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Conserved domains on  [gi|1958115126|gb|QQS60815|]
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hypothetical protein IPN41_04585 [Candidatus Falkowbacteria bacterium]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 9-78 6.76e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01672:

Pssm-ID: 450170  Cd Length: 200  Bit Score: 33.40  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958115126   9 DKLILLKANDEVILQRLSSRTSNDfgktTEIQEWIltskdEWENNIKKM----------NAIVIDTNKDINQVVIEILKV 78
Cdd:cd01672   127 DLTILLDIDPEVGLARIEARGRDD----RDEQEGL-----EFHERVREGylelaaqepeRIIVIDASQPLEEVLAEILKA 197
 
Name Accession Description Interval E-value
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 9-78 6.76e-03

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 33.40  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958115126   9 DKLILLKANDEVILQRLSSRTSNDfgktTEIQEWIltskdEWENNIKKM----------NAIVIDTNKDINQVVIEILKV 78
Cdd:cd01672   127 DLTILLDIDPEVGLARIEARGRDD----RDEQEGL-----EFHERVREGylelaaqepeRIIVIDASQPLEEVLAEILKA 197
 
Name Accession Description Interval E-value
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 9-78 6.76e-03

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 33.40  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958115126   9 DKLILLKANDEVILQRLSSRTSNDfgktTEIQEWIltskdEWENNIKKM----------NAIVIDTNKDINQVVIEILKV 78
Cdd:cd01672   127 DLTILLDIDPEVGLARIEARGRDD----RDEQEGL-----EFHERVREGylelaaqepeRIIVIDASQPLEEVLAEILKA 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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