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Conserved domains on  [gi|1089564395|emb|SDX14721|]
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UDP-N-acetylmuramate dehydrogenase [Myxococcus xanthus]

Protein Classification

UDP-N-acetylmuramate dehydrogenase( domain architecture ID 11487379)

UDP-N-acetylmuramate dehydrogenase is responsible for the synthesis of UDP-N-acetylmuramic acid in bacterial cell wall biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14652 PRK14652
UDP-N-acetylmuramate dehydrogenase;
3-310 6.72e-168

UDP-N-acetylmuramate dehydrogenase;


:

Pssm-ID: 237777 [Multi-domain]  Cd Length: 302  Bit Score: 468.20  E-value: 6.72e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395   3 EAGVKTALAARVESlggcEVKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGV 82
Cdd:PRK14652    3 EATWRDEIARRVRG----EVLRDAPLAPRTAVRVGGPADLLVRPADPDALSALLRAVRELGVPLSILGGGANTLVADAGV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  83 PGLTLKLPGDLFPEVADvgpeEGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAV 162
Cdd:PRK14652   79 RGVVLRLPQDFPGESTD----GGRLVLGAGAPISRLPARAHAHGLVGMEFLAGIPGTLGGAVAMNAGTKLGEMKDVVTAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 163 EVATADGVGWLTKAQVPYSYRHSELPPGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHA 242
Cdd:PRK14652  155 ELATADGAGFVPAAALGYAYRTCRLPPGAVITRVEVRLRPGDVAASEALMRADRERRRRTQPLDRPTFGSTFTNPPGDYA 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1089564395 243 GRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLGDFL 310
Cdd:PRK14652  235 GRLVEAVGLKGHRVGGAIWSPVHANFVTNLGGATARDVLALVRLARARVKERFGIALETEVRLLGEFL 302
 
Name Accession Description Interval E-value
PRK14652 PRK14652
UDP-N-acetylmuramate dehydrogenase;
3-310 6.72e-168

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237777 [Multi-domain]  Cd Length: 302  Bit Score: 468.20  E-value: 6.72e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395   3 EAGVKTALAARVESlggcEVKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGV 82
Cdd:PRK14652    3 EATWRDEIARRVRG----EVLRDAPLAPRTAVRVGGPADLLVRPADPDALSALLRAVRELGVPLSILGGGANTLVADAGV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  83 PGLTLKLPGDLFPEVADvgpeEGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAV 162
Cdd:PRK14652   79 RGVVLRLPQDFPGESTD----GGRLVLGAGAPISRLPARAHAHGLVGMEFLAGIPGTLGGAVAMNAGTKLGEMKDVVTAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 163 EVATADGVGWLTKAQVPYSYRHSELPPGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHA 242
Cdd:PRK14652  155 ELATADGAGFVPAAALGYAYRTCRLPPGAVITRVEVRLRPGDVAASEALMRADRERRRRTQPLDRPTFGSTFTNPPGDYA 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1089564395 243 GRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLGDFL 310
Cdd:PRK14652  235 GRLVEAVGLKGHRVGGAIWSPVHANFVTNLGGATARDVLALVRLARARVKERFGIALETEVRLLGEFL 302
MurB COG0812
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ...
 26-306 1.84e-114

UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440574 [Multi-domain]  Cd Length: 279  Bit Score: 331.59  E-value: 1.84e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  26 EPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPGDLFPEVADvgpeEG 105
Cdd:COG0812     1 EPLAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDGFDGLVIRLGRLKGIEVDD----GV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 106 RLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADG-VGWLTKAQVPYSYRH 184
Cdd:COG0812    77 LVTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLDRTGeVRTLSAEECGFGYRD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 185 SELP-PGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGRAQVST 263
Cdd:COG0812   157 SIFKrERYIILSVTFRLKKGDPAEIAAVMDAVLAIRRSKQPLELPSAGSFFKNPPGDSAGWLIEQAGLKGYRIGGAQVSE 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1089564395 264 LHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRL 306
Cdd:COG0812   237 KHANFLVNRGGATAADVLALIEEVQARVKEKFGVELEPEVRII 279
murB TIGR00179
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ...
 28-307 9.07e-81

UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 272945 [Multi-domain]  Cd Length: 284  Bit Score: 246.21  E-value: 9.07e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  28 LAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLpGDLFPEVADvgpEEGRL 107
Cdd:TIGR00179   1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINL-GKGIDIEDD---EGEYV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 108 TLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADG-VGWLTKAQVPYSYRHSE 186
Cdd:TIGR00179  77 HVGGGENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATILLATGkTEWLTNEQLGFGYRTSI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 187 LPP--GGVVTRVRFALRKGDVVAS-----KAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGRA 259
Cdd:TIGR00179 157 FQHkyVGLVLKAEFQLTLGFGTRLdpetiTAQQVFNKVCRMRTSHYPDPNAGSFFKNPSPNHAGRLIEECGLKGYQIGGA 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1089564395 260 QVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLG 307
Cdd:TIGR00179 237 AVSKQHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEPEVKIIG 284
MurB_C pfam02873
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ...
 209-306 3.95e-45

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 460730 [Multi-domain]  Cd Length: 99  Bit Score: 148.65  E-value: 3.95e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 209 KAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQ 288
Cdd:pfam02873   2 RAAMLELRRRRLAKQPLDPPSAGSFFKNPVGHSAGWLIEQAGLKGYRIGGAQVSEKHANFLVNTGGATAADVLALIEEVR 81

                          90
                  ....*....|....*...
gi 1089564395 289 QRVLEQSGVDMKPEVKRL 306
Cdd:pfam02873  82 ERVKEKFGVELEPEVRII 99
 
Name Accession Description Interval E-value
PRK14652 PRK14652
UDP-N-acetylmuramate dehydrogenase;
3-310 6.72e-168

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237777 [Multi-domain]  Cd Length: 302  Bit Score: 468.20  E-value: 6.72e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395   3 EAGVKTALAARVESlggcEVKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGV 82
Cdd:PRK14652    3 EATWRDEIARRVRG----EVLRDAPLAPRTAVRVGGPADLLVRPADPDALSALLRAVRELGVPLSILGGGANTLVADAGV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  83 PGLTLKLPGDLFPEVADvgpeEGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAV 162
Cdd:PRK14652   79 RGVVLRLPQDFPGESTD----GGRLVLGAGAPISRLPARAHAHGLVGMEFLAGIPGTLGGAVAMNAGTKLGEMKDVVTAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 163 EVATADGVGWLTKAQVPYSYRHSELPPGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHA 242
Cdd:PRK14652  155 ELATADGAGFVPAAALGYAYRTCRLPPGAVITRVEVRLRPGDVAASEALMRADRERRRRTQPLDRPTFGSTFTNPPGDYA 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1089564395 243 GRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLGDFL 310
Cdd:PRK14652  235 GRLVEAVGLKGHRVGGAIWSPVHANFVTNLGGATARDVLALVRLARARVKERFGIALETEVRLLGEFL 302
murB PRK13905
UDP-N-acetylmuramate dehydrogenase;
19-309 6.86e-122

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237553 [Multi-domain]  Cd Length: 298  Bit Score: 351.34  E-value: 6.86e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  19 GCEVKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPGDLfpevA 98
Cdd:PRK13905   10 RGRLLENEPLARYTSFRVGGPADYLVEPADIEDLQEFLKLLKENNIPVTVLGNGSNLLVRDGGIRGVVIRLGKGL----N 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  99 DVGPEEGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADG-VGWLTKAQ 177
Cdd:PRK13905   86 EIEVEGNRITAGAGAPLIKLARFAAEAGLSGLEFAAGIPGTVGGAVFMNAGAYGGETADVLESVEVLDRDGeIKTLSNEE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 178 VPYSYRHSELP-PGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSL 256
Cdd:PRK13905  166 LGFGYRHSALQeEGLIVLSATFQLEPGDKEEIKARMDELLARREATQPLEYPSAGSVFKNPPGHFAGKLIEEAGLKGYRI 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1089564395 257 GRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLGDF 309
Cdd:PRK13905  246 GGAQVSEKHANFIINTGGATAADIEDLIEHVQKTVKEKFGVELEWEVRIIGEF 298
MurB COG0812
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ...
 26-306 1.84e-114

UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440574 [Multi-domain]  Cd Length: 279  Bit Score: 331.59  E-value: 1.84e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  26 EPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPGDLFPEVADvgpeEG 105
Cdd:COG0812     1 EPLAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDGFDGLVIRLGRLKGIEVDD----GV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 106 RLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADG-VGWLTKAQVPYSYRH 184
Cdd:COG0812    77 LVTAGAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLDRTGeVRTLSAEECGFGYRD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 185 SELP-PGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGRAQVST 263
Cdd:COG0812   157 SIFKrERYIILSVTFRLKKGDPAEIAAVMDAVLAIRRSKQPLELPSAGSFFKNPPGDSAGWLIEQAGLKGYRIGGAQVSE 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1089564395 264 LHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRL 306
Cdd:COG0812   237 KHANFLVNRGGATAADVLALIEEVQARVKEKFGVELEPEVRII 279
murB TIGR00179
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ...
 28-307 9.07e-81

UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 272945 [Multi-domain]  Cd Length: 284  Bit Score: 246.21  E-value: 9.07e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  28 LAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLpGDLFPEVADvgpEEGRL 107
Cdd:TIGR00179   1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINL-GKGIDIEDD---EGEYV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 108 TLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADG-VGWLTKAQVPYSYRHSE 186
Cdd:TIGR00179  77 HVGGGENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATILLATGkTEWLTNEQLGFGYRTSI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 187 LPP--GGVVTRVRFALRKGDVVAS-----KAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGRA 259
Cdd:TIGR00179 157 FQHkyVGLVLKAEFQLTLGFGTRLdpetiTAQQVFNKVCRMRTSHYPDPNAGSFFKNPSPNHAGRLIEECGLKGYQIGGA 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1089564395 260 QVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLG 307
Cdd:TIGR00179 237 AVSKQHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEPEVKIIG 284
murB PRK13904
UDP-N-acetylmuramate dehydrogenase;
68-306 5.47e-62

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 184384 [Multi-domain]  Cd Length: 257  Bit Score: 197.45  E-value: 5.47e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  68 ILGGGANTLVGDGGVPgltLKLPGDLFPEVADVGpeeGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMN 147
Cdd:PRK13904   36 IIGGANNLLISPNPKN---LAILGKNFDYIKIDG---ECLEIGGATKSGKIFNYAKKNNLGGFEFLGKLPGTLGGLVKMN 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 148 AGTKNGEAFRVIEAVEVATadgvGWLTKAQVPYSYRHSELppGGVVTRVRFALRKGdvvASKAVMDADLGYRKRtQPlSQ 227
Cdd:PRK13904  110 AGLKEYEISNNLESICTNG----GWIEKEDIGFGYRSSGI--NGVILEARFKKTHG---FDEELLEAFKSMRKN-QP-KG 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1089564395 228 PNFGSVFTNPPGDHAGRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRL 306
Cdd:PRK13904  179 PSFGSCFKNPKGDYAGRLIEAVGLKGYCKGGAGFSEEHANFLVNLGGATFEDALDLIELAKKRVLEEFGINLEEEVIIL 257
PRK14649 PRK14649
UDP-N-acetylmuramate dehydrogenase;
26-307 1.28e-58

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173112 [Multi-domain]  Cd Length: 295  Bit Score: 190.05  E-value: 1.28e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  26 EPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPGDLFpEVADVGpEEG 105
Cdd:PRK14649    7 EPLAPYTSWRIGGPARYFVEPTTPDEAIAAAAWAEQRQLPLFWLGGGSNLLVRDEGFDGLVARYRGQRW-ELHEHG-DTA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 106 RLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADG--VGWLTkAQVPYSYR 183
Cdd:PRK14649   85 EVWVEAGAPMAGTARRLAAQGWAGLEWAEGLPGTIGGAIYGNAGCYGGDTATVLIRAWLLLNGSecVEWSV-HDFAYGYR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 184 HSEL-----------PPggVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQpNFGSVFTNPPGDHAGRLIELAGLK 252
Cdd:PRK14649  164 TSVLkqlradgitwrPP--LVLAARFRLHRDDPTALAARMEAIAAERKQKTPAGS-SCGSVFKNPPGDSAGRLIEAAGLK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1089564395 253 GYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLG 307
Cdd:PRK14649  241 GTRIGDAEIATRHANYIINLGGARAADILRLIDLARTRVLAQFGIELELEVRIIG 295
PRK12436 PRK12436
UDP-N-acetylmuramate dehydrogenase;
22-308 2.90e-57

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 171497 [Multi-domain]  Cd Length: 305  Bit Score: 186.75  E-value: 2.90e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  22 VKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPgdlfpEVADVG 101
Cdd:PRK12436   19 VKQDEMLKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYNIPVTFLGNGSNVIIKDGGIRGITVSLI-----HITGVT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 102 PEEGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADG-VGWLTKAQVPY 180
Cdd:PRK12436   94 VTGTTIVAQCGAAIIDVSRIALDHNLTGLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMTGDGeLRTLTKEAFEF 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 181 SYRHSELPPGG-VVTRVRFALRKGDVVASKAVMDaDLGYRKRT-QPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGR 258
Cdd:PRK12436  174 GYRKSVFANNHyIILEARFELEEGVYEEIKAKMD-DLTFKRESkQPLEYPSCGSVFKRPPNNFAGKLIQESGLQGKRIGG 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1089564395 259 AQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLGD 308
Cdd:PRK12436  253 VEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRIIGE 302
PRK14651 PRK14651
UDP-N-acetylmuramate dehydrogenase;
27-291 1.05e-55

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237776 [Multi-domain]  Cd Length: 273  Bit Score: 181.55  E-value: 1.05e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  27 PLAPLTSVRAGGAAEALVrprspdaLVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPGDLfpevadvgpEEGR 106
Cdd:PRK14651    8 PLARYTTLGVGGPAELWT-------VETHEQLAEATEAPYRVLGGGSNLLVSDAGVPERVIRLGGEF---------AEWD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 107 LT--LGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADGVGWLTKAQVPYSYRH 184
Cdd:PRK14651   72 LDgwVGGGVPLPGLVRRAARLGLSGLEGLVGIPAQVGGAVKMNAGTRFGEMADALHTVEIVHDGGFHQYSPDELGFGYRH 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 185 SELPPGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPnfGSVFTNPPGDHAGRLIELAGLKGYSLGRAQVSTL 264
Cdd:PRK14651  152 SGLPPGHVVTRVRLKLRPSTPEAVLAKMALVDAARKGQPKKKSA--GCAFKNPPGDSAGRLIDEAGLKGTRVGDAMISPE 229

                         250       260
                  ....*....|....*....|....*..
gi 1089564395 265 HANWIVNLGGATARDVLGLVTLMQQRV 291
Cdd:PRK14651  230 HGNFIVNLGGATAADVHALLRRVRARV 256
murB PRK13906
UDP-N-acetylmuramate dehydrogenase;
22-308 1.50e-55

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 184386 [Multi-domain]  Cd Length: 307  Bit Score: 182.33  E-value: 1.50e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  22 VKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPGDLFPEVADvg 101
Cdd:PRK13906   19 IKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSD-- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 102 peeGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIE-AVEVATADGVGWLTKAQVPY 180
Cdd:PRK13906   97 ---DAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDyALCVNEQGSLIKLTTKELEL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 181 SYRHSELPPGG-VVTRVRFALRKGDVVASKAVMDaDLGYRKRT-QPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGR 258
Cdd:PRK13906  174 DYRNSIIQKEHlVVLEAAFTLAPGKMTEIQAKMD-DLTERRESkQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGG 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1089564395 259 AQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLGD 308
Cdd:PRK13906  253 VEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGE 302
MurB_C pfam02873
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ...
 209-306 3.95e-45

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 460730 [Multi-domain]  Cd Length: 99  Bit Score: 148.65  E-value: 3.95e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 209 KAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQ 288
Cdd:pfam02873   2 RAAMLELRRRRLAKQPLDPPSAGSFFKNPVGHSAGWLIEQAGLKGYRIGGAQVSEKHANFLVNTGGATAADVLALIEEVR 81

                          90
                  ....*....|....*...
gi 1089564395 289 QRVLEQSGVDMKPEVKRL 306
Cdd:pfam02873  82 ERVKEKFGVELEPEVRII 99
PRK14653 PRK14653
UDP-N-acetylmuramate dehydrogenase;
19-304 4.45e-42

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237778 [Multi-domain]  Cd Length: 297  Bit Score: 147.29  E-value: 4.45e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  19 GCEVKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREeGVPVSILGGGANTLVGDGGVPGLTLKLPgdlfpEVA 98
Cdd:PRK14653   13 GNDVFINEEMKCHVSFKIGGPVPLFAIPNSTNGFIETINLLKE-GIEVKILGNGTNVLPKDEPMDFVVVSTE-----RLD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  99 DVGPEEGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADGVGWLTKAQV 178
Cdd:PRK14653   87 DIFVDNDKIICESGLSLKKLCLVAAKNGLSGFENAYGIPGSVGGAVYMNAGAYGWETAENIVEVVAYDGKKIIRLGKNEI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 179 PYSYRHSELPPGG--VVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNP-PGDHAGRLIELAGLKGYS 255
Cdd:PRK14653  167 KFSYRNSIFKEEKdlIILRVTFKLKKGNKNEIYNLMLETMKKRVEKQPLEFPSAGSVFKRPrKDFYVGSAIEKLGLKGFS 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1089564395 256 LGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVK 304
Cdd:PRK14653  247 IGGAQISEKHAGFIINYNNAKAEDVLKLIEYVKDKIYENYNVELETEIE 295
PRK14648 PRK14648
UDP-N-acetylmuramate dehydrogenase;
27-303 9.14e-33

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173111 [Multi-domain]  Cd Length: 354  Bit Score: 124.07  E-value: 9.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  27 PLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLpgDLFPEVADVGPEEGR 106
Cdd:PRK14648   17 PLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLMLSL--RRFRSLHTQTQRDGS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 107 LTL--GAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSM------------------------------------NA 148
Cdd:PRK14648   95 VLVhaGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAAYMnarcygraiadcfhsartlvlhpvrsrakelpevrkNA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 149 GTKNGEAFRV------IEAVEVATADGVGWLTKaQVPYSYRHS-ELPPG-GVVTRVRFALRKGDVVASKAVMDADLGYRK 220
Cdd:PRK14648  175 QDKRGECLGLdggpftCSSFQTVFARAGDWGYK-RSPFQSPHGvELHAGrRLILSLCVRLTPGNPAQIRKHMQEKIADRI 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 221 RTQPLSQPNFGSVFTNPP--GDHAGRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVD 298
Cdd:PRK14648  254 SKGQFRFPSAGSAFKNNPafGKPSGILIEEAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLRVVRQRVFETHGVW 333


                  ....*
gi 1089564395 299 MKPEV 303
Cdd:PRK14648  334 LEREI 338
murB PRK13903
UDP-N-acetylmuramate dehydrogenase;
8-302 6.17e-32

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 237552 [Multi-domain]  Cd Length: 363  Bit Score: 121.99  E-value: 6.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395   8 TALAARVESLGGCEVKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTL 87
Cdd:PRK13903    1 MKRSGVGSAFAGAEVAEDVPLAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDGFDGTVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  88 KLPGDLFpevaDVGPEEGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEV--A 165
Cdd:PRK13903   81 RVATRGV----TVDCGGGLVRAEAGAVWDDVVARTVEAGLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTITRVRLldR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 166 TADGVGWLTKAQVPYSYRHSELPPG--GVVTRVRFALRK--------------------GDVVASKAVMDADLGYRKRTQ 223
Cdd:PRK13903  157 RTGEVRWVPAADLGFGYRTSVLKHSdrAVVLEVEFQLDPsglsaplrygelaralgvepGERVPPAAVREAVLALRAGKG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 224 PLSQPN------FGSVFTNPPGDH-------------------------------AGRLIELAGL-KGYSL--GRAQVST 263
Cdd:PRK13903  237 MVLDPAdhdtwsAGSFFTNPVVSPavaerlaarvaerlgdpvprypagdggvklsAAWLIERAGFgKGYPGggAPARLST 316

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1089564395 264 LHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPE 302
Cdd:PRK13903  317 KHTLALTNRGGATTADLVALAREVRDGVRDAFGVTLVPE 355
murB PRK00046
UDP-N-acetylmuramate dehydrogenase;
40-303 1.10e-31

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 234593 [Multi-domain]  Cd Length: 334  Bit Score: 120.64  E-value: 1.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  40 AEALVRPRSPDALVALLKLAREEGVPVSILGGGANTL-VGDggVPGLTL--KLPGdlfPEVADVGPEEGRLTLGAGaaiv 116
Cdd:PRK00046   21 ARHLVEAESEEQLLEALADARAAGLPVLVLGGGSNVLfTED--FDGTVLlnRIKG---IEVLSEDDDAWYLHVGAG---- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 117 rlinvMRAHALV---------GAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEV---ATADGVgWLTKAQVPYSYRH 184
Cdd:PRK00046   92 -----ENWHDLVlwtlqqgmpGLENLALIPGTVGAAPIQNIGAYGVELKDVCDYVEAldlATGEFV-RLSAAECRFGYRD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 185 S----ELPPGGVVTRVRFALRK--------GDV-------VASKAVMDA--DLGYRKRTQPLSQPNFGSVFTNP--PGDH 241
Cdd:PRK00046  166 SifkhEYPDRYAITAVGFRLPKqwqpvldyGDLarldpdtVTAQDVFDAvcAIRRSKLPDPKVLGNAGSFFKNPvvSAEQ 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 242 ------------------------AGRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGV 297
Cdd:PRK00046  246 feallaqypdiphypqadgsvklaAGWLIDQCGLKGFQIGGAAVHEKQALVLVNYGNATGADVLALARHIQQDVREKFGV 325


                  ....*.
gi 1089564395 298 DMKPEV 303
Cdd:PRK00046  326 ELEPEP 331
PRK14650 PRK14650
UDP-N-acetylmuramate dehydrogenase;
28-307 2.65e-23

UDP-N-acetylmuramate dehydrogenase;


Pssm-ID: 173113 [Multi-domain]  Cd Length: 302  Bit Score: 97.22  E-value: 2.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  28 LAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPGDLfpevADVGPEEGRL 107
Cdd:PRK14650   21 LANYTTYKIGGISKLFLTPKTIKDAEHIFKAAIEEKIKIFILGGGSNILINDEEEIDFPIIYTGHL----NKIEIHDNQI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 108 TLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADGVGWLTK-AQVPYSYRHSE 186
Cdd:PRK14650   97 VAECGTNFEDLCKFALQNELSGLEFIYGLPGTLGGAIWMNARCFGNEISEILDKITFIDEKGKTICKKfKKEEFKYKISP 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395 187 LP-PGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNPPG--DHAGRLIELAGLKGYSLGRAQVST 263
Cdd:PRK14650  177 FQnKNTFILKATLNLKKGNKKHIEEIMKQNKQIRINKGHYLFPSSGSTFKNNKAflKPTGQIIEECKLKGLSIGGATVSH 256

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1089564395 264 LHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLG 307
Cdd:PRK14650  257 YHGNFIININNATSKDIKTLIEKVKTEVQIKTGFLLEEEVLYIG 300
FAD_binding_4 pfam01565
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most ...
 40-169 4.05e-21

FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.


Pssm-ID: 426326 [Multi-domain]  Cd Length: 139  Bit Score: 87.26  E-value: 4.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  40 AEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLpgDLFPEVADVGPEEGRLTLGAGAAIVRLI 119
Cdd:pfam01565   1 PAAVVLPESEEEVAAIVRLANENGLPVLPRGGGSSLLGGAVQTGGIVLDL--SRLNGILEIDPEDGTATVEAGVTLGDLV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1089564395 120 NVMRAHAL-VGAEFLAGIPGTLGGAVSMNAG----TKNGEAFRVIEAVEVATADG 169
Cdd:pfam01565  79 RALAAKGLlLGLDPGSGIPGTVGGAIATNAGgygsEKYGLTRDNVLGLEVVLADG 133
GlcD COG0277
FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];
1-200 1.60e-09

FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];


Pssm-ID: 440046 [Multi-domain]  Cd Length: 462  Bit Score: 58.37  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395   1 MVEAGVKTALAARVEslGGCEVKAGEPLAPLT--SVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANtLVG 78
Cdd:COG0277     1 MLTAALLAALRAILA--GRVLTDPADRAAYARdgNSLYRGRPDAVVRPRSTEDVAAVVRLAAEHGVPVVPRGGGTG-LAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1089564395  79 dGGVP---GLTLklpgDL--FPEVADVGPEEGRLTLGAGAAIVRLINVMRAHALvgaeFLAGIPG-----TLGGAVSMNA 148
Cdd:COG0277    78 -GAVPldgGVVL----DLsrMNRILEVDPEDRTATVEAGVTLADLNAALAPHGL----FFPPDPSsqgtaTIGGNIATNA 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1089564395 149 G----TKNGEAFRVIEAVEVATADGVGWLTKAQVPYS---------YRHSElppG--GVVTRVRFAL 200
Cdd:COG0277   149 GgprsLKYGLTRDNVLGLEVVLADGEVVRTGGRVPKNvtgydlfwlLVGSE---GtlGVITEATLRL 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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