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Conserved domains on  [gi|1483050800|gb|RJQ17368|]
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ArsR family transcriptional regulator [Candidatus Woesearchaeota archaeon]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-86 1.07e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 1.07e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483050800 11 LFKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNRVNALFKVL 86
Cdd:COG0640   13 LFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-86 1.07e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 1.07e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483050800 11 LFKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNRVNALFKVL 86
Cdd:COG0640   13 LFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 11-83 1.07e-23

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 85.20  E-value: 1.07e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1483050800 11 LFKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNRVNALF 83
Cdd:NF033788   4 LFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-78 7.07e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.79  E-value: 7.07e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1483050800 12 FKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNR 78
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-86 1.80e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 69.16  E-value: 1.80e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1483050800  22 KILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNRVNALFKVL 86
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 5-74 1.28e-10

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 53.28  E-value: 1.28e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1483050800   5 MMSDLNLFKALGEETKHKILQVLSD-GERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSI 74
Cdd:PRK10141    3 FLLPLQLFKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 18-61 4.70e-08

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 44.74  E-value: 4.70e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1483050800 18 ETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGII 61
Cdd:pfam01022  2 PTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-86 1.07e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 1.07e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483050800 11 LFKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNRVNALFKVL 86
Cdd:COG0640   13 LFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 11-83 1.07e-23

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 85.20  E-value: 1.07e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1483050800 11 LFKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNRVNALF 83
Cdd:NF033788   4 LFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-78 7.07e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.79  E-value: 7.07e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1483050800 12 FKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNR 78
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-86 1.80e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 69.16  E-value: 1.80e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1483050800  22 KILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDNRVNALFKVL 86
Cdd:smart00418  1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 5-74 1.28e-10

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 53.28  E-value: 1.28e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1483050800   5 MMSDLNLFKALGEETKHKILQVLSD-GERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSI 74
Cdd:PRK10141    3 FLLPLQLFKILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-76 2.28e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 49.57  E-value: 2.28e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1483050800  7 SDLNLFKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFR----RDG-KKILYSIKD 76
Cdd:COG4189    8 ESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEykpgKRGrQKICYLRVD 82
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 18-61 4.70e-08

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 44.74  E-value: 4.70e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1483050800 18 ETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGII 61
Cdd:pfam01022  2 PTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
8-77 9.73e-08

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 46.41  E-value: 9.73e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1483050800   8 DLNLFKALGEETKHKILQVLSDGERCA-CEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGKKILYSIKDN 77
Cdd:COG3398    87 EKKILAYLRRETPRRILLYLLENPGATnKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 9-68 1.76e-07

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 43.68  E-value: 1.76e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1483050800  9 LNLFKALGEETKHKILQVLSDGERCAC-EIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDGK 68
Cdd:pfam12840  1 DDVAEALADPTRLRILRALVGDEPLTAsELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
4-80 3.02e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 44.25  E-value: 3.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483050800   4 DMMSDLNLFKALGEETKHKILQVLSDGERCACEIPSKIDRTQSNTSMHLAKLLEWGIIKFRRDG-----KKILYSIKDNR 78
Cdd:COG1777     3 DDEDLDRLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGredgrARKYYRLSAFR 82


                  ..
gi 1483050800  79 VN 80
Cdd:COG1777    83 LE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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