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Conserved domains on  [gi|1562687284|gb|RXI24598|]
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MAG: acyltransferase [Candidatus Amulumruptor caecigallinarius]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 106732)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT super family cl17185
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 1-158 2.74e-61

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


The actual alignment was detected with superfamily member cd07988:

Pssm-ID: 473073 [Multi-domain]  Cd Length: 163  Bit Score: 187.04  E-value: 2.74e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284   1 MFGWEVSITVPDFPRCIICVAPHTSNWDFVLGKLAYASVGRKAGFLMKSSWFFFPLGCLFRAIGGIPVERKNKsVSLVEV 80
Cdd:cd07988     7 LSGWRIEGEPPNKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRA-GGLVEQ 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1562687284  81 LTERLRAASRLAIAITPEGTRSRTDRWHTGFLAIARNAGIPVVLGVLDYGAKRILIETVYGPSGDTEADIRAIKDYYK 158
Cdd:cd07988    86 VVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRAFYR 163
 
Name Accession Description Interval E-value
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 1-158 2.74e-61

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 187.04  E-value: 2.74e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284   1 MFGWEVSITVPDFPRCIICVAPHTSNWDFVLGKLAYASVGRKAGFLMKSSWFFFPLGCLFRAIGGIPVERKNKsVSLVEV 80
Cdd:cd07988     7 LSGWRIEGEPPNKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRA-GGLVEQ 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1562687284  81 LTERLRAASRLAIAITPEGTRSRTDRWHTGFLAIARNAGIPVVLGVLDYGAKRILIETVYGPSGDTEADIRAIKDYYK 158
Cdd:cd07988    86 VVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRAFYR 163
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-156 1.39e-27

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 102.78  E-value: 1.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284   1 MFGWEVSIT----VPDFPRCIIcVAPHTSNWDFVLgklAYASVGRKAGFLMKSSWFFFP-LGCLFRAIGGIPVERKNKSV 75
Cdd:COG0204    26 LLGVRVRVEglenLPADGPVLI-VANHQSWLDILL---LLAALPRPVRFVAKKELFKIPlLGWLLRALGAIPVDRSKRRA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  76 SL--VEVLTERLRAasRLAIAITPEGTRSRTDR---WHTGFLAIARNAGIPVVLGVLDYGA---------KRILIETVYG 141
Cdd:COG0204   102 ALraLRQAVEALKA--GESLVIFPEGTRSPDGRllpFKTGAARLALEAGVPIVPVAIDGTEralpkgflpRPGKVTVRIG 179

                         170
                  ....*....|....*....
gi 1562687284 142 P----SGDTEADIRAIKDY 156
Cdd:COG0204   180 PpidpSDLEGEDRRELAER 198
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 17-123 7.75e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 80.09  E-value: 7.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284   17 IICVAPHTSNWDFVLGKLAYASVGRKAGFLMKSSWFFFPL-GCLFRAIGGIPVERKNKS--VSLVEVLTERLRaaSRLAI 93
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLlGWLLRLLGAIFIDRSNGRkaRAALREAVELLK--EGEWL 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1562687284   94 AITPEGTRSRTDR---WHTGFLAIARNAGIPVV 123
Cdd:smart00563  79 LIFPEGTRSRPGKllpFKKGAARLALEAGVPIV 111
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 17-123 9.45e-17

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 72.31  E-value: 9.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  17 IICVAPHTSNWD-FVLGKLAYASVGRKAgFLMKSSWFFFPL-GCLFRAIGGIPVERKNKSV--SLVEVLTERLRAASRLA 92
Cdd:pfam01553  16 AIVVANHQSYLDvLLLSLALYKRGRPLV-FVAKKELFDIPLvGWLMRLLGCIFIDRKNRKDaaGTLEYLVELLREGKLVV 94

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1562687284  93 IAitPEGTRSRTDRWH---TGFLAIARNAGIPVV 123
Cdd:pfam01553  95 IF--PEGTRSREGELLpfkKGAFRLAIEAGVPIV 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 18-123 3.54e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 52.35  E-value: 3.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  18 ICVAPHTSNWD-FVLGklayASVGRKAGFLMKSSWFFFP-LGCLFRAIGGIPVERKNKS--VSLVEVLTERLRaaSRLAI 93
Cdd:TIGR00530  19 LVVANHQSNLDpLTLS----AAFPPPIVFIAKKELKWIPfFGIMLWLTGAIFIDRENIRaiATALKAAIEVLK--QGRSI 92

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1562687284  94 AITPEGTRSRTDRWH---TGFLAIARNAGIPVV 123
Cdd:TIGR00530  93 GVFPEGTRSRGRDILpfkKGAFHIAIKAGVPIL 125
 
Name Accession Description Interval E-value
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 1-158 2.74e-61

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 187.04  E-value: 2.74e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284   1 MFGWEVSITVPDFPRCIICVAPHTSNWDFVLGKLAYASVGRKAGFLMKSSWFFFPLGCLFRAIGGIPVERKNKsVSLVEV 80
Cdd:cd07988     7 LSGWRIEGEPPNKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRA-GGLVEQ 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1562687284  81 LTERLRAASRLAIAITPEGTRSRTDRWHTGFLAIARNAGIPVVLGVLDYGAKRILIETVYGPSGDTEADIRAIKDYYK 158
Cdd:cd07988    86 VVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRAFYR 163
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-156 1.39e-27

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 102.78  E-value: 1.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284   1 MFGWEVSIT----VPDFPRCIIcVAPHTSNWDFVLgklAYASVGRKAGFLMKSSWFFFP-LGCLFRAIGGIPVERKNKSV 75
Cdd:COG0204    26 LLGVRVRVEglenLPADGPVLI-VANHQSWLDILL---LLAALPRPVRFVAKKELFKIPlLGWLLRALGAIPVDRSKRRA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  76 SL--VEVLTERLRAasRLAIAITPEGTRSRTDR---WHTGFLAIARNAGIPVVLGVLDYGA---------KRILIETVYG 141
Cdd:COG0204   102 ALraLRQAVEALKA--GESLVIFPEGTRSPDGRllpFKTGAARLALEAGVPIVPVAIDGTEralpkgflpRPGKVTVRIG 179

                         170
                  ....*....|....*....
gi 1562687284 142 P----SGDTEADIRAIKDY 156
Cdd:COG0204   180 PpidpSDLEGEDRRELAER 198
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 17-123 7.75e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 80.09  E-value: 7.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284   17 IICVAPHTSNWDFVLGKLAYASVGRKAGFLMKSSWFFFPL-GCLFRAIGGIPVERKNKS--VSLVEVLTERLRaaSRLAI 93
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLlGWLLRLLGAIFIDRSNGRkaRAALREAVELLK--EGEWL 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1562687284   94 AITPEGTRSRTDR---WHTGFLAIARNAGIPVV 123
Cdd:smart00563  79 LIFPEGTRSRPGKllpFKKGAARLALEAGVPIV 111
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 17-123 9.45e-17

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 72.31  E-value: 9.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  17 IICVAPHTSNWD-FVLGKLAYASVGRKAgFLMKSSWFFFPL-GCLFRAIGGIPVERKNKSV--SLVEVLTERLRAASRLA 92
Cdd:pfam01553  16 AIVVANHQSYLDvLLLSLALYKRGRPLV-FVAKKELFDIPLvGWLMRLLGCIFIDRKNRKDaaGTLEYLVELLREGKLVV 94

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1562687284  93 IAitPEGTRSRTDRWH---TGFLAIARNAGIPVV 123
Cdd:pfam01553  95 IF--PEGTRSREGELLpfkKGAFRLAIEAGVPIV 126
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 1-123 1.06e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 68.07  E-value: 1.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284   1 MFGWEVSIT----VPDFPRCIIcVAPHTSNWD-FVLGklayASVGRKAGFLMKSSWFFFP-LGCLFRAIGGIPVERKN-- 72
Cdd:cd07989     7 LLGVRVRVEglenLPPKGPVII-VANHQSYLDpLVLG----AALPRPIRFVAKKELFKIPfLGWLLRLLGAIPIDRGNgr 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1562687284  73 KSVSLVEVLTERLRAASRLAIAitPEGTRSRTD---RWHTGFLAIARNAGIPVV 123
Cdd:cd07989    82 SAREALREAIEALKEGESVVIF--PEGTRSRDGellPFKSGAFRLAKEAGVPIV 133
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 17-130 1.04e-09

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 54.73  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  17 IICVAPHTSNWDFVLGKLAYASVGRKAGF--LMKSSWFFFPlgcLFRAIGGIPVERKN--KSVSLVEVLTERLRAASRlA 92
Cdd:cd06551    28 VLFVSNHSSWWDGLILFLLLERGLRRDVYglMDEELLERYP---FFTRLGAFSVDRDSprSAAKSLKYVARLLSKPGS-V 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1562687284  93 IAITPEGTRSRTD----RWHTGFLAIARNAGIPVVLGVLDYG 130
Cdd:cd06551   104 VWIFPEGTRTRRDkrplQFKPGVAHLAEKAGVPIVPVALRYT 145
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 18-123 3.54e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 52.35  E-value: 3.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  18 ICVAPHTSNWD-FVLGklayASVGRKAGFLMKSSWFFFP-LGCLFRAIGGIPVERKNKS--VSLVEVLTERLRaaSRLAI 93
Cdd:TIGR00530  19 LVVANHQSNLDpLTLS----AAFPPPIVFIAKKELKWIPfFGIMLWLTGAIFIDRENIRaiATALKAAIEVLK--QGRSI 92

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1562687284  94 AITPEGTRSRTDRWH---TGFLAIARNAGIPVV 123
Cdd:TIGR00530  93 GVFPEGTRSRGRDILpfkKGAFHIAIKAGVPIL 125
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 11-100 1.03e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 46.83  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  11 PDFPRCIICVAPHTSNWD--FVLGKLAYASVGRKAGFLMksswfffP-LGCLFRAIGGIPVER--KNKSVSLVEVLTERL 85
Cdd:cd07991    20 DPPEAPRIIVANHTSFIDplILFSDLFPSIVAKKELGKL-------PfIGTILRALGCIFVDRsePKDRKKVVEEIKERA 92

                          90
                  ....*....|....*
gi 1562687284  86 RAASRLAIAITPEGT 100
Cdd:cd07991    93 TDPNWPPILIFPEGT 107
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 10-100 2.79e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 45.72  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  10 VPDFPRCIICvAPHtSNwDFVLGKLAYASVGRKAGFLMKSSWFFFPL-GCLFRAIGGIPVERKNKSVS----------LV 78
Cdd:cd07992    24 VPKDGPVIFL-GNH-PN-ALIDPLLLAATLRRPVRFLAKADLFKNPLiGWLLESFGAIPVYRPKDLARggigkisnaaVF 100

                          90       100
                  ....*....|....*....|..
gi 1562687284  79 EVLTERLRAASrlAIAITPEGT 100
Cdd:cd07992   101 DAVGEALKAGG--AIGIFPEGG 120
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 10-123 2.74e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 36.88  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562687284  10 VPDFPRCIIcVAPH-TSNWDFVLgkLAYASV----GRKAGFLMKSSWFFFP-LGCLFRAIGGIPVERKNksvsLVEVLTE 83
Cdd:cd07987    16 IPDEGPALL-VHPHgGLPIDGAL--LAAAFLllfpGRLPRALADHFLFPLPgLRDLLRRLGAVPGSREN----CVRLLRE 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1562687284  84 RLraasrlAIAITPEGTR----SRTDR------WHTGFLAIARNAGIPVV 123
Cdd:cd07987    89 GE------LVLIFPGGARealkSKREEyyllwkKRKGFARLALRAGAPIV 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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