|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
224-885 |
1.25e-175 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 524.79 E-value: 1.25e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 224 PVLAAAWSEEGILLEPGFRLGNRSVLAATELDGRIHGRWARVGRHLCRVLDPPTPLVPFHRKGRQLLTGQAALRFLSLDH 303
Cdd:COG0553 12 ALGLLLTELLLLLRLGALLLELVLARELLLLLLAADALLLLALLLLLELLLLLAALLLLALLLLALSALALLLLRLLLAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 304 PQLRQHDWYLPRGALAKFRQPVVPKTDSLVVSQKNSGTILLQPTFTAEGHDFDWEAALDLRKSGFARIEGRLVHAPDLSA 383
Cdd:COG0553 92 LLLALLLLLAGLLALALLLLALLGLLLSLALLLLLLLLLLLLLLALLLVLLAALLLLLLLLLLLALLLGRLLLLALLLLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 384 FERAGFQVPRRGLHAGLRGDRLAFIRLVAETDIRVVSEDQDLADLAAL----LRGAKAADPGTPPGLISTLRPYQRDGVR 459
Cdd:COG0553 172 LEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVdafrLRRLREALESLPAGLKATLRPYQLEGAA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 460 WLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFAPGLGLHIFHGTDRQLPVA 539
Cdd:COG0553 252 WLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTRERAKGA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 540 S--KHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGTPMENRLLELWSVVELV 617
Cdd:COG0553 332 NpfEDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFL 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 618 LPGYLGSQREFKETYRHP----SQSQLALLRSRLGILTLRRLKDQVLSDLPEKVEDLRYCNLTPQQKRVYSTIhsgaISD 693
Cdd:COG0553 412 NPGLLGSLKAFRERFARPiekgDEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAV----LEY 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 694 IAAMLDDANQDIPFIHIFALMTRLKQVCDHSTLGGDAPNLDSGSSGKLEVFDEILNEALESGQEIVVFSQYVRMLDLLSS 773
Cdd:COG0553 488 LRRELEGAEGIRRRGLILAALTRLRQICSHPALLLEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEE 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 774 HLAAQDIGHLMLTGST--RDRGRVIRRFNSGQHERVLLASLLAGGVGIDLTGASVVIHYDRWWNPAKENQATDRIHRMGQ 851
Cdd:COG0553 568 RLEERGIEYAYLHGGTsaEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQ 647
|
650 660 670
....*....|....*....|....*....|....
gi 1490892739 852 KRFVQVFKLITRETIEERIDKLIRRKIALFEEVV 885
Cdd:COG0553 648 TRDVQVYKLVAEGTIEEKILELLEEKRALAESVL 681
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
446-656 |
4.28e-72 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 236.69 E-value: 4.28e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 446 LISTLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFAPGLG 525
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 526 LHIFHGTDRQ--LPVASKHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGTPM 603
Cdd:cd18012 81 VLVIHGTKRKreKLRALEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPI 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1490892739 604 ENRLLELWSVVELVLPGYLGSQREFKETYRHPSQSQ-----LALLRSRLGILTLRRLK 656
Cdd:cd18012 161 ENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDgdeeaLEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
443-880 |
3.44e-63 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 231.61 E-value: 3.44e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 443 PPGLISTLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRA----THPEasvLVVCPRGVLEHWTNLLE 518
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEyrgiTGPH---MVVAPKSTLGNWMNEIR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 519 TFAPGLGLHIFHGTDRQ-------LPVASKHNpVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIE 591
Cdd:PLN03142 240 RFCPVLRAVKFHGNPEErahqreeLLVAGKFD-VCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFS 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 592 AHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPSQ-------SQL-ALLRSRLgiltLRRLKDQVLSDL 663
Cdd:PLN03142 319 TNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGEndqqevvQQLhKVLRPFL----LRRLKSDVEKGL 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 664 PEKVEDLRYCNLTPQQKRVYST--------IHSGAisDIAAMLDDANQdipfihifalmtrLKQVCDHSTLGGDA---PN 732
Cdd:PLN03142 395 PPKKETILKVGMSQMQKQYYKAllqkdldvVNAGG--ERKRLLNIAMQ-------------LRKCCNHPYLFQGAepgPP 459
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 733 LDSG-----SSGKLEVFDEILNEALESGQEIVVFSQYVRMLDLLSSHLAAQDIGHLMLTGST--RDRGRVIRRFNSGQHE 805
Cdd:PLN03142 460 YTTGehlveNSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTggEDRDASIDAFNKPGSE 539
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490892739 806 R-VLLASLLAGGVGIDLTGASVVIHYDRWWNPAKENQATDRIHRMGQKRFVQVFKLITRETIEERIDKLIRRKIAL 880
Cdd:PLN03142 540 KfVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLAL 615
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
453-723 |
7.28e-57 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 197.52 E-value: 7.28e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 453 YQRDGVRWLWQRY-LAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEAS--VLVVCPRGVLEHWTNLLETFA--PGLGLH 527
Cdd:pfam00176 1 YQIEGVNWMLSLEnNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgpTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 528 IFHGTDR-QLPVASKHN-----PVIVTTYDILvRSSAELIPK-QWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSG 600
Cdd:pfam00176 81 VLHGNKRpQERWKNDPNfladfDVVITTYETL-RKHKELLKKvHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 601 TPMENRLLELWSVVELVLPGYLGSQREFKETYRHPSQSQLA-LLRSRLGILT----LRRLKDQVLSDLPEKVEDLRYCNL 675
Cdd:pfam00176 160 TPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGkKGVSRLHKLLkpflLRRTKKDVEKSLPPKVEYILFCRL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1490892739 676 TPQQKRVYSTIHSGAisDIAAMLDDANQDIPFIHIFALMTRLKQVCDH 723
Cdd:pfam00176 240 SKLQRKLYQTFLLKK--DLNAIKTGEGGREIKASLLNILMRLRKICNH 285
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
450-622 |
1.37e-56 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 192.78 E-value: 1.37e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEAS-VLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGpVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGTDR-----QLPVASKHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGTPM 603
Cdd:cd17919 81 YHGSQReraqiRAKEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPL 160
|
170
....*....|....*....
gi 1490892739 604 ENRLLELWSVVELVLPGYL 622
Cdd:cd17919 161 QNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
450-635 |
1.32e-51 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 180.65 E-value: 1.32e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFAPGLGLHIF 529
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 530 HGT-----DRQLPVASKHNPVIVTTYDILVRSSAELIPK-----QWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALS 599
Cdd:cd18001 81 HGTskkerERNLERIQRGGGVLLTTYGMVLSNTEQLSADdhdefKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILT 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 1490892739 600 GTPMENRLLELWSVVELVLPGY-LGSQREFKETYRHP 635
Cdd:cd18001 161 GTPIQNNLKELWALFDFACNGSlLGTRKTFKMEFENP 197
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
450-660 |
1.63e-51 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 180.62 E-value: 1.63e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLW--QRY-LAGVgvlLADDMGLGKTHQVMGLLC---HVRATHPEAS---VLVVCPRGVLEHWTNLLETF 520
Cdd:cd17999 1 LRPYQQEGINWLAflNKYnLHGI---LCDDMGLGKTLQTLCILAsdhHKRANSFNSEnlpSLVVCPPTLVGHWVAEIKKY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 521 AP--GLGLHIFHG---TDRQLPVASKHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFK 595
Cdd:cd17999 78 FPnaFLKPLAYVGppqERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHR 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1490892739 596 VALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHP-SQSQLALLRSR---LGILTLRRLKDQVL 660
Cdd:cd17999 158 LILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPiLASRDSKASAKeqeAGALALEALHKQVL 226
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
738-861 |
5.73e-51 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 174.97 E-value: 5.73e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 738 SGKLEVFDEILNEALESGQEIVVFSQYVRMLDLLSSHLAAQDIGHLMLTGST--RDRGRVIRRFNSGQHERVLLASLLAG 815
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTssKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1490892739 816 GVGIDLTGASVVIHYDRWWNPAKENQATDRIHRMGQKRFVQVFKLI 861
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
450-657 |
1.28e-45 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 164.09 E-value: 1.28e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLL---------------------CHVRATHPEASVLVVCPRG 508
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLaavlgktgtrrdrennrprfkKKPPASSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 509 VLEHWTNLLETFApGLGLHIFHGT--DRQLPVASKHN--PVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAA 584
Cdd:cd18005 81 VLYNWKDELDTWG-HFEVGVYHGSrkDDELEGRLKAGrlEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLT 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1490892739 585 RSARKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHP---SQSQLALLRS-RLGILTLRRLKD 657
Cdd:cd18005 160 QAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPikrGQRHTATARElRLGRKRKQELAV 236
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
450-622 |
3.04e-39 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 144.00 E-value: 3.04e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVmglLCHVRATHPEA----SVLVVCPRGVLEHWTNLLETFAPGLG 525
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQI---IAFLAALHHSKlglgPSLIVCPATVLKQWVKEFHRWWPPFR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 526 LHIFHGT----------------DRQLPVASKHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARK 589
Cdd:cd18000 78 VVVLHSSgsgtgseeklgsierkSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQ 157
|
170 180 190
....*....|....*....|....*....|...
gi 1490892739 590 IEAHFKVALSGTPMENRLLELWSVVELVLPGYL 622
Cdd:cd18000 158 LRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
450-635 |
7.05e-38 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 141.66 E-value: 7.05e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQR-------YLAGVGVLLADDMGLGKTHQVMGLL-CHVRATHPEASVLVVCPRGVLEHWTNLLETFA 521
Cdd:cd18007 1 LKPHQVEGVRFLWSNlvgtdvgSDEGGGCILAHTMGLGKTLQVITFLhTYLAAAPRRSRPLVLCPASTLYNWEDEFKKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 522 PG--LGLHIFHGTDRQLPVAS---------KHNPVIVTTYDILVR--------------SSAELIPKQWDIVIFDEAQRI 576
Cdd:cd18007 81 PPdlRPLLVLVSLSASKRADArlrkinkwhKEGGVLLIGYELFRNlasnattdprlkqeFIAALLDPGPDLLVLDEGHRL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1490892739 577 KNPRTKAARSARKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHP 635
Cdd:cd18007 161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKP 219
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
449-656 |
1.88e-36 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 137.52 E-value: 1.88e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 449 TLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18009 3 VMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGT-DRQLPVASKHN---------PVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVAL 598
Cdd:cd18009 83 YHGTkEERERLRKKIMkregtlqdfPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLL 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490892739 599 SGTPMENRLLELWSVVELVLPGYLGSQREFKE-------TYRHPSQSQLA------LLRSRLGILT---LRRLK 656
Cdd:cd18009 163 TGTPLQNNLSELWSLLNFLLPDVFDDLSSFESwfdfsslSDNAADISNLSeereqnIVHMLHAILKpflLRRLK 236
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
450-654 |
2.24e-36 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 137.42 E-value: 2.24e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRyLAGV------GVLLADDMGLGKTHQVMGL----LCHVRATHPEA-SVLVVCPRGVLEHWTNLLE 518
Cdd:cd18004 1 LRPHQREGVQFLYDC-LTGRrgygggGAILADEMGLGKTLQAIALvwtlLKQGPYGKPTAkKALIVCPSSLVGNWKAEFD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 519 TFAPGLGLHIFHGTDRQLPV--------ASKHNPVIVTTYDILVRSSAEL-IPKQWDIVIFDEAQRIKNPRTKAARSARK 589
Cdd:cd18004 80 KWLGLRRIKVVTADGNAKDVkasldffsSASTYPVLIISYETLRRHAEKLsKKISIDLLICDEGHRLKNSESKTTKALNS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 590 IEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHP---------SQSQLALLRSRLGILT-------LR 653
Cdd:cd18004 160 LPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPilrsrdpdaSEEDKELGAERSQELSeltsrfiLR 239
|
.
gi 1490892739 654 R 654
Cdd:cd18004 240 R 240
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
450-654 |
3.03e-35 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 133.53 E-value: 3.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRAT-HPEASVLVVCPRGVLEHWTNLLETFAPgLGLHI 528
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVeGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGT--DRQL-----------PVASKHNP----VIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIE 591
Cdd:cd17995 80 YHGSgeSRQIiqqyemyfkdaQGRKKKGVykfdVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490892739 592 AHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETY-RHPSQSQLALLRSRLGILTLRR 654
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFgDLKTAEQVEKLQALLKPYMLRR 223
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
450-632 |
1.63e-33 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 128.48 E-value: 1.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRylaGVGVLLADDMGLGKTHQVMGLLCHVRATHPeasVLVVCPRGVLEHWTNLLETFAPGLGLH-- 527
Cdd:cd18010 1 LLPFQREGVCFALRR---GGRVLIADEMGLGKTVQAIAIAAYYREEWP---LLIVCPSSLRLTWADEIERWLPSLPPDdi 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 528 --IFHGTDRQLPVASKhnpVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKI--EAHFKVALSGTPM 603
Cdd:cd18010 75 qvIVKSKDGLRDGDAK---VVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPA 151
|
170 180
....*....|....*....|....*....
gi 1490892739 604 ENRLLELWSVVELVLPGYLGSQREFKETY 632
Cdd:cd18010 152 LSRPIELFTQLDALDPKLFGRFHDFGRRY 180
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
450-654 |
2.13e-33 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 128.32 E-value: 2.13e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRAT-HPEASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRlKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHG-----TDRQLPVASKHN-PVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGTP 602
Cdd:cd18006 81 YMGdkekrLDLQQDIKSTNRfHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1490892739 603 MENRLLELWSVVELVLPGYLGSQR--EFKETYrHPSQSQLAL---LRSRLGILTLRR 654
Cdd:cd18006 161 IQNSLQELYALLSFIEPNVFPKDKldDFIKAY-SETDDESETveeLHLLLQPFLLRR 216
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
450-654 |
1.95e-31 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 123.17 E-value: 1.95e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRylagvGVLLADDMGLGKTHQVMGLLCHVRATHPEASV------------------LVVCPRGVLE 511
Cdd:cd18008 1 LLPYQKQGLAWMLPR-----GGILADEMGLGKTIQALALILATRPQDPKIPEeleenssdpkklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 512 HWTNLLETF--APGLGLHIFHGTDRQLPVASKHNP-VIVTTYDILVRSSAELIPKQ----------------WDIVIFDE 572
Cdd:cd18008 76 QWKDEIEKHtkPGSLKVYVYHGSKRIKSIEELSDYdIVITTYGTLASEFPKNKKGGgrdskekeasplhrirWYRVILDE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 573 AQRIKNPRTKAARSARKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPSQ----SQLALLRSRLG 648
Cdd:cd18008 156 AHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSkndrKALERLQALLK 235
|
....*.
gi 1490892739 649 ILTLRR 654
Cdd:cd18008 236 PILLRR 241
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
449-660 |
6.39e-31 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 121.71 E-value: 6.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 449 TLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRAT-HPEASVLVVCPRGVLEHWTNLLETFAPGLGLH 527
Cdd:cd17996 3 TLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKkKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 528 IFHGTD---RQLP---VASKHNpVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARS-ARKIEAHFKVALSG 600
Cdd:cd17996 83 VYKGTPdvrKKLQsqiRAGKFN-VLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTlNTYYHARYRLLLTG 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490892739 601 TPMENRLLELWSVVELVLPGYLGSQREFKETYRHPSQSQLALLRSRLG----ILTLRRLKdQVL 660
Cdd:cd17996 162 TPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVKIELNeeetLLIIRRLH-KVL 224
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
449-656 |
4.10e-30 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 118.96 E-value: 4.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 449 TLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQ---VMGLLCHVRA-THPEasvLVVCPRGVLEHWTNLLETFAPGL 524
Cdd:cd17997 3 TMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQtisLLGYLKHYKNiNGPH---LIIVPKSTLDNWMREFKRWCPSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 525 GLHIFHGTDRQLPVASKHN------PVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVAL 598
Cdd:cd17997 80 RVVVLIGDKEERADIIRDVllpgkfDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490892739 599 SGTPMENRLLELWSVVELVLPGYLGSQREFKETYR-----HPSQSQLALLRSRLGILTLRRLK 656
Cdd:cd17997 160 TGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNvnncdDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
450-619 |
9.12e-30 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 116.72 E-value: 9.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFAPGLGLHIF 529
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 530 HGTD---RQLPVASKHN----PVIVTTYDILVRSSAE---LIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALS 599
Cdd:cd17998 81 YGSQeerKHLRYDILKGledfDVIVTTYNLATSNPDDrsfFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
|
170 180
....*....|....*....|
gi 1490892739 600 GTPMENRLLELWSVVELVLP 619
Cdd:cd17998 161 GTPLQNNLLELMSLLNFIMP 180
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
450-635 |
1.40e-29 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 117.45 E-value: 1.40e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATH----PEasvLVVCPRGVLEHWTNLLETFAPGLG 525
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKgnwgPH---LIVVPTSVMLNWEMEFKRWCPGFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 526 LHIFHGTDRQLPVASK--HNP----VIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALS 599
Cdd:cd18003 78 ILTYYGSAKERKLKRQgwMKPnsfhVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLT 157
|
170 180 190
....*....|....*....|....*....|....*.
gi 1490892739 600 GTPMENRLLELWSVVELVLPGYLGSQREFKETYRHP 635
Cdd:cd18003 158 GTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNP 193
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
450-646 |
4.38e-27 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 110.71 E-value: 4.38e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQ-----RYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEAS------VLVVCPRGVLEHWTNLLE 518
Cdd:cd18066 1 LRPHQREGIEFLYEcvmgmRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGkpvikrALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 519 TFAPGLGLHIFhGTDRQLPV----ASKHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHF 594
Cdd:cd18066 81 KWLGSERIKVF-TVDQDHKVeefiASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALTSLSCER 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1490892739 595 KVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPsqsqlaLLRSR 646
Cdd:cd18066 160 RIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEP------IVRSR 205
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
449-654 |
1.16e-26 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 108.98 E-value: 1.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 449 TLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEAS-VLVVCPRGVLEHWTNLLETFAPGLGL- 526
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGpFLVVVPLSTMPAWQREFAKWAPDMNVi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 527 ---------------HIFHGTDRQLpvasKHNpVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIE 591
Cdd:cd17993 81 vylgdiksrdtireyEFYFSQTKKL----KFN-VLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFK 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490892739 592 AHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPSQSQLALLRSRLGILTLRR 654
Cdd:cd17993 156 TNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
450-654 |
1.24e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 106.63 E-value: 1.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHP-EASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18054 21 LRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQlYGPFLLVVPLSTLTSWQREFEIWAPEINVVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHG------TDRQLPVASKHNP-----VIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVA 597
Cdd:cd18054 101 YIGdlmsrnTIREYEWIHSQTKrlkfnALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1490892739 598 LSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPSQSQLALLRSRLGILTLRR 654
Cdd:cd18054 181 ITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRR 237
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
450-666 |
2.43e-25 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 105.90 E-value: 2.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRA-THPEASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHyRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGTDRQLPVASK------HNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGTP 602
Cdd:cd18064 96 LIGDKDQRAAFVRdvllpgEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTP 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490892739 603 MENRLLELWSVVELVLPGYLGSQREFKETYRHPS----QSQLALLRSRLGILTLRRLKDQVLSDLPEK 666
Cdd:cd18064 176 LQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNNclgdQKLVERLHMVLRPFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
450-646 |
5.70e-25 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 104.86 E-value: 5.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQ----RYLAGV-GVLLADDMGLGKTHQVMGLLCHVRATHPEAS-----VLVVCPRGVLEHWTNLLET 519
Cdd:cd18067 1 LRPHQREGVKFLYRcvtgRRIRGShGCIMADEMGLGKTLQCITLMWTLLRQSPQCKpeidkAIVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 520 F-APGLGLHIFHG-----TDRQLPV-ASKH-----NPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSA 587
Cdd:cd18067 81 WlGGRLQPLAIDGgskkeIDRKLVQwASQQgrrvsTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQAL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1490892739 588 RKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYrhpsqsQLALLRSR 646
Cdd:cd18067 161 DSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNF------ELPILKGR 213
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
450-654 |
1.33e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 103.21 E-value: 1.33e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFAPgLGLHIF 529
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTE-MNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 530 HGT--DRQL----------------PVASKHNPVIvTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIE 591
Cdd:cd18060 80 HGSlaSRQMiqqyemyckdsrgrliPGAYKFDALI-TTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMD 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490892739 592 AHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREF-KETYRHPSQSQLALLRSRLGILTLRR 654
Cdd:cd18060 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFlKDFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
449-656 |
1.44e-24 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 103.17 E-value: 1.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 449 TLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRA-THPEASVLVVCPRGVLEHWTNLLETFAPGLGLH 527
Cdd:cd18065 15 TLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHyRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 528 IFHGTD--RQLPVASKHNP----VIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGT 601
Cdd:cd18065 95 CLIGDKdaRAAFIRDVMMPgewdVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGT 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1490892739 602 PMENRLLELWSVVELVLPGYLGSQREFKETYRHPS----QSQLALLRSRLGILTLRRLK 656
Cdd:cd18065 175 PLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNclgdQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
450-630 |
1.81e-24 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 102.97 E-value: 1.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHP-EASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNiWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGTDRQLPVASKH-NP-----------VIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKV 596
Cdd:cd18002 81 YWGNPKDRKVLRKFwDRknlytrdapfhVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190
....*....|....*....|....*....|....
gi 1490892739 597 ALSGTPMENRLLELWSVVELVLPGYLGSQREFKE 630
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNE 194
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
450-654 |
5.73e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 101.66 E-value: 5.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHP-EASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18053 21 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQlYGPFLLVVPLSTLTSWQREIQTWAPQMNAVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGTDRQLPVASKHN-----------PVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVA 597
Cdd:cd18053 101 YLGDINSRNMIRTHEwmhpqtkrlkfNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1490892739 598 LSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPSQSQLALLRSRLGILTLRR 654
Cdd:cd18053 181 ITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRR 237
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
450-617 |
9.39e-24 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 101.02 E-value: 9.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWL-WQRYLAGVGVLLADDMGLGKTHQV-----------------------MGLLCHVRATHPEASVLVVC 505
Cdd:cd18072 1 LLLHQKQALAWLlWRERQKPRGGILADDMGLGKTLTMialilaqkntqnrkeeekekaltEWESKKDSTLVPSAGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 506 PRGVLEHWTNLLETFAPG--LGLHIFHGTDRQ--LPVASKHNpVIVTTYDILVR---------SSAELIPKQWDIVIFDE 572
Cdd:cd18072 81 PASLVHQWKNEVESRVASnkLRVCLYHGPNREriGEVLRDYD-IVITTYSLVAKeiptykeesRSSPLFRIAWARIILDE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1490892739 573 AQRIKNPRTKAARSARKIEAHFKVALSGTPMENRLLELWSVVELV 617
Cdd:cd18072 160 AHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL 204
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
450-654 |
5.80e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 97.51 E-value: 5.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHV-RATHPEASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLyKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGtdrqlpvaskhNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGTPMENRLL 608
Cdd:cd17994 81 YVG-----------DHVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLE 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1490892739 609 ELWSVVELVLPGYLGSQREFKETYRHPS-QSQLALLRSRLGILTLRR 654
Cdd:cd17994 150 ELFHLLNFLTPERFNNLQGFLEEFADISkEDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
450-635 |
1.55e-22 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 97.19 E-value: 1.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLW-------QRYL--AGVGVLLADDMGLGKTHQVMGLL-CHVRAThPEASVLVVCPRGVLEHWtnlLET 519
Cdd:cd18069 1 LKPHQIGGIRFLYdniieslERYKgsSGFGCILAHSMGLGKTLQVISFLdVLLRHT-GAKTVLAIVPVNTLQNW---LSE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 520 FapglglhifhgtDRQLPVASKHNPVIVTTYDILV--------RSSAELIpKQW--------------------DIVIFD 571
Cdd:cd18069 77 F------------NKWLPPPEALPNVRPRPFKVFIlndehkttAARAKVI-EDWvkdggvllmgyemfrlrpgpDVVICD 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490892739 572 EAQRIKNPRTKAARSARKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHP 635
Cdd:cd18069 144 EGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERP 207
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
450-654 |
3.97e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 95.88 E-value: 3.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFAPgLGLHIF 529
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWTE-MNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 530 HGT--DRQLPVA-------SKHNP--------VIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEA 592
Cdd:cd18058 80 HGSqiSRQMIQQyemyyrdEQGNPlsgifkfqVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMAL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490892739 593 HFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRH-PSQSQLALLRSRLGILTLRR 654
Cdd:cd18058 160 EHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDlKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
442-618 |
1.05e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 94.10 E-value: 1.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 442 TPPGLISTLRPYQRDGVRWLWQRYLagvGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVL-EHWTNLLETF 520
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 521 APGLGLH---IFHGTDRQL---PVASKHNPVIVTTYDILVRSSAE--LIPKQWDIVIFDEAQRIKNP-RTKAARSA--RK 589
Cdd:smart00487 78 GPSLGLKvvgLYGGDSKREqlrKLESGKTDILVTTPGRLLDLLENdkLSLSNVDLVILDEAHRLLDGgFGDQLEKLlkLL 157
|
170 180
....*....|....*....|....*....
gi 1490892739 590 IEAHFKVALSGTPMENRLLELWSVVELVL 618
Cdd:smart00487 158 PKNVQLLLLSATPPEEIENLLELFLNDPV 186
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
739-850 |
2.60e-21 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 89.58 E-value: 2.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 739 GKLEVFDEILNEalESGQEIVVFSQYVRMLDLlSSHLAAQDIGHLMLTGST--RDRGRVIRRFNSGQHeRVLLASLlAGG 816
Cdd:pfam00271 1 EKLEALLELLKK--ERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLsqEEREEILEDFRKGKI-DVLVATD-VAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 1490892739 817 VGIDLTGASVVIHYDRWWNPAKENQATDRIHRMG 850
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
449-655 |
4.20e-21 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 93.59 E-value: 4.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 449 TLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLC----HVRATHPeasVLVVCPRGVLEHWTNLLETFAPGL 524
Cdd:cd18063 23 TLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITylmeHKRLNGP---YLIIVPLSTLSNWTYEFDKWAPSV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 525 GLHIFHGTD---RQL--PVASKHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSarkIEAHF----K 595
Cdd:cd18063 100 VKISYKGTPamrRSLvpQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQV---LNTHYvaprR 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1490892739 596 VALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHP--SQSQLALLRSRLGILTLRRL 655
Cdd:cd18063 177 ILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfaMTGERVDLNEEETILIIRRL 238
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
450-654 |
5.08e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 92.79 E-value: 5.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFAPgLGLHIF 529
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTE-LNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 530 HGTD------------------RQLPVASKHNPVIvTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIE 591
Cdd:cd18059 80 HGSQasrrtiqlyemyfkdpqgRVIKGSYKFHAII-TTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMD 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1490892739 592 AHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRH-PSQSQLALLRSRLGILTLRR 654
Cdd:cd18059 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDlKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
470-654 |
5.33e-21 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 92.92 E-value: 5.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 470 GVLLADDMGLGKTHQVMGLLCHVRAthpeasvLVVCPRGVLEHW-TNLLETFAPG-LGLHIFHGTDRQLPVA--SKHNpV 545
Cdd:cd18071 50 GGILADDMGLGKTLTTISLILANFT-------LIVCPLSVLSNWeTQFEEHVKPGqLKVYTYHGGERNRDPKllSKYD-I 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 546 IVTTYDILV-----RSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGTPMENRLLELWSVVELVLPG 620
Cdd:cd18071 122 VLTTYNTLAsdfgaKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLK 201
|
170 180 190
....*....|....*....|....*....|....*...
gi 1490892739 621 YLGSQREFKETYRHP----SQSQLALLRSRLGILTLRR 654
Cdd:cd18071 202 PFSNPEYWRRLIQRPltmgDPTGLKRLQVLMKQITLRR 239
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
450-654 |
1.64e-20 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 91.28 E-value: 1.64e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHV-RATHPEASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLyKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGTDRQLPVASKHN-------------------------PVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKA 583
Cdd:cd18057 81 YTGDKESRSVIRENEfsfednairsgkkvfrmkkeaqikfHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1490892739 584 ARSARKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPS-QSQLALLRSRLGILTLRR 654
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISkEDQIKKLHDLLGPHMLRR 232
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
450-655 |
9.21e-20 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 89.72 E-value: 9.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLC----HVRATHPeasVLVVCPRGVLEHWTNLLETFAPGLG 525
Cdd:cd18062 24 LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITylmeHKRINGP---FLIIVPLSTLSNWVYEFDKWAPSVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 526 LHIFHGTDRQ----LPV--ASKHNpVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSarkIEAHF----K 595
Cdd:cd18062 101 KVSYKGSPAArrafVPQlrSGKFN-VLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQV---LNTHYvaprR 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1490892739 596 VALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHP--SQSQLALLRSRLGILTLRRL 655
Cdd:cd18062 177 LLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfaMTGEKVDLNEEETILIIRRL 238
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
450-654 |
3.14e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 87.37 E-value: 3.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFApGLGLHIF 529
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 530 HGT---------------DRQLPV--ASKHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKAARSARKIEA 592
Cdd:cd18061 80 HGSlisrqmiqqyemyfrDSQGRIirGAYRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490892739 593 HFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRH-PSQSQLALLRSRLGILTLRR 654
Cdd:cd18061 160 EHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDlKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
450-654 |
1.04e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 86.27 E-value: 1.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHV-RATHPEASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLyKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHG-------------------------TDRQLPVASKHNPVIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTKA 583
Cdd:cd18056 81 YVGdkdsraiirenefsfednairggkkASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1490892739 584 ARSARKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRH-PSQSQLALLRSRLGILTLRR 654
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADiAKEDQIKKLHDMLGPHMLRR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
450-637 |
6.01e-18 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 84.17 E-value: 6.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLW---------QRYLAGVGVLLADDMGLGKTHQVMGLLcHVRATHPE----ASVLVVCPRGVLEHWTNL 516
Cdd:cd18068 1 LKPHQVDGVQFMWdccceslkkTKKSPGSGCILAHCMGLGKTLQVVTFL-HTVLLCEKlenfSRVLVVCPLNTVLNWLNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 517 LETFAPGLG----LHIFH------GTDRQLPV--ASKHNPVIVTTYDILVRSSAELIPKQW----------------DIV 568
Cdd:cd18068 80 FEKWQEGLKdeekIEVNElatykrPQERSYKLqrWQEEGGVMIIGYDMYRILAQERNVKSReklkeifnkalvdpgpDFV 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1490892739 569 IFDEAQRIKNPRTKAARSARKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPSQ 637
Cdd:cd18068 160 VCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQ 228
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
450-610 |
1.33e-17 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 83.55 E-value: 1.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRylagvGVLLADDMGLGKTHQVMGLLCH------------------VRATHPEASV--------LV 503
Cdd:cd18070 1 LLPYQRRAVNWMLVP-----GGILADEMGLGKTVEVLALILLhprpdndldaadddsdemVCCPDCLVAEtpvsskatLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 504 VCPRGVLEHWTNLLETFAPGlGLHIFH-GTDRQLPVASKHNP-------VIVTTYDIL----------------VRSSAE 559
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPS-SLKVLTyQGVKKDGALASPAPeilaeydIVVTTYDVLrtelhyaeanrsnrrrRRQKRY 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1490892739 560 LIPK------QWDIVIFDEAQRIKNPRTKAARSARKIEAHFKVALSGTPMENRLLEL 610
Cdd:cd18070 155 EAPPsplvlvEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDL 211
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
450-654 |
2.74e-17 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 81.98 E-value: 2.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQVMGLLCHV-RATHPEASVLVVCPRGVLEHWTNLLETFAPGLGLHI 528
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLyKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 529 FHGtDRQLPVASKHNP--------------------------VIVTTYDILVRSSAELIPKQWDIVIFDEAQRIKNPRTK 582
Cdd:cd18055 81 YTG-DKDSRAIIRENEfsfddnavkggkkafkmkreaqvkfhVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSK 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490892739 583 AARSARKIEAHFKVALSGTPMENRLLELWSVVELVLPGYLGSQREFKETYRHPS-QSQLALLRSRLGILTLRR 654
Cdd:cd18055 160 FFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISkEDQIKKLHDLLGPHMLRR 232
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
450-654 |
7.97e-16 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 76.94 E-value: 7.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRwlwqRYLAG--VGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEHWTNLLETFApGLGLH 527
Cdd:cd18011 1 PLPHQIDAVL----RALRKppVRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDELQDKF-GLPFL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 528 IFHGTDRQLPVASKHNP-----VIVTTYDILVRS---SAELIPKQWDIVIFDEAQRIKNP-------RTKAARSARKIEA 592
Cdd:cd18011 76 ILDRETAAQLRRLIGNPfeefpIVIVSLDLLKRSeerRGLLLSEEWDLVVVDEAHKLRNSgggketkRYKLGRLLAKRAR 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1490892739 593 HFkVALSGTPMENRLLELWSVVELVLPGYLGSQREFketyrhpsqSQLALLRSRLGILTLRR 654
Cdd:cd18011 156 HV-LLLTATPHNGKEEDFRALLSLLDPGRFAVLGRF---------LRLDGLREVLAKVLLRR 207
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
769-850 |
3.16e-15 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 71.47 E-value: 3.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 769 DLLSSHLAAQDIGHLMLTGST--RDRGRVIRRFNSGqhERVLLASLLAGGVGIDLTGASVVIHYDRWWNPAKENQATDRI 846
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLsqEEREEILDKFNNG--KIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 1490892739 847 HRMG 850
Cdd:smart00490 79 GRAG 82
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
450-602 |
3.93e-15 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 73.49 E-value: 3.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGV-RWLWQRYlAGVGVLladDM--GLGKTHQVMGLLCHVRathpEASVLVVCPRGVL-EHWTNLLETFAPGLG 525
Cdd:cd17926 1 LRPYQEEALeAWLAHKN-NRRGIL---VLptGSGKTLTALALIAYLK----ELRTLIVVPTDALlDQWKERFEDFLGDSS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 526 LHIFHGTDRQLPVAskhNPVIVTTYDILVRSSAE--LIPKQWDIVIFDEAQRIknprtkAARSARKI----EAHFKVALS 599
Cdd:cd17926 73 IGLIGGGKKKDFDD---ANVVVATYQSLSNLAEEekDLFDQFGLLIVDEAHHL------PAKTFSEIlkelNAKYRLGLT 143
|
...
gi 1490892739 600 GTP 602
Cdd:cd17926 144 ATP 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
403-828 |
4.49e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 79.30 E-value: 4.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 403 DRLAFIRLVAETDIRVVSEDQDLADLAALLRGAKAADPGTPPGLisTLRPYQRDGVRWLWQRYLAGVG-VLLADDMGLGK 481
Cdd:COG1061 36 EARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSF--ELRPYQQEALEALLAALERGGGrGLVVAPTGTGK 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 482 ThqVMGLLChVRATHPEASVLVVCPRGVL-EHWtnlLETFAPGLGLHIFHGTDRQLpvaskHNPVIVTTYDILVRSSA-E 559
Cdd:COG1061 114 T--VLALAL-AAELLRGKRVLVLVPRRELlEQW---AEELRRFLGDPLAGGGKKDS-----DAPITVATYQSLARRAHlD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 560 LIPKQWDIVIFDEAQRIKNPRTKaaRSARKIEAHFKVALSGTP--MENRLLELWSVVELVlpgylgsqrefketYRhpsq 637
Cdd:COG1061 183 ELGDRFGLVIIDEAHHAGAPSYR--RILEAFPAAYRLGLTATPfrSDGREILLFLFDGIV--------------YE---- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 638 sqlallrsrlgiLTLRRL-KDQVLSDlPEKVEdlRYCNLTPQQKRVystihsgaiSDIAAMLDDAnqdipfihifalmtr 716
Cdd:COG1061 243 ------------YSLKEAiEDGYLAP-PEYYG--IRVDLTDERAEY---------DALSERLREA--------------- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 717 lkqvcdhstlggdapnLDSGSSGKLEVFDEILNEALESGQeIVVFSQYVRMLDLLSSHLAAQDIGHLMLTGST--RDRGR 794
Cdd:COG1061 284 ----------------LAADAERKDKILRELLREHPDDRK-TLVFCSSVDHAEALAELLNEAGIRAAVVTGDTpkKEREE 346
|
410 420 430
....*....|....*....|....*....|....
gi 1490892739 795 VIRRFNSGQHeRVLLASLLAgGVGIDLTGASVVI 828
Cdd:COG1061 347 ILEAFRDGEL-RILVTVDVL-NEGVDVPRLDVAI 378
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
450-637 |
1.31e-13 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 70.84 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGvgvLLADdMGLGKTHQVMGLLCHVRATHPEASVLVVCPRGVLEH-WTNLLETFA--PGLGL 526
Cdd:cd18013 1 PHPYQKVAINFIIEHPYCG---LFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKWNhlRNLTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 527 HIFHGTDRQLPVASKHNP-VIVTTYDI---LVRSSAELIPkqWDIVIFDEAQRIKNP---RTKAARSARKIEAHFkVALS 599
Cdd:cd18013 77 SVAVGTERQRSKAANTPAdLYVINRENlkwLVNKSGDPWP--FDMVVIDELSSFKSPrskRFKALRKVRPVIKRL-IGLT 153
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1490892739 600 GTPMENRLLELWSVVELVLPG-YLG-SQREFKETYRHPSQ 637
Cdd:cd18013 154 GTPSPNGLMDLWAQIALLDQGeRLGrSITAYRERWFDPDK 193
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
449-602 |
8.94e-12 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 64.23 E-value: 8.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 449 TLRPYQRDGVRWLWQRYLAG-VGVLLADDMGLGKTHQVMGLLCHVRATHPEASVLVVCPR-GVLEHWTNLLETFAPGLGL 526
Cdd:pfam04851 3 ELRPYQIEAIENLLESIKNGqKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRkDLLEQALEEFKKFLPNYVE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 527 HIFHGTDRQLPVASKHNPVIVTTYD----ILVRSSAELIPKQWDIVIFDEAQRIknprtkAARSARKIEAHFK----VAL 598
Cdd:pfam04851 83 IGEIISGDKKDESVDDNKIVVTTIQslykALELASLELLPDFFDVIIIDEAHRS------GASSYRNILEYFKpaflLGL 156
|
....
gi 1490892739 599 SGTP 602
Cdd:pfam04851 157 TATP 160
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
470-576 |
2.50e-07 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 50.86 E-value: 2.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 470 GVLLADDMGLGKTHQVM-GLLCHVRATHPEasVLVVCPRGVL--EHWTNLLETFAPGLGLHIFHGTDRQLPVASK---HN 543
Cdd:cd00046 3 NVLITAPTGSGKTLAALlAALLLLLKKGKK--VLVLVPTKALalQTAERLRELFGPGIRVAVLVGGSSAEEREKNklgDA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1490892739 544 PVIVTTYDILVRSSAELIP---KQWDIVIFDEAQRI 576
Cdd:cd00046 81 DIIIATPDMLLNLLLREDRlflKDLKLIIVDEAHAL 116
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
740-850 |
1.54e-06 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 48.27 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 740 KLEVFDEILNEALESGQeIVVFSQYVRMLDLLSSHLAAQDIGHLMLTG--STRDRGRVIRRFNSGQHeRVLLASLLAGGv 817
Cdd:cd18787 13 KKLLLLLLLLEKLKPGK-AIIFVNTKKRVDRLAELLEELGIKVAALHGdlSQEERERALKKFRSGKV-RVLVATDVAAR- 89
|
90 100 110
....*....|....*....|....*....|...
gi 1490892739 818 GIDLTGASVVIHYDrwwNPakeNQATDRIHRMG 850
Cdd:cd18787 90 GLDIPGVDHVINYD---LP---RDAEDYVHRIG 116
|
|
| DEXHc_XPB |
cd18029 |
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ... |
450-601 |
3.57e-06 |
|
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350787 [Multi-domain] Cd Length: 169 Bit Score: 48.07 E-value: 3.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 450 LRPYQRDGVRWLWQRYLAGVGVLLAdDMGLGKThqVMGLLCHVRAthpEASVLVVCPRGV--------LEHWTNLletfa 521
Cdd:cd18029 9 LRPYQEKALSKMFGNGRARSGVIVL-PCGAGKT--LVGITAACTI---KKSTLVLCTSAVsveqwrrqFLDWTTI----- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 522 PGLGLHIFHGTDRQLPVASkhnPVIVTTYDILVRS----------SAELIPKQWDIVIFDEAQRIKNPRTKaaRSARKIE 591
Cdd:cd18029 78 DDEQIGRFTSDKKEIFPEA---GVTVSTYSMLANTrkrspesekfMEFITEREWGLIILDEVHVVPAPMFR--RVLTLQK 152
|
170
....*....|
gi 1490892739 592 AHFKVALSGT 601
Cdd:cd18029 153 AHCKLGLTAT 162
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
740-902 |
5.15e-05 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 46.68 E-value: 5.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 740 KLEVFDEILNEalESGQEIVVFSQYVRMLDLLSSHLAAQDIGHLMLTG--STRDRGRVIRRFNSGQHeRVLLASLLAGGv 817
Cdd:COG0513 228 KLELLRRLLRD--EDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGdlSQGQRERALDAFRNGKI-RVLVATDVAAR- 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 818 GIDLTGASVVIHYDRwwnPakeNQATDRIHR------MGQKRfvQVFKLITRETIE--ERIDKLIRRKIalfEEVVAPTE 889
Cdd:COG0513 304 GIDIDDVSHVINYDL---P---EDPEDYVHRigrtgrAGAEG--TAISLVTPDERRllRAIEKLIGQKI---EEEELPGF 372
|
170
....*....|...
gi 1490892739 890 NVIRSIDRKEIAE 902
Cdd:COG0513 373 EPVEEKRLERLKP 385
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
814-852 |
1.07e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 41.54 E-value: 1.07e-04
10 20 30
....*....|....*....|....*....|....*....
gi 1490892739 814 AGGVGIDLTGASVVIHYDRWWNPAKENQATDRIHRMGQK 852
Cdd:cd18785 31 VLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
449-579 |
1.48e-03 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 40.71 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 449 TLRPYQRDGVRwlwQRYLAGVGVLLADDMGLGKThqVMGLLCHVRA-THPEASVLVVCPRGVL--EHWTNLLETFAP-GL 524
Cdd:cd17921 1 LLNPIQREALR---ALYLSGDSVLVSAPTSSGKT--LIAELAILRAlATSGGKAVYIAPTRALvnQKEADLRERFGPlGK 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1490892739 525 GLHIFHGTDRQLPVASKHNPVIVTTY---DILVRSSAELIPKQWDIVIFDEAQRIKNP 579
Cdd:cd17921 76 NVGLLTGDPSVNKLLLAEADILVATPeklDLLLRNGGERLIQDVRLVVVDEAHLIGDG 133
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
736-828 |
1.67e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 39.93 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 736 GSSGKLEVFDEILNEaLESGQEIVVFSQYVRMLDLLsshlaAQDIGHLMLTG--STRDRGRVIRRFNSGQHeRVLLASLL 813
Cdd:cd18789 31 MNPNKLRALEELLKR-HEQGDKIIVFTDNVEALYRY-----AKRLLKPFITGetPQSEREEILQNFREGEY-NTLVVSKV 103
|
90
....*....|....*
gi 1490892739 814 aGGVGIDLTGASVVI 828
Cdd:cd18789 104 -GDEGIDLPEANVAI 117
|
|
| SWIM |
COG4715 |
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown]; |
16-484 |
2.72e-03 |
|
Uncharacterized protein, contains SWIM-type Zn finger domain [Function unknown];
Pssm-ID: 443750 [Multi-domain] Cd Length: 508 Bit Score: 41.35 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 16 ALLRLKRGDILGRLDRVTAERAFRLYQEHSTERIVWSGEGIEATFSRSTI-TVHIPQPKKAHItEAVCSaCGA-VDPPCF 93
Cdd:COG4715 2 ARLELTEDDIRRLAGPRIFERGREYAREGRVLDLDVEDGRLEATVQGSEDyRVRVDLDDGGDL-DSSCT-CPYgGGGFCK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 94 HAMAALLRWLDIRATLVRLGPGSAW-----RAHSRHPFIAPTQSTEDRvdlsHLTGPDLRSALELQLSLQKTGTASVRLS 168
Cdd:COG4715 80 HVVAVLLALLDQPEEGAPRQSEREAleellERLSKEELVELLLELAAE----DPELRELRRALDDSGGDYLREELLELSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 169 GQEVHIRITLPSGEHRIVVFSATVLPSALPVLKTMNRMVlEGDLEQLELSEVRLHPVLAAAWSEEGILLEPGFRLGNRSV 248
Cdd:COG4715 156 LAALSLTATLAALAPRSTLALRLALLRLLLLLLAPSSLD-GAPPGLSLALVRELLPALAERALALLLLVPAPAGLLKLRL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 249 LAATELDGRIHGRWARVGRHLCRVLDPPTPLVPFHRKGRQLLTGQAALRFLSLDHPQLRQHDWYLPRGALAKFRQPVVPK 328
Cdd:COG4715 235 LLARPGALLLSLLDLLLRLDLLLGLLLLALLLLLLLLLQLLALLLLALRTLAALLLLLRLRLRLGLAAGLALAVLLLLLL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490892739 329 TDSLVVSQKNSGTILLQPTFTAEGHDFDWEAALDLRKSGFARIEGRLVHAPDLsAFERAGFQVPRRGLHAGLRGDRLAFI 408
Cdd:COG4715 315 LLLPLPLALLALSLLLRLLLALLRLALLVLLYLLLILLLLALLLLALLLLLEL-LLLLALLLLLAEVELARLLEEALLIR 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490892739 409 RLVAETDIRVVSEDQDLADLAALLRGAKAADPGTPPGLISTLRPYQRDGVRWLWQRYLAGVGVLLADDMGLGKTHQ 484
Cdd:COG4715 394 RRLLLLLLLLLRLLDLLALLALRLLLLLLLAVLSEAEDLLLELLETLGLHRLLLLEAREELLPELAADLALLLLLE 469
|
|
| |
