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Conserved domains on  [gi|1490918568|gb|RLE48155|]
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hypothetical protein DRJ25_00545 [Candidatus Woesearchaeota archaeon]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 11448415)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
20-88 4.28e-17

Predicted transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 441383  Cd Length: 113  Bit Score: 73.53  E-value: 4.28e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490918568  20 KVFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNC----IENGRKWKYFELSKE 88
Cdd:COG1777     9 RLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESyregREDGRARKYYRLSAF 81
 
Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
20-88 4.28e-17

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 73.53  E-value: 4.28e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490918568  20 KVFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNC----IENGRKWKYFELSKE 88
Cdd:COG1777     9 RLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESyregREDGRARKYYRLSAF 81
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-99 8.41e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 66.55  E-value: 8.41e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490918568  22 FKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRkWKYFELSKEGKAILHPEEKK 99
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR-RVYYSLTDAERLLALLESLL 77
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 20-89 8.87e-13

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 61.32  E-value: 8.87e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490918568  20 KVFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRkWKYFELSKEG 89
Cdd:NF033788    3 ELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGR-WVYYRLADEH 71
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 19-78 9.48e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 55.24  E-value: 9.48e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490918568  19 QKVFKALASPTRISILKELDRRR-FTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGR 78
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
32-88 1.00e-08

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 49.90  E-value: 1.00e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1490918568   32 SILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRkWKYFELSKE 88
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGK-RVYYSLTDE 56
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-71 1.61e-08

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 49.72  E-value: 1.61e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1490918568  21 VFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLV 71
Cdd:NF033789    1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLV 51
PRK05638 PRK05638
threonine synthase; Validated
 28-93 3.95e-04

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 40.57  E-value: 3.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1490918568  28 PTRISILKELDRRRFTQSELSENLGFAIP--TIKQHLQDLEKAGLV-NCIENGRKwKYFELSKEGKAIL 93
Cdd:PRK05638  371 GTKLEILKILSEREMYGYEIWKALGKPLKyqAVYQHIKELEELGLIeEAYRKGRR-VYYKLTEKGRRLL 438
 
Name Accession Description Interval E-value
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
20-88 4.28e-17

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 73.53  E-value: 4.28e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490918568  20 KVFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNC----IENGRKWKYFELSKE 88
Cdd:COG1777     9 RLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESyregREDGRARKYYRLSAF 81
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
13-71 7.50e-15

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 67.29  E-value: 7.50e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1490918568  13 MDIKLSQKVFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLV 71
Cdd:COG4189     4 LDDEESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLI 62
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-99 8.41e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 66.55  E-value: 8.41e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1490918568  22 FKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRkWKYFELSKEGKAILHPEEKK 99
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR-RVYYSLTDAERLLALLESLL 77
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
20-89 1.40e-14

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 66.45  E-value: 1.40e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490918568  20 KVFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRkWKYFELSKEG 89
Cdd:COG0640    12 ELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGR-WVYYRLADEA 80
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 20-89 8.87e-13

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 61.32  E-value: 8.87e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490918568  20 KVFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRkWKYFELSKEG 89
Cdd:NF033788    3 ELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGR-WVYYRLADEH 71
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 19-78 9.48e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 55.24  E-value: 9.48e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490918568  19 QKVFKALASPTRISILKELDRRR-FTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGR 78
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
32-88 1.00e-08

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 49.90  E-value: 1.00e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1490918568   32 SILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRkWKYFELSKE 88
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGK-RVYYSLTDE 56
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-71 1.61e-08

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 49.72  E-value: 1.61e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1490918568  21 VFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLV 71
Cdd:NF033789    1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLV 51
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
19-83 6.81e-08

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 49.88  E-value: 6.81e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490918568  19 QKVFKALASPTRISILKEL-DRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRKWKYF 83
Cdd:COG3398    88 KKILAYLRRETPRRILLYLlENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYY 153
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 27-71 4.11e-07

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 45.13  E-value: 4.11e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1490918568  27 SPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLV 71
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
27-93 9.57e-07

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 45.66  E-value: 9.57e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490918568   27 SPTRISILKELDR-RRFTQSELSENLGFAIPTIKQHLQDLEKAGLVN---CIENGRKwKYFELSKEGKAIL 93
Cdd:smart00347   9 TPTQFLVLRILYEeGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRrepSPEDRRS-VLVSLTEEGRELI 78
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
29-71 5.90e-06

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 42.04  E-value: 5.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1490918568  29 TRISILKELDRR-RFTQSELSENLGFAIPTIKQHLQDLEKAGLV 71
Cdd:pfam13412   2 TDRKILNLLQENpRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 33-90 9.09e-06

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 42.21  E-value: 9.09e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490918568  33 ILKELDRR--RFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRKwKYFELSKEGK 90
Cdd:COG2512    20 VLELLRENggRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRE-NVVELPEDEP 78
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
27-93 2.78e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 42.26  E-value: 2.78e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490918568  27 SPTRISILKELDRR-RFTQSELSENLGFAIPTIKQHLQDLEKAGLVN---CIENGRKwKYFELSKEGKAIL 93
Cdd:COG1846    37 TPAQFRVLAALAEAgGLTQSELAERLGLTKSTVSRLLDRLEEKGLVErepDPEDRRA-VLVRLTEKGRALL 106
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
24-71 3.33e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 42.99  E-value: 3.33e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1490918568  24 ALASPTRISILKEL-DRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLV 71
Cdd:COG2345     9 ALADPTRRRILELLkRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLV 57
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
13-93 1.87e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 41.03  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490918568  13 MDIKLSQKVFKALASPTRISILKELDRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCiENGRkwkyFELSKEGKAI 92
Cdd:COG4742     1 MGSMKLDLLDFLFLSEKRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIER-DDGE----YELTTLGRLV 75


                  .
gi 1490918568  93 L 93
Cdd:COG4742    76 V 76
PRK05638 PRK05638
threonine synthase; Validated
 28-93 3.95e-04

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 40.57  E-value: 3.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1490918568  28 PTRISILKELDRRRFTQSELSENLGFAIP--TIKQHLQDLEKAGLV-NCIENGRKwKYFELSKEGKAIL 93
Cdd:PRK05638  371 GTKLEILKILSEREMYGYEIWKALGKPLKyqAVYQHIKELEELGLIeEAYRKGRR-VYYKLTEKGRRLL 438
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
22-100 4.77e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.09  E-value: 4.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490918568  22 FKALASPTRISILKEL---DRRRF-----------TQSELSENLGFAIPTIKQHLQDLEKAGLVNCIENGRKWKYFELSK 87
Cdd:COG3398     2 FWALFLGYRRITRKNVldnDTRRRiyeyirenpgiHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRYFPNSG 81

                          90
                  ....*....|...
gi 1490918568  88 EgkaiLHPEEKKI 100
Cdd:COG3398    82 T----YSEEEKKI 90
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
33-101 2.05e-03

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 36.45  E-value: 2.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1490918568  33 ILKELDRRRFTQSELSENlgfaipTIKQHLQDLEKAGLVNC----IENGRKWKYFELSKEGKAILHpEEKKIW 101
Cdd:COG1695    28 IIKELEERSGGFWKVSEG------TLYPALKRLEKEGLVESeweeSEGGPRRKYYRLTEAGREELA-EWLEEW 93
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
27-98 2.19e-03

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 38.27  E-value: 2.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1490918568  27 SPTRISILKEL-DRRRFTQSELSENLGFAIPTIKQHLQDLEKAGLVNCIEngRKWKYFELSKEGKAILH---PEEK 98
Cdd:PRK04172    5 HPNEKKVLKALkELKEATLEELAEKLGLPPEAVMRAAEWLEEKGLVKVEE--RVEEVYVLTEEGKKYAEeglPERR 78
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 45-92 3.22e-03

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 35.66  E-value: 3.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1490918568   45 SELSENLGFAIPTIKQHLQDLEKAGLVNCIengrKWKYFELSKEGKAI 92
Cdd:smart00529   2 SEIAERLNVSPPTVTEMLKKLEKMGLVEYE----PYRGITLTEKGRRL 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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