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Conserved domains on  [gi|1490246533|gb|RKZ14113|]
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DNA gyrase subunit A, partial [bacterium]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-370 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 746.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:PRK05560   14 MKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:PRK05560   94 SMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKnGRQ 240
Cdd:PRK05560  174 GMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GRE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:PRK05560  253 AIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINMLAL 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490246533 321 VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:PRK05560  333 VDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIAL 382
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-370 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 746.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:PRK05560   14 MKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:PRK05560   94 SMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKnGRQ 240
Cdd:PRK05560  174 GMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GRE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:PRK05560  253 AIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINMLAL 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490246533 321 VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:PRK05560  333 VDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIAL 382
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-370 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 738.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:COG0188    19 MKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:COG0188    99 SMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAV 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKNGRQ 240
Cdd:COG0188   179 GMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGRE 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:COG0188   259 QIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTSFGINMLAL 338

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490246533 321 VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:COG0188   339 VDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIAL 388
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-370 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 650.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:TIGR01063  10 MKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:TIGR01063  90 SLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKNGRQ 240
Cdd:TIGR01063 170 GMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGRE 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:TIGR01063 250 AIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLAL 329

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490246533 321 VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:TIGR01063 330 VKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIAL 379
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 14-370 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 543.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  14 VARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEFSLRYPLVDGQGNF 93
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  94 GSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAVGMATNCPPHNITE 173
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 174 IVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKnGRQAIIVTEIPYYVNK 253
Cdd:cd00187   161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDDE-GRNTIEITELPYQVNK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 254 AELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLALVGS-QPKVLSMKD 332
Cdd:cd00187   240 AKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDPNgRPKKLNLKE 319

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1490246533 333 SMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:cd00187   320 ILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAI 357
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-370 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 512.11  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533    1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:smart00434   7 INKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDF 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   81 SLRYPLVDGQGNFGSI-DGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIA 159
Cdd:smart00434  87 SNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIA 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  160 VGMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIhgrqgifdyitTGRGKVIMRGRCDFEElkngR 239
Cdd:smart00434 167 VGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEI-----------VGPGKYVVRGKIEIED----D 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  240 QAIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDES-DRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNL 318
Cdd:smart00434 232 NTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINML 311

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1490246533  319 ALVGS-QPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAE-ARAHILEGYRIAL 370
Cdd:smart00434 312 ALFDNgRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIAL 365
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
16-370 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 509.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  16 RALPDVRDGLKPVHRRVLTAMDDLnLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEFSLRYPLVDGQGNFGS 95
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  96 -IDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAVGMATNCPPHNITEI 174
Cdd:pfam00521  80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 175 VDGMLALLENPElqPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEElkngRQAIIVTEIPYYVNKA 254
Cdd:pfam00521 160 IDALIALLDGPE--ATLLMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 255 ELITKMATLVREGVISGIADLNDESDrRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLALVGSQPKVLSMKDSM 334
Cdd:pfam00521 234 DLIEKIEELVKNGKIKGISDIRDESD-RGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEIL 312

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1490246533 335 QHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:pfam00521 313 KEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIAL 348
GyrA_w_intein NF038098
intein-containing DNA gyrase subunit A;
1-106 5.61e-56

intein-containing DNA gyrase subunit A;


Pssm-ID: 411680 [Multi-domain]  Cd Length: 1232  Bit Score: 197.64  E-value: 5.61e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533    1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:NF038098    11 MQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSYVKCARVVAETMGNYHPHGDSSIYDTLVRMAQPW 90

                           90       100
                   ....*....|....*....|....*.
gi 1490246533   81 SLRYPLVDGQGNFGSIDGDSAAAERY 106
Cdd:NF038098    91 SLRYPLVDGQGNFGSPGNDPAAAMRY 116
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-370 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 746.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:PRK05560   14 MKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVYDALVRMAQDF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:PRK05560   94 SMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKnGRQ 240
Cdd:PRK05560  174 GMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKAEIEEIK-GRE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:PRK05560  253 AIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQTSFGINMLAL 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490246533 321 VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:PRK05560  333 VDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIAL 382
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-370 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 738.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:COG0188    19 MKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVYDALVRMAQDF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:COG0188    99 SMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNLLVNGSSGIAV 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKNGRQ 240
Cdd:COG0188   179 GMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKAEIEELKRGRE 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:COG0188   259 QIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQTSFGINMLAL 338

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490246533 321 VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:COG0188   339 VDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIAL 388
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-370 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 650.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:TIGR01063  10 MKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYDTLVRMAQDF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:TIGR01063  90 SLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKNGRQ 240
Cdd:TIGR01063 170 GMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAEIEEDSKGRE 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:TIGR01063 250 AIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLAL 329

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490246533 321 VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:TIGR01063 330 VKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIAL 379
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-370 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 578.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:PRK05561   19 LEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYDAMVRMAQDF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:PRK05561   99 SYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLLLNGATGIAV 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGA-LIHGRQGIFDYITTGRGKVIMRGRCDFEELKNGR 239
Cdd:PRK05561  179 GMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGeIITGRDGIRKAYETGRGSIRVRARWEIEDLAGGR 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 240 QAIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRG-MRIVITMKKD-AHGQVILNQLYKHTLLQSTFGVNN 317
Cdd:PRK05561  259 WQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENpVRIVIEPKSNrVDPEALMNHLFATTDLESSYRVNM 338

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490246533 318 LAL-VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:PRK05561  339 NAIgLDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAF 392
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 14-370 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 543.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  14 VARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEFSLRYPLVDGQGNF 93
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  94 GSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAVGMATNCPPHNITE 173
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 174 IVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKnGRQAIIVTEIPYYVNK 253
Cdd:cd00187   161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDDE-GRNTIEITELPYQVNK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 254 AELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLALVGS-QPKVLSMKD 332
Cdd:cd00187   240 AKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDPNgRPKKLNLKE 319

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1490246533 333 SMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:cd00187   320 ILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAI 357
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-370 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 512.11  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533    1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:smart00434   7 INKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIVRMAQDF 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   81 SLRYPLVDGQGNFGSI-DGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIA 159
Cdd:smart00434  87 SNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIA 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  160 VGMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIhgrqgifdyitTGRGKVIMRGRCDFEElkngR 239
Cdd:smart00434 167 VGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEI-----------VGPGKYVVRGKIEIED----D 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  240 QAIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDES-DRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNL 318
Cdd:smart00434 232 NTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINML 311

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1490246533  319 ALVGS-QPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAE-ARAHILEGYRIAL 370
Cdd:smart00434 312 ALFDNgRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIAL 365
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
16-370 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 509.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  16 RALPDVRDGLKPVHRRVLTAMDDLnLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEFSLRYPLVDGQGNFGS 95
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  96 -IDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAVGMATNCPPHNITEI 174
Cdd:pfam00521  80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 175 VDGMLALLENPElqPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEElkngRQAIIVTEIPYYVNKA 254
Cdd:pfam00521 160 IDALIALLDGPE--ATLLMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 255 ELITKMATLVREGVISGIADLNDESDrRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLALVGSQPKVLSMKDSM 334
Cdd:pfam00521 234 DLIEKIEELVKNGKIKGISDIRDESD-RGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEIL 312

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1490246533 335 QHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIAL 370
Cdd:pfam00521 313 KEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIAL 348
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 1-366 1.16e-151

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 451.48  E-value: 1.16e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:PRK13979   22 MPENYLPYAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:PRK13979  102 TTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAV 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKNGRQ 240
Cdd:PRK13979  182 GLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRAKTKIEKLENGRL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAEL---ITKMATLVREG-VISGIADLNDESDRRGMRIVITMKKDAH---GQVILNQLYKHTLLQSTF 313
Cdd:PRK13979  262 GIVITEFPYRRNKAKLlqtISEMTADKKHSkALENISDIRDESDRNGIRAVIEFKKSADedvAEKVLKYLYKKTDLQCNI 341

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1490246533 314 GVNNLALVGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGY 366
Cdd:PRK13979  342 SFNMVALADGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKRFHIVEGF 394
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-365 1.00e-140

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 416.90  E-value: 1.00e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:TIGR01061  10 FGESFGKYAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDW 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:TIGR01061  90 KNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIAA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 161 GMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGALIHGRQGIFDYITTGRGKVIMRGRCDFEELKNGRQ 240
Cdd:TIGR01061 170 GYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIEIEVNKNGLN 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 241 AIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:TIGR01061 250 QIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQINYNFNMVAI 329

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1490246533 321 VGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEG 365
Cdd:TIGR01061 330 ANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEG 374
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-369 4.88e-130

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 389.65  E-value: 4.88e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:TIGR01062  10 TEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  81 SLRYPLVDGQGNFGSIDG-DSAAAERYTEARLTPLAMELLRDIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIA 159
Cdd:TIGR01062  90 SYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 160 VGMATNCPPHNITEIVDGMLALLENPELQPHEMLQYVKGPDFPTGA-LIHGRQGIFDYITTGRGKVIMRGRCDFEELkng 238
Cdd:TIGR01062 170 VGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAeIIDKAEEIRKIYETGRGSFRMRARWKKEDG--- 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 239 rqAIIVTEIPYYVNKAELITKMATLVREGVISGIADLNDESDRRG-MRIVITMKKDA-HGQVILNQLYKHTLLQSTFGVn 316
Cdd:TIGR01062 247 --QIVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHENpIRVVIVPRSNRvDPDIVMEHLFATTDLEKSYRL- 323

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1490246533 317 NLALVGS--QPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILEGYRIA 369
Cdd:TIGR01062 324 NMNMIGLdnVPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLHILEGLRIA 378
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 1-364 4.30e-66

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 220.35  E-value: 4.30e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTA---MDDLNLapnrpyRKSAKITGDTTgNYHPHGTAAVYDTLVRMA 77
Cdd:PRK09631    8 FKDNFLQYASYVIKDRAIPDVIDGLKPVQRRILHSlfeMHDGKF------HKVANVVGNTM-KYHPHGDASIYEALVNLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  78 -QEFslrypLVDGQGNFGSI-DGDSAAAERYTEARLTPLAMELLrdIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGT 155
Cdd:PRK09631   81 nKDL-----FIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPVILIQGA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 156 TGIAVGMATNCPPHNITEIVDGMLALLENPELQPHemlqyvkgPDFPTGALIHgrqgIFDYiTTGRGKVIMRGRCDFEEL 235
Cdd:PRK09631  154 EGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------PDFPTGGIVD----VSEY-ADGNGKVLVRAKIETKDE 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 236 KngrqAIIVTEIPYYVNKAELITKMATLVREGV--ISGIADLNDESdrrgMRIVITMKKDAHGQVILNQLYKHTLLQSTF 313
Cdd:PRK09631  221 K----TIVIREIPFGTTTESLIASIEKAARKGKikISSINDYTAEN----VEIEIKLPRGVYASEVIEALYAYTDCEVSI 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1490246533 314 GVNNLALVGSQPKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEAR--AHILE 364
Cdd:PRK09631  293 SVNLLVIKDRYPVIYTVTDIIKFHAEHLQKVLKMELELERAKLLEKifAKTLE 345
GyrA_w_intein NF038098
intein-containing DNA gyrase subunit A;
1-106 5.61e-56

intein-containing DNA gyrase subunit A;


Pssm-ID: 411680 [Multi-domain]  Cd Length: 1232  Bit Score: 197.64  E-value: 5.61e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533    1 MKRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTGNYHPHGTAAVYDTLVRMAQEF 80
Cdd:NF038098    11 MQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSYVKCARVVAETMGNYHPHGDSSIYDTLVRMAQPW 90

                           90       100
                   ....*....|....*....|....*.
gi 1490246533   81 SLRYPLVDGQGNFGSIDGDSAAAERY 106
Cdd:NF038098    91 SLRYPLVDGQGNFGSPGNDPAAAMRY 116
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
5-257 1.47e-49

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 178.27  E-value: 1.47e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   5 YLEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNlapNRPYRKSAKITGDTTgNYHPHGTAAVYDTLVRMAQefslRY 84
Cdd:PRK12758   31 FLDYASYVILERAVPHIEDGLKPVQRRILHSMKEMD---DGRYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  85 PLVDGQGNFGSI-DGDSAAAERYTEARLTPLAMELLrdIDRETVDYVPNYDGSREMPSVLPSAVPNFLINGTTGIAVGMA 163
Cdd:PRK12758  103 LLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLS 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 164 TNCPPHNITEIVDGMLALLENpelQPHEMLqyvkgPDFPTGALIHgrqgIFDYITTGRGKVImRGRCDFEELKNgrQAII 243
Cdd:PRK12758  181 TKILPHNFNELIDASIAYLKG---KEFKLY-----PDFPTGGIID----VSNYNDGERGGRV-RVRAKIEKLDK--KTLV 245

                         250
                  ....*....|....
gi 1490246533 244 VTEIPYYVNKAELI 257
Cdd:PRK12758  246 ITEIPYGTTTSSLI 259
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 2-310 3.26e-45

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 161.60  E-value: 3.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   2 KRSYLEYSMSVIVARALPDVRDGLKPVHRRVLTA---MDDLNLapnrpyRKSAKITGDTTGnYHPHGTAAVYDTLVRMAQ 78
Cdd:PRK09630    9 KTHFMHYASYVILERAIPHILDGLKPVQRRLLWTlfrMDDGKM------HKVANIAGRTMA-LHPHGDAPIVEALVVLAN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  79 efslRYPLVDGQGNFGS-IDGDSAAAERYTEARLTPLAMELLRDIDreTVDYVPNYDGSREMPSVLPSAVPNFLINGTTG 157
Cdd:PRK09630   82 ----KGYLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVLFNTD--LMTFHDSYDGREKEPDILPAKLPLLLLHGVDG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 158 IAVGMATNCPPHNITEIVDGMLALLENpelQPHEMLqyvkgPDFPTGALIHGRqgifDYiTTGRGKVIMRGRCDFEELKn 237
Cdd:PRK09630  156 IAVGMTTKIFPHNFCELLEAQIAILND---QPFTLL-----PDFPSGGTMDAS----EY-QDGLGSITLRASIDIINDK- 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490246533 238 grqAIIVTEIPYYVNKAELITKMATLVREGVISgIADLNDESDRRGmRIVITMKKDAHGQVILNQLYKHTLLQ 310
Cdd:PRK09630  222 ---TLLIKEICPSTTTETLIRSIENAAKRGIIK-IDSIQDFSTDLP-HIEIKLPKGIYAKDLLRPLFTHTECQ 289
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 6-359 4.10e-43

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 155.21  E-value: 4.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   6 LEYSMSVIVARALPDVRDGLKPVHRRVLTAMDDLNLAPNRPYRKSAKITGDTTG-NYHpHGTAAVYDTLVRMAQEFSLRY 84
Cdd:PHA02592   17 LEYAMYTVEERAIPNLIDGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVADlGYH-HGETSAQDAGALMANTWNNNI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  85 PLVDGQGNFGSIDGDSAAAERYTEARLTPLAMELLRDIdretvDYVPNYDGSREMPSV--LPsAVPNFLINGTTGIAVGM 162
Cdd:PHA02592   96 PLLDGQGNFGSRLVQKAAAARYIFARVHDNFRKIYKDE-----DLAPVHEDPEHIPPAfyLP-IIPMVLLNGVSGIATGY 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 163 ATNCPPHNITEIVDGMLALLENPELQPHEmlqyVKGPDFptgalihgrQGIFDYITTGRgkVIMRGRCDFeelkNGRQAI 242
Cdd:PHA02592  170 ATNILPHSPKSVIKAVLAALNGKDITEPK----VQFPEF---------KGEVVEIEPGS--YEIRGTYEL----NGKTKL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533 243 IVTEIPYYVNKAELITKMATLVREGVISGIADLNDEsdrrGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGvNNLALVG 322
Cdd:PHA02592  231 HITEIPVKYDRETYVAVLDPLEEKGKIVSYDDCTED----GFRFKVTLKREENEEATHEKIMKDFGLIERVS-QNITVIN 305

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1490246533 323 SQPKVLS---MKDSMQHYLDFREEVVVRRTRFDLAKAEAR 359
Cdd:PHA02592  306 ENGKLKVyenAEDLIRDFVEIRKTYVQKRIQYEIKETEEA 345
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 15-364 1.72e-24

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 105.51  E-value: 1.72e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   15 ARALPDVRDGLKPVHRRVLTAMDDLNLapnrpyRKSAKITgDTTG------NYHpHGTAAVYDTLVRMAQEF------SL 82
Cdd:PTZ00108   679 ERSIPSLVDGLKPGQRKILFACFKRNL------KNEIKVA-QLSGyvsehsAYH-HGEQSLQQTIVGMAQNFvgsnniNL 750

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   83 RYPlvDGQgnFGS--IDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVpNYDGSREMPSVLPSAVPNFLINGTTGIAV 160
Cdd:PTZ00108   751 LYP--CGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYL-EDDGQSVEPFYYVPIIPMVLVNGAEGIGT 825

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  161 GMATNCPPHNITEIVDGMLALLENPELQPheMLQYVKGpdFpTGALIHGRQGifDYITTGRGKVIMRGRcdfeelkngrq 240
Cdd:PTZ00108   826 GFSTSIPNYNPLDIIDNLRRRLNGEEVRP--LVPWYRG--F-KGTIERNPKG--KFISKGIYEKVPDGT----------- 887

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  241 aIIVTEIPYYV---NKAELITKmATLVREGVISGIADLNDESDrrgMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNN 317
Cdd:PTZ00108   888 -VEITELPIGKwteDYKEFLES-ETLKEKDVIVDYRDYSTANT---VHFTVKLNDGVLEQWEEEGIEKVFKLKSTISTTN 962

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1490246533  318 LALVGSQ---PKVLSMKDSMQHYLDFREEVVVRRTRFDLAKAEARAHILE 364
Cdd:PTZ00108   963 MVLFDENgkiKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLS 1012
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 15-365 1.24e-23

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 102.86  E-value: 1.24e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   15 ARALPDVRDGLKPVHRRVLTAMDDLNLAPNRpyrKSAKITGDTT--GNYHpHGTAAVYDTLVRMAQEF------SLRYPl 86
Cdd:PLN03128   672 ARSIPSMVDGLKPSQRKVLFACFKRNLKSEI---KVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgsnniNLLTP- 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   87 vdgQGNFGS--IDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVpNYDGSREMPSVLPSAVPNFLINGTTGIAVGMAT 164
Cdd:PLN03128   747 ---SGQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYL-NEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWST 822

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  165 NCPPHNITEIVDGMLALLENPELQPheMLQYVKGpdFPTGALIHGRQGIFDYITTGRgkvimrgrcdFEELKNgrQAIIV 244
Cdd:PLN03128   823 FIPNYNPRDIIANIRRLLRGEELEP--MHPWYRG--FKGTITEVSTSRSGSYTVTGI----------IEQIGD--TTIRI 886

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533  245 TEIPYYV----NKAELITKMATLVREGviSGIADLNDESDRRGMRIVITMKKDAHGQVILNQLYKHTLLQSTFGVNNLAL 320
Cdd:PLN03128   887 TELPVRKwtqdYKEFLEALLTGTKKKE--PEIKDFKENHTDTTVHFTVTLSEEKMARALAEGLEKKFKLSTTISTSNMHL 964

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1490246533  321 VGSQPK-------VLSMKDSMQHYLDF---REEVVVRRTRFDLAKAEARAHILEG 365
Cdd:PLN03128   965 FDKDGKikkydspEDILEEFFHLRLDLyvkRKEVLLENLEYELKKLDNKARFILA 1019
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 16-189 1.63e-15

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 78.37  E-value: 1.63e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   16 RALPDVRDGLKPVHRRVLTAmddlnlAPNRPYRKSAKITG-----DTTGNYHpHGTAAVYDTLVRMAQEF--SLRYPLVD 88
Cdd:PLN03237   698 RSIPSMVDGLKPGQRKILFC------SFKRNFVKEAKVAQlsgyvSEHSAYH-HGEQSLASTIIGMAQDFvgSNNINLLL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490246533   89 GQGNFG--SIDGDSAAAERYTEARLTPLAMELLRDIDRETVDYVpNYDGSREMPSVLPSAVPNFLINGTTGIAVGMATNC 166
Cdd:PLN03237   771 PNGQFGtrLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYL-NEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFI 849

                          170       180
                   ....*....|....*....|...
gi 1490246533  167 PPHNITEIVDGMLALLENPELQP 189
Cdd:PLN03237   850 PNYNPRDIVANIRRLLNGESMEP 872
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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