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Conserved domains on  [gi|1408825861|gb|RAN77678|]
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UDP-N-acetylenolpyruvoylglucosamine reductase [Bacillus sp. SRB_336]

Protein Classification

UDP-N-acetylmuramate dehydrogenase( domain architecture ID 11486937)

UDP-N-acetylmuramate dehydrogenase is responsible for the synthesis of UDP-N-acetylmuramic acid in bacterial cell wall biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
murB PRK13903
UDP-N-acetylmuramate dehydrogenase;
3-356 1.08e-171

UDP-N-acetylmuramate dehydrogenase;


:

Pssm-ID: 237552 [Multi-domain]  Cd Length: 363  Bit Score: 482.15  E-value: 1.08e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIASQGFKASsedsCGGASV 82
Cdd:PRK13903   21 LAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDGFDGTVVRVATRGVTVD----CGGGLV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 VVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVRTFTNSELKFGYRDS 162
Cdd:PRK13903   97 RAEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLLDRRTGEVRWVPAADLGFGYRTS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 163 VIKQttvtgSPRFVVLTVEFQLLLGRMSAPVKYAELARRLGVEVGKRANSLELRRTVLELRASKGMVLDPADRDTWSTGS 242
Cdd:PRK13903  177 VLKH-----SDRAVVLEVEFQLDPSGLSAPLRYGELARALGVEPGERVPPAAVREAVLALRAGKGMVLDPADHDTWSAGS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 243 FFTNPIVSAAEAASLPADA--------PRYPAAAGLTKLSAAWLIEHAGFSKGYglapdgsKGGGvasGRAALSTKHTLA 314
Cdd:PRK13903  252 FFTNPVVSPAVAERLAARVaerlgdpvPRYPAGDGGVKLSAAWLIERAGFGKGY-------PGGG---APARLSTKHTLA 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1408825861 315 VTNRGGASAEDVLAVAREVRSGVVRQFGISLHPEPVLVGCQL 356
Cdd:PRK13903  322 LTNRGGATTADLVALAREVRDGVRDAFGVTLVPEPVLVGCSL 363
 
Name Accession Description Interval E-value
murB PRK13903
UDP-N-acetylmuramate dehydrogenase;
3-356 1.08e-171

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237552 [Multi-domain]  Cd Length: 363  Bit Score: 482.15  E-value: 1.08e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIASQGFKASsedsCGGASV 82
Cdd:PRK13903   21 LAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDGFDGTVVRVATRGVTVD----CGGGLV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 VVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVRTFTNSELKFGYRDS 162
Cdd:PRK13903   97 RAEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLLDRRTGEVRWVPAADLGFGYRTS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 163 VIKQttvtgSPRFVVLTVEFQLLLGRMSAPVKYAELARRLGVEVGKRANSLELRRTVLELRASKGMVLDPADRDTWSTGS 242
Cdd:PRK13903  177 VLKH-----SDRAVVLEVEFQLDPSGLSAPLRYGELARALGVEPGERVPPAAVREAVLALRAGKGMVLDPADHDTWSAGS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 243 FFTNPIVSAAEAASLPADA--------PRYPAAAGLTKLSAAWLIEHAGFSKGYglapdgsKGGGvasGRAALSTKHTLA 314
Cdd:PRK13903  252 FFTNPVVSPAVAERLAARVaerlgdpvPRYPAGDGGVKLSAAWLIERAGFGKGY-------PGGG---APARLSTKHTLA 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1408825861 315 VTNRGGASAEDVLAVAREVRSGVVRQFGISLHPEPVLVGCQL 356
Cdd:PRK13903  322 LTNRGGATTADLVALAREVRDGVRDAFGVTLVPEPVLVGCSL 363
MurB COG0812
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ...
 3-352 3.52e-109

UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440574 [Multi-domain]  Cd Length: 279  Bit Score: 320.04  E-value: 3.52e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIAS-QGFKAssedsCGGAS 81
Cdd:COG0812     3 LAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDGFDGLVIRLGRlKGIEV-----DDGVL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  82 VVVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDaVRTFTNSELKFGYRD 161
Cdd:COG0812    78 VTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLDRTGE-VRTLSAEECGFGYRD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 162 SVIKQTtvtgspRFVVLTVEFQLllgrmsAPVKYAELARRlgvevgkranslelRRTVLELRASKgmvlDPAdrDTWSTG 241
Cdd:COG0812   157 SIFKRE------RYIILSVTFRL------KKGDPAEIAAV--------------MDAVLAIRRSK----QPL--ELPSAG 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 242 SFFTNPivsaaeaaslPADaprypaaagltklSAAWLIEHAGFsKGYGLapdgskgggvasGRAALSTKHTLAVTNRGGA 321
Cdd:COG0812   205 SFFKNP----------PGD-------------SAGWLIEQAGL-KGYRI------------GGAQVSEKHANFLVNRGGA 248

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1408825861 322 SAEDVLAVAREVRSGVVRQFGISLHPEPVLV 352
Cdd:COG0812   249 TAADVLALIEEVQARVKEKFGVELEPEVRII 279
murB TIGR00179
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ...
 3-353 2.30e-48

UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 272945 [Multi-domain]  Cd Length: 284  Bit Score: 164.55  E-value: 2.30e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIasqGFKASSEDSCGGaSV 82
Cdd:TIGR00179   1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINL---GKGIDIEDDEGE-YV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 VVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVRtFTNSELKFGYRDS 162
Cdd:TIGR00179  77 HVGGGENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATILLATGKTEW-LTNEQLGFGYRTS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 163 VIKQTTVtgsprFVVLTVEFQLLLGrmsapvkYAELARRLGVEVGKRANslelrrtvLELRASKGMVLDPadrdtwSTGS 242
Cdd:TIGR00179 156 IFQHKYV-----GLVLKAEFQLTLG-------FGTRLDPETITAQQVFN--------KVCRMRTSHYPDP------NAGS 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 243 FFTNPivsaaeaaslpadAPRYpaaagltklsAAWLIEHAGFsKGYGLapdgskgggvasGRAALSTKHTLAVTNRGGAS 322
Cdd:TIGR00179 210 FFKNP-------------SPNH----------AGRLIEECGL-KGYQI------------GGAAVSKQHANFLVNIDNAK 253

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1408825861 323 AEDVLAVAREVRSGVVRQFGISLHPEPVLVG 353
Cdd:TIGR00179 254 SEDVLDLIEHVKAEVGEKYGILLEPEVKIIG 284
MurB_C pfam02873
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ...
 216-352 1.35e-34

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 460730 [Multi-domain]  Cd Length: 99  Bit Score: 122.46  E-value: 1.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 216 RRTVLELRASKgMVLDPADrdTWSTGSFFTNPIvsaaeaaslpadaprypaaagltKLSAAWLIEHAGFsKGYGLapdgs 295
Cdd:pfam02873   2 RAAMLELRRRR-LAKQPLD--PPSAGSFFKNPV-----------------------GHSAGWLIEQAGL-KGYRI----- 49

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1408825861 296 kgggvasGRAALSTKHTLAVTNRGGASAEDVLAVAREVRSGVVRQFGISLHPEPVLV 352
Cdd:pfam02873  50 -------GGAQVSEKHANFLVNTGGATAADVLALIEEVRERVKEKFGVELEPEVRII 99
 
Name Accession Description Interval E-value
murB PRK13903
UDP-N-acetylmuramate dehydrogenase;
3-356 1.08e-171

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237552 [Multi-domain]  Cd Length: 363  Bit Score: 482.15  E-value: 1.08e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIASQGFKASsedsCGGASV 82
Cdd:PRK13903   21 LAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDGFDGTVVRVATRGVTVD----CGGGLV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 VVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVRTFTNSELKFGYRDS 162
Cdd:PRK13903   97 RAEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLLDRRTGEVRWVPAADLGFGYRTS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 163 VIKQttvtgSPRFVVLTVEFQLLLGRMSAPVKYAELARRLGVEVGKRANSLELRRTVLELRASKGMVLDPADRDTWSTGS 242
Cdd:PRK13903  177 VLKH-----SDRAVVLEVEFQLDPSGLSAPLRYGELARALGVEPGERVPPAAVREAVLALRAGKGMVLDPADHDTWSAGS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 243 FFTNPIVSAAEAASLPADA--------PRYPAAAGLTKLSAAWLIEHAGFSKGYglapdgsKGGGvasGRAALSTKHTLA 314
Cdd:PRK13903  252 FFTNPVVSPAVAERLAARVaerlgdpvPRYPAGDGGVKLSAAWLIERAGFGKGY-------PGGG---APARLSTKHTLA 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1408825861 315 VTNRGGASAEDVLAVAREVRSGVVRQFGISLHPEPVLVGCQL 356
Cdd:PRK13903  322 LTNRGGATTADLVALAREVRDGVRDAFGVTLVPEPVLVGCSL 363
MurB COG0812
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ...
 3-352 3.52e-109

UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440574 [Multi-domain]  Cd Length: 279  Bit Score: 320.04  E-value: 3.52e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIAS-QGFKAssedsCGGAS 81
Cdd:COG0812     3 LAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDGFDGLVIRLGRlKGIEV-----DDGVL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  82 VVVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDaVRTFTNSELKFGYRD 161
Cdd:COG0812    78 VTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLDRTGE-VRTLSAEECGFGYRD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 162 SVIKQTtvtgspRFVVLTVEFQLllgrmsAPVKYAELARRlgvevgkranslelRRTVLELRASKgmvlDPAdrDTWSTG 241
Cdd:COG0812   157 SIFKRE------RYIILSVTFRL------KKGDPAEIAAV--------------MDAVLAIRRSK----QPL--ELPSAG 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 242 SFFTNPivsaaeaaslPADaprypaaagltklSAAWLIEHAGFsKGYGLapdgskgggvasGRAALSTKHTLAVTNRGGA 321
Cdd:COG0812   205 SFFKNP----------PGD-------------SAGWLIEQAGL-KGYRI------------GGAQVSEKHANFLVNRGGA 248

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1408825861 322 SAEDVLAVAREVRSGVVRQFGISLHPEPVLV 352
Cdd:COG0812   249 TAADVLALIEEVQARVKEKFGVELEPEVRII 279
murB PRK00046
UDP-N-acetylmuramate dehydrogenase;
3-352 2.61e-93

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 234593 [Multi-domain]  Cd Length: 334  Bit Score: 281.65  E-value: 2.61e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDgFDGTVLKIASQGFKASSEDscGGASV 82
Cdd:PRK00046    9 LKPLNTFGIDARARHLVEAESEEQLLEALADARAAGLPVLVLGGGSNVLFTED-FDGTVLLNRIKGIEVLSED--DDAWY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 V-VAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVRTFTNSELKFGYRD 161
Cdd:PRK00046   86 LhVGAGENWHDLVLWTLQQGMPGLENLALIPGTVGAAPIQNIGAYGVELKDVCDYVEALDLATGEFVRLSAAECRFGYRD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 162 SVIKQttvTGSPRFVVLTVEFQLLlgRMSAPV-KYAELARRLGVEVGKRanslELRRTVLELRASKgmvL-DPAdrDTWS 239
Cdd:PRK00046  166 SIFKH---EYPDRYAITAVGFRLP--KQWQPVlDYGDLARLDPDTVTAQ----DVFDAVCAIRRSK---LpDPK--VLGN 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 240 TGSFFTNPIVSAAEAASLPA---DAPRYPAAAGLTKLSAAWLIEHAGFsKGYGLapdgskgggvasGRAALSTKHTLAVT 316
Cdd:PRK00046  232 AGSFFKNPVVSAEQFEALLAqypDIPHYPQADGSVKLAAGWLIDQCGL-KGFQI------------GGAAVHEKQALVLV 298

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1408825861 317 NRGGASAEDVLAVAREVRSGVVRQFGISLHPEPVLV 352
Cdd:PRK00046  299 NYGNATGADVLALARHIQQDVREKFGVELEPEPRFI 334
murB PRK13905
UDP-N-acetylmuramate dehydrogenase;
3-348 9.71e-52

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237553 [Multi-domain]  Cd Length: 298  Bit Score: 173.76  E-value: 9.71e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIaSQGFKASSEDscgGASV 82
Cdd:PRK13905   19 LARYTSFRVGGPADYLVEPADIEDLQEFLKLLKENNIPVTVLGNGSNLLVRDGGIRGVVIRL-GKGLNEIEVE---GNRI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 VVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDaVRTFTNSELKFGYRDS 162
Cdd:PRK13905   95 TAGAGAPLIKLARFAAEAGLSGLEFAAGIPGTVGGAVFMNAGAYGGETADVLESVEVLDRDGE-IKTLSNEELGFGYRHS 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 163 VIKQttvtgsPRFVVLTVEFQLLLGrmsapvKYAELARRLgvevgkRANsLELRRTV--LELRaskgmvldpadrdtwST 240
Cdd:PRK13905  174 ALQE------EGLIVLSATFQLEPG------DKEEIKARM------DEL-LARREATqpLEYP---------------SA 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 241 GSFFTNPivsaaeaaslpadaprypaaAGltkLSAAWLIEHAGFsKGYglapdgSKGGgvasgrAALSTKHTLAVTNRGG 320
Cdd:PRK13905  220 GSVFKNP--------------------PG---HFAGKLIEEAGL-KGY------RIGG------AQVSEKHANFIINTGG 263

                         330       340
                  ....*....|....*....|....*...
gi 1408825861 321 ASAEDVLAVAREVRSGVVRQFGISLHPE 348
Cdd:PRK13905  264 ATAADIEDLIEHVQKTVKEKFGVELEWE 291
murB TIGR00179
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ...
 3-353 2.30e-48

UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 272945 [Multi-domain]  Cd Length: 284  Bit Score: 164.55  E-value: 2.30e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIasqGFKASSEDSCGGaSV 82
Cdd:TIGR00179   1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINL---GKGIDIEDDEGE-YV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 VVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVRtFTNSELKFGYRDS 162
Cdd:TIGR00179  77 HVGGGENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATILLATGKTEW-LTNEQLGFGYRTS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 163 VIKQTTVtgsprFVVLTVEFQLLLGrmsapvkYAELARRLGVEVGKRANslelrrtvLELRASKGMVLDPadrdtwSTGS 242
Cdd:TIGR00179 156 IFQHKYV-----GLVLKAEFQLTLG-------FGTRLDPETITAQQVFN--------KVCRMRTSHYPDP------NAGS 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 243 FFTNPivsaaeaaslpadAPRYpaaagltklsAAWLIEHAGFsKGYGLapdgskgggvasGRAALSTKHTLAVTNRGGAS 322
Cdd:TIGR00179 210 FFKNP-------------SPNH----------AGRLIEECGL-KGYQI------------GGAAVSKQHANFLVNIDNAK 253

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1408825861 323 AEDVLAVAREVRSGVVRQFGISLHPEPVLVG 353
Cdd:TIGR00179 254 SEDVLDLIEHVKAEVGEKYGILLEPEVKIIG 284
PRK14649 PRK14649
UDP-N-acetylmuramate dehydrogenase;
2-353 3.18e-36

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173112 [Multi-domain]  Cd Length: 295  Bit Score: 133.04  E-value: 3.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   2 LLSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIASQGFKAssEDSCGGAS 81
Cdd:PRK14649    8 PLAPYTSWRIGGPARYFVEPTTPDEAIAAAAWAEQRQLPLFWLGGGSNLLVRDEGFDGLVARYRGQRWEL--HEHGDTAE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  82 VVVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVRtFTNSELKFGYRD 161
Cdd:PRK14649   86 VWVEAGAPMAGTARRLAAQGWAGLEWAEGLPGTIGGAIYGNAGCYGGDTATVLIRAWLLLNGSECVE-WSVHDFAYGYRT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 162 SVIKQTTVTGSPRF--VVLTVEFQLLLGRMSApvkyaeLARRLGvevgkranslelrRTVLElRASKgmvlDPADRdtwS 239
Cdd:PRK14649  165 SVLKQLRADGITWRppLVLAARFRLHRDDPTA------LAARME-------------AIAAE-RKQK----TPAGS---S 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 240 TGSFFTNPivsaaeaaslPADaprypaaagltklSAAWLIEHAGFSkgyglapdgskggGVASGRAALSTKHTLAVTNRG 319
Cdd:PRK14649  218 CGSVFKNP----------PGD-------------SAGRLIEAAGLK-------------GTRIGDAEIATRHANYIINLG 261

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1408825861 320 GASAEDVLAVAREVRSGVVRQFGISLHPEPVLVG 353
Cdd:PRK14649  262 GARAADILRLIDLARTRVLAQFGIELELEVRIIG 295
MurB_C pfam02873
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ...
 216-352 1.35e-34

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 460730 [Multi-domain]  Cd Length: 99  Bit Score: 122.46  E-value: 1.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 216 RRTVLELRASKgMVLDPADrdTWSTGSFFTNPIvsaaeaaslpadaprypaaagltKLSAAWLIEHAGFsKGYGLapdgs 295
Cdd:pfam02873   2 RAAMLELRRRR-LAKQPLD--PPSAGSFFKNPV-----------------------GHSAGWLIEQAGL-KGYRI----- 49

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1408825861 296 kgggvasGRAALSTKHTLAVTNRGGASAEDVLAVAREVRSGVVRQFGISLHPEPVLV 352
Cdd:pfam02873  50 -------GGAQVSEKHANFLVNTGGATAADVLALIEEVRERVKEKFGVELEPEVRII 99
PRK14652 PRK14652
UDP-N-acetylmuramate dehydrogenase;
3-353 1.10e-23

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237777 [Multi-domain]  Cd Length: 302  Bit Score: 99.18  E-value: 1.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIAsQGFKASSEDscgGASV 82
Cdd:PRK14652   24 LAPRTAVRVGGPADLLVRPADPDALSALLRAVRELGVPLSILGGGANTLVADAGVRGVVLRLP-QDFPGESTD---GGRL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 VVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVwdREKDAVRTFTNSELKFGYRDS 162
Cdd:PRK14652  100 VLGAGAPISRLPARAHAHGLVGMEFLAGIPGTLGGAVAMNAGTKLGEMKDVVTAVEL--ATADGAGFVPAAALGYAYRTC 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 163 VIkqttvtgSPRFVVLTVEFQLLLGRMSAP--VKYAELARRlgvevgkranslelRRTvlelraskgmvlDPADRDTWst 240
Cdd:PRK14652  178 RL-------PPGAVITRVEVRLRPGDVAASeaLMRADRERR--------------RRT------------QPLDRPTF-- 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 241 GSFFTNPivsaaeaaslPADaprypaaagltklSAAWLIEHAGFsKGYGLapdgskgggvasGRAALSTKHTLAVTNRGG 320
Cdd:PRK14652  223 GSTFTNP----------PGD-------------YAGRLVEAVGL-KGHRV------------GGAIWSPVHANFVTNLGG 266

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1408825861 321 ASAEDVLAVAREVRSGVVRQFGISLHPEPVLVG 353
Cdd:PRK14652  267 ATARDVLALVRLARARVKERFGIALETEVRLLG 299
PRK14651 PRK14651
UDP-N-acetylmuramate dehydrogenase;
1-334 1.98e-19

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237776 [Multi-domain]  Cd Length: 273  Bit Score: 86.80  E-value: 1.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   1 MLLSSLTTLGVGGPARTYVeAVTEAEIIAAVRtadhagEPLLIVGGGSNLVVSDDGFDGTVLKIASQgFKASSEDSCGGA 80
Cdd:PRK14651    7 VPLARYTTLGVGGPAELWT-VETHEQLAEATE------APYRVLGGGSNLLVSDAGVPERVIRLGGE-FAEWDLDGWVGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  81 SVVVAaghdwdSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWdrEKDAVRTFTNSELKFGYR 160
Cdd:PRK14651   79 GVPLP------GLVRRAARLGLSGLEGLVGIPAQVGGAVKMNAGTRFGEMADALHTVEIV--HDGGFHQYSPDELGFGYR 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 161 DSVIkqttvtgsPRFVVLTvefqlllgrmsapvkyaelarRLGVEVGKRANSLELRRTVLELRASKGmvlDPADRdtwST 240
Cdd:PRK14651  151 HSGL--------PPGHVVT---------------------RVRLKLRPSTPEAVLAKMALVDAARKG---QPKKK---SA 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 241 GSFFTNPivsaaeaaslPADaprypaaagltklSAAWLIEHAGFSkgyglapdgskggGVASGRAALSTKHTLAVTNRGG 320
Cdd:PRK14651  196 GCAFKNP----------PGD-------------SAGRLIDEAGLK-------------GTRVGDAMISPEHGNFIVNLGG 239

                         330
                  ....*....|....
gi 1408825861 321 ASAEDVLAVAREVR 334
Cdd:PRK14651  240 ATAADVHALLRRVR 253
PRK12436 PRK12436
UDP-N-acetylmuramate dehydrogenase;
2-353 3.51e-18

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 171497 [Multi-domain]  Cd Length: 305  Bit Score: 83.91  E-value: 3.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   2 LLSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIASqgfkaSSEDSCGGAS 81
Cdd:PRK12436   24 MLKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYNIPVTFLGNGSNVIIKDGGIRGITVSLIH-----ITGVTVTGTT 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  82 VVVAAGHDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQ--TVAAVRVWDREkdaVRTFTNSELKFGY 159
Cdd:PRK12436   99 IVAQCGAAIIDVSRIALDHNLTGLEFACGIPGSVGGALYMNAGAYGGEISFvlTEAVVMTGDGE---LRTLTKEAFEFGY 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 160 RDSVIKQTtvtgspRFVVLTVEFqlllgrmsapvkyaELARRLGVEVGKRANSLELRrtvlelRASKGMVLDPadrdtwS 239
Cdd:PRK12436  176 RKSVFANN------HYIILEARF--------------ELEEGVYEEIKAKMDDLTFK------RESKQPLEYP------S 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 240 TGSFFTNPivsaaeaaslpadaPRYPAAAgltklsaawLIEHAGFSkgyglapdGSKGGGVasgraALSTKHTLAVTNRG 319
Cdd:PRK12436  224 CGSVFKRP--------------PNNFAGK---------LIQESGLQ--------GKRIGGV-----EVSLKHAGFMVNVD 267

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1408825861 320 GASAEDVLAVAREVRSGVVRQFGISLHPEPVLVG 353
Cdd:PRK12436  268 NGTAQDYIDLIHFVQKTVEEKFGVKLEREVRIIG 301
murB PRK13906
UDP-N-acetylmuramate dehydrogenase;
3-353 4.38e-17

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 184386 [Multi-domain]  Cd Length: 307  Bit Score: 80.63  E-value: 4.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIASQGFKASSEDSC---GG 79
Cdd:PRK13906   25 LKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIiagSG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  80 ASVVVAAGHDWDsfvhqsvlHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVrTFTNSELKFGY 159
Cdd:PRK13906  105 AAIIDVSRVARD--------YALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLI-KLTTKELELDY 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 160 RDSVIKQTtvtgspRFVVLTVEFQLLLGRMSapvkyaelarrlgvEVGKRANSLELRrtvlelRASKGMVLDPadrdtwS 239
Cdd:PRK13906  176 RNSIIQKE------HLVVLEAAFTLAPGKMT--------------EIQAKMDDLTER------RESKQPLEYP------S 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 240 TGSFFTNPivsaaeaaslpadaPRYPAAAgltklsaawLIEHAGFSkgyglapdGSKGGGVasgraALSTKHTLAVTNRG 319
Cdd:PRK13906  224 CGSVFQRP--------------PGHFAGK---------LIQDSNLQ--------GHRIGGV-----EVSTKHAGFMVNVD 267

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1408825861 320 GASAEDVLAVAREVRSGVVRQFGISLHPEPVLVG 353
Cdd:PRK13906  268 NGTATDYENLIHYVQKTVKEKFGIELNREVRIIG 301
FAD_binding_4 pfam01565
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most ...
 18-149 3.49e-14

FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 426326 [Multi-domain]  Cd Length: 139  Bit Score: 68.77  E-value: 3.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  18 YVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIasQGFKASSEDSCGGASVVVAAGHDWDSFVHQS 97
Cdd:pfam01565   4 VVLPESEEEVAAIVRLANENGLPVLPRGGGSSLLGGAVQTGGIVLDL--SRLNGILEIDPEDGTATVEAGVTLGDLVRAL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1408825861  98 VLHA-WSGLEALSGIPGLTGATPVQNVGAYGA----DVSQTVAAVRVWDREKDAVRT 149
Cdd:pfam01565  82 AAKGlLLGLDPGSGIPGTVGGAIATNAGGYGSekygLTRDNVLGLEVVLADGEVVRL 138
PRK14653 PRK14653
UDP-N-acetylmuramate dehydrogenase;
11-348 1.69e-13

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237778 [Multi-domain]  Cd Length: 297  Bit Score: 70.25  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  11 VGGPARTYVEAVTEAEIIAAVRTADHAGEpLLIVGGGSNLVVSDDGFDGTVLKIASQGFKASSEDScggasVVVAAGHDW 90
Cdd:PRK14653   30 IGGPVPLFAIPNSTNGFIETINLLKEGIE-VKILGNGTNVLPKDEPMDFVVVSTERLDDIFVDNDK-----IICESGLSL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  91 DSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDrEKDAVRtFTNSELKFGYRDSVIKQttvt 170
Cdd:PRK14653  104 KKLCLVAAKNGLSGFENAYGIPGSVGGAVYMNAGAYGWETAENIVEVVAYD-GKKIIR-LGKNEIKFSYRNSIFKE---- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 171 gSPRFVVLTVEFQLLlgrmsapvkyaelarrlgveVGKRANSLELRRTVLELRASKGMVLDPadrdtwSTGSFFTNPivs 250
Cdd:PRK14653  178 -EKDLIILRVTFKLK--------------------KGNKNEIYNLMLETMKKRVEKQPLEFP------SAGSVFKRP--- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 251 aaeaaslpadaprypaaagltklsaawlieHAGFSKGYGLAPDGSKGGGVasGRAALSTKHTLAVTNRGGASAEDVLAVA 330
Cdd:PRK14653  228 ------------------------------RKDFYVGSAIEKLGLKGFSI--GGAQISEKHAGFIINYNNAKAEDVLKLI 275

                         330
                  ....*....|....*...
gi 1408825861 331 REVRSGVVRQFGISLHPE 348
Cdd:PRK14653  276 EYVKDKIYENYNVELETE 293
PRK14648 PRK14648
UDP-N-acetylmuramate dehydrogenase;
3-353 3.19e-13

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173111 [Multi-domain]  Cd Length: 354  Bit Score: 69.75  E-value: 3.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYVEAVTEAEIIAAVRTADHAGEPLLIVGGGSNLVVSDDGFDGTVLKIasQGFKASSEDSCGGASV 82
Cdd:PRK14648   18 LAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLMLSL--RRFRSLHTQTQRDGSV 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  83 VVAAGHDWD--SFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAVRTFTNSELKFGYR 160
Cdd:PRK14648   96 LVHAGAGLPvaALLAFCAHHALRGLETFAGLPGSVGGAAYMNARCYGRAIADCFHSARTLVLHPVRSRAKELPEVRKNAQ 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 161 DSVIKQTTVTGSPrfvVLTVEFQLLLGRMSA-PVKYAELARRLGVEV--GKR-----------ANSLELRRTVLEL---R 223
Cdd:PRK14648  176 DKRGECLGLDGGP---FTCSSFQTVFARAGDwGYKRSPFQSPHGVELhaGRRlilslcvrltpGNPAQIRKHMQEKiadR 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 224 ASKGMVLDPadrdtwSTGSFFTNpivsaaeaaslpadAPRYPAAAGLtklsaawLIEHAGFSkgyglapdgskggGVASG 303
Cdd:PRK14648  253 ISKGQFRFP------SAGSAFKN--------------NPAFGKPSGI-------LIEEAGLR-------------GTSCG 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1408825861 304 RAALSTKHTLAVTNRGGASAEDVLAVAREVRSGVVRQFGISLHPEPVLVG 353
Cdd:PRK14648  293 AAQVAPWHGNLIINTGNATAHQVRTLLRVVRQRVFETHGVWLEREIIFSG 342
murB PRK13904
UDP-N-acetylmuramate dehydrogenase;
43-352 6.60e-08

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 184384 [Multi-domain]  Cd Length: 257  Bit Score: 53.00  E-value: 6.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  43 IVGGGSNLVVS---------DDGFD-----GTVLKIasqGFKASSedscggaSVVVaaghdwdSFVHQsvlHAWSGLEAL 108
Cdd:PRK13904   36 IIGGANNLLISpnpknlailGKNFDyikidGECLEI---GGATKS-------GKIF-------NYAKK---NNLGGFEFL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 109 SGIPGLTGATPVQNVGAYGADVSQTVAAVRVWDREKDAvrtftnSELKFGYRDSVIKQttvtgsprfVVLTVEFQLllgr 188
Cdd:PRK13904   96 GKLPGTLGGLVKMNAGLKEYEISNNLESICTNGGWIEK------EDIGFGYRSSGING---------VILEARFKK---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 189 msapvkyaelarrlgvevgKRANSLELRRTVLELRASKgmvldPADRdtwSTGSFFTNPivsaaeaaslPADaprypaaa 268
Cdd:PRK13904  157 -------------------THGFDEELLEAFKSMRKNQ-----PKGP---SFGSCFKNP----------KGD-------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 269 gltklSAAWLIEHAGFsKGYGLapdgskgggvasGRAALSTKHTLAVTNRGGASAEDVLAVAREVRSGVVRQFGISLHPE 348
Cdd:PRK13904  192 -----YAGRLIEAVGL-KGYCK------------GGAGFSEEHANFLVNLGGATFEDALDLIELAKKRVLEEFGINLEEE 253


                  ....
gi 1408825861 349 PVLV 352
Cdd:PRK13904  254 VIIL 257
PRK14650 PRK14650
UDP-N-acetylmuramate dehydrogenase;
3-353 3.06e-06

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173113 [Multi-domain]  Cd Length: 302  Bit Score: 48.30  E-value: 3.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861   3 LSSLTTLGVGGPARTYV--EAVTEAEIIaaVRTADHAGEPLLIVGGGSNLVVSDDG-------FDGTVLKIASQGFKASS 73
Cdd:PRK14650   21 LANYTTYKIGGISKLFLtpKTIKDAEHI--FKAAIEEKIKIFILGGGSNILINDEEeidfpiiYTGHLNKIEIHDNQIVA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861  74 EdsCGGasvvvaaghDWDSFVHQSVLHAWSGLEALSGIPGLTGATPVQNVGAYGADVSQTVAAVR-VWDREKDAVRTFTN 152
Cdd:PRK14650   99 E--CGT---------NFEDLCKFALQNELSGLEFIYGLPGTLGGAIWMNARCFGNEISEILDKITfIDEKGKTICKKFKK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 153 SElkFGYRDSVIKQTTvtgsprFVVLTVEFQLllgrmsapvkyaelarrlgvEVGKRANSLELRRTVLELRASKGMVLDP 232
Cdd:PRK14650  168 EE--FKYKISPFQNKN------TFILKATLNL--------------------KKGNKKHIEEIMKQNKQIRINKGHYLFP 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408825861 233 adrdtwSTGSFFTNpivsaaeaaslpadaprypaaagltklsaawlieHAGFSKGYGLAPDGSKGGGVASGRAALSTKHT 312
Cdd:PRK14650  220 ------SSGSTFKN----------------------------------NKAFLKPTGQIIEECKLKGLSIGGATVSHYHG 259

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1408825861 313 LAVTNRGGASAEDVLAVAREVRSGVVRQFGISLHPEPVLVG 353
Cdd:PRK14650  260 NFIININNATSKDIKTLIEKVKTEVQIKTGFLLEEEVLYIG 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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