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Conserved domains on  [gi|1883779901|gb|QMT14874|]
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toll-like receptor 4, partial [Poecile gambeli]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-254 1.82e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901  66 IGNVSTVRLVNLGLEEISQVPAR----SKVKQLECKKCSFEDVPAlKLSLFKELRVLRItKNNRLKNFRQNFEGLTNLEV 141
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDL-SNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 142 IDLSENRLTFSgccSPQFQNCPNLKYLNLSFNSNIRLTGDFANVKNLLYLDLQHTTVfgpGSYPVFLSLQKLIYLDISHT 221
Cdd:COG4886   187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1883779901 222 KteVKSQCTFCGLNSLQVLKMAGNSFEGNKLAS 254
Cdd:COG4886   261 Q--LTDLPPLANLTNLKTLDLSNNQLTDLKLKE 291
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-254 1.82e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901  66 IGNVSTVRLVNLGLEEISQVPAR----SKVKQLECKKCSFEDVPAlKLSLFKELRVLRItKNNRLKNFRQNFEGLTNLEV 141
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDL-SNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 142 IDLSENRLTFSgccSPQFQNCPNLKYLNLSFNSNIRLTGDFANVKNLLYLDLQHTTVfgpGSYPVFLSLQKLIYLDISHT 221
Cdd:COG4886   187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1883779901 222 KteVKSQCTFCGLNSLQVLKMAGNSFEGNKLAS 254
Cdd:COG4886   261 Q--LTDLPPLANLTNLKTLDLSNNQLTDLKLKE 291
LRR_8 pfam13855
Leucine rich repeat;
114-173 7.41e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 7.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1883779901 114 ELRVLRITkNNRLKNFRQ-NFEGLTNLEVIDLSENRLTFSgccSPQ-FQNCPNLKYLNLSFN 173
Cdd:pfam13855   2 NLRSLDLS-NNRLTSLDDgAFKGLSNLKVLDLSNNLLTTL---SPGaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 105-173 1.58e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 1.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1883779901 105 PALKLSLFKELRVLRITkNNRLKNFRQnFEGLTNLEVIDLSENRLTFSGCCSPQFQNCPNLKYLNLSFN 173
Cdd:cd21340   112 PRSLAALSNSLRVLNIS-GNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 109-249 2.27e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 109 LSLFKELRVLRITKNNRLKNFRQNFEGLTNLEVIDLSENRLT----------------------FSGCCSPQFQNCPNLK 166
Cdd:PLN00113  160 IGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnLSGEIPYEIGGLTSLN 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 167 YLNLSFNSnirLTGD----FANVKNLLYLDLQHTTVFGPGSYPVFlSLQKLIYLDISHTKTEVKSQCTFCGLNSLQVLKM 242
Cdd:PLN00113  240 HLDLVYNN---LTGPipssLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHL 315


                  ....*..
gi 1883779901 243 AGNSFEG 249
Cdd:PLN00113  316 FSNNFTG 322
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-254 1.82e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901  66 IGNVSTVRLVNLGLEEISQVPAR----SKVKQLECKKCSFEDVPAlKLSLFKELRVLRItKNNRLKNFRQNFEGLTNLEV 141
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDL-SNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 142 IDLSENRLTFSgccSPQFQNCPNLKYLNLSFNSNIRLTGDFANVKNLLYLDLQHTTVfgpGSYPVFLSLQKLIYLDISHT 221
Cdd:COG4886   187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1883779901 222 KteVKSQCTFCGLNSLQVLKMAGNSFEGNKLAS 254
Cdd:COG4886   261 Q--LTDLPPLANLTNLKTLDLSNNQLTDLKLKE 291
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-261 4.13e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901  73 RLVNLGLEEISQVPARSKVKQLECKKCSFEDVPAlKLSLFKELRVLRITkNNRLKNFRQNFEGLTNLEVIDLSENRLTfs 152
Cdd:COG4886    97 NLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLS-NNQLTDLPEPLGNLTNLKSLDLSNNQLT-- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 153 gCCSPQFQNCPNLKYLNLSFNSNIRLTGDFANVKNLLYLDLQHTTVfgpGSYPVFLS-LQKLIYLDISHTKteVKSQCTF 231
Cdd:COG4886   173 -DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQL---TDLPEPLAnLTNLETLDLSNNQ--LTDLPEL 246

                         170       180       190
                  ....*....|....*....|....*....|
gi 1883779901 232 CGLNSLQVLKMAGNSFEGNKLASNFKNLSH 261
Cdd:COG4886   247 GNLTNLEELDLSNNQLTDLPPLANLTNLKT 276
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-261 9.48e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 9.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901  61 TLFNCIGNVSTVRLVNLGLEEISQVPAR----SKVKQLECKKCSFEDVPAlKLSLFKELRVLRITkNNRLKNFRQNFEGL 136
Cdd:COG4886   127 DLPEELANLTNLKELDLSNNQLTDLPEPlgnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS-NNQITDLPEPLGNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 137 TNLEVIDLSENRLTFsgcCSPQFQNCPNLKYLNLSFNsNIRLTGDFANVKNLLYLDLQHTTVfgpGSYPVFLSLQKLIYL 216
Cdd:COG4886   205 TNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNN-QLTDLPELGNLTNLEELDLSNNQL---TDLPPLANLTNLKTL 277

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1883779901 217 DISHTKTEVKSQCTFCGLNSLQVLKMAGNSFEGNKLASNFKNLSH 261
Cdd:COG4886   278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR_8 pfam13855
Leucine rich repeat;
114-173 7.41e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 7.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1883779901 114 ELRVLRITkNNRLKNFRQ-NFEGLTNLEVIDLSENRLTFSgccSPQ-FQNCPNLKYLNLSFN 173
Cdd:pfam13855   2 NLRSLDLS-NNRLTSLDDgAFKGLSNLKVLDLSNNLLTTL---SPGaFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-248 1.29e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 107 LKLSLFKELRVLRITKNNRLKNFRQNFEGLTNLEVIDLSENRltfsgccspQFQNCPNLKYLNLSFNSNIRLTGDFANVK 186
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANLT 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1883779901 187 NLLYLDLQHTTVfgpGSYPVFLS-LQKLIYLDISHTK-TEVKSqcTFCGLNSLQVLKMAGNSFE 248
Cdd:COG4886   137 NLKELDLSNNQL---TDLPEPLGnLTNLKSLDLSNNQlTDLPE--ELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
189-247 1.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1883779901 189 LYLDLQHTTVFGPGSypvFLSLQKLIYLDISHTKTEVKSQCTFCGLNSLQVLKMAGNSF 247
Cdd:pfam13855   6 LDLSNNRLTSLDDGA---FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 137-184 1.23e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 1.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1883779901 137 TNLEVIDLSENRLTFSgccsPQFQNCPNLKYLNLSFNSNIRLTGDFAN 184
Cdd:pfam12799   1 PNLEVLDLSNNQITDI----PPLAKLPNLETLDLSGNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
137-196 1.46e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 1.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1883779901 137 TNLEVIDLSENRLTfsGCCSPQFQNCPNLKYLNLSFNSNIRLTGD-FANVKNLLYLDLQHT 196
Cdd:pfam13855   1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 105-173 1.58e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 1.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1883779901 105 PALKLSLFKELRVLRITkNNRLKNFRQnFEGLTNLEVIDLSENRLTFSGCCSPQFQNCPNLKYLNLSFN 173
Cdd:cd21340   112 PRSLAALSNSLRVLNIS-GNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 109-249 2.27e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 109 LSLFKELRVLRITKNNRLKNFRQNFEGLTNLEVIDLSENRLT----------------------FSGCCSPQFQNCPNLK 166
Cdd:PLN00113  160 IGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnLSGEIPYEIGGLTSLN 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 167 YLNLSFNSnirLTGD----FANVKNLLYLDLQHTTVFGPGSYPVFlSLQKLIYLDISHTKTEVKSQCTFCGLNSLQVLKM 242
Cdd:PLN00113  240 HLDLVYNN---LTGPipssLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHL 315


                  ....*..
gi 1883779901 243 AGNSFEG 249
Cdd:PLN00113  316 FSNNFTG 322
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 135-249 2.48e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 135 GLTNLEVIDLSENRLTFSgccSPQ--FQNCPNLKYLNLSFNSnirLTGDFAN--VKNLLYLDLQHTTVFG--PGSYPVFL 208
Cdd:PLN00113   91 RLPYIQTINLSNNQLSGP---IPDdiFTTSSSLRYLNLSNNN---FTGSIPRgsIPNLETLDLSNNMLSGeiPNDIGSFS 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1883779901 209 SLQkliYLDISHTKTEVKSQCTFCGLNSLQVLKMAGNSFEG 249
Cdd:PLN00113  165 SLK---VLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG 202
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-254 3.29e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 100 SFEDVPALKLSLFKELRVLRITKNNRLKNFRQNFEGLTNLEVIDLSENRLtfSGCCSPQFQNCPNLKYLNLSFNSNIRLT 179
Cdd:PLN00113  391 SLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL--QGRINSRKWDMPSLQMLSLARNKFFGGL 468

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1883779901 180 GDFANVKNLLYLDLQHTTVfgPGSYPV-FLSLQKLIYLDISHTKT--EVKSQCTFCglNSLQVLKMAGNSFEGNKLAS 254
Cdd:PLN00113  469 PDSFGSKRLENLDLSRNQF--SGAVPRkLGSLSELMQLKLSENKLsgEIPDELSSC--KKLVSLDLSHNQLSGQIPAS 542
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 118-249 9.21e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883779901 118 LRITKNNRLKNFRQNFEGLTNLEVIDLSENRltFSGCCsPQFQNCPNLKYLNLSFNsniRLTG----DFANVKNLLYLDL 193
Cdd:PLN00113  433 LDISNNNLQGRINSRKWDMPSLQMLSLARNK--FFGGL-PDSFGSKRLENLDLSRN---QFSGavprKLGSLSELMQLKL 506

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1883779901 194 QHTTVfgPGSYPVFLS-LQKLIYLDISHTKTEVKSQCTFCGLNSLQVLKMAGNSFEG 249
Cdd:PLN00113  507 SENKL--SGEIPDELSsCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSG 561
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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