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Conserved domains on  [gi|1498198624|gb|RMG53620|]
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SdpI family protein [Chloroflexi bacterium]

Protein Classification

SdpI family protein( domain architecture ID 11475858)

SdpI family protein similar to Bacillus subtilis SdpI, an integral membrane protein that protects toxin-producing cells from being killed

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SdpI COG5658
Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family ...
2-211 6.07e-75

Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family [Defense mechanisms];


:

Pssm-ID: 444377 [Multi-domain]  Cd Length: 216  Bit Score: 225.10  E-value: 6.07e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198624   2 RNLRLMLIVVVLMWGFGLIMLPSIPDPAPIHWNAAGEVDGYGSPWIVALLPPIVATIMALLALVLPRIDPRGQGYTAFFR 81
Cdd:COG5658     5 WSLILSLLLILLSLILGLLAYPQLPDQVPTHWNAAGEVDGYGSKLEGAFLLPLLMLGLYLLFLVLPRIDPKKENYEKFRK 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198624  82 TYALIMNSLVLFFAGLQVITIGVAVGWPVSVPRLLCLGMSLLIVVLGNELGRVTPNYFVGIRTPWTLADPDVWRKTHRVG 161
Cdd:COG5658    85 VYRLIRVLIVLFMLVIHLVTLLAALGYEINVGRVVPLGIGLLFIVIGNYMPKVRPNYFVGIRTPWTLASEEVWRKTHRLG 164
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1498198624 162 ARLFVAGGGLAALSSLvVPEEWLFVATLLFVIVPVLATIPYSYVVWRQLR 211
Cdd:COG5658   165 GKLFVLGGLLILLAAF-LPGPWAFILLLGVILVAALVPVVYSYLLYRKEE 213
 
Name Accession Description Interval E-value
SdpI COG5658
Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family ...
2-211 6.07e-75

Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family [Defense mechanisms];


Pssm-ID: 444377 [Multi-domain]  Cd Length: 216  Bit Score: 225.10  E-value: 6.07e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198624   2 RNLRLMLIVVVLMWGFGLIMLPSIPDPAPIHWNAAGEVDGYGSPWIVALLPPIVATIMALLALVLPRIDPRGQGYTAFFR 81
Cdd:COG5658     5 WSLILSLLLILLSLILGLLAYPQLPDQVPTHWNAAGEVDGYGSKLEGAFLLPLLMLGLYLLFLVLPRIDPKKENYEKFRK 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198624  82 TYALIMNSLVLFFAGLQVITIGVAVGWPVSVPRLLCLGMSLLIVVLGNELGRVTPNYFVGIRTPWTLADPDVWRKTHRVG 161
Cdd:COG5658    85 VYRLIRVLIVLFMLVIHLVTLLAALGYEINVGRVVPLGIGLLFIVIGNYMPKVRPNYFVGIRTPWTLASEEVWRKTHRLG 164
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1498198624 162 ARLFVAGGGLAALSSLvVPEEWLFVATLLFVIVPVLATIPYSYVVWRQLR 211
Cdd:COG5658   165 GKLFVLGGLLILLAAF-LPGPWAFILLLGVILVAALVPVVYSYLLYRKEE 213
SdpI pfam13630
SdpI/YfhL protein family; This family of proteins includes the SdpI and YfhL proteins from B. ...
133-203 7.09e-19

SdpI/YfhL protein family; This family of proteins includes the SdpI and YfhL proteins from B. subtilis. The SdpI protein is a multipass integral membrane protein that protects toxin-producing cells from being killed. Killing is mediated by the exported toxic protein SdpC an extracellular protein that induces the synthesis of an immunity protein.


Pssm-ID: 463940  Cd Length: 71  Bit Score: 77.22  E-value: 7.09e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1498198624 133 RVTPNYFVGIRTPWTLADPDVWRKTHRVGARLFVAGGGLAALSSLVVPEEWLFVATLLFVIVPVLATIPYS 203
Cdd:pfam13630   1 KLKINYFVGIRTPWTLKSEETWKKAHRLAGKLWIIAGLLLLILALLLLILASTLLLLVVLLLAVIVPIIYS 71
 
Name Accession Description Interval E-value
SdpI COG5658
Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family ...
2-211 6.07e-75

Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family [Defense mechanisms];


Pssm-ID: 444377 [Multi-domain]  Cd Length: 216  Bit Score: 225.10  E-value: 6.07e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198624   2 RNLRLMLIVVVLMWGFGLIMLPSIPDPAPIHWNAAGEVDGYGSPWIVALLPPIVATIMALLALVLPRIDPRGQGYTAFFR 81
Cdd:COG5658     5 WSLILSLLLILLSLILGLLAYPQLPDQVPTHWNAAGEVDGYGSKLEGAFLLPLLMLGLYLLFLVLPRIDPKKENYEKFRK 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198624  82 TYALIMNSLVLFFAGLQVITIGVAVGWPVSVPRLLCLGMSLLIVVLGNELGRVTPNYFVGIRTPWTLADPDVWRKTHRVG 161
Cdd:COG5658    85 VYRLIRVLIVLFMLVIHLVTLLAALGYEINVGRVVPLGIGLLFIVIGNYMPKVRPNYFVGIRTPWTLASEEVWRKTHRLG 164
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1498198624 162 ARLFVAGGGLAALSSLvVPEEWLFVATLLFVIVPVLATIPYSYVVWRQLR 211
Cdd:COG5658   165 GKLFVLGGLLILLAAF-LPGPWAFILLLGVILVAALVPVVYSYLLYRKEE 213
SdpI pfam13630
SdpI/YfhL protein family; This family of proteins includes the SdpI and YfhL proteins from B. ...
133-203 7.09e-19

SdpI/YfhL protein family; This family of proteins includes the SdpI and YfhL proteins from B. subtilis. The SdpI protein is a multipass integral membrane protein that protects toxin-producing cells from being killed. Killing is mediated by the exported toxic protein SdpC an extracellular protein that induces the synthesis of an immunity protein.


Pssm-ID: 463940  Cd Length: 71  Bit Score: 77.22  E-value: 7.09e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1498198624 133 RVTPNYFVGIRTPWTLADPDVWRKTHRVGARLFVAGGGLAALSSLVVPEEWLFVATLLFVIVPVLATIPYS 203
Cdd:pfam13630   1 KLKINYFVGIRTPWTLKSEETWKKAHRLAGKLWIIAGLLLLILALLLLILASTLLLLVVLLLAVIVPIIYS 71
DUF1648 pfam07853
Domain of unknown function (DUF1648); This domain is found in proteins expressed by bacterial ...
9-57 4.10e-10

Domain of unknown function (DUF1648); This domain is found in proteins expressed by bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues. One protein containing this domain is immunity protein SdpI (swiss:O32241) from Bacillus subtilis, which provides protection for the cell against the toxic effects of its own SdpC killing factor, and also functions as a receptor/signal transduction protein.


Pssm-ID: 462289 [Multi-domain]  Cd Length: 49  Bit Score: 53.53  E-value: 4.10e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1498198624   9 IVVVLMWGFGLIMLPSIPDPAPIHWNAAGEVDGYGSPWIVALLPPIVAT 57
Cdd:pfam07853   1 LLLLLTLIVGLIAYPSLPDQIPTHWNASGEPDGYGSKLFGLFLLPLLML 49
COG4194 COG4194
Uncharacterized membrane protein, DUF1648 family [Function unknown];
8-128 1.12e-05

Uncharacterized membrane protein, DUF1648 family [Function unknown];


Pssm-ID: 443348 [Multi-domain]  Cd Length: 366  Bit Score: 45.12  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198624   8 LIVVVLMWGFGLIMLPSIPDPAPIHWNAAGEVDGYGSP-WIVALLPPIVATIMALLALVL--------PRIDP------- 71
Cdd:COG4194   140 LLIIIATLVVGLLGYPSLPDRIPTHWGFSGEPDAWAPKsPGSVFSPVLIQLGMTALLLFInvvilrskPQLDPanpaasa 219
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1498198624  72 -------RGQGYTAFFRTYALimnSLVLFFAGLQVITIGVAVGWPVSVPRLLCLGMSLLIVVLG 128
Cdd:COG4194   220 ernlkfrRAWSILLLITSILL---NLLLLLIQLSVWGPIAPLPLLLILVLIPVLLILLGALVLS 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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