NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1939517903|gb|QJF45319|]
View 

class I SAM-dependent methyltransferase [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 36-174 1.41e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.22  E-value: 1.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  36 INQLGITRGDSILEVGFGPGYCMQQMLKRekDVHLHGIDVSEAMLKLAARRVKPKG--VRLIQGSIETFPLPASFYDKVI 113
Cdd:COG2226    15 LAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGlnVEFVVGDAEDLPFPDGSFDLVI 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1939517903 114 SVNNYTIWNDQTKGIKQIYRALKPGGKAAITmqpreadaspEKTKSFGRQMIADFKAAGFE 174
Cdd:COG2226    93 SSFVLHHLPDPERALAEIARVLKPGGRLVVV----------DFSPPDLAELEELLAEAGFE 143
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 36-174 1.41e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.22  E-value: 1.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  36 INQLGITRGDSILEVGFGPGYCMQQMLKRekDVHLHGIDVSEAMLKLAARRVKPKG--VRLIQGSIETFPLPASFYDKVI 113
Cdd:COG2226    15 LAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGlnVEFVVGDAEDLPFPDGSFDLVI 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1939517903 114 SVNNYTIWNDQTKGIKQIYRALKPGGKAAITmqpreadaspEKTKSFGRQMIADFKAAGFE 174
Cdd:COG2226    93 SSFVLHHLPDPERALAEIARVLKPGGRLVVV----------DFSPPDLAELEELLAEAGFE 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 47-139 4.15e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 88.39  E-value: 4.15e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  47 ILEVGFGPGYCMQQMLKREKdVHLHGIDVSEAMLKLAARRVKPKG--VRLIQGSIETFPLPASFYDKVISVN--NYTIWN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGlnVEFVQGDAEDLPFPDGSFDLVVSSGvlHHLPDP 79

                          90
                  ....*....|....*..
gi 1939517903 123 DQTKGIKQIYRALKPGG 139
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 33-179 4.47e-18

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 78.83  E-value: 4.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  33 QWTINQLGITRGDSILEVGFGPGYCMQQMLKR-EKDVHLHGIDVSEAMLKLAARRVKPKG--VRLIQGSIETFPLPASFY 109
Cdd:PRK08317    9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRvGPEGRVVGIDRSEAMLALAKERAAGLGpnVEFVRGDADGLPFPDGSF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903 110 DKVISVNNYTIWNDQTKGIKQIYRALKPGGKAAI--------TMQPREADASPEKTKSF---------GRQMIADFKAAG 172
Cdd:PRK08317   89 DAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVldtdwdtlVWHSGDRALMRKILNFWsdhfadpwlGRRLPGLFREAG 168


                  ....*..
gi 1939517903 173 FEDIDIQ 179
Cdd:PRK08317  169 LTDIEVE 175
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-144 2.41e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.22  E-value: 2.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  47 ILEVGFGPGYCMQQMLKReKDVHLHGIDVSEAMLKLA---ARRVKPKGVRLIQGSIETFPLPA--SFyDKVISVNNYTIW 121
Cdd:cd02440     2 VLDLGCGTGALALALASG-PGARVTGVDISPVALELArkaAAALLADNVEVLKGDAEELPPEAdeSF-DVIISDPPLHHL 79

                          90       100
                  ....*....|....*....|....
gi 1939517903 122 -NDQTKGIKQIYRALKPGGKAAIT 144
Cdd:cd02440    80 vEDLARFLEEARRLLKPGGVLVLT 103
rADc smart00650
Ribosomal RNA adenine dimethylases;
36-114 5.52e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 39.03  E-value: 5.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903   36 INQLGITRGDSILEVGFGPGYCMQQMLKREKDVHLHGIDvsEAMLKLAARRVKPKG-VRLIQGSIETFPLPASFYDKVIS 114
Cdd:smart00650   6 VRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEID--PRLAPRLREKFAAADnLTVIHGDALKFDLPKLQPYKVVG 83
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 36-174 1.41e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.22  E-value: 1.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  36 INQLGITRGDSILEVGFGPGYCMQQMLKRekDVHLHGIDVSEAMLKLAARRVKPKG--VRLIQGSIETFPLPASFYDKVI 113
Cdd:COG2226    15 LAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGlnVEFVVGDAEDLPFPDGSFDLVI 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1939517903 114 SVNNYTIWNDQTKGIKQIYRALKPGGKAAITmqpreadaspEKTKSFGRQMIADFKAAGFE 174
Cdd:COG2226    93 SSFVLHHLPDPERALAEIARVLKPGGRLVVV----------DFSPPDLAELEELLAEAGFE 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 47-139 4.15e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 88.39  E-value: 4.15e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  47 ILEVGFGPGYCMQQMLKREKdVHLHGIDVSEAMLKLAARRVKPKG--VRLIQGSIETFPLPASFYDKVISVN--NYTIWN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGlnVEFVQGDAEDLPFPDGSFDLVVSSGvlHHLPDP 79

                          90
                  ....*....|....*..
gi 1939517903 123 DQTKGIKQIYRALKPGG 139
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
43-145 2.27e-20

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 81.41  E-value: 2.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  43 RGDSILEVGFGPGYCMQQMLKREKDVHLHGIDVSEAMLKLAARRVkPkGVRLIQGSIETFPLPASFyDKVISvnNYTI-W 121
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL-P-NVRFVVADLRDLDPPEPF-DLVVS--NAALhW 75

                          90       100
                  ....*....|....*....|....*
gi 1939517903 122 -NDQTKGIKQIYRALKPGGKAAITM 145
Cdd:COG4106    76 lPDHAALLARLAAALAPGGVLAVQV 100
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 41-144 1.37e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 77.75  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  41 ITRGDSILEVGFGPGYCMQQMLKREKDVhlHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISvnNYTI 120
Cdd:COG2227    22 LPAGGRVLDVGCGTGRLALALARRGADV--TGVDISPEALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVIC--SEVL 97

                          90       100
                  ....*....|....*....|....*.
gi 1939517903 121 W--NDQTKGIKQIYRALKPGGKAAIT 144
Cdd:COG2227    98 EhlPDPAALLRELARLLKPGGLLLLS 123
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 48-143 2.19e-18

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 76.16  E-value: 2.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  48 LEVGFGPGYCMQQMLKREKDVHlhGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYTIWNDQTKG 127
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVT--GVDISPEMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERA 78

                          90
                  ....*....|....*.
gi 1939517903 128 IKQIYRALKPGGKAAI 143
Cdd:pfam08241  79 LREIARVLKPGGILII 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
29-174 3.53e-18

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 78.12  E-value: 3.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  29 QTLNQWTINQLGITRGDSILEVGFGPGYCMQQMlkREKDVHLHGIDVSEAMLKLAARrvKPKGVRLIQGSIETFPLPASF 108
Cdd:COG4976    32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEAL--RPRGYRLTGVDLSEEMLAKARE--KGVYDRLLVADLADLAEPDGR 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1939517903 109 YDKVISVNNYTIWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIAdfkAAGFE 174
Cdd:COG4976   108 FDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVEDADGSGRYAHSLDYVRDLLA---AAGFE 170
PRK08317 PRK08317
hypothetical protein; Provisional
 33-179 4.47e-18

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 78.83  E-value: 4.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  33 QWTINQLGITRGDSILEVGFGPGYCMQQMLKR-EKDVHLHGIDVSEAMLKLAARRVKPKG--VRLIQGSIETFPLPASFY 109
Cdd:PRK08317    9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRvGPEGRVVGIDRSEAMLALAKERAAGLGpnVEFVRGDADGLPFPDGSF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903 110 DKVISVNNYTIWNDQTKGIKQIYRALKPGGKAAI--------TMQPREADASPEKTKSF---------GRQMIADFKAAG 172
Cdd:PRK08317   89 DAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVldtdwdtlVWHSGDRALMRKILNFWsdhfadpwlGRRLPGLFREAG 168


                  ....*..
gi 1939517903 173 FEDIDIQ 179
Cdd:PRK08317  169 LTDIEVE 175
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 24-144 3.78e-15

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 69.57  E-value: 3.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  24 MAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQMLKReKDVHLHGIDVSEAMLKLAARRVKPKG----VRLIQGSI 99
Cdd:COG2230    32 LEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARR-YGVRVTGVTLSPEQLEYARERAAEAGladrVEVRLADY 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1939517903 100 ETFPLPASFyDKVISVNNYTIWNDQTKG--IKQIYRALKPGGKAAIT 144
Cdd:COG2230   111 RDLPADGQF-DAIVSIGMFEHVGPENYPayFAKVARLLKPGGRLLLH 156
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 47-144 2.41e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.22  E-value: 2.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  47 ILEVGFGPGYCMQQMLKReKDVHLHGIDVSEAMLKLA---ARRVKPKGVRLIQGSIETFPLPA--SFyDKVISVNNYTIW 121
Cdd:cd02440     2 VLDLGCGTGALALALASG-PGARVTGVDISPVALELArkaAAALLADNVEVLKGDAEELPPEAdeSF-DVIISDPPLHHL 79

                          90       100
                  ....*....|....*....|....
gi 1939517903 122 -NDQTKGIKQIYRALKPGGKAAIT 144
Cdd:cd02440    80 vEDLARFLEEARRLLKPGGVLVLT 103
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 47-186 5.59e-13

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 66.07  E-value: 5.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  47 ILEVGFGPGYCMQQMLKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYTIWNDQTK 126
Cdd:PLN02490  117 VVDVGGGTGFTTLGIVKHVDAKNVTILDQSPHQLAKAKQKEPLKECKIIEGDAEDLPFPTDYADRYVSAGSIEYWPDPQR 196

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1939517903 127 GIKQIYRALKPGGKAAI------------------TMQPREadaspektksfgRQMIADFKAAGFEdiDIQFKNIKPE 186
Cdd:PLN02490  197 GIKEAYRVLKIGGKACLigpvhptfwlsrffadvwMLFPKE------------EEYIEWFTKAGFK--DVKLKRIGPK 260
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 35-147 1.56e-12

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 64.02  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  35 TINQLGITRGDSILEVGFGPGYCMQQMLKR-EKDVHLHGIDVSEAMLKLAARRVKPKG----VRLIQGSIETFPLPASFY 109
Cdd:PRK00216   43 TIKWLGVRPGDKVLDLACGTGDLAIALAKAvGKTGEVVGLDFSEGMLAVGREKLRDLGlsgnVEFVQGDAEALPFPDNSF 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1939517903 110 DKV-ISvnnYTIWN--DQTKGIKQIYRALKPGGKAAI--TMQP 147
Cdd:PRK00216  123 DAVtIA---FGLRNvpDIDKALREMYRVLKPGGRLVIleFSKP 162
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 48-140 2.36e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 60.46  E-value: 2.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  48 LEVGFGPGYCMQQMLKREKDVHLHGIDVSEAMLKLAARRVKPKG------VRLIQGSIETFPLPAsfYDKVISVNNYTIW 121
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGllnavrVELFQLDLGELDPGS--FDVVVASNVLHHL 78

                          90
                  ....*....|....*....
gi 1939517903 122 NDQTKGIKQIYRALKPGGK 140
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGV 97
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 43-144 1.66e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 60.70  E-value: 1.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  43 RGDSILEVGFGPGYCMQQMLKREKDvHLHGIDVSEAMLKLAARRVKPKG---VRLIQGSIETF-PLPASFYDKVISVNNY 118
Cdd:COG0500    26 KGGRVLDLGCGTGRNLLALAARFGG-RVIGIDLSPEAIALARARAAKAGlgnVEFLVADLAELdPLPAESFDLVVAFGVL 104

                          90       100
                  ....*....|....*....|....*....
gi 1939517903 119 TiWND---QTKGIKQIYRALKPGGKAAIT 144
Cdd:COG0500   105 H-HLPpeeREALLRELARALKPGGVLLLS 132
arsM PRK11873
arsenite methyltransferase;
69-179 4.27e-09

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 54.57  E-value: 4.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  69 HLHGIDVSEAMLKLAaRRVKPKG----VRLIQGSIETFPLPASFYDKVISvnNYTIwN---DQTKGIKQIYRALKPGGKA 141
Cdd:PRK11873  104 KVIGVDMTPEMLAKA-RANARKAgytnVEFRLGEIEALPVADNSVDVIIS--NCVI-NlspDKERVFKEAFRVLKPGGRF 179

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1939517903 142 AITMQPREADAsPEKTKS---------FGRQMIADFKA----AGFEDIDIQ 179
Cdd:PRK11873  180 AISDVVLRGEL-PEEIRNdaelyagcvAGALQEEEYLAmlaeAGFVDITIQ 229
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 38-144 3.53e-08

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 51.68  E-value: 3.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  38 QLGITRGDSILEVGFGPGYcMQQMLkREKDVHLHGIDVSEAMLKLAARRVKPKgvRLIQGSIETFPLPASFYDKVISvNN 117
Cdd:PRK10258   37 MLPQRKFTHVLDAGCGPGW-MSRYW-RERGSQVTALDLSPPMLAQARQKDAAD--HYLAGDIESLPLATATFDLAWS-NL 111

                          90       100
                  ....*....|....*....|....*...
gi 1939517903 118 YTIW-NDQTKGIKQIYRALKPGGKAAIT 144
Cdd:PRK10258  112 AVQWcGNLSTALRELYRVVRPGGVVAFT 139
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
35-140 3.99e-08

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 51.67  E-value: 3.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  35 TINQLGITRGDSILEVGFGPGYCMQQMLKR-EKDVHLHGIDVSEAMLKLAARRVKPKG---VRLIQGSIETFPLPASFYD 110
Cdd:pfam01209  34 TMKCMGVKRGNKFLDVAGGTGDWTFGLSDSaGSSGKVVGLDINENMLKEGEKKAKEEGkynIEFLQGNAEELPFEDDSFD 113

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1939517903 111 KV-IS--VNNYTiwnDQTKGIKQIYRALKPGGK 140
Cdd:pfam01209 114 IVtISfgLRNFP---DYLKVLKEAFRVLKPGGR 143
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
81-174 6.02e-08

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 51.46  E-value: 6.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  81 KLAARRVKPKGVRLIQGSIETFP-LPASFYDKVISVNNYTIWNDQT---KGIKQIYRALKPGGKAAITmQPR-EADASPE 155
Cdd:COG4798   119 KLAADPALYGNVRVTAFAPPDDPiAPPGSADLVLTFRNYHNWYRAGdaaAMFAAFFKALKPGGVLGVV-DHRaPPGTGLE 197

                          90       100
                  ....*....|....*....|...
gi 1939517903 156 KTKSFGR----QMIADFKAAGFE 174
Cdd:COG4798   198 AVATLGYideaYVIALAEAAGFE 220
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 47-144 8.43e-05

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 41.88  E-value: 8.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  47 ILEVGFG-PGYCMqqMLKREKDVHLHGIDVSEAMLKLAARRVKPKG-VRLIQGSIETFPLPASFYDKVISVNN--YTIWN 122
Cdd:PTZ00098   56 VLDIGSGlGGGCK--YINEKYGAHVHGVDICEKMVNIAKLRNSDKNkIEFEANDILKKDFPENTFDMIYSRDAilHLSYA 133

                          90       100
                  ....*....|....*....|..
gi 1939517903 123 DQTKGIKQIYRALKPGGKAAIT 144
Cdd:PTZ00098  134 DKKKLFEKCYKWLKPNGILLIT 155
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 9-143 1.41e-04

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 41.41  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903   9 FSRPKGVIGMIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPG---YCMQQmlKREKDVHLHGIDVSEAMLKLAAR 85
Cdd:PLN02233   39 FNRIAPVYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGdlaFLLSE--KVGSDGKVMGLDFSSEQLAVAAS 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1939517903  86 RVKP------KGVRLIQGSIETFPLPASFYDKVISvnNYTIWN--DQTKGIKQIYRALKPGGKAAI 143
Cdd:PLN02233  117 RQELkakscyKNIEWIEGDATDLPFDDCYFDAITM--GYGLRNvvDRLKAMQEMYRVLKPGSRVSI 180
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 39-176 3.10e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 39.72  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  39 LGITRGDSILEVGFGPGYCMQQMlkREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIetfplPASFYDkVISVNNY 118
Cdd:pfam13489  18 PKLPSPGRVLDFGCGTGIFLRLL--RAQGFSVTGVDPSPIAIERALLNVRFDQFDEQEAAV-----PAGKFD-VIVAREV 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1939517903 119 TIW-NDQTKGIKQIYRALKPGGKAAITMQpreaDASPEKTKSF-----------------GRQMIADFKAAGFEDI 176
Cdd:pfam13489  90 LEHvPDPPALLRQIAALLKPGGLLLLSTP----LASDEADRLLlewpylrprnghislfsARSLKRLLEEAGFEVV 161
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 20-139 3.23e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 40.14  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  20 AGYIMAAenqtlnqwtinqLGITRGDSILEVGFGPGYCMQQMLKREKDV-HLHGIDVSEAMLKLAARRVK----PKGVRL 94
Cdd:COG2519    80 AGYIIAR------------LDIFPGARVLEAGTGSGALTLALARAVGPEgKVYSYERREDFAEIARKNLErfglPDNVEL 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1939517903  95 IQGSIEtFPLPASFYDKVIsvnnytI-----WNdqtkGIKQIYRALKPGG 139
Cdd:COG2519   148 KLGDIR-EGIDEGDVDAVF------LdmpdpWE----ALEAVAKALKPGG 186
rADc smart00650
Ribosomal RNA adenine dimethylases;
36-114 5.52e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 39.03  E-value: 5.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903   36 INQLGITRGDSILEVGFGPGYCMQQMLKREKDVHLHGIDvsEAMLKLAARRVKPKG-VRLIQGSIETFPLPASFYDKVIS 114
Cdd:smart00650   6 VRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEID--PRLAPRLREKFAAADnLTVIHGDALKFDLPKLQPYKVVG 83
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 47-145 5.77e-04

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 39.54  E-value: 5.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  47 ILEVGFGPGYCMQQMLKREKDVHLHGIDVSEAMLKLAARRVkPkGVRLIQGSIETFpLPASFYDkVISVNNYTIW-NDQT 125
Cdd:PRK01683   35 VVDLGCGPGNSTELLVERWPAARITGIDSSPAMLAEARSRL-P-DCQFVEADIASW-QPPQALD-LIFANASLQWlPDHL 110

                          90       100
                  ....*....|....*....|
gi 1939517903 126 KGIKQIYRALKPGGKAAITM 145
Cdd:PRK01683  111 ELFPRLVSLLAPGGVLAVQM 130
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
16-139 7.36e-04

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 39.55  E-value: 7.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  16 IGMIAGYImaaenqtlnqwtINQLGITRGDSILEVGFGPGYCMQQMLKR-EKDVHLHGIDVSEAMLKLAARR--VKPKGV 92
Cdd:COG0827   100 IGLLIGYL------------VEKFTKKEGLRILDPAVGTGNLLTTVLNQlKKKVNAYGVEVDDLLIRLAAVLanLQGHPV 167

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1939517903  93 RLIQGSIETfPLPASFYDKVIS---VNNYTIW----NDQTKG-----------IKQIYRALKPGG 139
Cdd:COG0827   168 ELFHQDALQ-PLLIDPVDVVISdlpVGYYPNDerakRFKLKAdeghsyahhlfIEQSLNYLKPGG 231
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 36-176 1.17e-03

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 38.96  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  36 INQLGITRGDSILEVGFGPG---YCMQQmlkrEKDVHLHGIDVSEAMLKLAARRV--KPKGVRLIQGSIETFPLPASFYD 110
Cdd:PLN02336  259 VDKLDLKPGQKVLDVGCGIGggdFYMAE----NFDVHVVGIDLSVNMISFALERAigRKCSVEFEVADCTKKTYPDNSFD 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903 111 KVISVNnyTIWNDQTKG--IKQIYRALKPGGKAAITMQPREADA-SPE-------------KTKSFGrQMIADfkaAGFE 174
Cdd:PLN02336  335 VIYSRD--TILHIQDKPalFRSFFKWLKPGGKVLISDYCRSPGTpSPEfaeyikqrgydlhDVQAYG-QMLKD---AGFD 408


                  ..
gi 1939517903 175 DI 176
Cdd:PLN02336  409 DV 410
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
36-162 1.62e-03

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 38.34  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939517903  36 INQLGITRGDSILEVGFGPGYCMQQMLKREKDVHLhgIDVSEAMLKLAARRVKPKG-VRLIQGSIETFPLPAsfYDKVIS 114
Cdd:PRK14896   22 VEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYA--IELDPRLAEFLRDDEIAAGnVEIIEGDALKVDLPE--FNKVVS 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1939517903 115 VNNYTIWNDQTkgikqiYRALKPGGKAAITMQPRE-AD--ASPEKTKSFGR 162
Cdd:PRK14896   98 NLPYQISSPIT------FKLLKHGFEPAVLMYQKEfAErmVAKPGTKEYGR 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH