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Conserved domains on  [gi|1490960374|gb|RLE82098|]
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MAG: hypothetical protein DRJ52_02785 [Thermoprotei archaeon]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
carrier_LysW_Arch super family cl49193
alpha-aminoadipate/glutamate carrier protein LysW/ArgW; involved in lysine biosynthesis via ...
 1-36 8.49e-07

alpha-aminoadipate/glutamate carrier protein LysW/ArgW; involved in lysine biosynthesis via the alpha-aminoadipate pathway and also in arginine biosynthesis


The actual alignment was detected with superfamily member NF041070:

Pssm-ID: 468997 [Multi-domain]  Cd Length: 56  Bit Score: 45.40  E-value: 8.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1490960374   1 MKTRCPVCGAELEVPETA---QVFECPYCGTIFDTLKGS 36
Cdd:NF041070    1 MKKKCPECGADIEVPDDAldgEIVECPDCGASYEVVKSG 39
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 177-230 6.54e-03

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


:

Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 34.57  E-value: 6.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490960374 177 SEASSMAEQIVSVnyRVFKVDLKGLVHYPVWEIEYGYRGNIFKGYVDGVTGTVI 230
Cdd:pfam03413   5 EQALAIALKAVPG--AVIEAELEPEDGKLVYEVEVDPDGREYEVYIDAYTGEVL 56
 
Name Accession Description Interval E-value
carrier_LysW_Arch NF041070
alpha-aminoadipate/glutamate carrier protein LysW/ArgW; involved in lysine biosynthesis via ...
 1-36 8.49e-07

alpha-aminoadipate/glutamate carrier protein LysW/ArgW; involved in lysine biosynthesis via the alpha-aminoadipate pathway and also in arginine biosynthesis


Pssm-ID: 468997 [Multi-domain]  Cd Length: 56  Bit Score: 45.40  E-value: 8.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1490960374   1 MKTRCPVCGAELEVPETA---QVFECPYCGTIFDTLKGS 36
Cdd:NF041070    1 MKKKCPECGADIEVPDDAldgEIVECPDCGASYEVVKSG 39
RPC10 COG1996
DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger [Transcription]; ...
 1-27 4.30e-05

DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger [Transcription]; DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441599  Cd Length: 48  Bit Score: 40.45  E-value: 4.30e-05
                          10        20
                  ....*....|....*....|....*..
gi 1490960374   1 MKTRCPVCGAELEVPETAQVFECPYCG 27
Cdd:COG1996     4 VEYKCPRCGAEVELDEGTPAIRCPYCG 30
LysW cd13946
Lysine biosynthesis protein LysW; LysW functions as a carrier protein in the biosynthesis ...
 3-28 9.35e-05

Lysine biosynthesis protein LysW; LysW functions as a carrier protein in the biosynthesis pathway of lysine. The C-terminal glutamate sidechain of LysW attaches to the amino group of alpha-aminoadipate (AAA); this peptide bond formation is catalyzed by the ligase LysX. AAA remains associated with LysW throughout its biosynthetic conversion to lysine. LysW also acts to protect the amino group of glutamate in arginine biosynthesis.


Pssm-ID: 260118 [Multi-domain]  Cd Length: 54  Bit Score: 39.56  E-value: 9.35e-05
                          10        20
                  ....*....|....*....|....*....
gi 1490960374   3 TRCPVCGAELEVPETA---QVFECPYCGT 28
Cdd:cd13946     1 AKCPECGAEIELPDDAlvgEIVECPDCGA 29
lysW TIGR01206
lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown ...
 1-27 1.18e-04

lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown essential in Thermus thermophilus for an unusual pathway of Lys biosynthesis from aspartate by way of alpha-aminoadipate (AAA) rather than diaminopimelate. It is found also in Deinococcus radiodurans and Pyrococcus horikoshii, which appear to share the AAA pathway. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273499 [Multi-domain]  Cd Length: 54  Bit Score: 39.12  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|....*....
gi 1490960374   1 MKTRCPVCGAELEV--PETAQVFECPYCG 27
Cdd:TIGR01206   1 MQFECPECGAEIELenPELGELVICDECG 29
zinc_ribbon_4 pfam13717
zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as ...
 1-31 8.43e-04

zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, pfam12773.


Pssm-ID: 433426 [Multi-domain]  Cd Length: 36  Bit Score: 36.41  E-value: 8.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1490960374   1 MKTRCPVCGA-----ELEVPETAQVFECPYCGTIFD 31
Cdd:pfam13717   1 MIITCPSCKAkyridDEKIPASGVKVRCSKCGHVFR 36
PRK14890 PRK14890
putative Zn-ribbon RNA-binding protein; Provisional
 1-28 5.38e-03

putative Zn-ribbon RNA-binding protein; Provisional


Pssm-ID: 184884 [Multi-domain]  Cd Length: 59  Bit Score: 34.56  E-value: 5.38e-03
                          10        20
                  ....*....|....*....|....*...
gi 1490960374   1 MKTRCPVCGAELEVPETAQVFECPYCGT 28
Cdd:PRK14890    6 EPPKCTSCGIEIAPREKAVKFLCPNCGE 33
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 177-230 6.54e-03

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 34.57  E-value: 6.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490960374 177 SEASSMAEQIVSVnyRVFKVDLKGLVHYPVWEIEYGYRGNIFKGYVDGVTGTVI 230
Cdd:pfam03413   5 EQALAIALKAVPG--AVIEAELEPEDGKLVYEVEVDPDGREYEVYIDAYTGEVL 56
 
Name Accession Description Interval E-value
carrier_LysW_Arch NF041070
alpha-aminoadipate/glutamate carrier protein LysW/ArgW; involved in lysine biosynthesis via ...
 1-36 8.49e-07

alpha-aminoadipate/glutamate carrier protein LysW/ArgW; involved in lysine biosynthesis via the alpha-aminoadipate pathway and also in arginine biosynthesis


Pssm-ID: 468997 [Multi-domain]  Cd Length: 56  Bit Score: 45.40  E-value: 8.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1490960374   1 MKTRCPVCGAELEVPETA---QVFECPYCGTIFDTLKGS 36
Cdd:NF041070    1 MKKKCPECGADIEVPDDAldgEIVECPDCGASYEVVKSG 39
RPC10 COG1996
DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger [Transcription]; ...
 1-27 4.30e-05

DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger [Transcription]; DNA-directed RNA polymerase, subunit RPC12/RpoP, contains C4-type Zn-finger is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441599  Cd Length: 48  Bit Score: 40.45  E-value: 4.30e-05
                          10        20
                  ....*....|....*....|....*..
gi 1490960374   1 MKTRCPVCGAELEVPETAQVFECPYCG 27
Cdd:COG1996     4 VEYKCPRCGAEVELDEGTPAIRCPYCG 30
COG3877 COG3877
Predicted DNA-binding transcriptional regulator with XRE-family HTH domain, DUF2089 family ...
 1-61 6.17e-05

Predicted DNA-binding transcriptional regulator with XRE-family HTH domain, DUF2089 family [Transcription];


Pssm-ID: 443085  Cd Length: 120  Bit Score: 41.74  E-value: 6.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1490960374   1 MKTRCPVCGAELEVPEtaqvFECPYCGTifdTLKGskvdqqHFYFsptveNPYDYL----MRFIE 61
Cdd:COG3877     5 VPTKCPVCGGELIVTR----LKCPSCGT---TIEG------EFEL-----CKFARLtpeqLEFVE 51
LysW cd13946
Lysine biosynthesis protein LysW; LysW functions as a carrier protein in the biosynthesis ...
 3-28 9.35e-05

Lysine biosynthesis protein LysW; LysW functions as a carrier protein in the biosynthesis pathway of lysine. The C-terminal glutamate sidechain of LysW attaches to the amino group of alpha-aminoadipate (AAA); this peptide bond formation is catalyzed by the ligase LysX. AAA remains associated with LysW throughout its biosynthetic conversion to lysine. LysW also acts to protect the amino group of glutamate in arginine biosynthesis.


Pssm-ID: 260118 [Multi-domain]  Cd Length: 54  Bit Score: 39.56  E-value: 9.35e-05
                          10        20
                  ....*....|....*....|....*....
gi 1490960374   3 TRCPVCGAELEVPETA---QVFECPYCGT 28
Cdd:cd13946     1 AKCPECGAEIELPDDAlvgEIVECPDCGA 29
lysW TIGR01206
lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown ...
 1-27 1.18e-04

lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown essential in Thermus thermophilus for an unusual pathway of Lys biosynthesis from aspartate by way of alpha-aminoadipate (AAA) rather than diaminopimelate. It is found also in Deinococcus radiodurans and Pyrococcus horikoshii, which appear to share the AAA pathway. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273499 [Multi-domain]  Cd Length: 54  Bit Score: 39.12  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|....*....
gi 1490960374   1 MKTRCPVCGAELEV--PETAQVFECPYCG 27
Cdd:TIGR01206   1 MQFECPECGAEIELenPELGELVICDECG 29
zinc_ribbon_4 pfam13717
zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as ...
 1-31 8.43e-04

zinc-ribbon domain; This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, pfam12773.


Pssm-ID: 433426 [Multi-domain]  Cd Length: 36  Bit Score: 36.41  E-value: 8.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1490960374   1 MKTRCPVCGA-----ELEVPETAQVFECPYCGTIFD 31
Cdd:pfam13717   1 MIITCPSCKAkyridDEKIPASGVKVRCSKCGHVFR 36
OrfB_Zn_ribbon pfam07282
Putative transposase DNA-binding domain; This putative domain is found at the C-terminus of a ...
 3-31 2.06e-03

Putative transposase DNA-binding domain; This putative domain is found at the C-terminus of a large number of transposase proteins. This domain contains four conserved cysteines suggestive of a zinc binding domain. Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesize this domain is DNA-binding.


Pssm-ID: 284650 [Multi-domain]  Cd Length: 69  Bit Score: 36.04  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|....*....
gi 1490960374   3 TRCPVCGAELEVPETAQVFECPYCGTIFD 31
Cdd:pfam07282  29 KTCSVCGHKNKESLSGRTFVCPNCGFVAD 57
COG2888 COG2888
Predicted RNA-binding protein involved in translation, contains Zn-ribbon domain, DUF1610 ...
 4-28 3.69e-03

Predicted RNA-binding protein involved in translation, contains Zn-ribbon domain, DUF1610 family [General function prediction only];


Pssm-ID: 442134 [Multi-domain]  Cd Length: 52  Bit Score: 35.09  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*
gi 1490960374   4 RCPVCGAELeVPETAQVFECPYCGT 28
Cdd:COG2888     2 VCPSCGREI-APEGGVAFYCPNCGE 25
PRK14890 PRK14890
putative Zn-ribbon RNA-binding protein; Provisional
 1-28 5.38e-03

putative Zn-ribbon RNA-binding protein; Provisional


Pssm-ID: 184884 [Multi-domain]  Cd Length: 59  Bit Score: 34.56  E-value: 5.38e-03
                          10        20
                  ....*....|....*....|....*...
gi 1490960374   1 MKTRCPVCGAELEVPETAQVFECPYCGT 28
Cdd:PRK14890    6 EPPKCTSCGIEIAPREKAVKFLCPNCGE 33
PepSY pfam03413
Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory ...
 177-230 6.54e-03

Peptidase propeptide and YPEB domain; This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase _ Bacillus subtilis YPEB.


Pssm-ID: 427284 [Multi-domain]  Cd Length: 59  Bit Score: 34.57  E-value: 6.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1490960374 177 SEASSMAEQIVSVnyRVFKVDLKGLVHYPVWEIEYGYRGNIFKGYVDGVTGTVI 230
Cdd:pfam03413   5 EQALAIALKAVPG--AVIEAELEPEDGKLVYEVEVDPDGREYEVYIDAYTGEVL 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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