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Conserved domains on  [gi|1097524387|emb|SFA71247|]
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Signal transduction histidine kinase [Cellulomonas marina]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cztS_silS_copS super family cl36891
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 17-466 1.70e-41

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


The actual alignment was detected with superfamily member TIGR01386:

Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 156.01  E-value: 1.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  17 RSLRVRLTVLTAAVMCLALVAGAWTLGTVLQR-----------GRLAALDGIVAARVDTVAALVAEDRLPDPLPVEEPGE 85
Cdd:TIGR01386   2 RSLTLRLALLFAAVTALVFALSGFMLYSSLERhfeerdreelqGKLEQVRRFLRDPADLDEDIKRLQEKIDDLLVGHSDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  86 VVQVLDAQGRVVASSSTASRtlpVLPADLLSAAPGAAAPDPAVMTTSasaYADTARAAMRLVEGPSGPVTVVATMPLTEV 165
Cdd:TIGR01386  82 ALSILNPDGRLLFERAQGAA---LVPAVAANDALLELDQADAKMTHY---RSILRSVAALPGGKGRKPVQITVALDINAH 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 166 RGLLRALQVSFFGVVPTLTLLVAIAVWLVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDDEIAALARTLNDMLDRLD 245
Cdd:TIGR01386 156 THLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 246 AAAGRQRSFVADAAHELRSPLSSLRATIEVA-ADSRSGYTAEELAEDLAPEVLRMGALVDDL---LLLARLGSAPRGERp 321
Cdd:TIGR01386 236 DAFQRLSQFSADLAHELRTPLTNLLGQTQVAlSQPRTGEEYREVLESNLEELERLSRMVSDMlflARADNGQLALERVR- 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 322 VDLAAVAAEGVAAAVAGGAATDgpapgsaeVPVHLEGAGATRGDASALARVVRNLVENARRHAT--SRVEVHVA----PG 395
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERG--------VRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPdgGTITVRIErrsdEV 386

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1097524387 396 LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDVVLgDSPLGGLRAQLRL 466
Cdd:TIGR01386 387 RVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRF 456
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 521-579 5.57e-27

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


:

Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 103.35  E-value: 5.57e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1097524387 521 GDEVTWKSHGQTVHGEVEKKITSDTEAAGRTVRASKDDPQYLVKSDKTGKEAVHKPSAL 579
Cdd:pfam11160   1 GDKVSWKWGGGTAEGKVVEVLTEETEAKGVTVNASEDDPAYEIESDKTGKDVVHKPSEL 59
 
Name Accession Description Interval E-value
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 17-466 1.70e-41

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 156.01  E-value: 1.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  17 RSLRVRLTVLTAAVMCLALVAGAWTLGTVLQR-----------GRLAALDGIVAARVDTVAALVAEDRLPDPLPVEEPGE 85
Cdd:TIGR01386   2 RSLTLRLALLFAAVTALVFALSGFMLYSSLERhfeerdreelqGKLEQVRRFLRDPADLDEDIKRLQEKIDDLLVGHSDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  86 VVQVLDAQGRVVASSSTASRtlpVLPADLLSAAPGAAAPDPAVMTTSasaYADTARAAMRLVEGPSGPVTVVATMPLTEV 165
Cdd:TIGR01386  82 ALSILNPDGRLLFERAQGAA---LVPAVAANDALLELDQADAKMTHY---RSILRSVAALPGGKGRKPVQITVALDINAH 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 166 RGLLRALQVSFFGVVPTLTLLVAIAVWLVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDDEIAALARTLNDMLDRLD 245
Cdd:TIGR01386 156 THLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 246 AAAGRQRSFVADAAHELRSPLSSLRATIEVA-ADSRSGYTAEELAEDLAPEVLRMGALVDDL---LLLARLGSAPRGERp 321
Cdd:TIGR01386 236 DAFQRLSQFSADLAHELRTPLTNLLGQTQVAlSQPRTGEEYREVLESNLEELERLSRMVSDMlflARADNGQLALERVR- 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 322 VDLAAVAAEGVAAAVAGGAATDgpapgsaeVPVHLEGAGATRGDASALARVVRNLVENARRHAT--SRVEVHVA----PG 395
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERG--------VRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPdgGTITVRIErrsdEV 386

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1097524387 396 LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDVVLgDSPLGGLRAQLRL 466
Cdd:TIGR01386 387 RVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRF 456
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
156-466 4.85e-35

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 134.65  E-value: 4.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 156 VVATMPLTEVRGLLRALQVSFFGVVPTLTLLVAIAVWLVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDDEIAALAR 235
Cdd:COG0642    15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 236 TLNDMLDRLDAAAGRQRSFVADAAHELRSPLSSLRATIEVAADSRSGyTAEELAEDLAPEVLRMGA--LVDDLLLLARLG 313
Cdd:COG0642    95 LLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDE-EQREYLETILRSADRLLRliNDLLDLSRLEAG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 314 SAPRGERPVDLAAVAAEGVAAAVaggaatdgPAPGSAEVPVHLEGAGAT---RGDASALARVVRNLVENARRHAT--SRV 388
Cdd:COG0642   174 KLELEPEPVDLAELLEEVVELFR--------PLAEEKGIELELDLPDDLptvRGDPDRLRQVLLNLLSNAIKYTPegGTV 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 389 EVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARErgTGGSGLGLAIAREIAREHGGDVVLGDSPLGGLRAQL 464
Cdd:COG0642   246 TVSVRREgdrvRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTV 323


                  ..
gi 1097524387 465 RL 466
Cdd:COG0642   324 TL 325
PRK10604 PRK10604
sensor protein RstB; Provisional
 233-482 1.03e-33

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 133.19  E-value: 1.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 233 LARTLNDMLDRLDAAAGRQRSFVADAAHELRSPLSSLRATIEVaadSRSGYTAEELA--------EDLAPEVLRMGalvd 304
Cdd:PRK10604  194 LGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEM---SDNLSAAESQAlnrdigqlEALIEELLTYA---- 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 305 dllllarlgsapRGERP-VDLAAVAAEGVAAAVAGGAATDGPAPgsaEVPVHLEGAGAT---RGDASALARVVRNLVENA 380
Cdd:PRK10604  267 ------------RLDRPqNELHLSEPDLPAWLSTHLADIQAVTP---EKTVRLDTPHQGdygALDMRLMERVLDNLLNNA 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 381 RRHATSRVEVHV----APGLVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDVVLGDSP 456
Cdd:PRK10604  332 LRYAHSRVRVSLlldgNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESE 411

                         250       260
                  ....*....|....*....|....*.
gi 1097524387 457 LGGLRAQLRLRAGDDpaavVPPPADA 482
Cdd:PRK10604  412 LGGARFSFSWPVWHN----LPQFTSA 433
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-466 4.16e-27

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 105.20  E-value: 4.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHATSRVEVHVAPGL----VVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAR 444
Cdd:cd16939     1 MARALDNLLRNALRYAHRTVRIALLVSGgrltLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80

                          90       100
                  ....*....|....*....|..
gi 1097524387 445 EHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16939    81 WHGGHVECDDSELGGACFRLTW 102
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 521-579 5.57e-27

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 103.35  E-value: 5.57e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1097524387 521 GDEVTWKSHGQTVHGEVEKKITSDTEAAGRTVRASKDDPQYLVKSDKTGKEAVHKPSAL 579
Cdd:pfam11160   1 GDKVSWKWGGGTAEGKVVEVLTEETEAKGVTVNASEDDPAYEIESDKTGKDVVHKPSEL 59
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 364-467 7.47e-27

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 105.04  E-value: 7.47e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  364 GDASALARVVRNLVENARRHATSRVEVHVA------PGLVVVDDDGGGIDPADRERVFERFVRLDAaRERGTGGSGLGLA 437
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTlerdgdHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 1097524387  438 IAREIAREHGGDVVLGDSPLGGLRAQLRLR 467
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 364-467 4.01e-25

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 100.14  E-value: 4.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 364 GDASALARVVRNLVENARRHAT--SRVEVHVAPG---LVVVDDDGGGIDPADRERVFERFVRLDAareRGTGGSGLGLAI 438
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAkaGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77

                          90       100
                  ....*....|....*....|....*....
gi 1097524387 439 AREIAREHGGDVVLGDSPLGGLRAQLRLR 467
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLP 106
 
Name Accession Description Interval E-value
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 17-466 1.70e-41

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 156.01  E-value: 1.70e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  17 RSLRVRLTVLTAAVMCLALVAGAWTLGTVLQR-----------GRLAALDGIVAARVDTVAALVAEDRLPDPLPVEEPGE 85
Cdd:TIGR01386   2 RSLTLRLALLFAAVTALVFALSGFMLYSSLERhfeerdreelqGKLEQVRRFLRDPADLDEDIKRLQEKIDDLLVGHSDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  86 VVQVLDAQGRVVASSSTASRtlpVLPADLLSAAPGAAAPDPAVMTTSasaYADTARAAMRLVEGPSGPVTVVATMPLTEV 165
Cdd:TIGR01386  82 ALSILNPDGRLLFERAQGAA---LVPAVAANDALLELDQADAKMTHY---RSILRSVAALPGGKGRKPVQITVALDINAH 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 166 RGLLRALQVSFFGVVPTLTLLVAIAVWLVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDDEIAALARTLNDMLDRLD 245
Cdd:TIGR01386 156 THLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 246 AAAGRQRSFVADAAHELRSPLSSLRATIEVA-ADSRSGYTAEELAEDLAPEVLRMGALVDDL---LLLARLGSAPRGERp 321
Cdd:TIGR01386 236 DAFQRLSQFSADLAHELRTPLTNLLGQTQVAlSQPRTGEEYREVLESNLEELERLSRMVSDMlflARADNGQLALERVR- 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 322 VDLAAVAAEGVAAAVAGGAATDgpapgsaeVPVHLEGAGATRGDASALARVVRNLVENARRHAT--SRVEVHVA----PG 395
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERG--------VRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPdgGTITVRIErrsdEV 386

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1097524387 396 LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDVVLgDSPLGGLRAQLRL 466
Cdd:TIGR01386 387 RVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILRF 456
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
156-466 4.85e-35

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 134.65  E-value: 4.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 156 VVATMPLTEVRGLLRALQVSFFGVVPTLTLLVAIAVWLVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDDEIAALAR 235
Cdd:COG0642    15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 236 TLNDMLDRLDAAAGRQRSFVADAAHELRSPLSSLRATIEVAADSRSGyTAEELAEDLAPEVLRMGA--LVDDLLLLARLG 313
Cdd:COG0642    95 LLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDE-EQREYLETILRSADRLLRliNDLLDLSRLEAG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 314 SAPRGERPVDLAAVAAEGVAAAVaggaatdgPAPGSAEVPVHLEGAGAT---RGDASALARVVRNLVENARRHAT--SRV 388
Cdd:COG0642   174 KLELEPEPVDLAELLEEVVELFR--------PLAEEKGIELELDLPDDLptvRGDPDRLRQVLLNLLSNAIKYTPegGTV 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 389 EVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARErgTGGSGLGLAIAREIAREHGGDVVLGDSPLGGLRAQL 464
Cdd:COG0642   246 TVSVRREgdrvRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTV 323


                  ..
gi 1097524387 465 RL 466
Cdd:COG0642   324 TL 325
PRK10604 PRK10604
sensor protein RstB; Provisional
 233-482 1.03e-33

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 133.19  E-value: 1.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 233 LARTLNDMLDRLDAAAGRQRSFVADAAHELRSPLSSLRATIEVaadSRSGYTAEELA--------EDLAPEVLRMGalvd 304
Cdd:PRK10604  194 LGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEM---SDNLSAAESQAlnrdigqlEALIEELLTYA---- 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 305 dllllarlgsapRGERP-VDLAAVAAEGVAAAVAGGAATDGPAPgsaEVPVHLEGAGAT---RGDASALARVVRNLVENA 380
Cdd:PRK10604  267 ------------RLDRPqNELHLSEPDLPAWLSTHLADIQAVTP---EKTVRLDTPHQGdygALDMRLMERVLDNLLNNA 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 381 RRHATSRVEVHV----APGLVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDVVLGDSP 456
Cdd:PRK10604  332 LRYAHSRVRVSLlldgNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESE 411

                         250       260
                  ....*....|....*....|....*.
gi 1097524387 457 LGGLRAQLRLRAGDDpaavVPPPADA 482
Cdd:PRK10604  412 LGGARFSFSWPVWHN----LPQFTSA 433
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
105-466 1.72e-32

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 128.90  E-value: 1.72e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 105 RTLPVLPADLLSAAPGAAAPDPAVMTTSASAYADTARAAMRLVEGPSGPVTVVATMPLTEVRGLLRALQVSFFGVVPTLT 184
Cdd:COG5002    18 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 185 LLVAIAVWLVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDD-EIAALARTLNDMLDRLDAAAGRQRSFVADAAHELR 263
Cdd:COG5002    98 LLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALlLGLLLLAAVERDITELERLEQMRREFVANVSHELR 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 264 SPLSSLRATIEVAADSRSGyTAEELAEDLAP---EVLRMgalvddllllAR------------LGSAPRGERPVDLAAVA 328
Cdd:COG5002   178 TPLTSIRGYLELLLDGAAD-DPEERREYLEIileEAERL----------SRlvndlldlsrleSGELKLEKEPVDLAELL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 329 AEGVAAAVaggaatdgPAPGSAEVPVHLEGAGAT---RGDASALARVVRNLVENARRH--ATSRVEVHVAPG----LVVV 399
Cdd:COG5002   247 EEVVEELR--------PLAEEKGIELELDLPEDPllvLGDPDRLEQVLTNLLDNAIKYtpEGGTITVSLREEddqvRISV 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1097524387 400 DDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:COG5002   319 RDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
237-466 8.82e-31

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 120.40  E-value: 8.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 237 LNDMLDRLDAAAGRQRSFVADAAHELRSPLSSLRATIEVAADSRSGYTAE--ELAEDLAPEVLRMGA--LVDDLLLLARL 312
Cdd:COG2205     2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEErrELLEIIRESAERLLRliEDLLDLSRLES 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 313 GSAPRGERPVDLAAVAAEGVAAAVAGGAATDgpapgsAEVPVHLEGAGAT-RGDASALARVVRNLVENARRH--ATSRVE 389
Cdd:COG2205    82 GKLSLELEPVDLAELLEEAVEELRPLAEEKG------IRLELDLPPELPLvYADPELLEQVLANLLDNAIKYspPGGTIT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 390 VHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDaaRERGTGGSGLGLAIAREIAREHGGDVVLGDSPLGGLRAQLR 465
Cdd:COG2205   156 ISARREgdgvRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVT 233


                  .
gi 1097524387 466 L 466
Cdd:COG2205   234 L 234
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-466 4.16e-27

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 105.20  E-value: 4.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHATSRVEVHVAPGL----VVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAR 444
Cdd:cd16939     1 MARALDNLLRNALRYAHRTVRIALLVSGgrltLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80

                          90       100
                  ....*....|....*....|..
gi 1097524387 445 EHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16939    81 WHGGHVECDDSELGGACFRLTW 102
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 369-466 4.78e-27

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 104.99  E-value: 4.78e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHA--TSRVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARERGtgGSGLGLAIAREI 442
Cdd:cd00075     1 LEQVLSNLLDNALKYSppGGTIEISLRQEgdgvVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG--GTGLGLAIVRRI 78

                          90       100
                  ....*....|....*....|....
gi 1097524387 443 AREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd00075    79 VEAHGGRITVESEPGGGTTFTVTL 102
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 521-579 5.57e-27

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 103.35  E-value: 5.57e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1097524387 521 GDEVTWKSHGQTVHGEVEKKITSDTEAAGRTVRASKDDPQYLVKSDKTGKEAVHKPSAL 579
Cdd:pfam11160   1 GDKVSWKWGGGTAEGKVVEVLTEETEAKGVTVNASEDDPAYEIESDKTGKDVVHKPSEL 59
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 364-467 7.47e-27

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 105.04  E-value: 7.47e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  364 GDASALARVVRNLVENARRHATSRVEVHVA------PGLVVVDDDGGGIDPADRERVFERFVRLDAaRERGTGGSGLGLA 437
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTlerdgdHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 1097524387  438 IAREIAREHGGDVVLGDSPLGGLRAQLRLR 467
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
183-466 2.65e-26

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 111.95  E-value: 2.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 183 LTLLVAIAVWLVLGRALG-PVDQLRRAAAQVAstggRGVLPVGRDDD----EIAALARTLNDMLDRLDAAAGRQRSFVAD 257
Cdd:PRK09470  174 VTMLVSTPLLLWLAWSLAkPARKLKNAADEVA----QGNLRQHPELEtgpqEFRQAGASFNQMVTALERMMTSQQRLLSD 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 258 AAHELRSPLSSLR-AT---------------IEVAAD------------SRSGYTAE-------------ELAEDLAPEV 296
Cdd:PRK09470  250 ISHELRTPLTRLQlATallrrrqgeskelerIETEAQrldsmindllvlSRNQQKNHleretfkanslwsEVLEDAKFEA 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 297 LRMGALVDDllllarlgSAPRGERPVDlaavaaegvaaavaggaatdgpapgsaevpvhlegagatrGDASALARVVRNL 376
Cdd:PRK09470  330 EQMGKSLTV--------SAPPGPWPIN----------------------------------------GNPNALASALENI 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 377 VENARRHATSRVEVHV---APGL-VVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDVVL 452
Cdd:PRK09470  362 VRNALRYSHTKIEVAFsvdKDGLtITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKA 441

                         330
                  ....*....|....
gi 1097524387 453 GDSPLGGLRAQLRL 466
Cdd:PRK09470  442 EDSPLGGLRLTIWL 455
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 364-467 4.01e-25

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 100.14  E-value: 4.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 364 GDASALARVVRNLVENARRHAT--SRVEVHVAPG---LVVVDDDGGGIDPADRERVFERFVRLDAareRGTGGSGLGLAI 438
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAkaGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77

                          90       100
                  ....*....|....*....|....*....
gi 1097524387 439 AREIAREHGGDVVLGDSPLGGLRAQLRLR 467
Cdd:pfam02518  78 VRKLVELLGGTITVESEPGGGTTVTLTLP 106
envZ PRK09467
osmolarity sensor protein; Provisional
 351-466 2.29e-24

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 106.15  E-value: 2.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 351 EVPVHL-EGAGATRGDASALARVVRNLVENARRHATSRVEV--HVAPGLVV--VDDDGGGIDPADRERVFERFVRLDAAR 425
Cdd:PRK09467  313 EIETALqPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVssGTEGKRAWfqVEDDGPGIPPEQLKHLFQPFTRGDSAR 392

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1097524387 426 erGTGGSGLGLAIAREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:PRK09467  393 --GSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-466 1.05e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 95.86  E-value: 1.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHATSRVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAR 444
Cdd:cd16949     1 LARALENVLRNALRYSPSKILLDISQDgdqwTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80

                          90       100
                  ....*....|....*....|..
gi 1097524387 445 EHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16949    81 QHGGKIKASNRKPGGLRVRIWL 102
PRK10337 PRK10337
sensor protein QseC; Provisional
 182-465 2.29e-23

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 103.19  E-value: 2.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 182 TLTLLVAIAVWLvLGRALGPvdqLRRAAAQVA--STGGRGVLPVGRDDDEIAALARTLNDMLDRLDAAAGRQRSFVADAA 259
Cdd:PRK10337  170 ALPIMLIILMVL-LGRELAP---LKKLALALRmrDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 260 HELRSPLSSLRATIEVAADSRSgytaEELAEDLAPEVLRMGALVDD-------LLLLARLGSAPRGERPVDLAAVAAEGV 332
Cdd:PRK10337  246 HELRSPLAALKVQTEVAQLSDD----DPQARKKALLQLHAGIDRATrlvdqllTLSRLDSLDNLQDVAEIPLEDLLQSAV 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 333 AAAvaggaatDGPAPGSA-EVPVHLEGAGATR-GDASALARVVRNLVENARR--HATSRVEVHVAPGLVVVDDDGGGIDP 408
Cdd:PRK10337  322 MDI-------YHTAQQAGiDVRLTLNAHPVIRtGQPLLLSLLVRNLLDNAIRysPQGSVVDVTLNARNFTVRDNGPGVTP 394

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1097524387 409 ADRERVFERFVRLDAARERgtgGSGLGLAIAREIAREHGGDVVLGDSPLGGLRAQLR 465
Cdd:PRK10337  395 EALARIGERFYRPPGQEAT---GSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 364-466 4.46e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 94.39  E-value: 4.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 364 GDASALARVVRNLVENARRH--ATSRVEVHV---APGLVVVDDDGGGIDPADRERVFERFVRLDAareRGTGGSGLGLAI 438
Cdd:cd16940     9 GDALLLFLLLRNLVDNAVRYspQGSRVEIKLsadDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSI 85

                          90       100
                  ....*....|....*....|....*...
gi 1097524387 439 AREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16940    86 VKRIVELHGGQIFLGNAQGGGLEAWVRL 113
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
144-461 6.56e-23

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 102.02  E-value: 6.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 144 MRLVEGPSGPV-------------TVVATMPLTEVRGLLRALQVSF--------FGVVPTLTLLVAIAVWLVLGRALGPV 202
Cdd:PRK10549  113 NKVLVGPRGPIppdgtrrpilvngAEVGWVIASPVERLTRNTDINFdkqqrrtsWLIVALSTLLAALATFLLARGLLAPV 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 203 DQLRRAAAQVA----STggRgVLPVGRDddEIAALARTLNDMLDRLDAAAGRQRSFVADAAHELRSPLSSLRATIEVAAD 278
Cdd:PRK10549  193 KRLVEGTHKLAagdfTT--R-VTPTSRD--ELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 279 SRSGYTAEELAEDLApEV------------LRMgalvddllllARLGSAPRGERPVDLAAVAAEGVAAAvaggaaTDGPA 346
Cdd:PRK10549  268 GVRKFTPESVASLQA-EVgtltklvddlhqLSL----------SDEGALAYRKTPVDLVPLLEVAGGAF------RERFA 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 347 PGSAEVPVHLEGAGATRGDASALARVVRNLVENARRHATSRVEVHV-----APGLVVV-DDDGGGIDPADRERVFERFVR 420
Cdd:PRK10549  331 SRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHIsaeqrDKTLRLTfADSAPGVSDEQLQKLFERFYR 410

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1097524387 421 LDAARERGTGGSGLGLAIAREIAREHGGDVVLGDSPLGGLR 461
Cdd:PRK10549  411 TEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVS 451
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 364-466 7.69e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 94.24  E-value: 7.69e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 364 GDASALARVVRNLVENARRHATSRVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARErgtgGSGLGLAIA 439
Cdd:cd16954    33 GERNDLMELLGNLLDNACKWCLEFVEVTARQTdgglHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIA 108

                          90       100
                  ....*....|....*....|....*..
gi 1097524387 440 REIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16954   109 KEIVEQYGGELSLSDSPLGGARFEVVF 135
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 170-466 4.45e-22

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 99.53  E-value: 4.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 170 RALQVSFFGVVPTLTLLVAIAVWLVlgRALGpvdQLRRAAAQVaSTGGRGVLPVGRDDdEIAALARTLNDMLDRLDaaaG 249
Cdd:PRK11100  183 RILWAGALLLGIALLIGAGVVWWLN--RSIR---RLTRYADAV-TEGKPVPLPKLGSS-ELRELAQALESMRVKLE---G 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 250 RQ--RSFVADAAHELRSPLSSLRATIEVAADSRSGYTAEELAEDLAPEVLRMGALVDD--LLLLARLGSAPRGERPVDLA 325
Cdd:PRK11100  253 KAyvEQYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRllELARLEQRQELEVLEPVALA 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 326 AVAAEGVAAAVAGGAAtdgpapgsAEVPVHLEGAGAT-RGDASALARVVRNLVENAR--RHATSRVEVHVAP----GLVV 398
Cdd:PRK11100  333 ALLEELVEAREAQAAA--------KGITLRLRPDDARvLGDPFLLRQALGNLLDNAIdfSPEGGTITLSAEVdgeqVALS 404

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 399 VDDDGGGI-DPAdRERVFERFVRLdaAR-ERGTGGSGLGLAIAREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:PRK11100  405 VEDQGPGIpDYA-LPRIFERFYSL--PRpANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
221-468 1.89e-21

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 96.19  E-value: 1.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 221 LPVGRDDDEIAALARTLNDMLDRLDAAAGRQRSFVADAAHELRSPLSSLRATIEVAAD---------------------- 278
Cdd:PRK10755  107 IAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKqhhidvapliarldqmmhtveq 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 279 ----SRSG-------YTAEELAED----LAPEVLRMgalvddllllarlgSAPRGERpVDLAAvaaegvaaavaggaatd 343
Cdd:PRK10755  187 llqlARAGqsfssghYQTVKLLEDvilpSQDELSEM--------------LEQRQQT-LLLPE----------------- 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 344 gpapGSAEVPVHlegagatrGDASALARVVRNLVENARR----HATSRVEVHVAPG--LVVVDDDGGGIDPADRERVFER 417
Cdd:PRK10755  235 ----SAADITVQ--------GDATLLRLLLRNLVENAHRyspeGSTITIKLSQEDGgaVLAVEDEGPGIDESKCGELSKA 302

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1097524387 418 FVRLDaareRGTGGSGLGLAIAREIAREHGGDVVLGD-SPLGGLRAQLRLRA 468
Cdd:PRK10755  303 FVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLPK 350
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-466 2.73e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 88.66  E-value: 2.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHATSRVEVH--VAPGLVV--VDDDGGGIDPADRERVFERFVRLDAARerGTGGSGLGLAIAREIAR 444
Cdd:cd16950     1 LKRVLSNLVDNALRYGGGWVEVSsdGEGNRTRiqVLDNGPGIAPEEVDELFQPFYRGDNAR--GTSGTGLGLAIVQRISD 78

                          90       100
                  ....*....|....*....|..
gi 1097524387 445 EHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16950    79 AHGGSLTLANRAGGGLCARIEL 100
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 365-466 4.00e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 88.67  E-value: 4.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 365 DASALARVVRNLVENARR--HATSRVEVHVA--PGLV--VVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAI 438
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRytDTGGKLRIRAAqtPQEVrlDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80

                          90       100
                  ....*....|....*....|....*...
gi 1097524387 439 AREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16946    81 CHNIALAHGGTISAEHSPLGGLRLVLTL 108
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 365-466 5.28e-19

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 82.54  E-value: 5.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 365 DASALARVVRNLVENARRHATS------RVEVHVAPG-LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLA 437
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDggrircILEKFRLNRfLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80

                          90       100
                  ....*....|....*....|....*....
gi 1097524387 438 IAREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16925    81 IVKEFVELHGGTVTVSDAPGGGALFQVEL 109
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 363-473 4.94e-18

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 86.55  E-value: 4.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 363 RGDASALARVVRNLVENARrHATS-----RVEVHVAPGLVVVD--DDGGGIDPADRERVFERFVrldAARERGTGgsgLG 435
Cdd:COG5000   312 LADRDQLEQVLINLLKNAI-EAIEeggeiEVSTRREDGRVRIEvsDNGPGIPEEVLERIFEPFF---TTKPKGTG---LG 384

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1097524387 436 LAIAREIAREHGGDVVLGDSPLGGLRAQLRLRAGDDPA 473
Cdd:COG5000   385 LAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 1-450 3.67e-16

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 81.37  E-value: 3.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387   1 MSAAARHQPDRRGPAWRSLRVRLTVLTAAVMCLALVAGAWTLGTVLQRGRLAALDGIVAARVDTVAALVAEDRLPDPLPV 80
Cdd:COG4251    30 LALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  81 EEPGEVVQVLDAQGRVVASSSTASRTLPVLPADLLSAAPGAAAPDPAVMTTSASAYADTARAAMRLVEGPSGPVTVVATM 160
Cdd:COG4251   110 LALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLL 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 161 PLTEVRGLLRALQVSFFGVVPTLTLLVAIAVWL--VLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDDEIAALARTLN 238
Cdd:COG4251   190 LLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGggLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELE 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 239 DMLDRLDAAAGRQRSFVADAAHELRSPLSSLratievaadsrSGYT---AEELAEDLAPEVL-----------RMGALVD 304
Cdd:COG4251   270 ERTAELERSNEELEQFAYVASHDLREPLRKI-----------SGFSqllEEDYGDKLDEEGReylerirdaaeRMQALID 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 305 DLLLLARLGSAPRGERPVDLAAVAAEGVAAAVAGGAATDgpapgsaeVPVHLEGAGATRGDASALARVVRNLVENA---- 380
Cdd:COG4251   339 DLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERG--------AEIEVGPLPTVRGDPTLLRQVFQNLISNAikys 410

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1097524387 381 RRHATSRVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARERgtGGSGLGLAIAREIAREHGGDV 450
Cdd:COG4251   411 RPGEPPRIEIGAEREggewVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRI 482
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
87-450 6.16e-16

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 80.59  E-value: 6.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  87 VQVLDAQGRVVASSSTASR-----TLPVLPADLLSAAPGAAAPDPavMTTSASAYADTARAAMRLVEGPSGPvTVVATMP 161
Cdd:PRK09835   88 ISLADSHGKTVYHSPGAPDlrefvRDAIPDKDARGGEVFLWSGPT--PMMPGHGHGHMEHSNWRMIALPVGP-LVDGKPI 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 162 LTEVRGL--------LRALQVSFFGVVPTLTLLVAIAVWLVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDDEIAAL 233
Cdd:PRK09835  165 YTLLIALsidfhlhyINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQL 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 234 ARTLNDMLDRLDAAAGRQRSFVADAAHELRSPLSSLRATIEVA-ADSRSGYTAEELAEDLAPEVLRMGALVDDLLLLARL 312
Cdd:PRK09835  245 VLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIAlSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQA 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 313 GSAP-RGER-PVDLAAVAAEGVAAAVAGGAatdgpapgSAEVPVHLEGAG-ATRGDASALARVVRNLVENARRH--ATSR 387
Cdd:PRK09835  325 DNNQlIPEKkMLDLADEVGKVFDFFEAWAE--------ERGVELRFVGDPcQVAGDPLMLRRAISNLLSNALRYtpAGEA 396

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1097524387 388 VEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDV 450
Cdd:PRK09835  397 ITVRCQEVdhqvQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTV 463
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
372-461 1.59e-15

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 79.29  E-value: 1.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 372 VVRNLVENARRHATSRVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARErgtgGSGLGLAIAREIAREHG 447
Cdd:PRK10815  382 VMGNVLDNACKYCLEFVEISARQTdehlHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYE 457

                          90
                  ....*....|....
gi 1097524387 448 GDVVLGDSPLGGLR 461
Cdd:PRK10815  458 GKISAGDSPLGGAR 471
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 369-452 1.89e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 72.53  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENA-----RRHATSRVEVHVAPG-----LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAI 438
Cdd:cd16922     1 LRQILLNLLGNAikfteEGEVTLRVSLEEEEEdgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80

                          90
                  ....*....|....
gi 1097524387 439 AREIAREHGGDVVL 452
Cdd:cd16922    81 SKKLVELMGGDISV 94
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-448 1.53e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 69.72  E-value: 1.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHATSRVEVHVAPGL------VVVDDDGGGIDPADRERVFERFVRLDAARErgTGGSGLGLAIAREI 442
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLtddvvnIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78


                  ....*.
gi 1097524387 443 AREHGG 448
Cdd:cd16923    79 IELHGG 84
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 363-466 1.82e-13

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 72.14  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 363 RGDASALARVVRNLVENARrHATS-----RVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVrldaarergT---- 429
Cdd:COG4191   251 LGDPGQLEQVLLNLLINAI-DAMEegeggRITISTRREgdyvVISVRDNGPGIPPEVLERIFEPFF---------Ttkpv 320

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1097524387 430 -GGSGLGLAIAREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:COG4191   321 gKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 364-456 2.12e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 67.15  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 364 GDASALARVVRNLVENARRHAT---------SRVEVHVApglVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGL 434
Cdd:cd16947    16 ANTEALQRILKNLISNAIKYGSdgkflgmtlREDEKHVY---IDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGL 92

                          90       100
                  ....*....|....*....|..
gi 1097524387 435 GLAIAREIAREHGGDVVLGDSP 456
Cdd:cd16947    93 GLTITKRLAESMGGSIYVNSKP 114
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-451 7.72e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 64.90  E-value: 7.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHA---TSRVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIARE 441
Cdd:cd16953     1 LGQVLRNLIGNAISFSppdTGRITVSAMPTgkmvTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80

                          90
                  ....*....|
gi 1097524387 442 IAREHGGDVV 451
Cdd:cd16953    81 IIEAHGGISV 90
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-459 1.15e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 64.27  E-value: 1.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENA----RRHATSRVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLDAARErgTGGSGLGLAIAR 440
Cdd:cd16921     1 LGQVLTNLLGNAikfrRPRRPPRIEVGAEDVgeewTFYVRDNGIGIDPEYAEKVFGIFQRLHSREE--YEGTGVGLAIVR 78

                          90
                  ....*....|....*....
gi 1097524387 441 EIAREHGGDVVLGDSPLGG 459
Cdd:cd16921    79 KIIERHGGRIWLESEPGEG 97
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
363-438 1.54e-12

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 69.65  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 363 RGDASALARVVRNLVENARRHAT--SRVEV---HVAPG-LVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGL 436
Cdd:PRK11006  312 FGNEDQLRSAISNLVYNAVNHTPegTHITVrwqRVPQGaEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGL 391


                  ..
gi 1097524387 437 AI 438
Cdd:PRK11006  392 AI 393
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 365-459 2.06e-12

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 69.11  E-value: 2.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 365 DASALARVVRNLVENARRHATS--------RVEVHVAPG--LVVVDDDGGGIDPADRERVFERfvrldaarerGT----- 429
Cdd:COG3290   278 SDTDLVTILGNLLDNAIEAVEKlpeeerrvELSIRDDGDelVIEVEDSGPGIPEELLEKIFER----------GFstklg 347

                          90       100       110
                  ....*....|....*....|....*....|
gi 1097524387 430 GGSGLGLAIAREIAREHGGDVVLGDSPLGG 459
Cdd:COG3290   348 EGRGLGLALVKQIVEKYGGTIEVESEEGEG 377
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
363-450 1.45e-11

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 66.02  E-value: 1.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 363 RGDASALARVVRNLVENAR-------------RHATSRVEVHVAPGLVV---VDDDGGGIDPADRERVFERFVrldaare 426
Cdd:COG3852   239 LGDPDQLIQVLLNLVRNAAeampeggtitirtRVERQVTLGGLRPRLYVrieVIDNGPGIPEEILDRIFEPFF------- 311

                          90       100
                  ....*....|....*....|....*..
gi 1097524387 427 rgTG---GSGLGLAIAREIAREHGGDV 450
Cdd:COG3852   312 --TTkekGTGLGLAIVQKIVEQHGGTI 336
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 367-466 3.83e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 60.13  E-value: 3.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 367 SALARVVRNLVENA------RRHATSRVEVHVAPGLVVVDDDGGGIDPADRERVFERFVrldAARERGTgGSGLGLAIAR 440
Cdd:cd16943     2 SQLNQVLLNLLVNAaqamegRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF---TTKPVGE-GTGLGLSLSY 77

                          90       100
                  ....*....|....*....|....*.
gi 1097524387 441 EIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16943    78 RIIQKHGGTIRVASVPGGGTRFTIIL 103
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 365-466 8.41e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 59.01  E-value: 8.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 365 DASALARVVRNLVENAR----RHATSRVEVHVAPGLV--VVDDDGGGIDPADRERVFERFVRLdAARERGTGGSGLGLAI 438
Cdd:cd16945     1 DPFLLRQAINNLLDNAIdfspEGGLIALQLEADTEGIelLVFDEGSGIPDYALNRVFERFYSL-PRPHSGQKSTGLGLAF 79

                          90       100
                  ....*....|....*....|....*...
gi 1097524387 439 AREIAREHGGDVVLGDSPLGGLrAQLRL 466
Cdd:cd16945    80 VQEVAQLHGGRITLRNRPDGVL-AFLTL 106
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-466 2.23e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 57.68  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENA------RRHATSRVEV----HVAPGLVVVDDDGGGIDPADRERVFERFVRLDAARERgtggsGLGLAI 438
Cdd:cd16915     1 LITIVGNLIDNAldalaaTGAPNKQVEVflrdEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLAL 75

                          90       100
                  ....*....|....*....|....*...
gi 1097524387 439 AREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16915    76 VRQSVERLGGSITVESEPGGGTTFSIRI 103
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 367-461 4.28e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 57.21  E-value: 4.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 367 SALARVVRNLVENARRHATSRVEVHVAP--GLVVVDDDGGGIDPADRERVFERFVRLDAARERGTGGSGLGLAIAREIAR 444
Cdd:cd16952     3 SAFSNLVSNAVKYTPPSDTITVRWSQEEsgARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMS 82

                          90
                  ....*....|....*..
gi 1097524387 445 EHGGDVVLGDSPLGGLR 461
Cdd:cd16952    83 RHDARLLIASELGKGSR 99
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 361-484 1.13e-09

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 61.46  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 361 ATRGDASALARVVRNLVENARRHaTSRVEVHVAPG------LVVVDDDGGGIDPADRERVFERFVRLDAARergtGGSGL 434
Cdd:PRK11466  554 ALMGDPRRIRQVITNLLSNALRF-TDEGSIVLRSRtdgeqwLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGL 628

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1097524387 435 GLAIAREIAREHGGDVVLGDSPLGGLRAQLRLRAgddpAAVVPPPADAVA 484
Cdd:PRK11466  629 GLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL----RVATAPVPKTVN 674
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
219-466 2.48e-09

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 59.98  E-value: 2.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 219 GVLPVGRDDDEIAALARTLNdMLDRLdAAAGRqrsFVADAAHELRSPLSSLRATIEVAADSRSGYTAEELAEDLAPEVLR 298
Cdd:PRK11360  363 GALVIFSDLTERKRLQRRVA-RQERL-AALGE---LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDR 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 299 MGALVDDLLLLarlgSAPRGER--PVDLAAVAAEGVAAAvaggaatdGPAPGSAEVPVHLEGAG---ATRGDASALARVV 373
Cdd:PRK11360  438 LNKVIDQLLEF----SRPRESQwqPVSLNALVEEVLQLF--------QTAGVQARVDFETELDNelpPIWADPELLKQVL 505

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 374 RNLVENARRHATSRVEVHVAPGL-------VVVDDDGGGIDPADRERVFERFVRLDAArergtgGSGLGLAIAREIAREH 446
Cdd:PRK11360  506 LNILINAVQAISARGKIRIRTWQysdgqvaVSIEDNGCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAH 579

                         250       260
                  ....*....|....*....|
gi 1097524387 447 GGDVVLGDSPLGGLRAQLRL 466
Cdd:PRK11360  580 GGDIEVESEPGVGTTFTLYL 599
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 365-466 4.65e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 54.08  E-value: 4.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 365 DASALARVVRNLVENA----------RRHATSRVEVHVAPGLVV-VDDDGGGIDPADRERVFERFVrldAARERGTGgsg 433
Cdd:cd16944     1 DTTQISQVLTNILKNAaeaiegrpsdVGEVRIRVEADQDGRIVLiVCDNGKGFPREMRHRATEPYV---TTRPKGTG--- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1097524387 434 LGLAIAREIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16944    75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIIL 107
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-448 1.35e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 52.79  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENA-----------------RRHATSRVEVHVAPGLVVVDDDGGGIDPADRERVFERFVrldAARErgtGG 431
Cdd:cd16918     1 LIQVFLNLVRNAaqalagsggeiilrtrtQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV---SGRE---NG 74

                          90
                  ....*....|....*..
gi 1097524387 432 SGLGLAIAREIAREHGG 448
Cdd:cd16918    75 TGLGLAIAQNIVSQHGG 91
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 365-459 1.57e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 52.46  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 365 DASALARVVRNLVENARRHATSRVEVHVAPGL------VVVDDDGGGIDPADRERVFERFVRLDAARERGtGGSGLGLAI 438
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDeeeylyFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79

                          90       100
                  ....*....|....*....|.
gi 1097524387 439 AREIAREHGGDVVLGDSPLGG 459
Cdd:cd16975    80 AKNLVEKHGGSLIIENSQKGG 100
PRK10490 PRK10490
sensor protein KdpD; Provisional
 365-459 2.33e-08

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 56.97  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 365 DASALARVVRNLVENARRHATSRVEVHVAPGL------VVVDDDGGGIDPADRERVFERFVRldAARERGTGGSGLGLAI 438
Cdd:PRK10490  775 DGPLFERVLINLLENAVKYAGAQAEIGIDAHVegerlqLDVWDNGPGIPPGQEQLIFDKFAR--GNKESAIPGVGLGLAI 852

                          90       100
                  ....*....|....*....|.
gi 1097524387 439 AREIAREHGGDVVLGDSPLGG 459
Cdd:PRK10490  853 CRAIVEVHGGTIWAENRPEGG 873
PRK09303 PRK09303
histidine kinase;
364-448 9.76e-08

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 54.19  E-value: 9.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 364 GDASALARVVRNLVENARR-------------HATS-RVEVHVApglvvvdDDGGGIDPADRERVFERFVRLDaaRERGT 429
Cdd:PRK09303  268 ADQERIRQVLLNLLDNAIKytpeggtitlsmlHRTTqKVQVSIC-------DTGPGIPEEEQERIFEDRVRLP--RDEGT 338

                          90
                  ....*....|....*....
gi 1097524387 430 GGSGLGLAIAREIAREHGG 448
Cdd:PRK09303  339 EGYGIGLSVCRRIVRVHYG 357
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
251-456 2.47e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 53.97  E-value: 2.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  251 QRSFVADAAHELRSPLSSLRATIEVAadSRSGYTAEELAEDLA-----PEVLRMGALVDDLLLLARLGSAPRGERPVDLA 325
Cdd:PRK09959   712 KSQFLATMSHEIRTPISSIMGFLELL--SGSGLSKEQRVEAISlayatGQSLLGLIGEILDVDKIESGNYQLQPQWVDIP 789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387  326 AVAAEGVAAAVAGGAATDGPAPGSAEVPVHLegagATRGDASALARVVRNLVENARRHATSRVeVHVAPGLVVVDDD--- 402
Cdd:PRK09959   790 TLVQNTCHSFGAIAASKSIALSCSSTFPDHY----LVKIDPQAFKQVLSNLLSNALKFTTEGA-VKITTSLGHIDDNhav 864

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1097524387  403 --------GGGIDPADRERVFERFVRLDAARERGtgGSGLGLAIAREIAREHGGDVVLGDSP 456
Cdd:PRK09959   865 ikmtimdsGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHP 924
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-466 3.74e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 48.61  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHATS------RVEVHVAPG--LVVVDDDGGGIDPADRERVFERFVrldAARERGTGgSGLGLAIAR 440
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKvenpriRIAARRLGGrlVLVVRDNGPGIAEEHLSRVFDPFF---TTKPVGKG-TGLGLSISY 76

                          90       100
                  ....*....|....*....|....*.
gi 1097524387 441 EIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16976    77 GIVEEHGGRLSVANEEGAGARFTFDL 102
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-459 3.93e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 48.55  E-value: 3.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENA----------RRHATSRVEVHVAPGL-VVVDDDGGGIDPADRERVFERFVRLDAArergtgGSGLGLA 437
Cdd:cd16920     1 IQQVLINLVRNGieamseggceRRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74

                          90       100
                  ....*....|....*....|..
gi 1097524387 438 IAREIAREHGGDVVLGDSPLGG 459
Cdd:cd16920    75 ICRSIIEAHGGRLSVESPAGGG 96
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 349-450 4.54e-06

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 49.85  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 349 SAEVPVHLEGagatrgDASALARVVRNLVENA---------------RRHATSRVEVhvapgLVVVDDDGGGIDPADRER 413
Cdd:PRK11107  395 DPDVPDNVIG------DPLRLQQIITNLVGNAikftesgnidilvelRALSNTKVQL-----EVQIRDTGIGISERQQSQ 463

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1097524387 414 VFERFVRLDAARERGTGGSGLGLAIAREIAREHGGDV 450
Cdd:PRK11107  464 LFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDI 500
PRK15347 PRK15347
two component system sensor kinase;
349-458 5.10e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 49.64  E-value: 5.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 349 SAEVPVHLEGagatrgDASALARVVRNLVENARRHATS-----RVEVHVAPGLVVVDDDGGGIDPADRERVFERFVRLDA 423
Cdd:PRK15347  500 GAHVPLYLHL------DSLRLRQILVNLLGNAVKFTETggirlRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT 573

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1097524387 424 ARergtGGSGLGLAIAREIAREHGGDVVLgDSPLG 458
Cdd:PRK15347  574 HS----QGTGLGLTIASSLAKMMGGELTL-FSTPG 603
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 369-418 5.87e-06

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 47.05  E-value: 5.87e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1097524387 369 LARVVRNLVENA-RRHATsRVEVHVAPG---LVVVDDDGGGIDPADRERVFERF 418
Cdd:cd16926    14 PASVVKELVENSiDAGAT-RIDVEIEEGglkLIRVTDNGSGISREDLELAFERH 66
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-466 5.99e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 44.85  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 369 LARVVRNLVENARRHA---TSRVEVHVAPGLVV--VDDDGGGIDPADRErvferfvrldaarergtGGSGLGLAIAREIA 443
Cdd:cd16917     1 LYRIVQEALTNALKHAgasRVRVTLSYTADELTltVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERA 63

                          90       100
                  ....*....|....*....|...
gi 1097524387 444 REHGGDVVLGDSPLGGLRAQLRL 466
Cdd:cd16917    64 ELLGGTLTIGSRPGGGTRVTARL 86
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
347-448 8.59e-06

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 48.91  E-value: 8.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 347 PGSAEVPVHLEGAGAT-RGDASALARVVRNLVENA--------------RRHATSRVEV----HVAPG---LVVVDDDGG 404
Cdd:PRK13837  538 PPGVELDFDQDQEPAVvEGNPAELQQVLMNLCSNAaqamdgagrvdislSRAKLRAPKVlshgVLPPGryvLLRVSDTGA 617

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1097524387 405 GIDPADRERVFERFVRLDAarergtGGSGLGLAIAREIAREHGG 448
Cdd:PRK13837  618 GIDEAVLPHIFEPFFTTRA------GGTGLGLATVHGIVSAHAG 655
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 250-299 1.51e-05

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 42.97  E-value: 1.51e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1097524387 250 RQRSFVADAAHELRSPLSSLRATIEVAADSRSGYTAEELAEDLAPEVLRM 299
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERL 50
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 250-299 3.99e-05

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 41.78  E-value: 3.99e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1097524387  250 RQRSFVADAAHELRSPLSSLRATIEVAADSRSGYTAEELAEDLAPEVLRM 299
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERL 50
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 250-299 5.17e-05

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 41.43  E-value: 5.17e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1097524387 250 RQRSFVADAAHELRSPLSSLRATIEVAADSRSGY-TAEELAEDLAPEVLRM 299
Cdd:cd00082     3 AKGEFLANVSHELRTPLTAIRGALELLEEELLDDeEQREYLERIREEAERL 53
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 375-450 9.04e-05

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 45.35  E-value: 9.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 375 NLVENARrHATSR-VEVHV-----APGLVVVD--DDGGGIDPADRERVFERFVRLdaaRERGTGgsgLGLAIAREIAREH 446
Cdd:COG5809   386 NLLKNAI-EAMPEgGNITIetkaeDDDKVVISvtDEGCGIPEERLKKLGEPFYTT---KEKGTG---LGLMVSYKIIEEH 458


                  ....
gi 1097524387 447 GGDV 450
Cdd:COG5809   459 GGKI 462
HAMP pfam00672
HAMP domain;
193-244 9.10e-05

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 40.30  E-value: 9.10e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1097524387 193 LVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDdEIAALARTLNDMLDRL 244
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRD-EIGELARAFNQMAERL 51
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
366-466 1.09e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 44.22  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 366 ASALARVVRNLVENARRHA-TSRVEVHVAPG----LVVVDDDGGGIDPADrervferfvrldaarergTGGSGLGLAIAR 440
Cdd:COG4585   160 ELALYRIVQEALTNALKHAgATRVTVTLEVDdgelTLTVRDDGVGFDPEA------------------APGGGLGLRGMR 221

                          90       100
                  ....*....|....*....|....*.
gi 1097524387 441 EIAREHGGDVVLGDSPLGGLRAQLRL 466
Cdd:COG4585   222 ERAEALGGTLTIGSAPGGGTRVRATL 247
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
155-466 1.14e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 45.01  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 155 TVVATMPLTEVRGLLRALQVSFFGVVPTLTLLVAIAVWLVLGRALGPVDQLRRAAAQVAStgGRGVLPVGRDDDEIAALA 234
Cdd:COG2972   138 TLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEK--GDLVRLEVSGNDEIGILA 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 235 RTLNDMLDRLDAAAGRQRSFVADAAH-ELRS------P------LSSLRATIEVAADSRsgytAEELAEDLApEVLRMga 301
Cdd:COG2972   216 RSFNEMVERIKELIEEVYELELEKKEaELKAlqaqinPhflfntLNSIRWLAELEDPEE----AEEMLEALS-KLLRY-- 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 302 lvddllllarlgSAPRGERPVDLaavaaegvaaavaggaatdgpapgSAEV------------------PVHLEGAGATR 363
Cdd:COG2972   289 ------------SLSKGDELVTL------------------------EEELeliksyleiqklrfgdrlEVEIEIDEELL 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 364 gDASALARVVRNLVENARRHATS--------RVEVHVAPG--LVVVDDDGGGIDPADRERVFERFvrldaarERGTGGSG 433
Cdd:COG2972   333 -DLLIPKLILQPLVENAIEHGIEpkegggtiRISIRKEGDrlVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRG 404

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1097524387 434 LGLAIAREIAREHGGD---VVLGDSPLGGLRAQLRL 466
Cdd:COG2972   405 IGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRI 440
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 364-449 2.85e-04

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 43.57  E-value: 2.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 364 GDASALARVVRNLVENARRHATS--RVEVHVAPG----LVVVDDDGGGIDPADRERVFERFVRLdaaRERGTGgsgLGLA 437
Cdd:COG5805   391 CDENQIKQVFINLIKNAIEAMPNggTITIHTEEEdnsvIIRVIDEGIGIPEERLKKLGEPFFTT---KEKGTG---LGLM 464

                          90
                  ....*....|..
gi 1097524387 438 IAREIAREHGGD 449
Cdd:COG5805   465 VSYKIIENHNGT 476
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 201-244 3.72e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 38.19  E-value: 3.72e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1097524387 201 PVDQLRRAAAQVAStGGRGV-LPVGRDDdEIAALARTLNDMLDRL 244
Cdd:cd06225     3 PLRRLTEAARRIAE-GDLDVrVPVRSKD-EIGELARAFNQMAERL 45
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
197-249 5.59e-04

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 38.00  E-value: 5.59e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1097524387  197 RALGPVDQLRRAAAQVASTGGRGVLPVgRDDDEIAALARTLNDMLDRLDAAAG 249
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPV-DGRDEIGELARAFNEMADRLEETIA 53
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
352-438 6.42e-04

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 42.65  E-value: 6.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 352 VPVHLegagatRGDASALARVVRNLVENARRHATSR---VEVHVAPG--LVVVDDDGGGIDPADRERVFERFVRLDAARE 426
Cdd:PRK10841  552 VPVAL------NGDPMRLQQVISNLLSNAIKFTDTGcivLHVRVDGDylSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQ 625

                          90
                  ....*....|..
gi 1097524387 427 RGTGGSGLGLAI 438
Cdd:PRK10841  626 RNFQGTGLGLAI 637
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
256-450 6.59e-04

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 42.47  E-value: 6.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 256 ADAAHELRSPLSSLRATIE-VAADSRSGYTAEELAEDLAPEVLRMGALVDDLLLLArlgsaprgeRPVDLAAVAAEGVAA 334
Cdd:PRK10364  242 AGVAHEIRNPLSSIKGLAKyFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELV---------KPTHLALQAVDLNDL 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 335 AVAGGAATDGPAPgSAEVPVHL---EGAGATRGDASALARVVRNLVENA----RRHATSRVEV--HVAPGLVVVDDDGGG 405
Cdd:PRK10364  313 INHSLQLVSQDAN-SREIQLRFtanDTLPEIQADPDRLTQVLLNLYLNAiqaiGQHGVISVTAseSGAGVKISVTDSGKG 391

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1097524387 406 IDPADRERVFERFVRLDAArergtgGSGLGLAIAREIAREHGGDV 450
Cdd:PRK10364  392 IAADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTI 430
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
182-279 8.56e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 42.31  E-value: 8.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 182 TLTLLVAIAVWLVLGRALGPVDQLRRAAAQVASTGGRGVLPVGRDDdEIAALARTLNDMLDRLDAAAGRQRSF---VADA 258
Cdd:COG0840   190 ALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKD-EIGQLADAFNRMIENLRELVGQVRESaeqVASA 268

                          90       100
                  ....*....|....*....|.
gi 1097524387 259 AHELRSPLSSLRATIEVAADS 279
Cdd:COG0840   269 SEELAASAEELAAGAEEQAAS 289
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 183-452 6.88e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 39.28  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 183 LTLLVAIAV-WLVLGRAL-GPVDQLRRAAAQVASTGGRGVLPVGrDDDEIAALARTL----------------------- 237
Cdd:COG4192   334 LSLLLAVLInYFYVRRRLvKRLNALSDAMAAIAAGDLDVPIPVD-GNDEIGRIARLLrvfrdqaiektqeleteieerkr 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 238 -----NDMLDRLDAAAgrQRSFVADA----AHELRSPLSSLRA---TIEVAADSRSGYTAEELAEDLAPEVLRMGALVDD 305
Cdd:COG4192   413 ieknlRQTQDELIQAA--KMAVVGQTmtslAHELNQPLNAMSMylfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKS 490

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1097524387 306 LLLLARLGSAPRgeRPVDLAAVAAEGVAAAVAGGAATDGPapgsaevpVHLEGAGATRGDASALARVVRNLVENARRHAT 385
Cdd:COG4192   491 LRQFSRKSDTPL--QPVDLRQVIEQAWELVESRAKPQQIT--------LHIPDDLMVQGDQVLLEQVLVNLLVNALDAVA 560

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1097524387 386 SRVEVHV-----APGLVV-VDDDGGGIDPADRerVFERFVrldaarERGTGGSGLGLAIAREIAREHGGDVVL 452
Cdd:COG4192   561 TQPQISVdllsnAENLRVaISDNGNGWPLVDK--LFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYL 625
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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