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Conserved domains on  [gi|1498198619|gb|RMG53615|]
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DUF445 domain-containing protein [Chloroflexi bacterium]

Protein Classification

DUF445 domain-containing protein( domain architecture ID 11457727)

DUF445 domain-containing protein similar to Escherichia coli protein YjiN and Bacillus subtilis membrane protein YheB

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YjiN COG2733
Uncharacterized membrane-anchored protein YjiN, DUF445 family [Function unknown];
9-413 2.05e-168

Uncharacterized membrane-anchored protein YjiN, DUF445 family [Function unknown];


:

Pssm-ID: 442039  Cd Length: 421  Bit Score: 478.19  E-value: 2.05e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619   9 ADLRRMQRVATGLLVAAGIVFVLASIWRDVAPWVPFVRAFAEAAMVGAFADWFAVTALFRHPLGLPIPHTAIIPRRKERI 88
Cdd:COG2733     6 RALRRMKRLATGLLLLAAALFLAALALPDRGPWLGYVRAFAEAAMVGALADWFAVTALFRHPLGLPIPHTAIIPRNKDRI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619  89 AVSFGRFIEHNFLDPDQITKRIRHHDPITRIAHWLRQPEHSQQVADVVADAISGLLRVIDDDDVSQALARGLNQRLESIP 168
Cdd:COG2733    86 GDSLGDFVEENFLSPEVIREKLRRVDPARRLGDWLADPENAERLARELARLLPGALDVLDDERVQAFIERALRRRLRGID 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 169 AAPLAGRLLGIFLTGGRQRDALMQLIHLLAEVIAKNET------EIRRRIAGELPPWVPR----IVDQRIYERLLEGVQR 238
Cdd:COG2733   166 LAPLLGRLLEALTEDGRHQELLDLLLDRLAEWLADNETreflaeLIREWVREESPSWLPKlpddWVDDKLADRIVRALLS 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 239 LLRELRDTPDHPLFQQFTNLIDRWIVDLQFDPQVQQQGEALKRELMAHPMVRELVQASWRDLKLTLLAQSVSPASPLRHS 318
Cdd:COG2733   246 LLEEVRADPDHPLRQAFDRWLREFIDRLQHDPETAARVEELKRELLDHPALREYLGDLWESLRAWLLEDLADPDSALRRR 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 319 IATALTRFADLLEHNAEWRDKIDTWIAAAVVAIVRRYRHAIGEFVTQTVNNWDTEVTTRKIELQFGRDLQFIRINGTIVG 398
Cdd:COG2733   326 LAAALQSLGERLAEDPALRARLNEWLRDAAARLVERYRDEIGRLISDTVKRWDAEELSRKIELKVGRDLQFIRINGTLVG 405
                         410
                  ....*....|....*
gi 1498198619 399 GLVGLIIYSVSLLFS 413
Cdd:COG2733   406 GLVGLLLYALSQLLG 420
 
Name Accession Description Interval E-value
YjiN COG2733
Uncharacterized membrane-anchored protein YjiN, DUF445 family [Function unknown];
9-413 2.05e-168

Uncharacterized membrane-anchored protein YjiN, DUF445 family [Function unknown];


Pssm-ID: 442039  Cd Length: 421  Bit Score: 478.19  E-value: 2.05e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619   9 ADLRRMQRVATGLLVAAGIVFVLASIWRDVAPWVPFVRAFAEAAMVGAFADWFAVTALFRHPLGLPIPHTAIIPRRKERI 88
Cdd:COG2733     6 RALRRMKRLATGLLLLAAALFLAALALPDRGPWLGYVRAFAEAAMVGALADWFAVTALFRHPLGLPIPHTAIIPRNKDRI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619  89 AVSFGRFIEHNFLDPDQITKRIRHHDPITRIAHWLRQPEHSQQVADVVADAISGLLRVIDDDDVSQALARGLNQRLESIP 168
Cdd:COG2733    86 GDSLGDFVEENFLSPEVIREKLRRVDPARRLGDWLADPENAERLARELARLLPGALDVLDDERVQAFIERALRRRLRGID 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 169 AAPLAGRLLGIFLTGGRQRDALMQLIHLLAEVIAKNET------EIRRRIAGELPPWVPR----IVDQRIYERLLEGVQR 238
Cdd:COG2733   166 LAPLLGRLLEALTEDGRHQELLDLLLDRLAEWLADNETreflaeLIREWVREESPSWLPKlpddWVDDKLADRIVRALLS 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 239 LLRELRDTPDHPLFQQFTNLIDRWIVDLQFDPQVQQQGEALKRELMAHPMVRELVQASWRDLKLTLLAQSVSPASPLRHS 318
Cdd:COG2733   246 LLEEVRADPDHPLRQAFDRWLREFIDRLQHDPETAARVEELKRELLDHPALREYLGDLWESLRAWLLEDLADPDSALRRR 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 319 IATALTRFADLLEHNAEWRDKIDTWIAAAVVAIVRRYRHAIGEFVTQTVNNWDTEVTTRKIELQFGRDLQFIRINGTIVG 398
Cdd:COG2733   326 LAAALQSLGERLAEDPALRARLNEWLRDAAARLVERYRDEIGRLISDTVKRWDAEELSRKIELKVGRDLQFIRINGTLVG 405
                         410
                  ....*....|....*
gi 1498198619 399 GLVGLIIYSVSLLFS 413
Cdd:COG2733   406 GLVGLLLYALSQLLG 420
DUF445 pfam04286
Protein of unknown function (DUF445); Predicted to be a membrane protein.
49-412 3.35e-134

Protein of unknown function (DUF445); Predicted to be a membrane protein.


Pssm-ID: 427840 [Multi-domain]  Cd Length: 368  Bit Score: 389.29  E-value: 3.35e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619  49 AEAAMVGAFADWFAVTALFRHPLGLPIP-HTAIIPRRKERIAVSFGRFIEHNFLDPDQITKRIRHHDPITRIAHWLRQPE 127
Cdd:pfam04286   1 AEAAMVGALADWFAVTALFRHPLGLPIPfHTAIIPRNKDRIAENLGNFVEEHLLTPEVLARKLREADPAERLGRWLADPT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 128 HSQQVADVVADAISGLLRVIDDDDVSQALARGLNQRLESIPAAPLAGRLLGIFLTGGRQRDALMQLIHLLAEVIAKNETE 207
Cdd:pfam04286  81 NAERLAREVAKLLAEILEDLDDERVQRLLKKALRRRLEEIDLAPLLGKLLELLLAEGRHQALLDDLLDRLRDWLRSEEGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 208 --IRRRIAGELPPWVPR-IVDQRIYERLLEGVQRLLRELRDTPDHPLFQQFTNLIDRWIVDLQFDPQVQQQGEALKRELM 284
Cdd:pfam04286 161 qrIAEMIDEFLEEWGPLvALLGGIAEMILRALSSLLDEVQADPDHPLRLAFDRAVRELITDLLNDPELRAEVEELKQKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 285 AHPMVRELVQASWRDLKLTLLAQSVSPASPLRHSIATALTRFADLLEHNAEWRDKIDTWIAAAVVAIVRRYRHAIGEFVT 364
Cdd:pfam04286 241 ADPAVQDYVKALWESLRSLLLDDLSDPDSALRRRISELLAEFGERLAEDPELRDKLNEHLEDAAVGLLPRYRLEIGQLIS 320
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1498198619 365 QTVNNWDTEVTTRKIELQFGRDLQFIRINGTIVGGLVGLIIYSVSLLF 412
Cdd:pfam04286 321 DTVNRWDAEELEELIELIVGRDLQFIRINGTLVGGLIGLLLHLVSLLI 368
 
Name Accession Description Interval E-value
YjiN COG2733
Uncharacterized membrane-anchored protein YjiN, DUF445 family [Function unknown];
9-413 2.05e-168

Uncharacterized membrane-anchored protein YjiN, DUF445 family [Function unknown];


Pssm-ID: 442039  Cd Length: 421  Bit Score: 478.19  E-value: 2.05e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619   9 ADLRRMQRVATGLLVAAGIVFVLASIWRDVAPWVPFVRAFAEAAMVGAFADWFAVTALFRHPLGLPIPHTAIIPRRKERI 88
Cdd:COG2733     6 RALRRMKRLATGLLLLAAALFLAALALPDRGPWLGYVRAFAEAAMVGALADWFAVTALFRHPLGLPIPHTAIIPRNKDRI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619  89 AVSFGRFIEHNFLDPDQITKRIRHHDPITRIAHWLRQPEHSQQVADVVADAISGLLRVIDDDDVSQALARGLNQRLESIP 168
Cdd:COG2733    86 GDSLGDFVEENFLSPEVIREKLRRVDPARRLGDWLADPENAERLARELARLLPGALDVLDDERVQAFIERALRRRLRGID 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 169 AAPLAGRLLGIFLTGGRQRDALMQLIHLLAEVIAKNET------EIRRRIAGELPPWVPR----IVDQRIYERLLEGVQR 238
Cdd:COG2733   166 LAPLLGRLLEALTEDGRHQELLDLLLDRLAEWLADNETreflaeLIREWVREESPSWLPKlpddWVDDKLADRIVRALLS 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 239 LLRELRDTPDHPLFQQFTNLIDRWIVDLQFDPQVQQQGEALKRELMAHPMVRELVQASWRDLKLTLLAQSVSPASPLRHS 318
Cdd:COG2733   246 LLEEVRADPDHPLRQAFDRWLREFIDRLQHDPETAARVEELKRELLDHPALREYLGDLWESLRAWLLEDLADPDSALRRR 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 319 IATALTRFADLLEHNAEWRDKIDTWIAAAVVAIVRRYRHAIGEFVTQTVNNWDTEVTTRKIELQFGRDLQFIRINGTIVG 398
Cdd:COG2733   326 LAAALQSLGERLAEDPALRARLNEWLRDAAARLVERYRDEIGRLISDTVKRWDAEELSRKIELKVGRDLQFIRINGTLVG 405
                         410
                  ....*....|....*
gi 1498198619 399 GLVGLIIYSVSLLFS 413
Cdd:COG2733   406 GLVGLLLYALSQLLG 420
DUF445 pfam04286
Protein of unknown function (DUF445); Predicted to be a membrane protein.
49-412 3.35e-134

Protein of unknown function (DUF445); Predicted to be a membrane protein.


Pssm-ID: 427840 [Multi-domain]  Cd Length: 368  Bit Score: 389.29  E-value: 3.35e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619  49 AEAAMVGAFADWFAVTALFRHPLGLPIP-HTAIIPRRKERIAVSFGRFIEHNFLDPDQITKRIRHHDPITRIAHWLRQPE 127
Cdd:pfam04286   1 AEAAMVGALADWFAVTALFRHPLGLPIPfHTAIIPRNKDRIAENLGNFVEEHLLTPEVLARKLREADPAERLGRWLADPT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 128 HSQQVADVVADAISGLLRVIDDDDVSQALARGLNQRLESIPAAPLAGRLLGIFLTGGRQRDALMQLIHLLAEVIAKNETE 207
Cdd:pfam04286  81 NAERLAREVAKLLAEILEDLDDERVQRLLKKALRRRLEEIDLAPLLGKLLELLLAEGRHQALLDDLLDRLRDWLRSEEGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 208 --IRRRIAGELPPWVPR-IVDQRIYERLLEGVQRLLRELRDTPDHPLFQQFTNLIDRWIVDLQFDPQVQQQGEALKRELM 284
Cdd:pfam04286 161 qrIAEMIDEFLEEWGPLvALLGGIAEMILRALSSLLDEVQADPDHPLRLAFDRAVRELITDLLNDPELRAEVEELKQKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 285 AHPMVRELVQASWRDLKLTLLAQSVSPASPLRHSIATALTRFADLLEHNAEWRDKIDTWIAAAVVAIVRRYRHAIGEFVT 364
Cdd:pfam04286 241 ADPAVQDYVKALWESLRSLLLDDLSDPDSALRRRISELLAEFGERLAEDPELRDKLNEHLEDAAVGLLPRYRLEIGQLIS 320
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1498198619 365 QTVNNWDTEVTTRKIELQFGRDLQFIRINGTIVGGLVGLIIYSVSLLF 412
Cdd:pfam04286 321 DTVNRWDAEELEELIELIVGRDLQFIRINGTLVGGLIGLLLHLVSLLI 368
YheB COG4399
Uncharacterized membrane protein YheB, UPF0754 family [Function unknown];
52-241 1.36e-07

Uncharacterized membrane protein YheB, UPF0754 family [Function unknown];


Pssm-ID: 443525 [Multi-domain]  Cd Length: 210  Bit Score: 51.74  E-value: 1.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619  52 AMVGAFADWFAVTALFR--HP---LGLPIPhtAIIPRRKERIAVSFGRFIEHNFLDPDQITKRirhhdpitriahwLRQP 126
Cdd:COG4399    14 ALIGYFTNWLAIKMLFRpyKPiyiGGFRLQ--GLIPKRREELAKSIGEVVEEELLTPEEILEK-------------LLTG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619 127 EHSQQVADVVADAISgllRVIDDDDVSQalarglnqrlesipaapLAGRLLGIFLTGGRQRDALMQLIHLLAEVIAKNET 206
Cdd:COG4399    79 ELKDRIRELIKLALR---EILDDKALPG-----------------LLGPLLQFFLGEPDSIRDRIQYDKLKNILAKEVEE 138
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1498198619 207 EIRRRIAGELPPWVPRI-VDQRIYERL----LEGVQRLLR 241
Cdd:COG4399   139 YLEELLEDIVEYILEALdIEQLVEERVnalsPEELEELIL 178
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
22-361 7.56e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 41.78  E-value: 7.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619   22 LVAAGIVFVLASIWRDVAPWVPFVRAFAEAAMVGAFADWFAV--------TAL----FRHPLGLPIPHTAIIPRRKERIA 89
Cdd:COG3321    811 LAAAGDAVVLPSLRRGEDELAQLLTALAQLWVAGVPVDWSALypgrgrrrVPLptypFQREDAAAALLAAALAAALAAAA 890
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619   90 VSFGRFIEHNFLDPDQITKRIRHHDPITRIAHWLRQPEHSQQVADVVADAISGLLRVIDDDDVSQALARGLNQRLESIPA 169
Cdd:COG3321    891 ALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAA 970
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619  170 APLAGRLLGIFLTGGRQRDALMQLIHLLAEVIAKNETEIRRRIAGELPPWVPRIVDQRIYERLLEGVQRLLRELRDTPDH 249
Cdd:COG3321    971 AAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAA 1050
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198619  250 PLFQQFTNLIDRWIVDLQFDPQVQQQGEALKRELMAHPMVRELVQASWRDLKLTLLAQSVSPASPLRHSIATALTRFADL 329
Cdd:COG3321   1051 LAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAAL 1130
                          330       340       350
                   ....*....|....*....|....*....|..
gi 1498198619  330 LEHNAEWRDKIDTWIAAAVVAIVRRYRHAIGE 361
Cdd:COG3321   1131 LAAAAAAAALAAAAAAAAALALAAAAAALAAA 1162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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