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Conserved domains on  [gi|1490726396|gb|RLC97391|]
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thiolase family protein [Chloroflexi bacterium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06064 super family cl35422
thiolase domain-containing protein;
1-396 4.00e-148

thiolase domain-containing protein;


The actual alignment was detected with superfamily member PRK06064:

Pssm-ID: 235688 [Multi-domain]  Cd Length: 389  Bit Score: 425.08  E-value: 4.00e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   1 MRgKVAIIGVGMIPFGELFEMGLEEMVQQAYINCLNsvDKGISTKDIKAAWFGQWSGGGMIGQgALCGASLATMIGNREI 80
Cdd:PRK06064    1 MR-DVAIIGVGQTKFGELWDVSLRDLAVEAGLEALE--DAGIDGKDIDAMYVGNMSAGLFVSQ-EHIAALIADYAGLAPI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  81 PITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGIlglhpsWMLGMGG--PVLQALY 158
Cdd:PRK06064   77 PATRVEAACASGGAALRQAYLAVASGEADVVLAAGVEKMTDVPTPDATEAIARAGDYE------WEEFFGAtfPGLYALI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 159 ATRQMHELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFT 238
Cdd:PRK06064  151 ARRYMHKYGTTEEDLALVAVKNHYNGSKNPYAQFQKEITVEQVLNSPPVADPLKLLDCSPITDGAAAVILASEEKAKEYT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 239 DKPVYVLGSNTGLDHKNMWDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLL 318
Cdd:PRK06064  231 DTPVWIKASGQASDTIALHDRKDFTTLDAAVVAAEKAYKMAGIEPKDIDVAEVHDCFTIAEILAYEDLGFAKKGEGGKLA 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490726396 319 REGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEPERQVKLKNGIALSHNVGGDAfGVSCVTILSR 396
Cdd:PRK06064  311 REGQTYIGGDIPVNPSGGLKAKGHPVGATGVSQAVEIVWQLRGEAEKGRQQVIGAGYGLTHNVGGTG-HTAVVHILSR 387
 
Name Accession Description Interval E-value
PRK06064 PRK06064
thiolase domain-containing protein;
1-396 4.00e-148

thiolase domain-containing protein;


Pssm-ID: 235688 [Multi-domain]  Cd Length: 389  Bit Score: 425.08  E-value: 4.00e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   1 MRgKVAIIGVGMIPFGELFEMGLEEMVQQAYINCLNsvDKGISTKDIKAAWFGQWSGGGMIGQgALCGASLATMIGNREI 80
Cdd:PRK06064    1 MR-DVAIIGVGQTKFGELWDVSLRDLAVEAGLEALE--DAGIDGKDIDAMYVGNMSAGLFVSQ-EHIAALIADYAGLAPI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  81 PITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGIlglhpsWMLGMGG--PVLQALY 158
Cdd:PRK06064   77 PATRVEAACASGGAALRQAYLAVASGEADVVLAAGVEKMTDVPTPDATEAIARAGDYE------WEEFFGAtfPGLYALI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 159 ATRQMHELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFT 238
Cdd:PRK06064  151 ARRYMHKYGTTEEDLALVAVKNHYNGSKNPYAQFQKEITVEQVLNSPPVADPLKLLDCSPITDGAAAVILASEEKAKEYT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 239 DKPVYVLGSNTGLDHKNMWDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLL 318
Cdd:PRK06064  231 DTPVWIKASGQASDTIALHDRKDFTTLDAAVVAAEKAYKMAGIEPKDIDVAEVHDCFTIAEILAYEDLGFAKKGEGGKLA 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490726396 319 REGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEPERQVKLKNGIALSHNVGGDAfGVSCVTILSR 396
Cdd:PRK06064  311 REGQTYIGGDIPVNPSGGLKAKGHPVGATGVSQAVEIVWQLRGEAEKGRQQVIGAGYGLTHNVGGTG-HTAVVHILSR 387
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
 8-394 1.93e-136

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 394.71  E-value: 1.93e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   8 IGVGMIPFGELFEMGLEEMVQQAYINCLNsvDKGISTKDIKAAWFGQWSGGGMIGqgaLCGASLATMIGNREIPITRTEN 87
Cdd:cd00829     1 VGVGMTPFGRRSDRSPLELAAEAARAALD--DAGLEPADIDAVVVGNAAGGRFQS---FPGALIAEYLGLLGKPATRVEA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  88 GCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGILGLHPswmLGMGGPVLQALYATRQMHELG 167
Cdd:cd00829    76 AGASGSAAVRAAAAAIASGLADVVLVVGAEKMSDVPTGDEAGGRASDLEWEGPEPP---GGLTPPALYALAARRYMHRYG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 168 YTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFTDKPVYVLGS 247
Cdd:cd00829   153 TTREDLAKVAVKNHRNAARNPYAQFRKPITVEDVLNSRMIADPLRLLDCCPVSDGAAAVVLASEERARELTDRPVWILGV 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 248 NTGLDHKNMWDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLLREGYWNRDG 327
Cdd:cd00829   233 GAASDTPSLSERDDFLSLDAARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLGFCEKGEGGKLVREGDTAIGG 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490726396 328 AKPINPSGGLKAHGHPIAATGIGQICENYWQLREEvEPERQVKlKNGIALSHNVGGDafGVSCVTIL 394
Cdd:cd00829   313 DLPVNTSGGLLSKGHPLGATGLAQAVEAVRQLRGE-AGARQVP-GARVGLAHNIGGT--GSAAVVTI 375
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
 5-232 6.75e-12

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 65.02  E-value: 6.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   5 VAIIGVGMIPFG------------ELFEMGLEEMVQQAyinclnsvdkGISTKDIKAAWFGQWSGGGMiGQGALCGASLA 72
Cdd:pfam00108   1 VVIVSAARTPFGsfggslkdvsavELGAEAIKAALERA----------GVDPEDVDEVIVGNVLQAGE-GQNPARQAALK 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  73 TMIGNrEIPITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGILGLH----PSWMLG 148
Cdd:pfam00108  70 AGIPD-SAPAVTINKVCGSGLKAVYLAAQSIASGDADVVLAGGVESMSHAPYALPTDARSGLKHGDEKKHdlliPDGLTD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 149 MGGPVLQALYATRQMHELGYTMEDYARVAVKNHHNGVACPYAHY---------------RFEVTMERVLNSPIVCWPLHL 213
Cdd:pfam00108 149 AFNGYHMGLTAENVAKKYGISREEQDAFAVKSHQKAAAAPKAGKfkdeivpvtvkgrkgKPTVDKDEGIRPPTTAEPLAK 228

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1490726396 214 L-------------DCCPQTDGAACAIVCRAD 232
Cdd:pfam00108 229 LkpafdkegtvtagNASPINDGAAAVLLMSES 260
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
 89-348 4.17e-09

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 57.77  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  89 CPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGggilglHPSWMLGMGGPVLQALYATRQM----- 163
Cdd:COG0183    88 CGSGLQAVALAAQAIAAGDADVVIAGGVESMSRAPMLLPKARWGYRM------NAKLVDPMINPGLTDPYTGLSMgetae 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 164 ---HELGYTMEDYARVAVKNHHNGVA-----------CPYA--------------HYRFEVTMERV--LNspivcwPLHL 213
Cdd:COG0183   162 nvaERYGISREEQDAFALRSHQRAAAaiaagrfddeiVPVEvpdrkgevvvdrdeGPRPDTTLEKLakLK------PAFK 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 214 LD-------CCPQTDGAACAIVCRADIAKSFTDKP-VYVLG-SNTGLDHKNMwdkhsfveMLSTVRAARGAFEMAGIKPD 284
Cdd:COG0183   236 KDgtvtagnASGINDGAAALLLMSEEAAKELGLKPlARIVAyAVAGVDPEIM--------GIGPVPATRKALARAGLTLD 307

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490726396 285 DVDFAEIHDCFtntelmnledigfckkgeAANLLregYWNRD-GAKP--INPSGGLKAHGHPIAATG 348
Cdd:COG0183   308 DIDLIEINEAF------------------AAQVL---AVLRElGLDPdkVNVNGGAIALGHPLGASG 353
AcCoA-C-Actrans TIGR01930
acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze ...
 216-348 2.61e-06

acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273881 [Multi-domain]  Cd Length: 385  Bit Score: 49.15  E-value: 2.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 216 CCPQTDGAACAIVCRADIAKSFTDKPVYVLGS--NTGLDHKNMwdkhsfveMLSTVRAARGAFEMAGIKPDDVDFAEIHD 293
Cdd:TIGR01930 241 SSPLNDGAAALLLMSEEKAKELGLTPLARIVSfaVAGVDPEIM--------GLGPVPAIPKALKKAGLSISDIDLFEINE 312

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1490726396 294 CFTNTELMNLEDIGFckkgeaanllregywnrDGAKpINPSGGLKAHGHPIAATG 348
Cdd:TIGR01930 313 AFAAQVLACIKELGL-----------------DLEK-VNVNGGAIALGHPLGASG 349
 
Name Accession Description Interval E-value
PRK06064 PRK06064
thiolase domain-containing protein;
1-396 4.00e-148

thiolase domain-containing protein;


Pssm-ID: 235688 [Multi-domain]  Cd Length: 389  Bit Score: 425.08  E-value: 4.00e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   1 MRgKVAIIGVGMIPFGELFEMGLEEMVQQAYINCLNsvDKGISTKDIKAAWFGQWSGGGMIGQgALCGASLATMIGNREI 80
Cdd:PRK06064    1 MR-DVAIIGVGQTKFGELWDVSLRDLAVEAGLEALE--DAGIDGKDIDAMYVGNMSAGLFVSQ-EHIAALIADYAGLAPI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  81 PITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGIlglhpsWMLGMGG--PVLQALY 158
Cdd:PRK06064   77 PATRVEAACASGGAALRQAYLAVASGEADVVLAAGVEKMTDVPTPDATEAIARAGDYE------WEEFFGAtfPGLYALI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 159 ATRQMHELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFT 238
Cdd:PRK06064  151 ARRYMHKYGTTEEDLALVAVKNHYNGSKNPYAQFQKEITVEQVLNSPPVADPLKLLDCSPITDGAAAVILASEEKAKEYT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 239 DKPVYVLGSNTGLDHKNMWDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLL 318
Cdd:PRK06064  231 DTPVWIKASGQASDTIALHDRKDFTTLDAAVVAAEKAYKMAGIEPKDIDVAEVHDCFTIAEILAYEDLGFAKKGEGGKLA 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490726396 319 REGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEPERQVKLKNGIALSHNVGGDAfGVSCVTILSR 396
Cdd:PRK06064  311 REGQTYIGGDIPVNPSGGLKAKGHPVGATGVSQAVEIVWQLRGEAEKGRQQVIGAGYGLTHNVGGTG-HTAVVHILSR 387
SCP-x_thiolase cd00829
Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; ...
 8-394 1.93e-136

Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.


Pssm-ID: 238425 [Multi-domain]  Cd Length: 375  Bit Score: 394.71  E-value: 1.93e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   8 IGVGMIPFGELFEMGLEEMVQQAYINCLNsvDKGISTKDIKAAWFGQWSGGGMIGqgaLCGASLATMIGNREIPITRTEN 87
Cdd:cd00829     1 VGVGMTPFGRRSDRSPLELAAEAARAALD--DAGLEPADIDAVVVGNAAGGRFQS---FPGALIAEYLGLLGKPATRVEA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  88 GCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGILGLHPswmLGMGGPVLQALYATRQMHELG 167
Cdd:cd00829    76 AGASGSAAVRAAAAAIASGLADVVLVVGAEKMSDVPTGDEAGGRASDLEWEGPEPP---GGLTPPALYALAARRYMHRYG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 168 YTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFTDKPVYVLGS 247
Cdd:cd00829   153 TTREDLAKVAVKNHRNAARNPYAQFRKPITVEDVLNSRMIADPLRLLDCCPVSDGAAAVVLASEERARELTDRPVWILGV 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 248 NTGLDHKNMWDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLLREGYWNRDG 327
Cdd:cd00829   233 GAASDTPSLSERDDFLSLDAARLAARRAYKMAGITPDDIDVAELYDCFTIAELLALEDLGFCEKGEGGKLVREGDTAIGG 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490726396 328 AKPINPSGGLKAHGHPIAATGIGQICENYWQLREEvEPERQVKlKNGIALSHNVGGDafGVSCVTIL 394
Cdd:cd00829   313 DLPVNTSGGLLSKGHPLGATGLAQAVEAVRQLRGE-AGARQVP-GARVGLAHNIGGT--GSAAVVTI 375
PRK06157 PRK06157
acetyl-CoA acetyltransferase; Validated
 2-396 8.64e-120

acetyl-CoA acetyltransferase; Validated


Pssm-ID: 180433 [Multi-domain]  Cd Length: 398  Bit Score: 353.18  E-value: 8.64e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   2 RGKVAIIGVGMIPFGELFEMGLEEMVQQAYINCLnsVDKGISTKDIKAAWFGqwSGGGMIGQGaLCGASLATMIGNREIP 81
Cdd:PRK06157    6 KDKVAILGMGCTKFGERWDAGAEDLMVEAFLEAL--ADAGIEPKDIDAAWFG--THYDEIGSG-KSGTPLSRALRLPNIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  82 ITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDkpgvesLIAAGGGGGGILGLHPSWMLGMGGPVLQALYATR 161
Cdd:PRK06157   81 VTRVENFCATGSEAFRGAVYAVASGAYDIALALGVEKLKD------TGYGGLPVANPGTLADMTMPNVTAPGNFAQLASA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 162 QMHELGYTMED----YARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSF 237
Cdd:PRK06157  155 YAAKYGVSREDlkraMAHVSVKSHANGARNPKAHLRKAVTEEQVLKAPMIAGPLGLFDCCGVSDGAAAAIVTTPEIARAL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 238 TDK-PVYV------LGSNTGLDHkNMWDKHSFVEmlsTVRAARGAFEMAGIK-P-DDVDFAEIHDCFTNTELMNLEDIGF 308
Cdd:PRK06157  235 GKKdPVYVkalqlaVSNGWELQY-NGWDGSYFPT---TRIAARKAYREAGITdPrEELSMAEVHDCFSITELVTMEDLGL 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 309 CKKGEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEpERQVKLKNgIALSHNVGGDAFG- 387
Cdd:PRK06157  311 SERGQAWRDVLDGFFDADGGLPCQIDGGLKCFGHPIGASGLRMLYEMYLQLLGRAG-ERQLKNPR-LALTHNLGGAPGQn 388


                  ....*....
gi 1490726396 388 VSCVTILSR 396
Cdd:PRK06157  389 VCSVSIVGR 397
PRK12578 PRK12578
thiolase domain-containing protein;
4-396 3.72e-95

thiolase domain-containing protein;


Pssm-ID: 183606 [Multi-domain]  Cd Length: 385  Bit Score: 289.82  E-value: 3.72e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   4 KVAIIGVGMIPFGELFEMGLEEMVQQAYINCLNsvDKGISTKDIKAAWFGQWSGGGMIGQGALCGASLATMIGnrEIPIt 83
Cdd:PRK12578    2 RVAVIGVGNSKFGRRDDVSVQELAWESIKEALN--DAGVSQTDIELVVVGSTAYRGIELYPAPIVAEYSGLTG--KVPL- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  84 RTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGILGLHpswMLGMGGPVLQALYATRQM 163
Cdd:PRK12578   77 RVEAMCATGLAASLTAYTAVASGLVDMAIAVGVDKMTEVDTSTSLAIGGRGGNYQWEYH---FYGTTFPTYYALYATRHM 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 164 HELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSF-TDKPV 242
Cdd:PRK12578  154 AVYGTTEEQMALVSVKAHKYGAMNPKAHFQKPVTVEEVLKSRAISWPIKLLDSCPISDGSATAIFASEEKVKELkIDSPV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 243 YVLGSNTGLDHKNMWDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLLREGY 322
Cdd:PRK12578  234 WITGIGYANDYAYVARRGEWVGFKATQLAARQAYNMAKVTPNDIEVATVHDAFTIAEIMGYEDLGFTEKGKGGKFIEEGQ 313

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490726396 323 WNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEPeRQVKLKNGIALSHNVGGDA-FGVscVTILSR 396
Cdd:PRK12578  314 SEKGGKVGVNLFGGLKAKGHPLGATGLSMIYEITKQLRDEAGK-LQQPLKKYIGLVHNVGGTGhFAY--VMILRR 385
PRK08256 PRK08256
lipid-transfer protein; Provisional
 4-394 5.39e-70

lipid-transfer protein; Provisional


Pssm-ID: 181327 [Multi-domain]  Cd Length: 391  Bit Score: 225.16  E-value: 5.39e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   4 KVAIIGVGMIPF---GElfEMGLEEMVQQAYINCLNsvDKGISTKDIKAAWFGQWSGGGMIGQGALCGASlatMIGnreI 80
Cdd:PRK08256    2 KVFVAGVGMTPFekpGA--SWDYPDMAAEAGRAALA--DAGIDYDAVQQAYVGYVYGDSTSGQRALYEVG---MTG---I 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  81 PITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMR---------DKPGVESLIAAGGGGGGILGLHPS--WMLGM 149
Cdd:PRK08256   72 PIVNVNNNCSTGSTALFLARQAVRSGAADCALALGFEQMQpgalgsvwdDRPSPLERFDKALAELQGFDPAPPalRMFGG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 150 GGpvlqalyatRQ-MHELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIV 228
Cdd:PRK08256  152 AG---------REhMEKYGTTAETFAKIGVKARRHAANNPYAQFRDEYTLEDVLASPMIWGPLTRLQCCPPTCGAAAAIV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 229 CRADIAKSF-TDKPVYVLGSNTGLDHKNMWDKHSFVEMLS---TVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLE 304
Cdd:PRK08256  223 CSEEFARKHgLDRAVEIVAQAMTTDTPSTFDGRSMIDLVGydmTRAAAQQVYEQAGIGPEDIDVVELHDCFSANELLTYE 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 305 DIGFCKKGEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEPeRQVKlknG--IALSHNVG 382
Cdd:PRK08256  303 ALGLCPEGEAEKFIDDGDNTYGGRWVVNPSGGLLSKGHPLGATGLAQCAELTWQLRGTAGA-RQVE---GarLALQHNLG 378

                         410
                  ....*....|..
gi 1490726396 383 gdaFGVSCVTIL 394
Cdd:PRK08256  379 ---LGGACVVTL 387
PRK06059 PRK06059
lipid-transfer protein; Provisional
 1-396 6.03e-68

lipid-transfer protein; Provisional


Pssm-ID: 180373 [Multi-domain]  Cd Length: 399  Bit Score: 220.41  E-value: 6.03e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   1 MRGKVAIIGVGMIPFGELFEMGLEEMVQQAYINClnsVDKGISTKDIKAAWFGQWSGGGmiGQGALCGASLATMIGNREI 80
Cdd:PRK06059    2 MPEPVYILGAGMHPWGKWGRDFVEYGVVAARAAL---ADAGLDWRDVQLVVGADTIRNG--YPGFVAGATFAQALGWNGA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  81 PITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMR---------DKPGvesliaaggggggilglHPSWM----L 147
Cdd:PRK06059   77 PVSSSYAACASGSQALQSARAQILAGLCDVALVVGADTTPkgffapvggERPD-----------------DPDWLrfhlI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 148 GMGGPVLQALYATRQMHELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAI 227
Cdd:PRK06059  140 GATNPVYFALLARRRMDLYGATVEDFAQVKVKNARHGLLNPNARYRKEVTVEDVLASPVVSDPLRLLDICATSDGAAALI 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 228 VCRAD--------------IAKSFTDKPVYvlgSNTGLDHKNMWDKHSFV----EMLSTVRAARGAFEMAGIKPDDVDFA 289
Cdd:PRK06059  220 VASKSfarrhlgsvagvpsVRAISTVTPRY---PQHLPELPDIATDSTAAvpapERVFKDQILDAAYAEAGIGPEDLSLA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 290 EIHDCFTNTELMNLEDIGFCKKGEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEpERQV 369
Cdd:PRK06059  297 EVYDLSTALELDWYEHLGLCPKGEAEALLRSGATTLGGRIPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQAG-GRQV 375

                         410       420
                  ....*....|....*....|....*..
gi 1490726396 370 KLKNgIALSHNVGgdAFGVSCVTILSR 396
Cdd:PRK06059  376 EGAR-VGITANQG--LFGHGSSVIVAR 399
PRK06365 PRK06365
thiolase domain-containing protein;
20-379 3.00e-66

thiolase domain-containing protein;


Pssm-ID: 235785 [Multi-domain]  Cd Length: 430  Bit Score: 216.70  E-value: 3.00e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  20 EMGLEEMVQQAYINCLNsvDKGISTKDIK---AAWFGQWSGGGMIGqgalcGASLATMIGNREIPITRTENGCPTGSDAF 96
Cdd:PRK06365   34 YMDFRERVKKAFDYAMN--DAGLTLADIDgsvASYFSDHFQRQLLA-----GIMVQDYLGLVPKPSKRIEGGGATGGLAF 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  97 RNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGilglhpSWMLGMGG--PVLQALYATRQMHELGYTMEDYA 174
Cdd:PRK06365  107 QAGYEEIASGRMDCVAVYGFETMSHVNTWKGNEFIALASDT------NFDYPLGGfyTGYYAMMAVRHMYEFGTTVEQLA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 175 RVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFTDKPVYVLGSNTGLDHK 254
Cdd:PRK06365  181 KVSVKNHGNAIHNPFAQSPMKITVEDVRKSPMVSYPLTRLDVCAMSDGAACAILASEDKAFEITDKPVLIKAIGTGSDTL 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 255 NMWDK------------------------HSFvemLSTVRAARGAFEMAGIKP--DDVDFAEIHDCFTNTELMNLEDIGF 308
Cdd:PRK06365  261 RLADRpfgevpllpnespddykdlrypgvHSF---RAGRMAAKEAYEMAGITDplNDLDLIELHDAYTSSEIQTYEDLGL 337

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490726396 309 CKKGEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEPE-----RQVK-LKNGIALSH 379
Cdd:PRK06365  338 CKYGEGGQFIESGKPELPGKLPVNPSGGLLAAGHAVGATGIMQAVFMFWQLQGRIKKHfhddyLQVKnAKRGLIHSH 414
PRK07516 PRK07516
thiolase domain-containing protein;
4-351 3.39e-64

thiolase domain-containing protein;


Pssm-ID: 181013 [Multi-domain]  Cd Length: 389  Bit Score: 210.19  E-value: 3.39e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   4 KVAIIGVGMIPFGELFEMGLEEMVQQAYINCLnsVDKGISTKDIKAAWFGQWSGGgMIGQGAlcGASLATMI--GNREIP 81
Cdd:PRK07516    3 TASIVGWAHTPFGKLDAETLESLIVRVAREAL--AHAGIAAGDVDGIFLGHFNAG-FSPQDF--PASLVLQAdpALRFKP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  82 ITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVE-SLIAAGGGGGGILGLHPSWMLGMGGPVLQAlYAT 160
Cdd:PRK07516   78 ATRVENACATGSAAVYAALDAIEAGRARIVLVVGAEKMTATPTAEvGDILLGASYLKEEGDTPGGFAGVFGRIAQA-YFQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 161 RqmheLGYTMEDYARVAVKNHHNGVACPYAHYR----FEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKS 236
Cdd:PRK07516  157 R----YGDQSDALAMIAAKNHANGVANPYAQMRkdlgFEFCRTVSEKNPLVAGPLRRTDCSLVSDGAAALVLADAETARA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 237 FtDKPVYVLGSNTGLDHKNMwDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAAN 316
Cdd:PRK07516  233 L-QRAVRFRARAHVNDFLPL-SRRDPLAFEGPRRAWQRALAQAGVTLDDLSFVETHDCFTIAELIEYEAMGLAPPGQGAR 310

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1490726396 317 LLREGYWNRDGAKPINPSGGLKAHGHPIAATGIGQ 351
Cdd:PRK07516  311 AIREGWTAKDGKLPVNPSGGLKAKGHPIGATGVSM 345
PRK06065 PRK06065
thiolase domain-containing protein;
2-395 1.43e-57

thiolase domain-containing protein;


Pssm-ID: 180379 [Multi-domain]  Cd Length: 392  Bit Score: 193.12  E-value: 1.43e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   2 RGKVAIIGVGMIPF-GELFEMGlEEMVQQAYINCLNSVdkGISTKDIKAAWFGQ----WSGGGMIGQGALCGAslatmiG 76
Cdd:PRK06065    8 NKRVAVIGAGLTLFrRRLLETP-QELAWEAASKALDEA--GLELKDIDCVVIGSapdaFDGVHMKGEYLSHGS------G 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  77 NREIPITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMR-DKPGVESLIAAGGGGGGILGLHPS--WMLgmggpv 153
Cdd:PRK06065   79 GIRKPVSRVYVGGATGVMTAIAGWYHVASGLCQKVLAVAEEKMSpARPHPQAVFRYIWDPILEKPLNPNliWIF------ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 154 lqALYATRQMHELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADI 233
Cdd:PRK06065  153 --AMEMHRYMATYGIKKEEIALVSVKNKRNALNNPYAQLGSKITVEDVLKSEVLVWPVQLLDVSPVSDGAAAIVLASEDL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 234 AKSFTDKPVYVLGSNTGLDHKNmWDKHSFVEMLSTVRAARGAFEMAGI-KP-DDVDFAEIHDCFTNTELMNLEDIGFCKK 311
Cdd:PRK06065  231 ARRYTDTPVWVEGVGWTLDNTE-WPNRDLAYPRYVEFAARMAYKMAGIeRPrKEIDVAEPYDPFDYKELHHLEGLQLAKR 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 312 GEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEpERQVK--LKNGIAlshNVGGDAFGVS 389
Cdd:PRK06065  310 GEAPKLLKEGVFDIDGDIPSSPSGGLLGVGNPIAAAGLMKVISIYWQLKGTAG-KMQVKkpVHTGVA---QAWGDLMQAG 385


                  ....*.
gi 1490726396 390 CVTILS 395
Cdd:PRK06065  386 TVIVLR 391
PRK06066 PRK06066
thiolase domain-containing protein;
143-378 1.46e-49

thiolase domain-containing protein;


Pssm-ID: 180380 [Multi-domain]  Cd Length: 385  Bit Score: 171.86  E-value: 1.46e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 143 PSWMLGMGGP---VLQALYATRQMHELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQ 219
Cdd:PRK06066  131 PIYVRPIGPPnphFIAGLDAVKFMSRKGITREDLALVVEKNKKAGLSNPRASYASNISLEDVLSSEYVVYPLTELDIAPF 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 220 TDGAACAIVCRADIAKSFTDKPVYVLGSNTGLDHKNMwDKHSFVEMLSTVRAARGAFEMAGI-KPD-DVDFAEIHDCFTN 297
Cdd:PRK06066  211 VDGAIVVVLASEEVAKKLTDDPVWIKGIGWSTESSNL-ETAELGKANYMRIAADMAYKMAGIeSPRkEVDAAEVDDRYSY 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 298 TELMNLEDIGFCKKGEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEpERQVKLKNGIAL 377
Cdd:PRK06066  290 KELQHIEALRLSEEPEKDSLLREGNFDPQGELPVNPSGGHLAKGVPLEASGLSLLLDAVEYLRGEAG-ARQGKAERAVVA 368


                  .
gi 1490726396 378 S 378
Cdd:PRK06066  369 S 369
PRK06158 PRK06158
thiolase; Provisional
 2-383 2.82e-47

thiolase; Provisional


Pssm-ID: 180434 [Multi-domain]  Cd Length: 384  Bit Score: 165.59  E-value: 2.82e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   2 RGKVAIIGVGMIPFGELFEMGLEEMVQQAYINCLNsvDKGISTKDIKaawfgqwsgGGMIG--QGALCGASLATMIGNRE 79
Cdd:PRK06158    7 RGRTAIVGAATAGLGEAPGLSAMELLAQAAHRALA--DAGLTMADVD---------GLFTAspDDALWGLSVAEYLGIRP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  80 ipitRTENGCPTGSDAF----RNACLGVASGVYDVVLAMGAEKMRDKPGvesliaaggggGGILGLHPSWMLGMGGPVLQ 155
Cdd:PRK06158   76 ----RFVDGTMIGGSSFlahlLPAALALEAGLCDVALICYGSNQRSAGG-----------KLRSMLDPQPYEAPYKPVNP 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 156 ----ALYATRQMHELGYTMEDYARVAVKNHHNGVACPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRA 231
Cdd:PRK06158  141 vsayALAAARHMHQYGTTREQLAEVAVAARQWAQLNPEAFMRDPLTIDDVLAARMVSDPLSVRDCCLVTDGAGAVVMVRA 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 232 DIAKSFTDKPVYVLGSNTGLDHK---NMWDkhsfvemlSTVRAA----RGAFEMAGIKPDDVDFAEIHDCFTNTELMNLE 304
Cdd:PRK06158  221 DRARDLPRPPVYVLGAAAATWHRqisSMPD--------LTVTAAaesgPRAFAMAGLTPADIDVVELYDAFTINTILFLE 292

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1490726396 305 DIGFCKKGEAANLLREGYWNRDGAKPINPSGGLKAHGHPiAATGIGQICENYWQLREEVePERQVKlKNGIALSHNVGG 383
Cdd:PRK06158  293 DLGFCAKGEGGAFVEGGRIAPGGRLPVNTNGGGLSCVHP-GMYGLFLLIEAVRQLRGEA-GERQVA-GAEVALAHGNGG 368
PRK08142 PRK08142
thiolase domain-containing protein;
151-396 8.43e-47

thiolase domain-containing protein;


Pssm-ID: 236164 [Multi-domain]  Cd Length: 388  Bit Score: 164.49  E-value: 8.43e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 151 GPVLQALY---ATRQMHELGYTMEDYA--RVAVKNH--HNgvacPYAHYRFEVTMERVLNSPIVCWPLHLLDCCPQTDGA 223
Cdd:PRK08142  139 GPTTHNLYamcAMRHMHEYGTTSEQLAwiKVAASHHaqHN----PHAMLRDVVTVEDVLNSPMIADPLHRLDCCVVTDGG 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 224 ACAIVCRADIAKSFTDKPVYVLGSNTGLDHKNMWDkhsfVEMLST--VRAARGAFEMAGIKPDDVDFAEIHDCFTNTELM 301
Cdd:PRK08142  215 GALVVVRPEIARSLKRPLVKVLGAGEAIKGQMGGK----VDLTYSgaAWSGPAAFAEAGVTPADIKYASIYDSFTITVLM 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 302 NLEDIGFCKKGEAANLLREG-YWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEPERQVKlKNGIALSHN 380
Cdd:PRK08142  291 QLEDLGFCKKGEGGKFVADGnLISGVGKLPFNTDGGGLCNNHPANRGGMTKVIEAVRQLRGEAHPAVQVP-NCDLALAHG 369

                         250
                  ....*....|....*....
gi 1490726396 381 VGGdAFGV---SCVTILSR 396
Cdd:PRK08142  370 TGG-LLGSrhgSATLILER 387
PRK07855 PRK07855
lipid-transfer protein; Provisional
 99-352 2.33e-41

lipid-transfer protein; Provisional


Pssm-ID: 181147 [Multi-domain]  Cd Length: 386  Bit Score: 150.13  E-value: 2.33e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  99 ACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGILGLHPSWML--GMGGPVLQ-ALYATRQMHELGYTMEDYAR 175
Cdd:PRK07855   91 AAMAVATGVADVVVCYRAFNERSGMRFGQGQTGLAENPTSTGVDYGWSYphGLLTPAAWvAMLARRYMHEYGATSEDFGR 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 176 VAVKNHHNGVACPYAH-YRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFTDKPVYVLGSNTGL--D 252
Cdd:PRK07855  171 VAVADRKHAATNPKAWfYGRPITLEDHQNSRWIAEPLRLLDCCQESDGAVALVVTSAERARDLKQRPAVIKAAAQGSgaD 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 253 HKNMWDKHSfvEMLSTVR----AARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLLREGYWNRDGA 328
Cdd:PRK07855  251 QYMMTSYYR--DDITGLPemglVARQLWAQSGLGPADIDTAILYDHFTPFVLMQLEELGFCGRGEAKDFIADGALELGGR 328

                         250       260
                  ....*....|....*....|....*...
gi 1490726396 329 KPINPSGGLKA----HGHPIAATGIGQI 352
Cdd:PRK07855  329 LPINTHGGQLGeayiHGMNGIAEAVRQL 356
nondecarbox_cond_enzymes cd00826
nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic ...
 41-392 3.70e-36

nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238422 [Multi-domain]  Cd Length: 393  Bit Score: 136.08  E-value: 3.70e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  41 GISTKDIKAAWFGQWSGGGmigQGALCGASLAT-MIGNREIPITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKM 119
Cdd:cd00826    39 GVAAGAVEEACLGQVLGAG---EGQNCAQQAAMhAGGLQEAPAIGMNNLCGSGLRALALAMQLIAGGDANCILAGGFEKM 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 120 R--DKPGVESLIAAGGGGGGILGLHPSwmlgmgGPVLQALYATRQMHELGYTMEDYARVAVKN---HHNGVACPYAHYRF 194
Cdd:cd00826   116 EtsAENNAKEKHIDVLINKYGMRACPD------AFALAGQAGAEAAEKDGRFKDEFAKFGVKGrkgDIHSDADEYIQFGD 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 195 EVTMERVLNS-PIVCWP--LHLLDCCPQTDGAACAIVCRADIAKS--FTDKPVYVLGSNTGLDHKNMWDKHSFVEMLS-- 267
Cdd:cd00826   190 EASLDEIAKLrPAFDKEdfLTAGNACGLNDGAAAAILMSEAEAQKhgLQSKAREIQALEMITDMASTFEDKKVIKMVGgd 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 268 -TVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAA 346
Cdd:cd00826   270 gPIEAARKALEKAGLGIGDLDLIEAHDAFAANACATNEALGLCPEGQGGALVDRGDNTYGGKSIINPNGGAIAIGHPIGA 349

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1490726396 347 TGIGQICENYWQLREEVePERQVKLKnGIALSHNVGGdaFGVSCVT 392
Cdd:cd00826   350 SGAAICAELCFELKGEA-GKRQGAGA-GLALLCIGGG--GGAAMCI 391
PTZ00455 PTZ00455
3-ketoacyl-CoA thiolase; Provisional
 81-384 1.27e-34

3-ketoacyl-CoA thiolase; Provisional


Pssm-ID: 240424 [Multi-domain]  Cd Length: 438  Bit Score: 132.71  E-value: 1.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  81 PITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMrdkpgvESLIAAGGGGGGILGLHPSWMLGMGGPVLQALYAT 160
Cdd:PTZ00455  112 PAMRVEGACASGGLAVQSAWEALLAGTSDIALVVGVEVQ------TTVSARVGGDYLARAADYRRQRKLDDFTFPCLFAK 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 161 RqMHEL----GYTMEDYARVAVKNHHNGVACPYAH-YRFEVTME----------RVLNSPIVCWPLHLLDCCPQTDGAAC 225
Cdd:PTZ00455  186 R-MKYIqehgHFTMEDTARVAAKAYANGNKNPLAHmHTRKLSLEfctgasdknpKFLGNETYKPFLRMTDCSQVSDGGAG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 226 AIVCRADIAKSFTDKP-----VYVLGSNTGLDhkNMW-DKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTE 299
Cdd:PTZ00455  265 LVLASEEGLQKMGLSPndsrlVEIKSLACASG--NLYeDPPDATRMFTSRAAAQKALSMAGVKPSDLQVAEVHDCFTIAE 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 300 LMNLEDIGFCKKGEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEpERQVKLKNGIALSH 379
Cdd:PTZ00455  343 LLMYEALGIAEYGHAKDLIRNGATALEGRIPVNTGGGLLSFGHPVGATGVKQIMEVYRQMKGQCG-EYQMKNIPALGATL 421


                  ....*
gi 1490726396 380 NVGGD 384
Cdd:PTZ00455  422 NMGGD 426
PRK08313 PRK08313
thiolase domain-containing protein;
1-383 2.75e-33

thiolase domain-containing protein;


Pssm-ID: 181378 [Multi-domain]  Cd Length: 386  Bit Score: 128.31  E-value: 2.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   1 MRGKVAIIGVGMIPF-GELFEMGLEEMVQQAYINCLNsvDKGISTKDIKAAWFGQ---WSGGGMIGQgalcgASLATMIG 76
Cdd:PRK08313    1 MKRLAAVLGTGQTKYvAKRQDVSMAGLVREAIDRALA--DAGLTWDDIDAVVVGKapdFFEGVMMPE-----LFLADALG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  77 NREIPITRTEN-GCPTGSDAFRNACLgVASGVYDVVLAMGAEKMRDkpgvesliaaggggggilgLHPSWMLGMGGPVLQ 155
Cdd:PRK08313   74 ATGKPLIRVHTaGSVGGSTAVVAASL-VQSGVYRRVLAVAWEKQSE-------------------SNAMWALSIPVPFTK 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 156 AL----------YATRQMHELGYTMEDYARVAVKNHHNGVACPYAHYRF-EVTMERVLNSPIVCWPLHLLDCCPQTDGAA 224
Cdd:PRK08313  134 PVgagaggyfapHVRAYIRRSGAPEHIGAMVAVKDRLNGAKNPYAHLHQpDITLEKVMASQMLWDPIRFDETCPSSDGAC 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 225 CAIVCRADIAKSFTDKPV-YVLGsnTGLDHKNMWDKH-SFVEMLSTVRAARGAFEMAGIKP--DDVDFAEIHDCFTNTEL 300
Cdd:PRK08313  214 AVVIGDEEAADAAAGRPVaWIHG--TAMRTEPLAFAGrDQVNPQAGRDAAAALWKAAGITDprDEIDVAEIYVPFSWFEP 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 301 MNLEDIGFCKKGEAANLLREGYWNRDGAKPINPSGGLKAhGHPIAATGIGQICENYWQLREEVEpERQVKlknGI--ALS 378
Cdd:PRK08313  292 MWLENLGFAPEGEGWKLTEAGETAIGGRLPVNPSGGVLS-SNPIGASGMIRFAEAALQVMGKAG-EHQVD---GArkALG 366


                  ....*
gi 1490726396 379 HNVGG 383
Cdd:PRK08313  367 HAYGG 371
PRK06289 PRK06289
acetyl-CoA acetyltransferase; Provisional
 21-349 4.92e-30

acetyl-CoA acetyltransferase; Provisional


Pssm-ID: 235771 [Multi-domain]  Cd Length: 403  Bit Score: 119.41  E-value: 4.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  21 MGLEEMVQQAYINCLNSVdkGISTKDIKAAWFGQWSGGGMIGQGALcGASLATMI-GNREIPITRTENGCPTGSDAFRNA 99
Cdd:PRK06289   24 RDFADLTREVVDGTLAAA--GVDADDIEVVHVGNFFGELFAGQGHL-GAMPATVHpALWGVPASRHEAACASGSVATLAA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 100 CLGVASGVYDVVLAMGAEKMRDKPGVE------SLIAAGGGGGGILGLHPsWMLGMGGPVLQALYATRQMHelgytmedY 173
Cdd:PRK06289  101 MADLRAGRYDVALVVGVELMKTVPGDVaaehlgAAAWTGHEGQDARFPWP-SMFARVADEYDRRYGLDEEH--------L 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 174 ARVAVKNHHNGVACPYAHYRF-----EVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFTDK-PVYVL-- 245
Cdd:PRK06289  172 RAIAEINFANARRNPNAQTRGwafpdEATNDDDATNPVVEGRLRRQDCSQVTDGGAGVVLASDAYLRDYADArPIPRIkg 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 246 -GSNT---GLDHKNMWDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFCKKGEAANLLREG 321
Cdd:PRK06289  252 wGHRTaplGLEQKLDRSAGDPYVLPHVRQAVLDAYRRAGVGLDDLDGFEVHDCFTPSEYLAIDHIGLTGPGESWKAIENG 331

                         330       340
                  ....*....|....*....|....*...
gi 1490726396 322 YWNRDGAKPINPSGGLKAHGHPIAATGI 349
Cdd:PRK06289  332 EIAIGGRLPINPSGGLIGGGHPVGASGV 359
PRK07937 PRK07937
lipid-transfer protein; Provisional
 169-354 1.79e-16

lipid-transfer protein; Provisional


Pssm-ID: 181173 [Multi-domain]  Cd Length: 352  Bit Score: 80.12  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 169 TMEDYARVAVKNHHNGVACPYAhyRFEVTMERVLNSPIVCWPLHLLDCCPQTDGAACAIVCRADIAKSFTDKPVYVlgsn 248
Cdd:PRK07937  156 TEEQMAEVAARSRADARRNPSA--EPSISVDELLARPYFADPLRRHDIAPITDGAAAVVLAAGDRARELRERPAWI---- 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 249 TGLDHKnmWDKHSF-VEMLSTVRAARGAFEMA-GIKPDDVDFAEIHDCFTNTELmnledigfckkgeaanLLREGYWNRD 326
Cdd:PRK07937  230 TGIEHR--IESPSLgARDLTRSPSTALAAEAAtGGDAGGVDVAELHAPFTHQEL----------------ILREALGLGD 291

                         170       180
                  ....*....|....*....|....*...
gi 1490726396 327 GAKpINPSGGLKAhGHPIAATGIGQICE 354
Cdd:PRK07937  292 KTK-VNPSGGALA-ANPMFAAGLERIGE 317
cond_enzymes cd00327
Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) ...
 215-383 6.07e-15

Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the production of polyketides, a diverse group of natural products.


Pssm-ID: 238201 [Multi-domain]  Cd Length: 254  Bit Score: 74.02  E-value: 6.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 215 DCCPQTDGAACAIVCR-ADIAKSFTDKPVYVLGSNTGLDHKNMWDKHSfVEMLstVRAARGAFEMAGIKPDDVDFAEIHD 293
Cdd:cd00327    96 EEFVFGDGAAAAVVESeEHALRRGAHPQAEIVSTAATFDGASMVPAVS-GEGL--ARAARKALEGAGLTPSDIDYVEAHG 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 294 CFTNTELMNLEDIGfckkgeaanllregyWNRDGAKPINPSGGLKAHGHPIAATGIGQICENYWQLREEVEPERQVKLKN 373
Cdd:cd00327   173 TGTPIGDAVELALG---------------LDPDGVRSPAVSATLIMTGHPLGAAGLAILDELLLMLEHEFIPPTPREPRT 237

                         170
                  ....*....|
gi 1490726396 374 GIALSHNVGG 383
Cdd:cd00327   238 VLLLGFGLGG 247
thiolase cd00751
Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of ...
 41-348 3.72e-12

Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.


Pssm-ID: 238383 [Multi-domain]  Cd Length: 386  Bit Score: 67.12  E-value: 3.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  41 GISTKDIKAAWFG---QWSGGGMIGQGAlcgaSLATMIGNrEIP---ITRTengCPTGSDAFRNACLGVASGVYDVVLAM 114
Cdd:cd00751    38 GLDPEEVDDVIMGnvlQAGEGQNPARQA----ALLAGLPE-SVPattVNRV---CGSGLQAVALAAQSIAAGEADVVVAG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 115 GAEKMRDKPGVESLIAAGGGGGGILGLHPSWmlgmggPVLQALYATRQM--------HELGYTMEDYARVAVKNHHNGVA 186
Cdd:cd00751   110 GVESMSRAPYLLPKARRGGRLGLNTLDGMLD------DGLTDPFTGLSMgitaenvaEKYGISREEQDEFALRSHQRAAA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 187 C-----------PYA--------------HYRFEVTMERV--L-------------NSpivcwplhlldcCPQTDGAACA 226
Cdd:cd00751   184 AqeagrfkdeivPVEvpgrkgpvvvdrdeGPRPDTTLEKLakLkpafkkdgtvtagNA------------SGINDGAAAV 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 227 IVCRADIAKSFTDKP--VYVLGSNTGLDHKNMwdkhsfveMLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLE 304
Cdd:cd00751   252 LLMSEEKAKELGLKPlaRIVGYAVAGVDPAIM--------GIGPVPAIPKALKRAGLTLDDIDLIEINEAFAAQALACLK 323

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1490726396 305 DIGFckkgeaanllregywnrDGAKpINPSGGLKAHGHPIAATG 348
Cdd:cd00751   324 ELGL-----------------DPEK-VNVNGGAIALGHPLGASG 349
Thiolase_N pfam00108
Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
 5-232 6.75e-12

Thiolase, N-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 459676 [Multi-domain]  Cd Length: 260  Bit Score: 65.02  E-value: 6.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396   5 VAIIGVGMIPFG------------ELFEMGLEEMVQQAyinclnsvdkGISTKDIKAAWFGQWSGGGMiGQGALCGASLA 72
Cdd:pfam00108   1 VVIVSAARTPFGsfggslkdvsavELGAEAIKAALERA----------GVDPEDVDEVIVGNVLQAGE-GQNPARQAALK 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  73 TMIGNrEIPITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGGGILGLH----PSWMLG 148
Cdd:pfam00108  70 AGIPD-SAPAVTINKVCGSGLKAVYLAAQSIASGDADVVLAGGVESMSHAPYALPTDARSGLKHGDEKKHdlliPDGLTD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 149 MGGPVLQALYATRQMHELGYTMEDYARVAVKNHHNGVACPYAHY---------------RFEVTMERVLNSPIVCWPLHL 213
Cdd:pfam00108 149 AFNGYHMGLTAENVAKKYGISREEQDAFAVKSHQKAAAAPKAGKfkdeivpvtvkgrkgKPTVDKDEGIRPPTTAEPLAK 228

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1490726396 214 L-------------DCCPQTDGAACAIVCRAD 232
Cdd:pfam00108 229 LkpafdkegtvtagNASPINDGAAAVLLMSES 260
PRK08257 PRK08257
acetyl-CoA acetyltransferase; Validated
 99-295 1.44e-09

acetyl-CoA acetyltransferase; Validated


Pssm-ID: 236204 [Multi-domain]  Cd Length: 498  Bit Score: 59.54  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  99 ACLGVASGVYDVVLAMGAE---------KMRDKPG----VESLIAAGGGGGGILGLHPSWMLGMGGPVLQ-ALY--ATR- 161
Cdd:PRK08257   99 AALRIAAGEADVALVAGAEaqstatklrKAGEKLDwtpqDEGPLADRGGDPRPMASPAELRHGLDRPVYVyPLFenALRa 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 162 --------QMHELGYTMEDYARVAVKNhhngvacPYAHYRFEVTMERVL-----NSPIvCWPLH-LLDCCPQTDGAACAI 227
Cdd:PRK08257  179 algrspeeHRAEMGELWAPFSAVAAKN-------PHAWIPRERSAEEIVtptpdNRMI-AWPYTkLMNANDMVDQGAAVL 250

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490726396 228 VCRADIAKSF---TDKPVYVLGSNTGLDHKNMWDKHSFVEMLSTVRAARGAFEMAGIKPDDVDFAEIHDCF 295
Cdd:PRK08257  251 LTSVAKARRLgvpEDRWVYLHGGADAHDPYDILERPDLHRSPAIRAAGRRALALAGLGIDDIDAFDLYSCF 321
PaaJ COG0183
Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is ...
 89-348 4.17e-09

Acetyl-CoA acetyltransferase [Lipid transport and metabolism]; Acetyl-CoA acetyltransferase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 439953 [Multi-domain]  Cd Length: 391  Bit Score: 57.77  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  89 CPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKPGVESLIAAGGGGggilglHPSWMLGMGGPVLQALYATRQM----- 163
Cdd:COG0183    88 CGSGLQAVALAAQAIAAGDADVVIAGGVESMSRAPMLLPKARWGYRM------NAKLVDPMINPGLTDPYTGLSMgetae 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 164 ---HELGYTMEDYARVAVKNHHNGVA-----------CPYA--------------HYRFEVTMERV--LNspivcwPLHL 213
Cdd:COG0183   162 nvaERYGISREEQDAFALRSHQRAAAaiaagrfddeiVPVEvpdrkgevvvdrdeGPRPDTTLEKLakLK------PAFK 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 214 LD-------CCPQTDGAACAIVCRADIAKSFTDKP-VYVLG-SNTGLDHKNMwdkhsfveMLSTVRAARGAFEMAGIKPD 284
Cdd:COG0183   236 KDgtvtagnASGINDGAAALLLMSEEAAKELGLKPlARIVAyAVAGVDPEIM--------GIGPVPATRKALARAGLTLD 307

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490726396 285 DVDFAEIHDCFtntelmnledigfckkgeAANLLregYWNRD-GAKP--INPSGGLKAHGHPIAATG 348
Cdd:COG0183   308 DIDLIEINEAF------------------AAQVL---AVLRElGLDPdkVNVNGGAIALGHPLGASG 353
PRK07801 PRK07801
acetyl-CoA C-acetyltransferase;
79-348 1.35e-06

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181123 [Multi-domain]  Cd Length: 382  Bit Score: 50.09  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  79 EIPITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAEKMRDKP-GVESLIAAGGGGGGILGLHPSWMLGMG-GPVLQA 156
Cdd:PRK07801   79 EVPGVTVDRQCGSSQQAIHFAAQAVMSGTQDLVVAGGVQNMSQIPiSSAMTAGEQLGFTSPFAESKGWLHRYGdQEVSQF 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 157 LYATRQMHELGYTMEDYARVAVKNHHNGVAC-----------PYAHYRF-----EVTMERV--LNSPIVCWPLhLLDCCP 218
Cdd:PRK07801  159 RGAELIAEKWGISREEMERFALESHRRAFAAiragrfdneivPVGGVTVdegprETSLEKMagLKPLVEGGRL-TAAVAS 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 219 QT-DGAACAIVCRADIAKSFTDKP------VYVLGSNTgldhknmwdkhsfVEMLST-VRAARGAFEMAGIKPDDVDFAE 290
Cdd:PRK07801  238 QIsDGASAVLLASERAVKRHGLTPrarihhLSVRGDDP-------------VFMLTApIPATRYALEKTGLSIDDIDVVE 304

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1490726396 291 IHDCFTNTELMNLEDIGFckkgeaanllregywnrDGAKpINPSGGLKAHGHPIAATG 348
Cdd:PRK07801  305 INEAFAPVVLAWLKETGA-----------------DPAK-VNPNGGAIALGHPLGATG 344
AcCoA-C-Actrans TIGR01930
acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze ...
 216-348 2.61e-06

acetyl-CoA acetyltransferases; This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273881 [Multi-domain]  Cd Length: 385  Bit Score: 49.15  E-value: 2.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 216 CCPQTDGAACAIVCRADIAKSFTDKPVYVLGS--NTGLDHKNMwdkhsfveMLSTVRAARGAFEMAGIKPDDVDFAEIHD 293
Cdd:TIGR01930 241 SSPLNDGAAALLLMSEEKAKELGLTPLARIVSfaVAGVDPEIM--------GLGPVPAIPKALKKAGLSISDIDLFEINE 312

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1490726396 294 CFTNTELMNLEDIGFckkgeaanllregywnrDGAKpINPSGGLKAHGHPIAATG 348
Cdd:TIGR01930 313 AFAAQVLACIKELGL-----------------DLEK-VNVNGGAIALGHPLGASG 349
Thiolase_C pfam02803
Thiolase, C-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl ...
 269-348 1.29e-05

Thiolase, C-terminal domain; Thiolase is reported to be structurally related to beta-ketoacyl synthase (pfam00109), and also chalcone synthase.


Pssm-ID: 397094 [Multi-domain]  Cd Length: 123  Bit Score: 44.17  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 269 VRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFckkgeaanllregywnrDGAKpINPSGGLKAHGHPIAATG 348
Cdd:pfam02803  25 AYAIPKALKKAGLTVNDIDLFEINEAFAAQALAVAKDLGI-----------------DPEK-VNVNGGAIALGHPLGASG 86
PRK06025 PRK06025
acetyl-CoA C-acetyltransferase;
221-348 4.59e-05

acetyl-CoA C-acetyltransferase;


Pssm-ID: 235675 [Multi-domain]  Cd Length: 417  Bit Score: 45.15  E-value: 4.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 221 DGAACAIVCRADIAKSFTDKP--VYVLGSNTGLDHKNMWDkhsfvemlSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNT 298
Cdd:PRK06025  276 DGAAALLLASKAYAEKHGLKPraRIVAMANMGDDPTLMLN--------APVPAAKKVLAKAGLTKDDIDLWEINEAFAVV 347

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490726396 299 elmnledigfckkgeAANLLREGYWNRDgakPINPSGGLKAHGHPIAATG 348
Cdd:PRK06025  348 ---------------AEKFIRDLDLDRD---KVNVNGGAIALGHPIGATG 379
fadI PRK08963
3-ketoacyl-CoA thiolase; Reviewed
 218-353 7.97e-05

3-ketoacyl-CoA thiolase; Reviewed


Pssm-ID: 181597 [Multi-domain]  Cd Length: 428  Bit Score: 44.59  E-value: 7.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 218 PQTDGAACAIVCRADIAKSFTDKPVYVLGSN--TGLDhknMWDkhsfvEML-STVRAARGAFEMAGIKPDDVDFAEIHDC 294
Cdd:PRK08963  266 PLTDGAAAVLLMSESRAKALGLTPLGYLRSYafAAID---VWQ-----DMLlGPAYATPLALERAGLTLADLTLIDMHEA 337

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 295 FTNTELMNLEdiGFCKKGEAANLLregywNRDgaKPI--------NPSGGLKAHGHPIAATG---IGQIC 353
Cdd:PRK08963  338 FAAQTLANLQ--MFASERFAREKL-----GRS--QAIgevdmskfNVLGGSIAYGHPFAATGarmITQTL 398
PRK07851 PRK07851
acetyl-CoA C-acetyltransferase;
215-348 1.44e-04

acetyl-CoA C-acetyltransferase;


Pssm-ID: 181146 [Multi-domain]  Cd Length: 406  Bit Score: 43.84  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 215 DCCPQTDGAACAIVCRADIAKSFTDKPVYVLGSN--TGLDHKNMWdkhsfvemLSTVRAARGAFEMAGIKPDDVDFAEIH 292
Cdd:PRK07851  258 NACPLNDGAAAVVIMSDTKARELGLTPLARIVSTgvSGLSPEIMG--------LGPVEASKQALARAGMSIDDIDLVEIN 329

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1490726396 293 DCFTNTELMNLEDIGFckkgeaanllregywnrDGAKpINPSGGLKAHGHPIAATG 348
Cdd:PRK07851  330 EAFAAQVLPSARELGI-----------------DEDK-LNVSGGAIALGHPFGMTG 367
PRK05790 PRK05790
putative acyltransferase; Provisional
 221-348 2.57e-04

putative acyltransferase; Provisional


Pssm-ID: 180261 [Multi-domain]  Cd Length: 393  Bit Score: 42.83  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 221 DGAACAIVCRADIAKSFTDKPVYVLGS--NTGLDHKNMwdkHSfvemlSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNT 298
Cdd:PRK05790  252 DGAAAVVVMSEAKAKELGLTPLARIVSyaVAGVDPAIM---GI-----GPVPAIRKALEKAGWSLADLDLIEINEAFAAQ 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490726396 299 ELMNLEDIGfckkgeaanllregyWNRDgakPINPSGGLKAHGHPIAATG 348
Cdd:PRK05790  324 ALAVEKELG---------------LDPE---KVNVNGGAIALGHPIGASG 355
PRK09268 PRK09268
acetyl-CoA C-acetyltransferase;
279-352 3.01e-04

acetyl-CoA C-acetyltransferase;


Pssm-ID: 236440 [Multi-domain]  Cd Length: 427  Bit Score: 42.58  E-value: 3.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1490726396 279 AGIKPDDVDFAEIHDCFTNTELMNL---EDIGFCKK--GEAANLlreGYWNRdgAKpINPSGGLKAHGHPIAATGiGQI 352
Cdd:PRK09268  322 NGLTLQDFDFYEIHEAFASQVLATLkawEDEEYCRErlGLDAPL---GSIDR--SK-LNVNGSSLAAGHPFAATG-GRI 393
PRK09052 PRK09052
acetyl-CoA C-acyltransferase;
275-348 6.92e-04

acetyl-CoA C-acyltransferase;


Pssm-ID: 181626 [Multi-domain]  Cd Length: 399  Bit Score: 41.53  E-value: 6.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490726396 275 AFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFckkgeaanllregywnrDGAKpINPSGGLKAHGHPIAATG 348
Cdd:PRK09052  306 ALKQAGLKQDDLDWIELNEAFAAQSLAVIRDLGL-----------------DPSK-VNPLGGAIALGHPLGATG 361
PRK06205 PRK06205
acetyl-CoA C-acetyltransferase;
41-348 1.54e-03

acetyl-CoA C-acetyltransferase;


Pssm-ID: 235741 [Multi-domain]  Cd Length: 404  Bit Score: 40.36  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396  41 GISTKDIKAAWFGQWSGGG---MIGQGALCGASLATmignrEIPITRTENGCPTGSDAFRNACLGVASGVYDVVLAMGAE 117
Cdd:PRK06205   42 GIDPARIDDVIFGQGYPNGeapAIGRVAALDAGLPV-----TVPGMQLDRRCGSGLQAVITAAMQVQTGAADVVIAGGAE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 118 KMRdkpGVEsliaaggggggilglHPS----WMLGMGGPVLQ-ALYATRQM--------------------HELGYTMED 172
Cdd:PRK06205  117 SMS---NVE---------------FYTtdmrWGVRGGGVQLHdRLARGRETaggrrfpvpggmietaenlrREYGISREE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 173 YARVAVKNHHNGVACPYA--------------------------HYRFEVTMERVLN-SPIvcwpLHLLD---------C 216
Cdd:PRK06205  179 QDALAVRSHQRAVAAQEAgrfddeivpvtvpqrkgdptvvdrdeHPRADTTLESLAKlRPI----MGKQDpeatvtagnA 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 217 CPQTDGAACAIVCRADIAKSFTDKPVYVLGS--NTGLDHKNMWdkhsfvemLSTVRAARGAFEMAGIKPDDVDFAEIHDC 294
Cdd:PRK06205  255 SGQNDAAAACLVTTEDKAEELGLRPLARLVSwaVAGVEPSRMG--------IGPVPATEKALARAGLTLDDIDLIELNEA 326

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490726396 295 FTntelmnledigfckkGEAANLLREGYWNRDGAKPINPSGGLKAHGHPIAATG 348
Cdd:PRK06205  327 FA---------------AQVLAVLKEWGFGADDEERLNVNGSGISLGHPVGATG 365
PRK06445 PRK06445
acetyl-CoA C-acetyltransferase;
269-348 3.16e-03

acetyl-CoA C-acetyltransferase;


Pssm-ID: 180563 [Multi-domain]  Cd Length: 394  Bit Score: 39.32  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 269 VRAARGAFEMAGIKPDDVDFAEIHDCFTNTELMNLEDIGFckkgeaanllregywnrdGAKPINPSGGLKAHGHPIAATG 348
Cdd:PRK06445  295 VPASKKALEKAGLSVKDIDLWEINEAFAVVVLYAIKELGL------------------DPETVNIKGGAIAIGHPLGATG 356
PRK09050 PRK09050
beta-ketoadipyl CoA thiolase; Validated
 221-348 5.55e-03

beta-ketoadipyl CoA thiolase; Validated


Pssm-ID: 181624 [Multi-domain]  Cd Length: 401  Bit Score: 38.78  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 221 DGAACAIVCRADIAKSFTDKPV-YVLGSNT-GLDHKNMWdkhsfvemLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNT 298
Cdd:PRK09050  258 DGAAALLLASEAAAKKHGLTPRaRILGMATaGVEPRIMG--------IGPAPATRKLLARLGLTIDQFDVIELNEAFAAQ 329

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490726396 299 ELMNLEDIGFckkgeaanllregywnRDGAKPINPSGGLKAHGHPIAATG 348
Cdd:PRK09050  330 GLAVLRQLGL----------------ADDDARVNPNGGAIALGHPLGMSG 363
PRK09051 PRK09051
beta-ketothiolase BktB;
221-348 5.93e-03

beta-ketothiolase BktB;


Pssm-ID: 181625 [Multi-domain]  Cd Length: 394  Bit Score: 38.40  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490726396 221 DGAACAIVCRADIAKSFTDKPVYVLGS--NTGLDHKNMWdkhsfvemLSTVRAARGAFEMAGIKPDDVDFAEIHDCFTNT 298
Cdd:PRK09051  253 DGAAAVVLAEADAAEARGLKPLARLVGyaHAGVDPEYMG--------IGPVPATQKALERAGLTVADLDVIEANEAFAAQ 324

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1490726396 299 ELMNLEDIGFckkgeaanllregywnrDGAKpINPSGGLKAHGHPIAATG 348
Cdd:PRK09051  325 ACAVTRELGL-----------------DPAK-VNPNGSGISLGHPVGATG 356
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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