSLLT 626
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ---DPVDLrCASPSSLRG-PLLELL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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