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Conserved domains on  [gi|1088800277|emb|SDX79538|]
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chorismate mutase [Eubacterium barkeri]

Protein Classification

PheB family protein( domain architecture ID 11468247)

PheB family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PheB COG4492
ACT domain-containing protein, UPF0735 family [General function prediction only];
1-144 3.65e-61

ACT domain-containing protein, UPF0735 family [General function prediction only];


:

Pssm-ID: 443581 [Multi-domain]  Cd Length: 147  Bit Score: 184.96  E-value: 3.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088800277   1 MIRDYLIVNKKILPDYFDKVLEARMLLESAQCKSISDAVKQVGISRSTYYKYKDHIFRPSED-FGRKFTLSLSLADNQGI 79
Cdd:COG4492     3 KEKKFYLVREDILPEAILKVVEAKELLESGEVKTVNEAVKKVGISRSAFYKYKDYVFPFYEMsKGKIITLSLLLEDEPGV 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1088800277  80 LAQVLGILRERETSVVTIHQDIPINHAAFVIITLDGQNLTCTIDALIGELSAIDGIHEVNLVAME 144
Cdd:COG4492    83 LSSVLNIIAEAGGNILTINQSIPIQGIANVTISIETSDMTIDIEELLEELRELEGVRKVEILGRE 147
 
Name Accession Description Interval E-value
PheB COG4492
ACT domain-containing protein, UPF0735 family [General function prediction only];
1-144 3.65e-61

ACT domain-containing protein, UPF0735 family [General function prediction only];


Pssm-ID: 443581 [Multi-domain]  Cd Length: 147  Bit Score: 184.96  E-value: 3.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088800277   1 MIRDYLIVNKKILPDYFDKVLEARMLLESAQCKSISDAVKQVGISRSTYYKYKDHIFRPSED-FGRKFTLSLSLADNQGI 79
Cdd:COG4492     3 KEKKFYLVREDILPEAILKVVEAKELLESGEVKTVNEAVKKVGISRSAFYKYKDYVFPFYEMsKGKIITLSLLLEDEPGV 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1088800277  80 LAQVLGILRERETSVVTIHQDIPINHAAFVIITLDGQNLTCTIDALIGELSAIDGIHEVNLVAME 144
Cdd:COG4492    83 LSSVLNIIAEAGGNILTINQSIPIQGIANVTISIETSDMTIDIEELLEELRELEGVRKVEILGRE 147
PRK04435 PRK04435
ACT domain-containing protein;
1-144 9.09e-56

ACT domain-containing protein;


Pssm-ID: 179848 [Multi-domain]  Cd Length: 147  Bit Score: 171.14  E-value: 9.09e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088800277   1 MIRDYLIVNKKILPDYFDKVLEARMLLESAQCKSISDAVKQVGISRSTYYKYKDHIFRPSEDF-GRKFTLSLSLADNQGI 79
Cdd:PRK04435    3 MKKKFYLVREDVLPEAVEKTLKAKELLKSGKVKSINEAVKQVGISRSAFYKYKDYVFPFDEMVkGKIITLSLLLEDRSGT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1088800277  80 LAQVLGILRERETSVVTIHQDIPINHAAFVIITLDGQNLTCTIDALIGELSAIDGIHEVNLVAME 144
Cdd:PRK04435   83 LSKVLNVIAEAGGNILTINQSIPLQGRANVTISIDTSSMEGDIDELLEKLRNLDGVEKVELIGME 147
ACT_PheB-BS cd04888
C-terminal ACT domain of a small (~147 a.a.) putative phenylalanine biosynthetic pathway ...
 67-142 2.74e-20

C-terminal ACT domain of a small (~147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; This CD includes the C-terminal ACT domain of a small (~147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and other related ACT domains. In B. subtilis, the upstream gene of pheB, pheA encodes prephenate dehydratase (PDT). The presumed product of the pheB gene is chorismate mutase (CM). The deduced product of the B. subtilis pheB gene, however, has no significant homology to the CM portion of the bifunctional CM-PDT of Escherichia coli. The presence of an ACT domain lends support to the prediction that these proteins function as a phenylalanine-binding regulatory protein. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153160  Cd Length: 76  Bit Score: 78.77  E-value: 2.74e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1088800277  67 FTLSLSLADNQGILAQVLGILRERETSVVTIHQDIPINHAAFVIITLDGQNLTCTIDALIGELSAIDGIHEVNLVA 142
Cdd:cd04888     1 VTLSLLLEHRPGVLSKVLNTIAQVRGNVLTINQNIPIHGRANVTISIDTSTMNGDIDELLEELREIDGVEKVELVG 76
 
Name Accession Description Interval E-value
PheB COG4492
ACT domain-containing protein, UPF0735 family [General function prediction only];
1-144 3.65e-61

ACT domain-containing protein, UPF0735 family [General function prediction only];


Pssm-ID: 443581 [Multi-domain]  Cd Length: 147  Bit Score: 184.96  E-value: 3.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088800277   1 MIRDYLIVNKKILPDYFDKVLEARMLLESAQCKSISDAVKQVGISRSTYYKYKDHIFRPSED-FGRKFTLSLSLADNQGI 79
Cdd:COG4492     3 KEKKFYLVREDILPEAILKVVEAKELLESGEVKTVNEAVKKVGISRSAFYKYKDYVFPFYEMsKGKIITLSLLLEDEPGV 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1088800277  80 LAQVLGILRERETSVVTIHQDIPINHAAFVIITLDGQNLTCTIDALIGELSAIDGIHEVNLVAME 144
Cdd:COG4492    83 LSSVLNIIAEAGGNILTINQSIPIQGIANVTISIETSDMTIDIEELLEELRELEGVRKVEILGRE 147
PRK04435 PRK04435
ACT domain-containing protein;
1-144 9.09e-56

ACT domain-containing protein;


Pssm-ID: 179848 [Multi-domain]  Cd Length: 147  Bit Score: 171.14  E-value: 9.09e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088800277   1 MIRDYLIVNKKILPDYFDKVLEARMLLESAQCKSISDAVKQVGISRSTYYKYKDHIFRPSEDF-GRKFTLSLSLADNQGI 79
Cdd:PRK04435    3 MKKKFYLVREDVLPEAVEKTLKAKELLKSGKVKSINEAVKQVGISRSAFYKYKDYVFPFDEMVkGKIITLSLLLEDRSGT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1088800277  80 LAQVLGILRERETSVVTIHQDIPINHAAFVIITLDGQNLTCTIDALIGELSAIDGIHEVNLVAME 144
Cdd:PRK04435   83 LSKVLNVIAEAGGNILTINQSIPLQGRANVTISIDTSSMEGDIDELLEKLRNLDGVEKVELIGME 147
ACT_PheB-BS cd04888
C-terminal ACT domain of a small (~147 a.a.) putative phenylalanine biosynthetic pathway ...
 67-142 2.74e-20

C-terminal ACT domain of a small (~147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; This CD includes the C-terminal ACT domain of a small (~147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and other related ACT domains. In B. subtilis, the upstream gene of pheB, pheA encodes prephenate dehydratase (PDT). The presumed product of the pheB gene is chorismate mutase (CM). The deduced product of the B. subtilis pheB gene, however, has no significant homology to the CM portion of the bifunctional CM-PDT of Escherichia coli. The presence of an ACT domain lends support to the prediction that these proteins function as a phenylalanine-binding regulatory protein. Members of this CD belong to the superfamily of ACT regulatory domains.


Pssm-ID: 153160  Cd Length: 76  Bit Score: 78.77  E-value: 2.74e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1088800277  67 FTLSLSLADNQGILAQVLGILRERETSVVTIHQDIPINHAAFVIITLDGQNLTCTIDALIGELSAIDGIHEVNLVA 142
Cdd:cd04888     1 VTLSLLLEHRPGVLSKVLNTIAQVRGNVLTINQNIPIHGRANVTISIDTSTMNGDIDELLEELREIDGVEKVELVG 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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