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Conserved domains on  [gi|2084074098|gb|QZD85327|]
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TetR family transcriptional regulator [Klebsiella pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_29 pfam17938
Tetracyclin repressor-like, C-terminal domain; This domain is found in the C-terminal region ...
 84-206 6.02e-37

Tetracyclin repressor-like, C-terminal domain; This domain is found in the C-terminal region of putative TetR-family regulatory proteins.


:

Pssm-ID: 436158 [Multi-domain]  Cd Length: 119  Bit Score: 124.93  E-value: 6.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  84 PVEALVRLVRWSVRYHATHADYMRVICMENMQRGKWLKSSGELKPLNRTALSILEDILLRGQQQGVFQAGLDARDVHRLI 163
Cdd:pfam17938   1 PVEALRRLVEFTFDYHAANPDFVRLVNIENLHRGRHLAQSERIRELNSPLILQLDRILERGQAAGVFRPGVDALDLYLLI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2084074098 164 SSFSFYQVSNFYTFSSLYLDDPLpaidDEAMVAHHCDIAVRAV 206
Cdd:pfam17938  81 SALCFFRVSNRHTFSALFGRDLT----SPEALARRRRHIVDMV 119
PRK15008 super family cl33059
HTH-type transcriptional regulator RutR; Provisional
 13-129 1.56e-13

HTH-type transcriptional regulator RutR; Provisional


The actual alignment was detected with superfamily member PRK15008:

Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 66.49  E-value: 1.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  13 KARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYArIRETEQQLGLENVPPVEALVRLV 92
Cdd:PRK15008   20 KKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILD-IWLAPLKAFREDFAPLAAIKEYI 98

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2084074098  93 RWSVRYHATHADYMRVICMENMQRGKWLKS--SGELKPL 129
Cdd:PRK15008   99 RLKLEVSRDYPQASRLFCMEMLAGAPLLMDelTGDLKAL 137
 
Name Accession Description Interval E-value
TetR_C_29 pfam17938
Tetracyclin repressor-like, C-terminal domain; This domain is found in the C-terminal region ...
 84-206 6.02e-37

Tetracyclin repressor-like, C-terminal domain; This domain is found in the C-terminal region of putative TetR-family regulatory proteins.


Pssm-ID: 436158 [Multi-domain]  Cd Length: 119  Bit Score: 124.93  E-value: 6.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  84 PVEALVRLVRWSVRYHATHADYMRVICMENMQRGKWLKSSGELKPLNRTALSILEDILLRGQQQGVFQAGLDARDVHRLI 163
Cdd:pfam17938   1 PVEALRRLVEFTFDYHAANPDFVRLVNIENLHRGRHLAQSERIRELNSPLILQLDRILERGQAAGVFRPGVDALDLYLLI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2084074098 164 SSFSFYQVSNFYTFSSLYLDDPLpaidDEAMVAHHCDIAVRAV 206
Cdd:pfam17938  81 SALCFFRVSNRHTFSALFGRDLT----SPEALARRRRHIVDMV 119
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-166 8.60e-19

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 79.56  E-value: 8.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098   9 AQSLKARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYARIRETEQQLgLENVPPVEAL 88
Cdd:COG1309     4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEA-LAAEDPRERL 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2084074098  89 VRLVRWSVRYHATHADYMRVICMENMQrgkwlksSGELKPLNRTALSILEDILLRGQQQGVFQAGLDARDVHRLISSF 166
Cdd:COG1309    83 RALLRAYLEFLAENPALARLLLAEAAE-------LPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLAL 153
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 13-129 1.56e-13

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 66.49  E-value: 1.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  13 KARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYArIRETEQQLGLENVPPVEALVRLV 92
Cdd:PRK15008   20 KKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILD-IWLAPLKAFREDFAPLAAIKEYI 98

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2084074098  93 RWSVRYHATHADYMRVICMENMQRGKWLKS--SGELKPL 129
Cdd:PRK15008   99 RLKLEVSRDYPQASRLFCMEMLAGAPLLMDelTGDLKAL 137
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
13-91 5.47e-10

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 56.45  E-value: 5.47e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2084074098  13 KARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYARIRETEQQLGLENVPPVEALVRL 91
Cdd:NF041196    8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGGGSKLQELVDL 86
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
14-108 3.28e-09

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 54.17  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  14 ARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYARIRETEQQLGLENVPPVEALVRLVR 93
Cdd:COG3226    11 ERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEALAD 90

                          90
                  ....*....|....*
gi 2084074098  94 WSVRYHATHADYMRV 108
Cdd:COG3226    91 LLAELLPADRDRLLA 105
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
16-62 4.14e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 50.48  E-value: 4.14e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2084074098  16 IFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEV 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR_C_29 pfam17938
Tetracyclin repressor-like, C-terminal domain; This domain is found in the C-terminal region ...
 84-206 6.02e-37

Tetracyclin repressor-like, C-terminal domain; This domain is found in the C-terminal region of putative TetR-family regulatory proteins.


Pssm-ID: 436158 [Multi-domain]  Cd Length: 119  Bit Score: 124.93  E-value: 6.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  84 PVEALVRLVRWSVRYHATHADYMRVICMENMQRGKWLKSSGELKPLNRTALSILEDILLRGQQQGVFQAGLDARDVHRLI 163
Cdd:pfam17938   1 PVEALRRLVEFTFDYHAANPDFVRLVNIENLHRGRHLAQSERIRELNSPLILQLDRILERGQAAGVFRPGVDALDLYLLI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2084074098 164 SSFSFYQVSNFYTFSSLYLDDPLpaidDEAMVAHHCDIAVRAV 206
Cdd:pfam17938  81 SALCFFRVSNRHTFSALFGRDLT----SPEALARRRRHIVDMV 119
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-166 8.60e-19

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 79.56  E-value: 8.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098   9 AQSLKARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYARIRETEQQLgLENVPPVEAL 88
Cdd:COG1309     4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEA-LAAEDPRERL 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2084074098  89 VRLVRWSVRYHATHADYMRVICMENMQrgkwlksSGELKPLNRTALSILEDILLRGQQQGVFQAGLDARDVHRLISSF 166
Cdd:COG1309    83 RALLRAYLEFLAENPALARLLLAEAAE-------LPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLAL 153
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 13-129 1.56e-13

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 66.49  E-value: 1.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  13 KARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYArIRETEQQLGLENVPPVEALVRLV 92
Cdd:PRK15008   20 KKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILD-IWLAPLKAFREDFAPLAAIKEYI 98

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2084074098  93 RWSVRYHATHADYMRVICMENMQRGKWLKS--SGELKPL 129
Cdd:PRK15008   99 RLKLEVSRDYPQASRLFCMEMLAGAPLLMDelTGDLKAL 137
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
13-91 5.47e-10

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 56.45  E-value: 5.47e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2084074098  13 KARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYARIRETEQQLGLENVPPVEALVRL 91
Cdd:NF041196    8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGGGSKLQELVDL 86
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
14-108 3.28e-09

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 54.17  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  14 ARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYARIRETEQQLGLENVPPVEALVRLVR 93
Cdd:COG3226    11 ERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEALAD 90

                          90
                  ....*....|....*
gi 2084074098  94 WSVRYHATHADYMRV 108
Cdd:COG3226    91 LLAELLPADRDRLLA 105
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
16-62 4.14e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 50.48  E-value: 4.14e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2084074098  16 IFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEV 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 13-72 9.72e-07

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 47.74  E-value: 9.72e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  13 KARIFSAAIAVFAEHGLSgARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYARIRE 72
Cdd:PRK11552   15 KQQLIAAALAQFGEYGLH-ATTRDIAAQAGQNIAAITYYFGSKEDLYLAVAQWIADFIGE 73
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 8-90 3.37e-06

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 45.88  E-value: 3.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098   8 EAQSLKARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQhvyarireteQQlglenvPPVEA 87
Cdd:PRK09975    8 EALKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWL----------QQ------PPLRE 71


                  ...
gi 2084074098  88 LVR 90
Cdd:PRK09975   72 LIQ 74
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 8-74 7.10e-06

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 45.00  E-value: 7.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2084074098   8 EAQSLKARIFSAAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHVYARIRETE 74
Cdd:PRK10668    8 QAQETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGELE 74
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 19-66 3.68e-04

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 39.83  E-value: 3.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2084074098  19 AAIAVFAEHGLSGARMEQIATEAQTTKRMVVYYFKSKEQLYQEVLQHV 66
Cdd:PRK00767   17 ATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHL 64
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 83-163 3.71e-03

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 36.00  E-value: 3.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2084074098  83 PPVEALVRLVRWSVRYHATHADYMRVIcmenmqrgkwLKSSGELKPLNRTAL--------SILEDILLRGQQQGVFQAgL 154
Cdd:pfam17932   3 SPVERLRALVRAHVRVHAERRDEAAVF----------LRELRSLSPEHRAEIralrreyeRLLRDLIEEGVAAGEFRD-L 71


                  ....*....
gi 2084074098 155 DARDVHRLI 163
Cdd:pfam17932  72 DPKLAALAI 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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