notch homolog 1b, partial [Nothobranchius pienaari]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
450-663 | 5.00e-39 | ||||
Ankyrin repeat [Signal transduction mechanisms]; : Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 147.02 E-value: 5.00e-39
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JMTM_Notch1 | cd21702 | juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ... |
264-343 | 2.96e-33 | ||||
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand. : Pssm-ID: 411985 Cd Length: 80 Bit Score: 122.98 E-value: 2.96e-33
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NOD | pfam06816 | NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ... |
109-164 | 1.79e-27 | ||||
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated. : Pssm-ID: 462014 Cd Length: 56 Bit Score: 105.67 E-value: 1.79e-27
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NODP | pfam07684 | NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ... |
215-267 | 3.68e-23 | ||||
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated. : Pssm-ID: 462229 Cd Length: 59 Bit Score: 93.49 E-value: 3.68e-23
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
69-105 | 1.30e-13 | ||||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. : Pssm-ID: 459658 Cd Length: 35 Bit Score: 65.63 E-value: 1.30e-13
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
28-65 | 1.41e-13 | ||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. : Pssm-ID: 197463 Cd Length: 38 Bit Score: 65.43 E-value: 1.41e-13
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
1-24 | 1.16e-07 | ||||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. : Pssm-ID: 459658 Cd Length: 35 Bit Score: 48.68 E-value: 1.16e-07
|
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Name | Accession | Description | Interval | E-value | ||||
ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
450-663 | 5.00e-39 | ||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 147.02 E-value: 5.00e-39
|
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JMTM_Notch1 | cd21702 | juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ... |
264-343 | 2.96e-33 | ||||
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand. Pssm-ID: 411985 Cd Length: 80 Bit Score: 122.98 E-value: 2.96e-33
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NOD | pfam06816 | NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ... |
109-164 | 1.79e-27 | ||||
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated. Pssm-ID: 462014 Cd Length: 56 Bit Score: 105.67 E-value: 1.79e-27
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NODP | pfam07684 | NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ... |
215-267 | 3.68e-23 | ||||
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated. Pssm-ID: 462229 Cd Length: 59 Bit Score: 93.49 E-value: 3.68e-23
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
477-570 | 2.76e-17 | ||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 77.85 E-value: 2.76e-17
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
69-105 | 1.30e-13 | ||||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 65.63 E-value: 1.30e-13
|
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
28-65 | 1.41e-13 | ||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 65.43 E-value: 1.41e-13
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
31-66 | 1.93e-13 | ||||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 65.24 E-value: 1.93e-13
|
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
65-105 | 2.65e-13 | ||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 64.65 E-value: 2.65e-13
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
417-625 | 1.91e-12 | ||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 70.82 E-value: 1.91e-12
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TRPV5-6 | cd22192 | Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
473-633 | 5.01e-11 | ||||
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues. Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 66.57 E-value: 5.01e-11
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
1-24 | 1.16e-07 | ||||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 48.68 E-value: 1.16e-07
|
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
1-23 | 5.38e-07 | ||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 46.94 E-value: 5.38e-07
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Name | Accession | Description | Interval | E-value | |||||
ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
450-663 | 5.00e-39 | |||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 147.02 E-value: 5.00e-39
|
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
417-637 | 6.73e-39 | |||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 146.64 E-value: 6.73e-39
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
452-663 | 7.51e-38 | |||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 143.94 E-value: 7.51e-38
|
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JMTM_Notch1 | cd21702 | juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ... |
264-343 | 2.96e-33 | |||||
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand. Pssm-ID: 411985 Cd Length: 80 Bit Score: 122.98 E-value: 2.96e-33
|
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
417-610 | 1.09e-32 | |||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 128.92 E-value: 1.09e-32
|
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NOD | pfam06816 | NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ... |
109-164 | 1.79e-27 | |||||
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated. Pssm-ID: 462014 Cd Length: 56 Bit Score: 105.67 E-value: 1.79e-27
|
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
455-657 | 9.68e-27 | |||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 111.58 E-value: 9.68e-27
|
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NODP | pfam07684 | NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ... |
215-267 | 3.68e-23 | |||||
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated. Pssm-ID: 462229 Cd Length: 59 Bit Score: 93.49 E-value: 3.68e-23
|
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
477-570 | 2.76e-17 | |||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 77.85 E-value: 2.76e-17
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JMTM_Notch | cd21701 | juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ... |
259-341 | 2.63e-16 | |||||
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand. Pssm-ID: 411984 Cd Length: 85 Bit Score: 74.72 E-value: 2.63e-16
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
492-658 | 7.26e-16 | |||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 79.23 E-value: 7.26e-16
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JMTM_Notch3 | cd21704 | juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ... |
254-339 | 2.88e-14 | |||||
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand. Pssm-ID: 411987 Cd Length: 90 Bit Score: 69.39 E-value: 2.88e-14
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
69-105 | 1.30e-13 | |||||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 65.63 E-value: 1.30e-13
|
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JMTM_Notch2 | cd21703 | juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ... |
258-341 | 1.34e-13 | |||||
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand. Pssm-ID: 411986 Cd Length: 82 Bit Score: 67.09 E-value: 1.34e-13
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
28-65 | 1.41e-13 | |||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 65.43 E-value: 1.41e-13
|
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
31-66 | 1.93e-13 | |||||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 65.24 E-value: 1.93e-13
|
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
65-105 | 2.65e-13 | |||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 64.65 E-value: 2.65e-13
|
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JMTM_Notch4 | cd21705 | juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ... |
258-342 | 6.10e-13 | |||||
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand. Pssm-ID: 411988 Cd Length: 92 Bit Score: 65.49 E-value: 6.10e-13
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
544-636 | 1.41e-12 | |||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 1.41e-12
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
417-625 | 1.91e-12 | |||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 70.82 E-value: 1.91e-12
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
463-631 | 1.62e-11 | |||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 67.74 E-value: 1.62e-11
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TRPV5-6 | cd22192 | Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
473-633 | 5.01e-11 | |||||
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues. Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 66.57 E-value: 5.01e-11
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PHA02878 | PHA02878 | ankyrin repeat protein; Provisional |
462-633 | 1.14e-10 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 65.29 E-value: 1.14e-10
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
417-627 | 3.55e-10 | |||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 63.51 E-value: 3.55e-10
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
477-657 | 1.95e-09 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 61.22 E-value: 1.95e-09
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Ank_5 | pfam13857 | Ankyrin repeats (many copies); |
462-513 | 2.81e-09 | |||||
Ankyrin repeats (many copies); Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 53.89 E-value: 2.81e-09
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PHA02876 | PHA02876 | ankyrin repeat protein; Provisional |
416-688 | 3.79e-09 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 60.85 E-value: 3.79e-09
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PHA02875 | PHA02875 | ankyrin repeat protein; Provisional |
467-658 | 4.27e-09 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 60.00 E-value: 4.27e-09
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PLN03192 | PLN03192 | Voltage-dependent potassium channel; Provisional |
469-607 | 1.17e-08 | |||||
Voltage-dependent potassium channel; Provisional Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 59.11 E-value: 1.17e-08
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
411-503 | 2.13e-08 | |||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 52.43 E-value: 2.13e-08
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
592-657 | 1.01e-07 | |||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 50.50 E-value: 1.01e-07
|
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Notch | pfam00066 | LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ... |
1-24 | 1.16e-07 | |||||
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase. Pssm-ID: 459658 Cd Length: 35 Bit Score: 48.68 E-value: 1.16e-07
|
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
453-531 | 1.72e-07 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 55.06 E-value: 1.72e-07
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PHA02874 | PHA02874 | ankyrin repeat protein; Provisional |
417-642 | 3.44e-07 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 53.81 E-value: 3.44e-07
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Ank_4 | pfam13637 | Ankyrin repeats (many copies); |
475-526 | 4.39e-07 | |||||
Ankyrin repeats (many copies); Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.65 E-value: 4.39e-07
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TRPV3 | cd22194 | Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
473-640 | 4.47e-07 | |||||
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 53.99 E-value: 4.47e-07
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PHA02876 | PHA02876 | ankyrin repeat protein; Provisional |
455-642 | 4.60e-07 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 53.91 E-value: 4.60e-07
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PHA02876 | PHA02876 | ankyrin repeat protein; Provisional |
492-633 | 4.84e-07 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 53.91 E-value: 4.84e-07
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
1-23 | 5.38e-07 | |||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 46.94 E-value: 5.38e-07
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
417-628 | 9.14e-07 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 52.75 E-value: 9.14e-07
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
447-640 | 1.35e-06 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 51.97 E-value: 1.35e-06
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JMTM_dNotch | cd21706 | juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ... |
259-327 | 3.62e-06 | |||||
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand. Pssm-ID: 411989 Cd Length: 90 Bit Score: 46.10 E-value: 3.62e-06
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PHA02874 | PHA02874 | ankyrin repeat protein; Provisional |
487-631 | 4.91e-06 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 50.35 E-value: 4.91e-06
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PHA02874 | PHA02874 | ankyrin repeat protein; Provisional |
523-660 | 1.03e-05 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 49.19 E-value: 1.03e-05
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TRPV | cd21882 | Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
472-647 | 2.93e-05 | |||||
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic). Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 47.95 E-value: 2.93e-05
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Ank_5 | pfam13857 | Ankyrin repeats (many copies); |
492-547 | 4.85e-05 | |||||
Ankyrin repeats (many copies); Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.95 E-value: 4.85e-05
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PHA02876 | PHA02876 | ankyrin repeat protein; Provisional |
467-631 | 1.03e-04 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 46.21 E-value: 1.03e-04
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PTZ00322 | PTZ00322 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
591-692 | 1.44e-04 | |||||
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 46.04 E-value: 1.44e-04
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PHA02874 | PHA02874 | ankyrin repeat protein; Provisional |
454-658 | 1.93e-04 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 45.34 E-value: 1.93e-04
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PTZ00322 | PTZ00322 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
467-535 | 2.07e-04 | |||||
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.27 E-value: 2.07e-04
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
526-631 | 2.37e-04 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 44.66 E-value: 2.37e-04
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Ank_3 | pfam13606 | Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
473-501 | 3.08e-04 | |||||
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 38.78 E-value: 3.08e-04
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Ank | pfam00023 | Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
473-504 | 3.09e-04 | |||||
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity. Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.19 E-value: 3.09e-04
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PHA02878 | PHA02878 | ankyrin repeat protein; Provisional |
454-661 | 3.14e-04 | |||||
ankyrin repeat protein; Provisional Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 44.49 E-value: 3.14e-04
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TRPV1-4 | cd22193 | Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
473-646 | 3.98e-04 | |||||
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 44.40 E-value: 3.98e-04
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PHA02946 | PHA02946 | ankyin-like protein; Provisional |
423-578 | 1.55e-03 | |||||
ankyin-like protein; Provisional Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 42.35 E-value: 1.55e-03
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Ank | pfam00023 | Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
539-571 | 4.23e-03 | |||||
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity. Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.73 E-value: 4.23e-03
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PHA02917 | PHA02917 | ankyrin-like protein; Provisional |
467-514 | 6.11e-03 | |||||
ankyrin-like protein; Provisional Pssm-ID: 165231 [Multi-domain] Cd Length: 661 Bit Score: 40.75 E-value: 6.11e-03
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PHA02736 | PHA02736 | Viral ankyrin protein; Provisional |
453-547 | 6.52e-03 | |||||
Viral ankyrin protein; Provisional Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 38.32 E-value: 6.52e-03
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Blast search parameters | ||||
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