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Conserved domains on  [gi|1491203175|gb|RLG82539|]
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MAG: hypothetical protein DRO09_00145 [Thermoprotei archaeon]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11440453)

glycosyltransferase family 2 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
50-98 1.65e-06

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


:

Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 46.91  E-value: 1.65e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1491203175  50 ARNAIVEEAlrnEVEWLFFLDSDVILEPDALQRLLSHnlpivSALYYRR 98
Cdd:COG1216    72 ARNLGLRAA---GGDYLLFLDDDTVVEPDWLERLLAA-----ACLLIRR 112
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 50-212 5.02e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd02526:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 237  Bit Score: 43.04  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491203175  50 ARNAIVEEALRNEVEWLFFLDSDVILEPDALQRLLShnlpIVSAlyYRRHPSIGPAGPIMQPVPAAWRYAPeeVRKPGAL 129
Cdd:cd02526    63 ALNIGIKAALENGADYVLLFDQDSVPPPDMVEKLLA----YKIL--SDKNSNIGAVGPRIIDRRTGENSPG--VRKSGYK 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491203175 130 FTPIMDPPAQLFEADVIGMGACLIHTSVFKrlkppwfkwtagwgKYGLadpweeMSEDFY-------FCIRAKKeLGLKI 202
Cdd:cd02526   135 LRIQKEGEEGLKEVDFLITSGSLISLEALE--------------KVGG------FDEDLFidyvdteWCLRARS-KGYKI 193

                         170
                  ....*....|
gi 1491203175 203 MVDGSVRARH 212
Cdd:cd02526   194 YVVPDAVLKH 203
 
Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
50-98 1.65e-06

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 46.91  E-value: 1.65e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1491203175  50 ARNAIVEEAlrnEVEWLFFLDSDVILEPDALQRLLSHnlpivSALYYRR 98
Cdd:COG1216    72 ARNLGLRAA---GGDYLLFLDDDTVVEPDWLERLLAA-----ACLLIRR 112
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 50-212 5.02e-05

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 43.04  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491203175  50 ARNAIVEEALRNEVEWLFFLDSDVILEPDALQRLLShnlpIVSAlyYRRHPSIGPAGPIMQPVPAAWRYAPeeVRKPGAL 129
Cdd:cd02526    63 ALNIGIKAALENGADYVLLFDQDSVPPPDMVEKLLA----YKIL--SDKNSNIGAVGPRIIDRRTGENSPG--VRKSGYK 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491203175 130 FTPIMDPPAQLFEADVIGMGACLIHTSVFKrlkppwfkwtagwgKYGLadpweeMSEDFY-------FCIRAKKeLGLKI 202
Cdd:cd02526   135 LRIQKEGEEGLKEVDFLITSGSLISLEALE--------------KVGG------FDEDLFidyvdteWCLRARS-KGYKI 193

                         170
                  ....*....|
gi 1491203175 203 MVDGSVRARH 212
Cdd:cd02526   194 YVVPDAVLKH 203
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 21-88 8.14e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 41.72  E-value: 8.14e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1491203175  21 TMEWALAFKQLIVPMPFLMtFQRGQPLDLARNAIVEEAlrnEVEWLFFLDSDVILEPDALQRLLSHNL 88
Cdd:cd00761    40 TLEILEEYAKKDPRVIRVI-NEENQGLAAARNAGLKAA---RGEYILFLDADDLLLPDWLERLVAELL 103
Anp1 pfam03452
Anp1; The members of this family (Anp1, Van1 and Mnn9) are membrane proteins required for ...
 49-100 8.31e-05

Anp1; The members of this family (Anp1, Van1 and Mnn9) are membrane proteins required for proper Golgi function. These proteins co-localize within the cis Golgi, and that they are physically associated in two distinct complexes.


Pssm-ID: 427303  Cd Length: 265  Bit Score: 42.48  E-value: 8.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1491203175  49 LARNAIVEEALRNEVEWLFFLDSDVILEPDAL-QRLLSHNLPIVSALYYRRHP 100
Cdd:pfam03452 125 RARNWLLFSALKPEHSWVLWLDADIVETPPTLiQDLMAHDKDVIVPNVWRRYP 177
 
Name Accession Description Interval E-value
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
50-98 1.65e-06

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 46.91  E-value: 1.65e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1491203175  50 ARNAIVEEAlrnEVEWLFFLDSDVILEPDALQRLLSHnlpivSALYYRR 98
Cdd:COG1216    72 ARNLGLRAA---GGDYLLFLDDDTVVEPDWLERLLAA-----ACLLIRR 112
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 50-212 5.02e-05

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 43.04  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491203175  50 ARNAIVEEALRNEVEWLFFLDSDVILEPDALQRLLShnlpIVSAlyYRRHPSIGPAGPIMQPVPAAWRYAPeeVRKPGAL 129
Cdd:cd02526    63 ALNIGIKAALENGADYVLLFDQDSVPPPDMVEKLLA----YKIL--SDKNSNIGAVGPRIIDRRTGENSPG--VRKSGYK 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491203175 130 FTPIMDPPAQLFEADVIGMGACLIHTSVFKrlkppwfkwtagwgKYGLadpweeMSEDFY-------FCIRAKKeLGLKI 202
Cdd:cd02526   135 LRIQKEGEEGLKEVDFLITSGSLISLEALE--------------KVGG------FDEDLFidyvdteWCLRARS-KGYKI 193

                         170
                  ....*....|
gi 1491203175 203 MVDGSVRARH 212
Cdd:cd02526   194 YVVPDAVLKH 203
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 21-88 8.14e-05

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 41.72  E-value: 8.14e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1491203175  21 TMEWALAFKQLIVPMPFLMtFQRGQPLDLARNAIVEEAlrnEVEWLFFLDSDVILEPDALQRLLSHNL 88
Cdd:cd00761    40 TLEILEEYAKKDPRVIRVI-NEENQGLAAARNAGLKAA---RGEYILFLDADDLLLPDWLERLVAELL 103
Anp1 pfam03452
Anp1; The members of this family (Anp1, Van1 and Mnn9) are membrane proteins required for ...
 49-100 8.31e-05

Anp1; The members of this family (Anp1, Van1 and Mnn9) are membrane proteins required for proper Golgi function. These proteins co-localize within the cis Golgi, and that they are physically associated in two distinct complexes.


Pssm-ID: 427303  Cd Length: 265  Bit Score: 42.48  E-value: 8.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1491203175  49 LARNAIVEEALRNEVEWLFFLDSDVILEPDAL-QRLLSHNLPIVSALYYRRHP 100
Cdd:pfam03452 125 RARNWLLFSALKPEHSWVLWLDADIVETPPTLiQDLMAHDKDVIVPNVWRRYP 177
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 50-212 1.65e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 37.92  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491203175  50 ARNAIVEEAlrnEVEWLFFLDSDVILEPDALQRLLShnlpivsalYYRRHPSIGPAGPimqpvpaawryapeevrkpgal 129
Cdd:cd04186    65 GNNQGIREA---KGDYVLLLNPDTVVEPGALLELLD---------AAEQDPDVGIVGP---------------------- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491203175 130 ftpimdppaqlfeadvIGMGACL-IHTSVFKRLkppwfkwtagwgkyGLADPWEEM-SEDFYFCIRAKKeLGLKIMVDGS 207
Cdd:cd04186   111 ----------------KVSGAFLlVRREVFEEV--------------GGFDEDFFLyYEDVDLCLRARL-AGYRVLYVPQ 159


                  ....*
gi 1491203175 208 VRARH 212
Cdd:cd04186   160 AVIYH 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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