NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1883890762|gb|QMT29715|]
View 

NADH dehydrogenase subunit 4, partial (mitochondrion) [Cratera arucuia]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
2-123 1.27e-14

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00150:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 417  Bit Score: 68.33  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883890762   2 TRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHGK 81
Cdd:MTH00150  298 SRSLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLYTSIQHGG 377
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1883890762  82 FN*AIISNNLIELHYFiyIVLIFHFYLVFF*IIF*DTYLSII 123
Cdd:MTH00150  378 SSSFLKPFNELKSSEM--LLLLLHWVPLLLLILKSDLLFMWI 417
 
Name Accession Description Interval E-value
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
2-123 1.27e-14

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 68.33  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883890762   2 TRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHGK 81
Cdd:MTH00150  298 SRSLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLYTSIQHGG 377
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1883890762  82 FN*AIISNNLIELHYFiyIVLIFHFYLVFF*IIF*DTYLSII 123
Cdd:MTH00150  378 SSSFLKPFNELKSSEM--LLLLLHWVPLLLLILKSDLLFMWI 417
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
1-52 8.92e-03

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 34.60  E-value: 8.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1883890762   1 GTRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMN 52
Cdd:pfam00361 228 HTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAAS 279
 
Name Accession Description Interval E-value
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
2-123 1.27e-14

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 68.33  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883890762   2 TRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHGK 81
Cdd:MTH00150  298 SRSLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLYTSIQHGG 377
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1883890762  82 FN*AIISNNLIELHYFiyIVLIFHFYLVFF*IIF*DTYLSII 123
Cdd:MTH00150  378 SSSFLKPFNELKSSEM--LLLLLHWVPLLLLILKSDLLFMWI 417
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
1-117 2.35e-11

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 59.01  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883890762   1 GTRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHG 80
Cdd:MTH00163  326 GSRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSYSQHG 405
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1883890762  81 KFN*AIISNNLIELHyfIYIVLIFHFYLVFF*IIF*D 117
Cdd:MTH00163  406 KYYSGLYSCSSGKVR--EYLLLFLHWLPLNLLILKSD 440
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
1-113 2.26e-09

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 53.44  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883890762   1 GTRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHG 80
Cdd:MTH00205  330 NSRSMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMSLLSSSKISGIPLSLISFLSGAYSLYLYSQSQHG 409
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1883890762  81 KFN*AIISNnlIELHYFIYIVLIFHFYLVFF*I 113
Cdd:MTH00205  410 KVSSQISSF--LAISEREYYILILHWFPLNILI 440
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
2-118 6.66e-09

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 52.05  E-value: 6.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883890762   2 TRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHGk 81
Cdd:MTH00014  333 TRSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSILSSSLSTAILLAITSFLAAAYSLFLYTSTQHG- 411
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1883890762  82 fN*AIISNNLIELHYFIYIVLIFHFYLVFF*IIF*DT 118
Cdd:MTH00014  412 -SPPSFMNPLNLFTPRNHTLMTLHLVPLFILILKPDL 447
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
1-115 1.39e-06

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 45.70  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883890762   1 GTRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHG 80
Cdd:MTH00206  334 HTRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSLFSWSNFTLPLLGLGFLFTAIYSLYMFVMTQHG 413
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1883890762  81 KFN*AIISNNLIELHYFIYIVLifHFYLVFF*IIF 115
Cdd:MTH00206  414 KTPNHLLSLSPSSTREHLLLFL--HLFPVILLILN 446
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
1-114 1.69e-06

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 45.35  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883890762   1 GTRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHG 80
Cdd:MTH00044  340 GTRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISSIISWSILSFPIIGLATVFGAIYSLLIYQLTNSG 419
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1883890762  81 KFN*AIISNNLIELHYfiYIVLIFHFYLVFF*II 114
Cdd:MTH00044  420 SFPSWISNVSPISSRE--HLLIFLHLLPLILIII 451
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
2-80 1.57e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 36.96  E-value: 1.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1883890762   2 TRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMNISSLVIYIFNIFFCGLYSMFLYLFISHG 80
Cdd:MTH00204  356 TRLIKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFFSLLAAFEYSLGLGVLVTSGMVWSAAYSLYLYNRISFG 434
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
1-52 8.92e-03

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 34.60  E-value: 8.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1883890762   1 GTRNIFINRGFIFFIPLLCLMWFFFSSLNCSIPFSLNFISEFLLICSGVNMN 52
Cdd:pfam00361 228 HTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAAS 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure