Anti-sigma regulatory factor (Ser/Thr protein kinase) [Ruminococcaceae bacterium YRB3002]
ATP-binding protein( domain architecture ID 10005496)
ATP-binding protein with a histidine kinase-like ATPase domain, similar to serine/threonine-protein kinase BtrW, which phosphorylates and inactivates its specific antagonist protein BtrV and may function as a negative regulator of sigma-B activity
List of domain hits
Name | Accession | Description | Interval | E-value | |||
RsbW | COG2172 | Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
3-135 | 3.86e-27 | |||
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; : Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 97.68 E-value: 3.86e-27
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Name | Accession | Description | Interval | E-value | |||
RsbW | COG2172 | Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
3-135 | 3.86e-27 | |||
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 97.68 E-value: 3.86e-27
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HATPase_c_2 | pfam13581 | Histidine kinase-like ATPase domain; |
11-133 | 4.43e-24 | |||
Histidine kinase-like ATPase domain; Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 89.66 E-value: 4.43e-24
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HATPase_RsbW-like | cd16936 | Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
40-133 | 7.49e-20 | |||
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B. Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 77.69 E-value: 7.49e-20
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PRK04069 | PRK04069 | serine-protein kinase RsbW; Provisional |
34-134 | 8.15e-06 | |||
serine-protein kinase RsbW; Provisional Pssm-ID: 235217 [Multi-domain] Cd Length: 161 Bit Score: 42.99 E-value: 8.15e-06
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Name | Accession | Description | Interval | E-value | |||
RsbW | COG2172 | Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
3-135 | 3.86e-27 | |||
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 97.68 E-value: 3.86e-27
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HATPase_c_2 | pfam13581 | Histidine kinase-like ATPase domain; |
11-133 | 4.43e-24 | |||
Histidine kinase-like ATPase domain; Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 89.66 E-value: 4.43e-24
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HATPase_RsbW-like | cd16936 | Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
40-133 | 7.49e-20 | |||
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B. Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 77.69 E-value: 7.49e-20
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PRK04069 | PRK04069 | serine-protein kinase RsbW; Provisional |
34-134 | 8.15e-06 | |||
serine-protein kinase RsbW; Provisional Pssm-ID: 235217 [Multi-domain] Cd Length: 161 Bit Score: 42.99 E-value: 8.15e-06
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Blast search parameters | ||||
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