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Conserved domains on  [gi|1490642199|gb|RLC35404|]
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hypothetical protein DRZ76_00280 [Candidatus Nealsonbacteria bacterium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GemA super family cl01815
Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, ...
 2-114 4.66e-10

Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, including GemA (also known as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants. This family also includes the Mu-like prophage FluMu protein gp16 from Haemophilus influenzae.


The actual alignment was detected with superfamily member COG4382:

Pssm-ID: 470357  Cd Length: 150  Bit Score: 53.43  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490642199   2 ALIHIIKKELKLSDSEYRSILKQAAGVDSAKELDEEKFRKLMHFFVR--------SKHYRLNPYGLTIKQKlyieyLANK 73
Cdd:COG4382    10 AKIHIAKRQLGLDDDTYRALLQRVTGKTSSKDMTDAELEKVLAELKRkgfkpkskKKKHGGRPAAAKVRRA-----LLAK 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1490642199  74 LG--WKKGH------------LDNFINKYYHKLGVDKLTRKEAMKAIESLK--HVRE 114
Cdd:COG4382    85 IRalWAEMGkagflrdkswayANAFAKRMFGVDRVEWLDDDQLRKVIEALKkwARRH 141
 
Name Accession Description Interval E-value
gp16 COG4382
Mu-like prophage protein gp16 [Mobilome: prophages, transposons];
2-114 4.66e-10

Mu-like prophage protein gp16 [Mobilome: prophages, transposons];


Pssm-ID: 443508  Cd Length: 150  Bit Score: 53.43  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490642199   2 ALIHIIKKELKLSDSEYRSILKQAAGVDSAKELDEEKFRKLMHFFVR--------SKHYRLNPYGLTIKQKlyieyLANK 73
Cdd:COG4382    10 AKIHIAKRQLGLDDDTYRALLQRVTGKTSSKDMTDAELEKVLAELKRkgfkpkskKKKHGGRPAAAKVRRA-----LLAK 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1490642199  74 LG--WKKGH------------LDNFINKYYHKLGVDKLTRKEAMKAIESLK--HVRE 114
Cdd:COG4382    85 IRalWAEMGkagflrdkswayANAFAKRMFGVDRVEWLDDDQLRKVIEALKkwARRH 141
GemA pfam06252
Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, ...
 13-110 6.01e-10

Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, including GemA (also known as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants. This family also includes the Mu-like prophage FluMu protein gp16 from Haemophilus influenzae.


Pssm-ID: 428851  Cd Length: 118  Bit Score: 52.68  E-value: 6.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490642199  13 LSDSEYRSILKQAAGVDSAKELDEEKFRKLMHFFVR--------SKHYRLNPYGLTIKQKLYIEYLANKLGWKKGH---- 80
Cdd:pfam06252   1 LDDDTYRAMLERITGKTSAKDLTDAELAKVLAELKAlgfkpkpkKRAGRKPPAKATSPQLRKIRALWIQLHKLGVVrdrs 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1490642199  81 ---LDNFINKYYHKLGVDKLTRKEAMKAIESLK 110
Cdd:pfam06252  81 eaaLNAFVKRQTGVDRLEWLDDAQASKVIEALK 113
 
Name Accession Description Interval E-value
gp16 COG4382
Mu-like prophage protein gp16 [Mobilome: prophages, transposons];
2-114 4.66e-10

Mu-like prophage protein gp16 [Mobilome: prophages, transposons];


Pssm-ID: 443508  Cd Length: 150  Bit Score: 53.43  E-value: 4.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490642199   2 ALIHIIKKELKLSDSEYRSILKQAAGVDSAKELDEEKFRKLMHFFVR--------SKHYRLNPYGLTIKQKlyieyLANK 73
Cdd:COG4382    10 AKIHIAKRQLGLDDDTYRALLQRVTGKTSSKDMTDAELEKVLAELKRkgfkpkskKKKHGGRPAAAKVRRA-----LLAK 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1490642199  74 LG--WKKGH------------LDNFINKYYHKLGVDKLTRKEAMKAIESLK--HVRE 114
Cdd:COG4382    85 IRalWAEMGkagflrdkswayANAFAKRMFGVDRVEWLDDDQLRKVIEALKkwARRH 141
GemA pfam06252
Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, ...
 13-110 6.01e-10

Bacteriophage Mu, GemA protein; This family consists of several bacterial and phage proteins, including GemA (also known as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants. This family also includes the Mu-like prophage FluMu protein gp16 from Haemophilus influenzae.


Pssm-ID: 428851  Cd Length: 118  Bit Score: 52.68  E-value: 6.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490642199  13 LSDSEYRSILKQAAGVDSAKELDEEKFRKLMHFFVR--------SKHYRLNPYGLTIKQKLYIEYLANKLGWKKGH---- 80
Cdd:pfam06252   1 LDDDTYRAMLERITGKTSAKDLTDAELAKVLAELKAlgfkpkpkKRAGRKPPAKATSPQLRKIRALWIQLHKLGVVrdrs 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1490642199  81 ---LDNFINKYYHKLGVDKLTRKEAMKAIESLK 110
Cdd:pfam06252  81 eaaLNAFVKRQTGVDRLEWLDDAQASKVIEALK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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