|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-435 |
7.89e-49 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 170.48 E-value: 7.89e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 24 FGIISFSLLLTGFLSYSGNVVLAKLVS--NGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAA 101
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 102 TGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS----WRI 177
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 178 MFLLGGIGILLAWFLsgkyfiesprwlagkgqiagaesqlreveqqierekrirlppltlnqsnskvkvikgtfwllfkg 257
Cdd:cd17316 161 LFLIGALPALLALLL----------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 258 gmLRRTLVAITVLIAMNISLYTITVWIPTIFVN-SGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIII 336
Cdd:cd17316 176 --RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 337 AVLGYIYSIQ-TTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGS 415
Cdd:cd17316 254 GILALPLFYLlSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
410 420
....*....|....*....|
gi 1970692088 416 ITVFMVLGVMLVLCALVLSI 435
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
54-447 |
8.95e-37 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 140.92 E-value: 8.95e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 54 SNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYA 133
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 134 SFTEFIPATVRGkWSARLSFVGnWSpmlsaaIGVVVIAFF-----SWRIMFLL----GGIGILLAWFLsgkyfIESPRWL 204
Cdd:TIGR00898 204 LNTEFLPKKQRA-IVGTLIQVF-FS------LGLVLLPLVayfipDWRWLQLAvslpTFLFFLLSWFV-----PESPRWL 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 205 AGKGQIAGAESQLreveQQIEREKRIRLPP----LTLNQSNSKVKVIKGTFWLLFKGGMLRRTLVAITVLIAMNISLYTI 280
Cdd:TIGR00898 271 ISQGRIEEALKIL----QRIAKINGKKLPAevlsLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGL 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 281 TVWIPTIFVNSGIDVdksILMTAVIMIGApvgiFIAALIIDHFPRR--------LFGSALLIIIAVLGYIYSIQTtewAI 352
Cdd:TIGR00898 347 VLDLGNLGGNIYLDL---FISGLVELPAK----LITLLLIDRLGRRytmaasllLAGVALLLLLFVPVDLYFLRT---AL 416
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 353 LIYGLVMIFFLYMYVCfasaVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAAllthyGSITVFMVLGVMLVLC--A 430
Cdd:TIGR00898 417 AVLGKFGITSAFQMVY----LYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYL-----GEKWLFLPLVLFGGLAllA 487
|
410
....*....|....*..
gi 1970692088 431 LVLSIFGIETRKVSLEE 447
Cdd:TIGR00898 488 GILTLFLPETKGVPLPE 504
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
64-410 |
1.46e-31 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 124.78 E-value: 1.46e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:TIGR00895 59 SAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 144 RGKwSARLSFVG-NWSPMLSAAIGVVVIAFFSWRIMFLLGGIG-ILLAWFLSgKYFIESPRWLAGKGQIAGAEsQLREVE 221
Cdd:TIGR00895 139 RGT-AVGLMFCGyPIGAAVGGFLAGWLIPVFGWRSLFYVGGIApLLLLLLLM-RFLPESIDFLVSKRPETVRR-IVNAIA 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 222 QQIEREKRIRLPPltlnqSNSKVKVIKGTFWLLFKGGMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILM 301
Cdd:TIGR00895 216 PQMQAEAQSALPE-----QKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATG 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 302 TAVIMIGAPVGIFIAALIIDHFPRRLFGSaLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPT 381
Cdd:TIGR00895 291 GALFNFGGVIGSIIFGWLADRLGPRVTAL-LLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPT 369
|
330 340
....*....|....*....|....*....
gi 1970692088 382 HLRLRGSGFVNAVGRIVAVFTPYGVAALL 410
Cdd:TIGR00895 370 AIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
24-451 |
2.54e-29 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 119.30 E-value: 2.54e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 24 FGIISFSLLLTGFLSYSGnvvLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRIN--LLIVGIAA 101
Cdd:pfam00083 16 TGVIGAFLTLIDFFKNFG---LSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvLFVIGAVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 102 TGAAFVPDMYWLIFF-RFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS---WRI 177
Cdd:pfam00083 93 QGAAKGKWSVYQLIVgRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNsdgWRI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 178 MF----LLGGIGILLAWFLSgkyfiESPRWLAGKGQIAGAESQLREVEQQIEREKRIrlppLTLNQSNSKVKVIKGTFWL 253
Cdd:pfam00083 173 PLglqlVPALLLIIGLLFLP-----ESPRWLVEKGRLEEAREVLAKLRGVPDVDREL----DEIKDSLEAGQEAEKASWK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 254 LFKGGMLRRTLVAITVLIAMNISLYTITVWI---PTIFVNSGidVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---L 327
Cdd:pfam00083 244 ELFSTKTRRQRLLIGVMLQIFQQLTGINAIFyysTTIFENLG--LSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRpllL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 328 FGSA----LLIIIAVLGYIYSiQTTEWAiliyGLVMIFFLYMYVCFASA-------VYIPELWPTHLRLRGSGFVNAVGR 396
Cdd:pfam00083 322 LGAAgmaiCFVILGIVALLGV-SKSDWA----GIVAIVFIALFIAFFAMgwgpvpwVIVSELFPLSVRSKAMALATAANW 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1970692088 397 IVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVLSIFGIETRKVSLEEISEV 451
Cdd:pfam00083 397 LANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDEL 451
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-442 |
5.19e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 116.89 E-value: 5.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 18 RFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSN-GWSNNFLnAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLI 96
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADlGLSAAQL-GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 97 VGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWR 176
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 177 IMFLLGGIGILLAWFLsgkyfiesprwlagkgqiagaesqlreveqqierekrirlppltlnqsnskvkvikgtfwllfk 256
Cdd:COG2271 165 AAFLILGLPGLLLALL---------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 257 ggmlrRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR----LFGSA 331
Cdd:COG2271 181 -----RFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrklvLAIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 332 LLIIIAVLGYIYSiqTTEWAILIYGLVMIFFLYMYVCFASAvYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLT 411
Cdd:COG2271 256 LLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWA-LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
410 420 430
....*....|....*....|....*....|.
gi 1970692088 412 HYGSITVFMVLGVMLVLCALVLSIFGIETRK 442
Cdd:COG2271 333 ATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
63-440 |
9.95e-27 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 110.85 E-value: 9.95e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17371 40 GTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPAR 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 143 VRGKwsaRLSFV-GNWSPMLSAAIGVVVIAF------FSWRIMFLLGGIGILLAWFLSgKYFIESPRWLAGKGqiAGAES 215
Cdd:cd17371 120 HRGK---ALGYVqSGWAVGWLLATLLAALLFpllppeIAWRVLFLLGALPALLVLFIR-RFVKEPPQWQAARA--ARRHF 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 216 QLREveqqierekrirlppltlnqsnskvkvikgTFWLLFKGGMLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GID 294
Cdd:cd17371 194 ADRP------------------------------SLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGErGLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 295 VDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSALLIIIAVLGYIYSIQTTEwAILIYGLVMIFFLYMYVCFASA 372
Cdd:cd17371 244 FEGSAGYLVVTILGGFLGYLAGGFLADRIGRRnnFALFALGSAISILLYFFLPLSPT-LILILGFPLGFFASGPFSGMGA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1970692088 373 vYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVLSIFGIET 440
Cdd:cd17371 323 -YLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
25-448 |
1.81e-26 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 111.28 E-value: 1.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 25 GIISFSLLLTGFLSYSGNVVLAKLVSNGWSNnflnaaFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATG- 103
Cdd:TIGR00879 45 GVIGGALALPAFEFKFTSANSDSYSSSLWGL------VVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILm 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 104 --AAFVPDMYWLIFFRFLMGTGMG--ALIMVGYASftEFIPATVRGKwsarlsfvGNWSPMLSAAIGVVVIAFFS----- 174
Cdd:TIGR00879 119 glAAFALSVEMLIVGRVLLGIGVGiaSALVPMYLS--EIAPKALRGA--------LTSLYQLAITFGILVAYGFGsgkvs 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 175 ------WRIMFLLGGIGILLAwFLSGKYFIESPRWLAGKGQIAGAESQLREVEQQIEREKRIR--LPPLTLNQSNSKVKV 246
Cdd:TIGR00879 189 lnntlgWRIPLGLQLIPAGLL-FLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGEDKELLdeLELIDIKRSIEKRSV 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 247 IK--GTFWLLFKGGMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFP 324
Cdd:TIGR00879 268 QPswGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFG 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 325 RR-------LFGSALLIIIAVLGYIYSIQTTEWAiliyGLVMIFFLYMYVCFASA-------VYIPELWPthLRLRGSGF 390
Cdd:TIGR00879 348 RRpllligaAGMAICLFVLGILGASFVTGSSKSS----GNVAIVFILLFIAFFAMgwgpvpwVIVSEIFP--LSLRPKGI 421
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1970692088 391 VNAVGR------IVAVFTPYGVAALlthyGSITVFMVLGVMLVLCALVLSIFGIETRKVSLEEI 448
Cdd:TIGR00879 422 SIAVAAnwlanfIVGFLFPTMLESI----GVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-397 |
6.22e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.36 E-value: 6.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 17 ARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLI 96
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 97 VGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWR 176
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 177 IMFLLGGIGILLAWFLSGKYFIESPRWLAGKgqiagaesqlreveqqierekrirlppltlnqsnskvkvIKGTFWLLFK 256
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARAR---------------------------------------LRGSLRELLR 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 257 ggmLRRTLVAITVLIAMNISLYTITVWIPTIFVN-SGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLII 335
Cdd:COG2814 206 ---RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1970692088 336 IAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAvYIPELWPTHLRLRGSGFVNAVGRI 397
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA-LVAELAPPEARGRASGLYNSAFFL 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-444 |
1.46e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 98.80 E-value: 1.46e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 20 HYRIFGIISFSLLLTGFLSYSGNVVLAKLVSN-GWSNNFLnAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVG 98
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEfGLSAAQL-GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 99 IAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIM 178
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 179 FLLGGIGILLAWFLSGKYFIESPrwlagKGQIAGAESQLREVeQQIEREKRirlppltlnqsnskvkvikgtFWLLFkgg 258
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPP-----AGAAAAAKASLRDQ-LEALRDPR---------------------FWLLS--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 259 mlrrtlvaiTVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIA 337
Cdd:COG2223 212 ---------LLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 338 VLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSIT 417
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYT 362
|
410 420
....*....|....*....|....*...
gi 1970692088 418 -VFMVLGVMLVLCALVLSIFGIETRKVS 444
Cdd:COG2223 363 aAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
63-431 |
5.95e-22 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 96.87 E-value: 5.95e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17359 42 VSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 143 VRGKWSAR----------LSFVGNWSPMLSAAIGVVVIAffSWRIMFLLGGIGILLawFLSGKYFI-ESPRWLAGKGQIA 211
Cdd:cd17359 122 IRGRLVSLnqlmivfgqlLAYIVNYLIANAGGADWLGAE--GWRWMLGLEAIPAIL--FLLGMLFIpESPRWLVSKGKPI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 212 gaesqlreveqqierekrirlppltlnqsnskvkVIKGTFWLLFKGgmlrrtlvaitvLIAMNISLYtitvWIPTIFVNS 291
Cdd:cd17359 198 ----------------------------------LIIGIGLAIFQQ------------FVGINVIFY----YGPEIFQNA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 292 GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGSALLIII-AVLGYIYSI----QTTEWAILIYGLVMIFFL 363
Cdd:cd17359 228 GFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKpllLIGSIGMAISlLLIGTAFYFapgsQASGIVALVLILLFVAFF 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1970692088 364 YMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCAL 431
Cdd:cd17359 308 AMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFL 375
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
62-447 |
9.37e-22 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 96.88 E-value: 9.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 62 FTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17358 46 FGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPK 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 142 TVRGkwsaRLSFVgnwsPMLSAAIGVVVI----AFFSWRIMFLLGGIgiLLAWFLSGKYFI-ESPRWLAGKGQIAGAESQ 216
Cdd:cd17358 126 NVRG----ALGSL----NQLLVNIGILLGyvlgSFLPWRTLALIGAI--PPVVFLILLFFIpESPRWLAKKGREEEAEKS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 217 L---REVEQQIEREKRirlpplTLNQSNSKVKVI-KGTFWLLFKGGMLRRTLVAITVLIAMN--ISLYTITVWIPTIFVN 290
Cdd:cd17358 196 LqflRGKDADISKEAA------EIQEELAELEKEaKESSFSDLFQRKYLKPLVIGLGLMLFQqlSGINAVIFYASSIFDE 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 291 SGIDVDKSI--LMTAVIMIgapVGIFIAALIIDHFPRR--LFGSALLIIIA--VLGYIYSIQTTEWAILIYGLVMIFFLY 364
Cdd:cd17358 270 AGSGLDPNTatIIIGVVQV---VGTLVATLLVDRLGRRplLLVSAIGMGIGllALGLYFYLQEHGALLSSVSWLPLVGLV 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 365 MYVCFASAVYIP-------ELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVLSIFG 437
Cdd:cd17358 347 IYIISFSIGLGPlpwvimsEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFV 426
|
410
....*....|
gi 1970692088 438 IETRKVSLEE 447
Cdd:cd17358 427 PETKGKSLEE 436
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
64-435 |
1.34e-21 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 95.34 E-value: 1.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17365 41 SAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 144 RGKWSArLSFVG-NWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLawflsgkyfiesprwlagkgqiagaesqlreveq 222
Cdd:cd17365 121 RSLAVT-LMFCGyPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI---------------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 223 qierekrirLPPLTlnqsnskvkVIKGTFWLLFKGGMLrrtlvaitvliamniSLYTITVWIPTIFVNSGIDVDKSILMT 302
Cdd:cd17365 166 ---------LLPLL---------RGTLLLWVTFFMGLL---------------LVYLLNSWLPKLMVEAGYSLSQALTIT 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 303 AVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVLGYIYSIQTTEWAILiygLVMIFFLYMYVCFASAV---YIPELW 379
Cdd:cd17365 213 LLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLL---YVLVFLAGACVNGAQVGlyaLAARFY 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1970692088 380 PTHLRLRGSGFVNAVGRIVAVFTPYGVAALLT-HYGSITVFMVLGVMLVLCALVLSI 435
Cdd:cd17365 290 PTEVRATGVGWALGVGRLGAILGPLLGGLLLAaGLGPESVFLALAIPAALGALAVLL 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-403 |
9.23e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 84.01 E-value: 9.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 27 ISFSLLLTGFLSYSGNVVLAKLVSN--GWSNNFLNAAFTsALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGA 104
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEdlGISPTEIGLLLT-LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 105 AFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGI 184
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 185 GILLAWFLsgKYFIESPRWLAGKGQIAGAESQLREVEQQIEREKRIRLppltlnqsnskvkvikgtfwllfkggmlrrtl 264
Cdd:pfam07690 160 LSLLAAVL--LLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWL-------------------------------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 265 vaITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSALLIIIAVLGYI 342
Cdd:pfam07690 206 --LLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrLLLALLLLILAALGLL 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 343 YSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTP 403
Cdd:pfam07690 284 LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
72-433 |
5.09e-17 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 82.57 E-value: 5.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDM----YW----LIFFRFLMGTGM-----GALIMVgyasfTEF 138
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigILapilLVLLRLLQGLALggewgGAVLMA-----VEH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 139 IPATVRGKWSarlSFVGNWSP---MLSAAIGVVVIAFFS--------WRIMFLLGGIGILLAwflsgkYFI-----ESPr 202
Cdd:cd17369 134 APPKRRGFYG---SFPQLGAPvglLLATGVFLLLSALLSdeaflswgWRIPFLLSAVLVAVG------LYIrlrleETP- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 203 wlagkgqiagaesqlrEVEQQIEREKRIRLPPLTLNQSNSKVkvikgtfwllfkggmlrrTLVAITVLIAMNISLYTITV 282
Cdd:cd17369 204 ----------------VFRRAKEAGQVVRAPLVEVLRRHWRA------------------LLLAIGLRLAENVLFYLFTT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 283 WIpTIFVNSGIDVDKSIlMTAVIMIGAPVG---IFIAALIIDHFPRR--LFGSALLIIIAVLGYIYSIQTTEWAILIYGL 357
Cdd:cd17369 250 FA-LSYATQTLGVDRST-VLLAVLIASVVAaitIPLFGWLSDRVGRRpvYLAGALLAALFAFPFFWLLDTGSTWLIVLAA 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1970692088 358 VMIFFLYMYVCFAS-AVYIPELWPTHLRLRGSGFVNAVGRIVAV-FTPYGVAALLTHYGSIT-VFMVLGVMLVLCALVL 433
Cdd:cd17369 328 VVVLGVLHGMMYGPqAAFLAELFPTRVRYTGASLGYQLGAILGGgFAPLIATALVAATGSWWpVALYLAALAVISLVAA 406
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
61-441 |
7.67e-17 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 82.31 E-value: 7.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 61 AFTSALMFGYFIGSLTGGFIGDYFGRRRAFRIN--LLIVGIAATGAAFVPDMY-WLIFFRFLMGTGMGALIMVGYASFTE 137
Cdd:cd17357 53 LIVSIFFIGGAIGSFISAFLANRFGRKNGLLISnaLLVVSSLLMFLSKSAKSPeLLIFGRFLVGIACGLSTGFVPMYLQE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 138 FIPATVRGKWSARLSFVGNWSPMLSAAIGV--VVIAFFSWRIMFLLGGIGILLAWFLSGKYFiESPRWLAG-KGQIAGAE 214
Cdd:cd17357 133 ISPSELRGALGSLTQIGVTLGILLGQVFGLpsVLGTETLWPYLLFFPGIPALLQLAALPFFP-ESPKFLLIsKGDEEEAE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 215 SQLR----------EVEQQIEREKRirlppltlnqsnSKVKVIKGTFWLLFKGGMLR-RTLVAITVLIAMNISLYTITVW 283
Cdd:cd17357 212 KSLKflrgieddvdQELEEIKKESE------------QMGDQKQVSLMQLLRDPSLRlPLLLVLVVSASQQFSGINAIFF 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 284 IPT-IFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR------LFGSALLIIIAVLGYIYSIQTTEWAiliYG 356
Cdd:cd17357 280 YSTfIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRplllisLSVCAVALLLMSVFLFLSEQNSWMS---YG 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 357 LVMIFFLYMYvCFASAV------YIPELWPTHLR---LRGSGFVNAVGR-IVAVFTPYgvaalLTHYGSITVFMVLGVML 426
Cdd:cd17357 357 CIVAIFLFIF-FFAIGLgpipwfIGAELFPQAPRsaaQSLGSSVNWTSNfIVGMAFPP-----LQSIGGGFVFIIFAIPC 430
|
410
....*....|....*
gi 1970692088 427 VLCALVLSIFGIETR 441
Cdd:cd17357 431 ALFLLYLYRYLPETK 445
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-192 |
3.22e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 78.70 E-value: 3.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 17 ARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLI 96
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 97 VGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWR 176
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170
....*....|....*.
gi 1970692088 177 IMFLLGGIGILLAWFL 192
Cdd:COG0477 169 WIFLINAPLGLLALVL 184
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
54-436 |
2.12e-15 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 76.85 E-value: 2.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 54 SNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYA 133
Cdd:cd17317 22 DRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 134 SFTEFIPATVRgkwsarlsfvgnwspmlsaaIGVVVIAFFSWRI-MFLLGGIGillawflsgkYFIESPRWLagkgQIAg 212
Cdd:cd17317 102 LGMEIVGPKYR--------------------SFVGILFGLFWALgYMLLALLA----------YLIRDWRWL----QLA- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 213 aesqlreveqqierekrIRLPPLTLnqsnskvkvikgtFWLLFkgGMLRRTLVAITVLIAMNISLYTITVWIPT----IF 288
Cdd:cd17317 147 -----------------ISLPGLLF-------------LLLLW--WLPRRTIIVGLIWFVTSLVYYGLSLNSSNlggnLY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 289 VNsgidvdkSILMTAVIMIgapvGIFIAALIIDHFPRR--LFGSALLIIIAVLGYIYSIQTTEWAILIygLVMIFFLYMY 366
Cdd:cd17317 195 LN-------FFLSGLVEIP----AYFLALLLLDRLGRRwtLSGSLLLAGLACLVTALLPDDENTLALT--LALVGKFAIS 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 367 VCFA-SAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYgvAALLTHYGSITVFMVLGVMLVLCALVLSIF 436
Cdd:cd17317 262 AAFSvIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPF--IVLLGKIGPLLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
63-436 |
2.08e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.14 E-value: 2.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17319 44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLL-GGIGILLAWflsgkyfiesprwlagkgqiagaesqlreve 221
Cdd:cd17319 124 ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIeGLLGLLLAV------------------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 222 qqierekrirlppltlnqsnskvkvikgtFWLLFkggmLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSIL 300
Cdd:cd17319 173 -----------------------------LWWFY----LRQVWGLALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 301 MTAVIMIGAPVGIFIAALIIDHFP----RRLFGSALLIIIAVLGYIYSIQTTEWAILiyGLVMIFFLYMYVCFASAVYIP 376
Cdd:cd17319 220 LAAIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVI--LLSLAGFGIGAASPVFWSLPA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 377 ELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVLSIF 436
Cdd:cd17319 298 DLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
63-437 |
5.84e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 70.29 E-value: 5.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVgyasftefIPAT 142
Cdd:COG2807 59 TTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL--------LPGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 143 VRGKWSARLSFV-------GNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLsgkyfiesprWLAgkgqiagaes 215
Cdd:COG2807 131 IKRWFPDRVGLMtglytaaMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLL----------WLP---------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 216 QLREveqqierekrirlppltlNQSNSKVKVIKGTFWLLFKggmlRRTLVAITVLIAMNISL-YTITVWIPTIFVNSGID 294
Cdd:COG2807 191 LLRR------------------RPAAAAAAPAAASLRSLWR----SPLAWLLTLFFGLQSLLyYAVVAWLPPILRDAGLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 295 VDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGSALLIIIAVLGYIYSIQTTE--WAILI-YGLVMIFFLYMyvc 368
Cdd:COG2807 249 AATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrplLLLLGLLGLAGLLGLLLAPGSLPwlWAVLLgLGQGGLFPLAL--- 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 369 fasaVYIPELWPTHLRL-RGSGFVNAVGRIVAVFTPYGVAALLTHYGSITV-FMVLGVMLVLCALVLSIFG 437
Cdd:COG2807 326 ----TLIGLRARTPAEAaALSGMAQSVGYLLAALGPLLVGALHDATGSWTAaLLLLAALAVLMLVAGLLAG 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-433 |
1.53e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.61 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 27 ISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAF 106
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 107 VPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAF--FSWRIMFLLGGI 184
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 185 GILLaWFLSGKYFIESPRWLAgkgqiagaesqlreveqqieREKRIRLPPLTLNQSNSKVKVIKGTFWLLFkggmlrrtl 264
Cdd:cd06174 161 LALL-AAILLLLVVPDPPESA--------------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLL--------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 265 vaitVLIAMNISLYTITVWIPTIFVNSGIDVDKSI-LMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVLGYIY 343
Cdd:cd06174 211 ----AIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAgLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 344 SIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSIT-VFMVL 422
Cdd:cd06174 287 LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTgAFLVL 366
|
410
....*....|.
gi 1970692088 423 GVMLVLCALVL 433
Cdd:cd06174 367 AVLLLLAAILL 377
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
64-201 |
2.35e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 67.99 E-value: 2.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17320 41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAE 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1970692088 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESP 201
Cdd:cd17320 121 LAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL 178
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
63-451 |
6.44e-12 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 66.89 E-value: 6.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAAT-GAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17356 51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIiQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 142 TVRGK------WSARL-SFVGNWSPMLSAAIGvvviAFFSWRIMFLLGGIGILLAWFlsGKYFI-ESPRWLagkgqiaga 213
Cdd:cd17356 131 HIRGTlvslyqLAITIgILVAYCINYGTHKLD----GSAQWRIPLGLQIVWGLLLLI--GMFFLpESPRWL--------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 214 esqlreveqqierekrirlppltlnqsnskvkvikgtfWLLFKGGMLRrtlvAITVLIAMNISLYtitvWIPTIFVNSGI 293
Cdd:cd17356 196 --------------------------------------YRTILGIMLQ----LFQQLTGINYFFY----YGTTIFQSTGL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 294 DVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFG----SALLIIIAVLGYIYSIQTTEWAILIY--GLVMIFFLY 364
Cdd:cd17356 230 TGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRtclLIGaagmSICLFIYAAVGVRYLIPNPQSGTSNKsaGNGMIVFIC 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 365 MYVCFASA-------VYIPELWPTHLRLRGSGFVNAV----GRIVAVFTPYGVAALlthygSITVFMVLGVMLVLCALVL 433
Cdd:cd17356 310 LFIFSFATtwgpiawVYVAEVFPLRVRSKGMALATAFnwlwNFLISFFTPFIIGSI-----GFKYYYIFAGCNLLAFIVV 384
|
410
....*....|....*...
gi 1970692088 434 SIFGIETRKVSLEEISEV 451
Cdd:cd17356 385 FFFVPETKGLTLEEIDEL 402
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-436 |
7.22e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 7.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 27 ISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAF 106
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 107 VPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGI 186
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 187 LLAWFLsgkyfiesprwlagkgqiagaesqlreveqqierekRIRLPPLTLNQSNSKVKVIKGTFWLLFKGGMLRRTLVA 266
Cdd:cd17325 161 LLALVL------------------------------------ALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLAL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 267 ITVLIAMNISLYTITVWIPTIFVNSGIDVDKSI-LMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVLGYIYSI 345
Cdd:cd17325 205 FLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIgLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 346 QTTEWAILIYGLVMIFFLYMYVcFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVM 425
Cdd:cd17325 285 ATSFWLLLLLLALLGLGLGLVF-PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL 363
|
410
....*....|.
gi 1970692088 426 LVLCALVLSIF 436
Cdd:cd17325 364 LLLAAVLFLLL 374
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
46-450 |
1.51e-11 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 66.25 E-value: 1.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 46 AKLVSNGWSNNFLNAAFTSALMfGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFV---------PDMYWLI-- 114
Cdd:PRK10077 45 PQNLSESAANSLLGFCVASALI-GCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSAWPefgftsigpDNTGYVPef 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 115 -FFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFV----------GNWSPMLSAAIGVVVIafFSWRIMFLLGG 183
Cdd:PRK10077 124 vIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAiifgqlvvyfVNYFIARSGDASWLNT--DGWRYMFASEA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 184 IGILLawFLSGKYFI-ESPRWLAGKGQIAGAESQLREVEQQIEREKRIRLPPLTLNQSNSKVKVikgtfwLLFKGGMLRR 262
Cdd:PRK10077 202 IPALL--FLMLLYFVpETPRYLMSRGKQEQAEGILRKIMGNTLATQALQEIKHSLDHGRKTGGK------LLMFGVGVIV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 263 TLVAITVL---IAMNISLYtitvWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRlfgsaLLIIIAVL 339
Cdd:PRK10077 274 IGVMLSVFqqfVGINVVLY----YAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRK-----PLQIIGAL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 340 GY---IYSIQTTEWAILIyGLVMIFFLYMYVCFASA-------VYIPELWPTHLRLRGSGFVNAVGRIVAVFTP------ 403
Cdd:PRK10077 345 GMaigMFSLGTAFYTQAP-GIVALLSMLFYVAAFAMswgpvcwVLLSEIFPNAIRGKALAIAVAAQWIANYFVSwtfpmm 423
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1970692088 404 YGVAALLTHYGSITVFMVLGVMLVLCALVLSIFGIETRKVSLEEISE 450
Cdd:PRK10077 424 DKNSWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEA 470
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
62-139 |
3.24e-11 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 64.29 E-value: 3.24e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1970692088 62 FTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFI 139
Cdd:cd17379 38 FQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFV 115
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
60-433 |
6.79e-11 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 63.71 E-value: 6.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGAlIMVGYASFTEFI 139
Cdd:cd17372 37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGG-GPQLASWYLEFL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 140 PATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLawflsgkyFIESPRWLAgkgqiagaesqlre 219
Cdd:cd17372 116 PAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSL--------LLVFYRWTP-------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 220 veqqierEKRIRLPPLTLNQSNSKVKVIKGTFWLLFKGGMLRRTLVAITVLIAMNISLYTITvwiptifvnsgiDVDKSI 299
Cdd:cd17372 174 -------KTTLLLWVIWFGNAFAYYGVVLLTTELNNSHNVCGSKSDSDSGESPTEKQCRNSN------------DVDYRD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 300 LMTAVimIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVLGYIYSIQTTEwailiygLVMIFFLYMYVCFASA------V 373
Cdd:cd17372 235 VFIAT--FAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSP-------FILTVLLFGGRACISAaftvvyI 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1970692088 374 YIPELWPTHLRLRGSGFVNAVGRIVAVFTPYgVAALLTH---YGSITVFMVLGVMLVLCALVL 433
Cdd:cd17372 306 YTPEVYPTAVRALGVGTGSSVGRIGAILCPF-IAQVLVHgsqTIALLLFSVVCLVSAICVCLL 367
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
64-432 |
5.37e-10 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 61.13 E-value: 5.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:PRK11551 57 SAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 144 RGK----WSARLSFVGnwspMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESPRWLAGKGQIAGAEsqlre 219
Cdd:PRK11551 137 RGTavslMYCGVPFGG----ALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRA----- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 220 veqqierekrirlppltlnqsnskvkvikGTFWLLFKGGMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSI 299
Cdd:PRK11551 208 -----------------------------PVLRALFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 300 LMTAVIMIGAPVGIFIAALIIDHFPRR----LFGSALLIIIAVLGYIYSIQTTEWAILIYGLVMifflymyVCFASAVY- 374
Cdd:PRK11551 259 LVQIAFNIGGALGSLLIGALMDRLRPRrvvlLIYAGILASLAALAAAPSFAGMLLAGFAAGLFV-------VGGQSVLYa 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 375 -IPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALL-THYGSITVFMVLGVMLVLCALV 432
Cdd:PRK11551 332 lAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLaLGRSTVGVIGASIPVILVAALA 391
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
55-439 |
5.48e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 60.67 E-value: 5.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 55 NNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYAS 134
Cdd:cd17315 32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 135 FTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS--WRIMFLLGGIGILLAWFLsGKYFIESPRWLAGKGqiag 212
Cdd:cd17315 112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLL-MFFLPESRALLVGVG---- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 213 aesqlreveqqierekrirlppltlnqsnskvkvikgtfwllfkggmlrrtLVAITVLIAMNISLYtitvWIPTIFVNSG 292
Cdd:cd17315 187 ---------------------------------------------------LQLLQQLTGINAVMY----YAPTIFKSAG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 293 iDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFA 370
Cdd:cd17315 212 -GGTASILASIIVGVVNLLATLVAIRLVDKVGRRplLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFA 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1970692088 371 ------SAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVLSIFGIE 439
Cdd:cd17315 291 mgagpvPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-432 |
6.24e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.64 E-value: 6.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 18 RFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIV 97
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 98 GIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYAsfteFIPATVRGKWSARLSFVGNWSPmLSAAIGVVVIAFF---- 173
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANP----YVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLillg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 174 ---SWRIMFLLGGIGILLAWFLSgkYFIESPRWLAGKGQIAGAESQLREVEQQierekrirlppltlnqsnskvkvikgt 250
Cdd:COG0738 159 lslSWHLPYLILAVLLLLLALLF--LRSKLPEIEEEEEEAAGSAASLKSLLKN--------------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 251 fwllfkggmlRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHF-PRRLF 328
Cdd:COG0738 210 ----------PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFgPVRLL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 329 gsALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFlymyvcFASAVY------IPELWPTHLRLRGSGFVnAVGRIVAVFT 402
Cdd:COG0738 280 --RLSALLAAVGLLLALLAPGPWLALIGLALVGL------GLSLMFptifslALDGLGKRTAAAVSAVL-IMGIVGGAIG 350
|
410 420 430
....*....|....*....|....*....|
gi 1970692088 403 PYGVAALLTHYGSITVFMVLGVMLVLCALV 432
Cdd:COG0738 351 PPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-189 |
9.69e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.94 E-value: 9.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 23 IFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTsalmFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAAT 102
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG----VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 103 GAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLG 182
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
....*..
gi 1970692088 183 GIGILLA 189
Cdd:cd06173 370 GALLLLA 376
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
54-441 |
2.21e-09 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 59.23 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 54 SNNFLNAAFTSALMF--GYF---IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDM----YW----LIFFRFLM 120
Cdd:cd17367 32 SGDPTVALLSTAAVFavGFLmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigIWapiiLLLARLLQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 121 GTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS--------WRIMFLLGGIGILLAWFL 192
Cdd:cd17367 112 GLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGedqmaawgWRIPFLLGGVLAVVVLWL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 193 sgkyfiesprwlagkgqiagaESQLREVEQQIEREKRIRLPPLTLnqsnskvkvikGTFWllfkgGMLRRTLVAITVLIA 272
Cdd:cd17367 192 ---------------------RRGLEETESFEAIAESNEASAGTL-----------RELR-----RHPRELLLVVGLTAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 273 MNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRlfgsALLIIIAVLGYIYSI------ 345
Cdd:cd17367 235 GTLAFYTWTTYLQKFLVNTaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRR----PLLLFFGIGGTLATVpllsal 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 346 --QTTEWAILIYGLVMIFFLYMYVCFaSAVYIPELWPTHLRLRGSGFVNAVGriVAVF---TPYgVAALLTHYGSITVFM 420
Cdd:cd17367 311 dhTDSPYTAFALVLVGLVFLSGYTSI-NAVVKAELFPTHVRALGVGLPYALA--VAIFggtAPY-VALWLKSIGHEWVFF 386
|
410 420
....*....|....*....|.
gi 1970692088 421 VLGVMLVLCALVLSIFGIETR 441
Cdd:cd17367 387 WYVAGLIAISLVVYLRMPETR 407
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-437 |
3.34e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 3.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARL 151
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 152 SFVGNWSPMLSAAIGvVVIAFFSWRIMFLLGGIGILLAWFLSgkYFIESPrwlagkgqiagAESQLREVEQQIEREKRIR 231
Cdd:cd17473 130 SAAMSLGGVVFLLLG-GALAEIGWRAPFLVYLLALPVLILVL--LFLPEP-----------ARKSKSAASPGAATAAALP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 232 LPPLtlnqsnskvkvikgtfwllfkggmlrrTLVAITVLIAMnISLYTITVWIPTIFVNSGIDVDKSI-LMTAVIMIGAP 310
Cdd:cd17473 196 WKRV---------------------------LPIYFLAFLAM-LLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 311 VGIFIAALIIDHFPRRLFgSALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGF 390
Cdd:cd17473 248 IGALLFGRLKRRLGKRRL-LAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1970692088 391 VNAVGRIVAVFTPYGVAALLTHYGSIT-VFMVLGVMLVLCALVLSIFG 437
Cdd:cd17473 327 VTSAFFLGQFLSPLVLGPLVNLTGGLSgAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
65-193 |
5.73e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.57 E-value: 5.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 65 ALMFGYFIgsLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVR 144
Cdd:cd17321 41 LLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1970692088 145 GKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLS 193
Cdd:cd17321 119 GRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
62-448 |
2.18e-08 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 55.82 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 62 FTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17362 44 VVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 142 TVRGKWSARLSFVGNWSPMLSAAIGVVVI-AFFSWRIMFllgGIGILLAWFLS-GKYFI-ESPRWlagkgqiagaesqlr 218
Cdd:cd17362 124 HIRGLLVSLKELFIVLGILLGYVSGYAFAdVVGGWRYMY---GLAAPPALLLGiGMWFLpPSPRW--------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 219 eveqqierekrirlppltlnqsnskvkvikgtfwllfKGGMLRRTLVAITVLIAMNIS-LYTITVWIPTIFVNSGIDVDK 297
Cdd:cd17362 186 -------------------------------------QGNYRKPLIIGLGLVLFQQITgQPSVLYYAATIFKSAGFSAAS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 298 SILMTAVImigapVGIF------IAALIIDHFPRR--LFGSALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYV-C 368
Cdd:cd17362 229 DATLVSVG-----LGVFkllmtiVAVLLVDKLGRRplLLGGVSGMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVgA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 369 FA------SAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVLSIFGIETRK 442
Cdd:cd17362 304 YQisfgpiSWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKG 383
|
....*.
gi 1970692088 443 VSLEEI 448
Cdd:cd17362 384 LSLEEI 389
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
2-287 |
2.68e-08 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 56.14 E-value: 2.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 2 EQYDQIgarLDRLPLARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIG 81
Cdd:TIGR01299 150 QQYELI---IQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLA 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 82 DYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGK---WSARLSFVGNws 158
Cdd:TIGR01299 227 DKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEhlsWLCMFWMIGG-- 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 159 pMLSAAIGVVVI-------------AFFSWRIMFLLGGIGILLAwFLSGKYFIESPRWLAGKGQIAGAESQLREVEQQIE 225
Cdd:TIGR01299 305 -IYAAAMAWAIIphygwsfqmgsayQFHSWRVFVIVCAFPCVFA-IGALTFMPESPRFFLENGKHDEAWMILKLIHDTNM 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 226 REK----------RIRLP----PLTLNQSN-------------SKVKVIKGTFWLLFKGGMLRRTLVAITVLIAMNISLY 278
Cdd:TIGR01299 383 RAKghpekvfsvnHIKTIhqedELIEIESDtgtwyqrcfvralSEGGGIWGNFLRCFNPEVREITIKLMGVWFTLSFGYY 462
|
....*....
gi 1970692088 279 TITVWIPTI 287
Cdd:TIGR01299 463 GLSVWFPDM 471
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
64-435 |
3.16e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 55.25 E-value: 3.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17324 41 SAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 144 RGKWSARL---SFVGNwspMLSAAIGVVVIAFFSWRIMFL-LGGIGILLAWFLsgkyfiesprwlagkgqiagaesqlre 219
Cdd:cd17324 121 RGRAIGLVfsgLTLGL---VLGRPLGGLLGQLLGWRAAFLaIAVLALLAALLL--------------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 220 veqqierekRIRLPPLTlnQSNSKVKVIKGTFWLLFKGGMLRRTLVAITVLIAMNISLYTITVwiPTIFVNSGIDVDKSI 299
Cdd:cd17324 171 ---------WRLLPSLP--PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLA--PFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 300 LMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVLGYIYSIQTTEWAILIyGLVMIFFLYMYVCFASAVYIPELW 379
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLV-GLVLWGLGFFAAHSALQTRVLRLA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1970692088 380 PTHlRLRGSGFVNAVGRI-VAVFTPYGvAALLTHYGSITVFMVLGVMLVLcALVLSI 435
Cdd:cd17324 317 PEA-RGLASSLYLAAYNLgGALGAALG-GLVLDHGGWAGVGWVGAALLLL-ALLLAL 370
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
21-449 |
3.31e-08 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 55.50 E-value: 3.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 21 YRIFgIISFSLLLTGFLSYSGNvvlAKLVSNgwsnnfLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIA 100
Cdd:TIGR00887 30 YDLF-CISLVTKMLGYVYYHGK---GPLPSS------VSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 101 ATGAAFVPD------MYWLIFFRFLMGTGMG------ALIMVGYAS----------------FTEFIPATVRGKWSARLS 152
Cdd:TIGR00887 100 TVASGLSPGsspksvMATLCFWRFWLGVGIGgdyplsAIITSEFATkkwrgammaavfamqgFGILAGAIVALIVLAGFK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 153 FVGNWSPMLSAAIGVVVIAF-FSWRIMFLLGGIGILLAWFLSGKyFIESPRWLAGKG----QIAGAESQLREVEQQIERE 227
Cdd:TIGR00887 180 HSLEAAADEASCTGSCVPAVdYMWRILIGFGAVPALLALYFRLT-IPETPRYTADVAkdveQAASDMSAVLQVKIEAEPD 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 228 KrirlppltLNQSNSKVKVIKGTFWLLFKGGMLRRT----LVAITVLIAMNISLYTITVWIPTIFVNSGI------DVDK 297
Cdd:TIGR00887 259 E--------VEKASTAVEVPKASWSDFFTHFFKWRHgkhlLGTAGSWFLLDIAFYGVNLNQKVILSAIGYsppaatNNAY 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 298 SILM------TAVIMIGAPVGIFIAALIIDH---FPRRLFGSALL-IIIAVLGYIYSIQTTEWAILIYglVMIFFLYMYV 367
Cdd:TIGR00887 331 EELYktavgnLIIALAGTVPGYWVTVFLVDIigrKPIQLMGFFILtVLFFVLGFAYNHLSTHGFLAIY--VLAQFFANFG 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 368 CFASAVYIP-ELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTH----YGSITVFMVLGVMLVLCALVL-----SIFG 437
Cdd:TIGR00887 409 PNATTFIVPgEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHgdptKGYPTGIWMGHVLEIFALFMFlgilfTLLI 488
|
490
....*....|..
gi 1970692088 438 IETRKVSLEEIS 449
Cdd:TIGR00887 489 PETKGKSLEELS 500
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
20-436 |
3.75e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.97 E-value: 3.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 20 HYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGI 99
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 100 AATGAAFVpdmYWLIFFRFLMGtgmgaliMVGYASFTEFIPATV----------RGKWSARLSFVGNWSPMLSAAIGVVV 169
Cdd:cd17312 81 ANIFMGFS---TSLWFFAVLWG-------LNGLFQSMGWPPCVKllgnwfskkeRGTVYGIWSTSHNFGGILAPILAASL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 170 IAFFSWRIMFLLGGIGILLAWFLSGKYFIESPRWLagkgqiagaesqlreveqqierekrirlppltlnqsnskvkvikg 249
Cdd:cd17312 151 ASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPYV--------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 250 tfWLLfkggmlrrtlvaITVLIAMNISLYTITVWIPTIFVNS-GID-VDKSILMTAVIMIGAPVGIFIAALIIDHFPRRL 327
Cdd:cd17312 186 --WVL------------SLAYAFVYIVRYACLDWGPLYLYEVkGYSlIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRR 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 328 FGSALLIIIAVLGYIYSIQTTEWAILIYGLVMI---FFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPY 404
Cdd:cd17312 252 APIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFligFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGL 331
|
410 420 430
....*....|....*....|....*....|..
gi 1970692088 405 GVAALLTHYGSITVFMVLGVMLVLCALVLSIF 436
Cdd:cd17312 332 PLGYIIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
35-433 |
4.76e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 54.97 E-value: 4.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 35 GFLSYSGNVVLAKLVSNGWSNnflnAAFTSALMFGYFIGSLTGGFIG---DYFGRRRAFRINLLIVGIAATGAAFVPDMY 111
Cdd:cd17355 17 GIRYYFGVFIIPIIAEFGWSR----AVISLAFTVGLLAFGLAQPFVGrllDRFGPRRVMLLGLLLLAAGLVLLALATSLW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 112 WLIFFRFLM-GTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAW 190
Cdd:cd17355 93 QLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 191 FLSGKYFIESPRWLAGKGQIAGAESQLREVEQQIEREKRirlppltlnqsnskvkvikgtFWLLFKGGmlrrtlvaITVL 270
Cdd:cd17355 173 VPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSAS---------------------FWLLALAF--------FLCG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 271 IAMNIslytITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSALLIIIAVLGYIYSIQTT 348
Cdd:cd17355 224 FAVVG----LIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRrlLAASYALRALGLALLLLLPFPP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 349 EWAILIygLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVL 428
Cdd:cd17355 300 LALLLF--AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGL 377
|
....*
gi 1970692088 429 CALVL 433
Cdd:cd17355 378 IAALL 382
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
68-285 |
1.44e-07 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 53.77 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKW 147
Cdd:cd17438 45 LGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 148 SARLSFVGNWSPMLSAAIGVVVIA-------------FFSWRIMFLLGGIGIlLAWFLSGKYFIESPRWLAGKGQIAGAE 214
Cdd:cd17438 125 LSWLCMFWMIGGLYASAMAWSIIPhygwgfsmgtnyhFHSWRVFVIICALPC-IASIIALKFMPESPRFLLEMGKHDEAW 203
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 215 SQLREVEQQIEREKRIrlPPLTLNQSNSKVKvikgtfwllfkggmlrRTLVAITVLIAMNISLYTITVWIP 285
Cdd:cd17438 204 MILKNIHDTNMRAKGT--PEKVFTVSNIKRK----------------NTLFLAVVWFTMAFSYYGLTVWFP 256
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-436 |
1.94e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.98 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 27 ISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAF 106
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 107 VPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGI 186
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 187 LLAWFLSgkyfiesprwlagkgqiagaesqlreveqqierekrirlppLTLNQSNSKVKVIKGTFWLLFKGGMLRRTLVA 266
Cdd:cd17489 161 LLALLLV-----------------------------------------FLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPP 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 267 ITVLIAMNISLYTITVWIPtIFVNSGIDVDKSILMTAVImIGAPVGIFIAALIIDHFPRRLFGSALLIIIAvLGYIYSIQ 346
Cdd:cd17489 200 ALILFLASIAYGAISTFLP-LYAAERGISNAGLFFTVYA-IALLLSRPFSGKLSDRKGPKTVIIPGLLLLA-LGLLLLSF 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 347 TTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYgVAALLTHYGSITVFMVLGVML 426
Cdd:cd17489 277 AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGL-LLGLVAELFGYRAMFLLAAVV 355
|
410
....*....|
gi 1970692088 427 VLCALVLSIF 436
Cdd:cd17489 356 VLLALVLYIF 365
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
30-191 |
2.46e-07 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 52.63 E-value: 2.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 30 SLLLTGFLSYSGN---------VVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTggfigDYFGRRRAFRINLLIVGIA 100
Cdd:PRK15402 17 CLVLFEFATYIANdmiqpgmlaVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLS-----DRIGRRPVMLAGVAFFILT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 101 ATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFL 180
Cdd:PRK15402 92 CLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFV 171
|
170
....*....|.
gi 1970692088 181 LGGIGILLAWF 191
Cdd:PRK15402 172 LFAALAALSFF 182
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
58-193 |
2.86e-07 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 52.29 E-value: 2.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 58 LNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTE 137
Cdd:cd17374 36 LKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTE 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 138 FIPatvrGKWSARLSFVGnwspMLSAAIGVVVIA-----FFSWRIMFLLGGIGILLAWFLS 193
Cdd:cd17374 116 WTT----PRHRALAITLT----SCFFSIGQMLLAglayaIRDWRLLQLVVSVPFFLFFLYS 168
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
72-448 |
4.10e-07 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 52.02 E-value: 4.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARL 151
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFP 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 152 SFVGNWSPMLsaaiGVVVIAFFS-------WRIMFllgGIGILLAWFLS-GKYFI-ESPRWLAGkgqiagaesqlreveq 222
Cdd:cd17437 127 EIFINIGILL----GYVSNYAFSglplhvgWRLML---GVGAVPSLFLAiGVLAMpESPRWTPA---------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 223 qierekrirlppltlnqsnskvkvikgtfwllfkggmLRRTL-VAITVLIAMNISLYTITVWI-PTIFVNSGI-DVDKSI 299
Cdd:cd17437 184 -------------------------------------VRRMLiAALGIHFFQQASGIDAVVLYsPRIFKKAGIkSKDKLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 300 LMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSA--LLIIIAVLGYIYSI-----QTTEWAIliygLVMIFFLYMYVCFA 370
Cdd:cd17437 227 LATVAVGVTKTLFILVATFLLDKVGRRplLLTSTggMTLSLTALATSLTFidrngGGLTWAL----VLAITAVCSFVAFF 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 371 SA-------VYIPELWPTHLRLRGSGFVNAVGRIVAvftpyGVAAL--LTHYGSITV---FMVLGVMLVLCALVLSIFGI 438
Cdd:cd17437 303 SIgagpitwVYSSEIFPLRLRAQGASLGVVVNRLMS-----GTVSMtfLSMSKAITTggtFFLFAGVAAAAWVFFYFFLP 377
|
410
....*....|
gi 1970692088 439 ETRKVSLEEI 448
Cdd:cd17437 378 ETKGKSLEEI 387
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
259-412 |
4.26e-07 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 51.97 E-value: 4.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 259 MLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGSALLI 334
Cdd:cd17366 191 LRRPLLICIGLVLVFNVTNYMLLSYMPSYLEETlGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKpvyAAGLAGLL 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1970692088 335 IIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVyIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTH 412
Cdd:cd17366 271 VLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMAST-LPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVS 347
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
63-203 |
5.42e-07 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 51.50 E-value: 5.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17360 41 VSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPR 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1970692088 143 VRGKWSARLSFVGNWSPMLSAAI-GVVVIAFFSWRIMFLLGGIGILLawFLSGKYFI-ESPRW 203
Cdd:cd17360 121 IRGRLVTINVLFITGGQFVAYVInGAFSYLPGGWRWMLGLAAVPAVL--QFIGLLFLpESPRW 181
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
55-184 |
5.60e-07 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 51.51 E-value: 5.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 55 NNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPD------MYWLIFFRFLMGTGMGALI 128
Cdd:cd17364 37 PSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDY 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 129 MVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS--------------WRIMFLLGGI 184
Cdd:cd17364 117 PLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEhplpagtyhhadlvWRIVLGLGAI 186
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
60-192 |
2.67e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 49.70 E-value: 2.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDmYWLIF-FRFLMGTGMGALIMVGYASFTEF 138
Cdd:PRK03893 58 ASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPG-YWTLFiARLVIGMGMAGEYGSSATYVIES 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1970692088 139 IPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFL 192
Cdd:PRK03893 137 WPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWL 190
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
57-433 |
2.84e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 57 FLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFT 136
Cdd:cd17477 31 ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 137 EFIPATVRGKWSARLSFVGnwspMLSAAIGVVVIAFFSWR--IMFLLGGIGILLAWFLSGKYFIESPRwlagkgqiagae 214
Cdd:cd17477 111 ALATNENRGRVLGLYSTVL----GLGFALGPLLLALVGTAgaLPFLIAAVLLLLALVPLLLTRRAAPE------------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 215 sqlREVEQQIEREKRIRLPPLtlnqsnskvkvikgtfwllfkggmlrrTLVAITVLIAMNISLYTItvwIPTIFVNSGID 294
Cdd:cd17477 175 ---IEEAESISLRRLLRIAPL---------------------------ALLGAFVAGFLEGAFYSL---LPLYGLRLGLS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 295 VDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCfaSA 372
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRFDRRrvLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTL--AL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 373 VYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVL 433
Cdd:cd17477 300 ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
64-144 |
3.18e-06 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 48.95 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
.
gi 1970692088 144 R 144
Cdd:cd17446 120 R 120
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
68-285 |
3.21e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 49.26 E-value: 3.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKW 147
Cdd:cd17439 45 LGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 148 SARLSFVGNWSPMLSAAIGVVVI-------------AFFSWRIMFLLGGIGILLAwFLSGKYFIESPRWLAGKGQIAGAE 214
Cdd:cd17439 125 LSWLCMFWMIGGIYASAMAWAIIphygwsfqmgsayQFHSWRVFVLVCAFPSVFA-IGALTTMPESPRFFLENGKHDEAW 203
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 215 SQLREVEQQIEREKriRLPPLTLNQSNSKVKVikgtfwllfkggmlrrTLVAITVLIAMNISLYTITVWIP 285
Cdd:cd17439 204 MVLKQVHDTNMRAK--GHPERVFSVTHIKRRI----------------TLMMMAVWFTMSFSYYGLTVWFP 256
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
78-192 |
4.48e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.73 E-value: 4.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILL 131
|
90 100 110
....*....|....*....|....*....|....*....
gi 1970692088 158 SPMLSAAIGVVVIAFFSWRIMFL----LGGIGILLAWFL 192
Cdd:cd17503 132 APAIGPTLGGWLTDNLSWRWIFYinlpIGILALLLAPLL 170
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
69-285 |
5.14e-06 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 48.64 E-value: 5.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 69 GYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWS 148
Cdd:cd17363 46 GMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 149 ARLSFVGNWSPMLSAAIGVVVIA-------------FFSWRIMFLLGGIGILLAwFLSGKYFIESPRWLAGKGQIAGAES 215
Cdd:cd17363 126 SWLCMFWMIGGLYASAMAWAIIPhygwgfsmgtayqFHSWRVFVIVCALPSVAS-VVALTFMPESPRFLLEVGKHDEAWM 204
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 216 QLREVEQQIEREKRIRLPPLTLNQsnskvkvIKgtfwllfkggmLRRTLVAITVLIAMNISLYTITVWIP 285
Cdd:cd17363 205 ILKQVHDTNMRAKGHPERVFTVSH-------IK-----------RMNTLFLAIVWFTMSFSYYGLTVWFP 256
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
60-193 |
5.44e-06 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 48.27 E-value: 5.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGAlIMVGYASFTEFI 139
Cdd:cd17441 37 ALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGG-VPQSVTLYAEFL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1970692088 140 PATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLS 193
Cdd:cd17441 116 PMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLC 169
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
78-202 |
5.46e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 48.37 E-value: 5.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMgtGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1970692088 158 SPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESPR 202
Cdd:cd17472 131 AFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPK 175
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
72-191 |
6.36e-06 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 48.53 E-value: 6.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARL 151
Cdd:TIGR00711 52 ISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIW 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1970692088 152 SFVGNWSPMLSAAIGVVVIAFFSWRIMFLL----GGIGILLAWF 191
Cdd:TIGR00711 132 GLTVLVAPALGPTLGGWIIENYHWRWIFLInvpiGIIVVVVAFF 175
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
60-433 |
1.13e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPD-----MYWLIFFRFLMGTGMGALIMVGYAS 134
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALlgslsLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 135 FTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSgkYFIesprwlagkgqiagae 214
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL--LFI---------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 215 sqlreveqqierekRIRLPPLTLNQSNSKVKVIKGTFWLLFKGGMLRRTLVAITVLIAMNISLYTITVwiPTIFVNSGID 294
Cdd:cd06173 179 --------------RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLP--LLAKEVLGGG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 295 VDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVLGYIYSIqTTEWAILIYGLVMIFFLYMYVCFASAVY 374
Cdd:cd06173 243 AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-SPSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1970692088 375 IPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVL 433
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
78-433 |
1.24e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALI-----MVGyASFTEFIPATVRGKWSARLS 152
Cdd:cd17474 55 GVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGplaltLIG-DLFEGGERAKAMGLYEAALG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 153 FVGNWSPMLSAAIGVvviafFSWRIMFLLGGIGILLAwFLSGKYFIESPRwlagkgqiagaesqlreveqqierekrirl 232
Cdd:cd17474 134 LGIAVGPLLGGLLAA-----ISWRYPFFLLAALIPVA-FLAILFLLPEPK------------------------------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 233 ppltlnqsnSKVKVIKGTFWLLFKGGMLRRTLVAITVLIAM-NISLYTITVWIPTIFVNSgidVDKSILMTAVIMIGAPV 311
Cdd:cd17474 178 ---------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLyFFLYFAFLTYLPFLLELL---YGISPIIIGLLFAGWSV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 312 GIFIAALIIDHFPRRLFGSALLIIIAVLGYIYSIQtteWAILIYGLVMIFFLYMYVCFASAVYIP-------ELWPTHLR 384
Cdd:cd17474 246 LLALGSLFVGRLLKKRFGARRILVIGLLLYALSLL---LLGFVPSLALLLIAIVLFGLGLGLNLPllttlvtELAPEEER 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1970692088 385 LRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVL 433
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
64-192 |
1.90e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 46.61 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:TIGR00710 47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEE 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1970692088 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWR----IMFLLGGIGILLAWFL 192
Cdd:TIGR00710 127 LSRIYSILMPVLALAPAVAPLLGGYILVWLSWHaifaFLSLAGILLSALIFFI 179
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
63-414 |
2.04e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.60 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:TIGR00881 36 LSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFF-SWRIMFLLGGIGILLAWFLSGKYFIESPRwlaGKGQIAGAESQLREVE 221
Cdd:TIGR00881 116 ERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSLICFLLLRDSPQ---SCGLPPAEEMPNEEPD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 222 QQIEREKRIRLPPLTLNQSNSKVKVIkgtfWLLFkggmlrrtlvaiTVLIAMNISLYTITVWIPTIFVNS-GIDVDKSIL 300
Cdd:TIGR00881 193 GDAEKKEEELTKKQIFLQYVLLNKVL----WYIS------------LGYVFVYVVRTGILDWSPLYLTQEkGFSKEKASW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 301 MTAVIMIGAPVGIFIAALIIDH-FPRRLFGSAL----LIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASaVYI 375
Cdd:TIGR00881 257 AFTLYELGGLVGTLLAGWLSDKlFNGRRGPLAVffmaLIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIG-VIA 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 1970692088 376 PELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYG 414
Cdd:TIGR00881 336 SELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
64-436 |
2.77e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.16 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17333 38 SSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFL-LGGIGILLAWFLSGKYFIESPRWLagkgqiagaesqlreveq 222
Cdd:cd17333 118 ATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLiIGLIYLLLAILILLTLFPELPSAR------------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 223 qierekrirlppLTLNQSNSKVKVIKGTFWLLFkggmlrrTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILM 301
Cdd:cd17333 180 ------------NPQQSVGAFSASASRLLRNPS-------IILGALALFLYVGAETAFSSWVPSYLVEKkHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 302 TAVIMIGAPVGIFIAALIIDHFPRRLFgSALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLyMYVCFASAVYIPELWPT 381
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRIKPHTL-LVLSGSGALLGLLILLLAPTLVVGLVATALLGLF-MAALFPTILSLGISNLP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1970692088 382 HLRLRGSGFVNAVGRIVAVFTPYgVAALLTHYGSITVFMVLGVMLVLCALVLSIF 436
Cdd:cd17333 319 YAKGKGTSVLLAAGSIGGAIIPF-IMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-200 |
3.59e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.41 E-value: 3.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 69 GYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWS 148
Cdd:TIGR00880 10 GQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVAL 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1970692088 149 ARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIES 200
Cdd:TIGR00880 90 GLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
72-433 |
3.97e-05 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 45.86 E-value: 3.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDM----YWLIFFRFLM---------GTGMGALIMVGyasftEF 138
Cdd:PRK10642 72 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigIWAPILLLLCkmaqgfsvgGEYTGASIFVA-----EY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 139 IPATVRGkwsarlsFVGNW---------------SPMLSAAIGVVVIAFFSWRIMFL----LGGIGILLAWFLSgkyfiE 199
Cdd:PRK10642 147 SPDRKRG-------FMGSWldfgsiagfvlgagvVVLISTIVGEANFLDWGWRIPFFialpLGIIGLYLRHALE-----E 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 200 SPrwlagkgqiagAESQLREVEQQIEREKRIRLPPLTLNQSNSKVKvikgtfwllfkggmlRRTLVAITVLIAMNISLYT 279
Cdd:PRK10642 215 TP-----------AFQQHVDKLEQGDREGLQDGPKVSFKEIATKHW---------------RSLLTCIGLVIATNVTYYM 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 280 ITVWIPTIFV-NSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLF---GSALLIIIAVLGYIYsIQTTEWAILIY 355
Cdd:PRK10642 269 LLTYMPSYLShNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFvilGSVALFVLAIPAFIL-INSNVIGLIFA 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 356 GLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITV----FMVLGVMLVLCAL 431
Cdd:PRK10642 348 GLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESTQNLMMpayyLMVVAVIGLITGV 427
|
..
gi 1970692088 432 VL 433
Cdd:PRK10642 428 TM 429
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
265-452 |
5.17e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 5.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 265 VAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVLGYIYS 344
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 345 IQTTEWAILIYGLVMIFFLYMYVCfASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGV 424
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFP-AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180
....*....|....*....|....*...
gi 1970692088 425 MLVLCALVLSIFGIETRKVSLEEISEVN 452
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEAR 187
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
63-193 |
6.88e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.87 E-value: 6.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17323 40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLS 193
Cdd:cd17323 120 ERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
260-436 |
7.30e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 7.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 260 LRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVL 339
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 340 GYIYSIQTTEWAILIYGLVMIFFLYMYVcFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVF 419
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALF-PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*..
gi 1970692088 420 MVLGVMLVLCALVLSIF 436
Cdd:COG2814 168 LVNAVLALLALLLLLRL 184
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
78-193 |
8.47e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.49 E-value: 8.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMvGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:cd17504 52 GRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPL-AFALVREEFPPERVPVAQGILSATFGI 130
|
90 100 110
....*....|....*....|....*....|....*.
gi 1970692088 158 SPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLS 193
Cdd:cd17504 131 GAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV 166
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
78-181 |
8.54e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 44.48 E-value: 8.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:cd17502 51 GKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGI 130
|
90 100
....*....|....*....|....
gi 1970692088 158 SPMLSAAIGVVVIAFFSWRIMFLL 181
Cdd:cd17502 131 ASVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
5-189 |
8.57e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.48 E-value: 8.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 5 DQIGARLDRLPLARFHYRIFGIISFS-----LLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIgslTGGF 79
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSaflyfFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF---VGRL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 80 IGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSP 159
Cdd:cd17474 258 LKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQ 337
|
170 180 190
....*....|....*....|....*....|
gi 1970692088 160 MLSAAIGVVVIAFFSWRIMFLLGGIGILLA 189
Cdd:cd17474 338 AVGPLLFGLLLEIFGLSAPFLVGAAIALAA 367
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
68-436 |
8.96e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 8.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKW 147
Cdd:cd17329 46 VAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 148 SARLSFVGNWSPMLSAAIG-VVVIAFFSWRIMFLLGGIGILLAWFLsgkyfiesprwlagkgqiagaesqlreveqqier 226
Cdd:cd17329 126 FSLLYWAINLGVAIGPLLGgLLLLYSFRLLFLAAAVLFLLAALVLL---------------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 227 ekrIRLPPLTLNQSNSKVKVIKGTFWLLFKGGMLRRTLVAITVLIAMNISLYTItvwIPTIFVNSGIDVDKsilMTAVIM 306
Cdd:cd17329 172 ---FLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST---LPVYVVEILGLGES---LLGLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 307 IGAPVGIFIAALIIDHFPRRlFGSALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLY----MYVCFASAVYIPELWPTH 382
Cdd:cd17329 243 ALNALLIVLLQFPVARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLtlgeMLVFPAVQTLVAALAPPD 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1970692088 383 LRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVLSIF 436
Cdd:cd17329 322 KRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
78-433 |
1.55e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATvRGKWSARLSFVGNW 157
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 158 SPMLSAAIGVVVIAFF---SWRIMFLLGGIGILLAWFLSGKYFIESPRWLAGKGQIAgaesqlreveqqierekrirlpp 234
Cdd:cd17478 131 GFALGPLIAAALVALFgglGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSAR----------------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 235 ltlnqsnSKVKVIKGTFWLLFKGGMLRrtlvaitvliamNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIF 314
Cdd:cd17478 188 -------STLKGVWRALLLLLIIVFLR------------SWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 315 IAALIIDHFPRR--LFGSALLIIIAVLGYIYsiqTTEWAILIygLVMIFFLYMYVCF-ASAVYIPELWPTHLRLrGSGFV 391
Cdd:cd17478 249 IGGPLSDRFGRRrvIIASLLLAAPFLLLFLL---TPGIWSYI--LLVLAGFLLFASFpVTVVLAQELLPGNVGL-ASGLM 322
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1970692088 392 NAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLVLCALVL 433
Cdd:cd17478 323 MGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
66-206 |
2.00e-04 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 43.20 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 66 LMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRG 145
Cdd:cd17375 44 FMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKART 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1970692088 146 KWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIG-ILLAWFLSGKYFIESPRWLAG 206
Cdd:cd17375 124 WASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPfILCCWMLPKRTITVWLIWFTG 185
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
60-188 |
4.65e-04 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 42.10 E-value: 4.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMvGYASFTEFI 139
Cdd:cd17442 39 ALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHSQ-GLIIKTEFL 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1970692088 140 PATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGI-GILL 188
Cdd:cd17442 118 PTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIpGIIL 167
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
63-375 |
1.36e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.68 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17328 40 QTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 143 VRGKWSARLSFVGNWSPMLSAAIG-VVVIAFFSWRIMFLL-GGIGILLAWFLsgKYFIESPRwlagKGQIAGAESQlrev 220
Cdd:cd17328 120 KRTRALGVFYFAIPLGSGLGYVVGgLVAQATGGWRWAFRVtGVLGVLLAILL--LLFVREPP----RGAAEGGVMA---- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 221 eqqierekrirlppltlnqsNSKVKVIKGTFWLLFKggmlRRTLVAITV-LIAMNISLYTITVWIPTIF-----VNSGID 294
Cdd:cd17328 190 --------------------KSTATSFLADLKALAK----NPSFILSTLgFTAVSFVTGALAFWAPTFFlrafgVGDLSS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 295 VDKSILMTAVIMIGAPVGIFIAALIIDHFPRR------------LFGSALLIIIAVLGYIYSIqtteWAILIYGLVMIFF 362
Cdd:cd17328 246 ADVGLIFGAITCIAGVLGVLLGGILADRLRRKtpradplvcavgLLAAAPFLFLALVLALSNL----LLAWVLLFLGEFL 321
|
330
....*....|....*
gi 1970692088 363 LYMY--VCFASAVYI 375
Cdd:cd17328 322 LSLNwaPVFAILLYV 336
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
78-192 |
1.63e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 40.58 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110
....*....|....*....|....*....|....*
gi 1970692088 158 SPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFL 192
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVG 186
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
64-192 |
2.06e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIA--ATGAAFVPDMYWLIFFRFLMGTGMGalimVGYASFTEFIPA 141
Cdd:cd17380 41 SSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLAtlLTPLLAYSSLPLLILSRILLGLGEG----VHFPSMTSLFSR 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1970692088 142 TVRGKWSAR-LSFV---GNWSPMLSAAIGVVVIAFFSWRIMFLL-GGIGILLAWFL 192
Cdd:cd17380 117 WVPVSERSRaVSIVtagSYLGTLLGGLIGPLLLEYYGWPSVFYFfGLLGLLWALVW 172
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
64-327 |
2.06e-03 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 40.29 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAA-----TGAAFVPDMywLIFFRFLMGTGMGALIMVGYASFTEF 138
Cdd:cd17432 57 SIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAilmglSKIAKSFEM--IIVGRFLVGINAGISLNVVPMYLGES 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 139 IPATVRGkwsarlsFVGnWSPMLSAAIGVVVIAFFS----------WRIMFLLGGIGILLAwFLSGKYFIESPRW-LAGK 207
Cdd:cd17432 135 APKNLRG-------AVG-LVPAIFITLGILLGQVLGlrellgneegWPLLLALTGVPALLQ-LLTLPFFPESPRYlLIEK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 208 GQIAGAESQLR------EVEQQIE---REKRirlppltlnqSNSKVKVIKgtFWLLFKGGMLRRTLVAITVL-IAMNIS- 276
Cdd:cd17432 206 GDEEAARKALQrlrgkeDVDDEMEemlEEQR----------AEKGVGTVS--VLELFRDRSVRWQLISIIVLmAGQQLCg 273
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 277 LYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRL 327
Cdd:cd17432 274 INAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRP 324
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
58-437 |
2.26e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 40.30 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 58 LNAAFTSALMF-GYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFT 136
Cdd:PRK12307 53 MEGAFLATAAFiGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 137 EFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSgKYFIESPRWLAGKGQIAGAESQ 216
Cdd:PRK12307 133 ESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIR-ARAPESKEWEEAKLSGKGKHSQ 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 217 lreveqqierekrirlppltlnqsnSKVKVIKGTFWLLFKGGMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGID-V 295
Cdd:PRK12307 212 -------------------------SAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAGEGFDtG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 296 DKSILMTAViMIGAPVGIFIAALIIDHFP-RRLFGSALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVY 374
Cdd:PRK12307 267 VVSNLMTAA-AFGTVLGNIVWGLCADRIGlKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGACLFGLMATNVGVGGLVPKF 345
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1970692088 375 IPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYG---SITVFMVLGVMLVLCALVLSIFG 437
Cdd:PRK12307 346 LYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGlgaALTFIVAFWTATILLIIGLSIPD 411
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
278-438 |
2.36e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 39.87 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 278 YTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGSALLIIIAVLGYIYSiqtteWAILI 354
Cdd:cd17339 213 YTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQrpiVVLLAVLFIIGVLGLLFA-----PTALA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 355 YGLVMIFFLYMYVCFASAVYIPELWPTHLRLRG--SGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLgvmLVLCALV 432
Cdd:cd17339 288 LLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAalSGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVL---LLALTVL 364
|
....*.
gi 1970692088 433 LSIFGI 438
Cdd:cd17339 365 QLVAGL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-141 |
2.37e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVP--DMYWLIFFRFLMGTGMGALIMVGYASFTE 137
Cdd:COG2211 267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLAD 346
|
....
gi 1970692088 138 FIPA 141
Cdd:COG2211 347 VVDY 350
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
71-141 |
2.56e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.14 E-value: 2.56e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1970692088 71 FIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:COG2270 288 ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPP 358
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
68-128 |
2.65e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 40.07 E-value: 2.65e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1970692088 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLI-----VGIAATGAAFVPDMYWLIFFRFLMGTGMGALI 128
Cdd:PRK03893 322 FGAAVGCCVGGFLGDWLGTRKAYVCSLLIsqlliIPVFAIGGANVWVLGLLLFFQQMLGQGISGLL 387
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
18-126 |
2.89e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 18 RFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIV 97
Cdd:cd17478 191 KGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLA 270
|
90 100
....*....|....*....|....*....
gi 1970692088 98 GIAATGAAFVPDmYWLIFFRFLMGTGMGA 126
Cdd:cd17478 271 APFLLLFLLTPG-IWSYILLVLAGFLLFA 298
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
64-192 |
3.48e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 3.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAA--TGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17318 63 SSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTllTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPP 142
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1970692088 142 TVRGKWSArLSFVG-NWSPMLSAAIGVVVIAFFSWR-IMFLLGGIGIL--LAWFL 192
Cdd:cd17318 143 LERSRLTS-IAYSGsQFGTVIAMPLSGFLCESLGWPsIFYIFGGLGLLwcLLWFF 196
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
60-195 |
3.73e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 3.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFI 139
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL 328
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1970692088 140 PATVRGKWSArLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGK 195
Cdd:COG0738 329 GKRTAAAVSA-VLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
62-434 |
3.96e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.14 E-value: 3.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 62 FTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17475 36 LLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 142 TVRG-KWSARLSFVgNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESPRWLAGKGQIAGAESQLREV 220
Cdd:cd17475 116 RERGlAMGIRQTGV-PLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 221 eqqierekrIRLPPltlnqsnskvkvikgtfwllfkggmLRRTLVAITVLIAMNISLYTITVwiptIFVNSGID---VDK 297
Cdd:cd17475 195 ---------LRNRD-------------------------VWLIAIAGALLVAPQFALLTFLL----LFLHDHLGlsvVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 298 SILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSALLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFA----SAV 373
Cdd:cd17475 237 GALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnglYLT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1970692088 374 YIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSIT-VFMVLGVMLVLCALVLS 434
Cdd:cd17475 317 LVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYApAWLALALLLVLAALLLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
16-189 |
4.61e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 16 LARFHYRIFGIISFSLLLTGFLSYSGNVVLA-KLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINL 94
Cdd:cd17473 191 AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 95 LIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAI-GVVVIAFF 173
Cdd:cd17473 271 ALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlGPLVNLTG 350
|
170
....*....|....*.
gi 1970692088 174 SWRIMFLLGGIGILLA 189
Cdd:cd17473 351 GLSGAFLILGVLALVL 366
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
67-192 |
9.43e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 38.22 E-value: 9.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1970692088 67 MFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFI--PATVR 144
Cdd:cd17445 46 ILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCdpPQRLL 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1970692088 145 GKWSARLSFVGNWSPMLSAAIGVVviaffSWRimFLLGGIGILLAWFL 192
Cdd:cd17445 126 VAMAGGLTMVGGHFLLLGLALGCG-----SWR--VLQGTITAPLSLFL 166
|
|
| |
