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Conserved domains on  [gi|1173202411|emb|SFW10571|]
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DNA gyrase subunit A, partial [Aeromonas crassostreae]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 2-170 1.89e-149

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 433.30  E-value: 1.89e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   2 EITPVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVY 81
Cdd:PRK05560    4 RIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  82 DTIVRMAQDFSMRYMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTL 161
Cdd:PRK05560   84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163


                  ....*....
gi 1173202411 162 LINGSSGIA 170
Cdd:PRK05560  164 LVNGSSGIA 172
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 2-170 1.89e-149

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 433.30  E-value: 1.89e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   2 EITPVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVY 81
Cdd:PRK05560    4 RIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  82 DTIVRMAQDFSMRYMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTL 161
Cdd:PRK05560   84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163


                  ....*....
gi 1173202411 162 LINGSSGIA 170
Cdd:PRK05560  164 LVNGSSGIA 172
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
2-170 5.08e-145

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 422.14  E-value: 5.08e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   2 EITPVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVY 81
Cdd:COG0188     9 RIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  82 DTIVRMAQDFSMRYMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTL 161
Cdd:COG0188    89 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNL 168


                  ....*....
gi 1173202411 162 LINGSSGIA 170
Cdd:COG0188   169 LVNGSSGIA 177
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 3-170 1.11e-125

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 372.03  E-value: 1.11e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   3 ITPVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYD 82
Cdd:TIGR01063   1 IVPVNIEEEMKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  83 TIVRMAQDFSMRYMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLL 162
Cdd:TIGR01063  81 TLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLL 160


                  ....*...
gi 1173202411 163 INGSSGIA 170
Cdd:TIGR01063 161 VNGSSGIA 168
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 6-173 2.14e-112

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 327.21  E-value: 2.14e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411    6 VNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIV 85
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   86 RMAQDFSMRYMLVDGQGNFGSV-DGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLIN 164
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160

                          170
                   ....*....|
gi 1173202411  165 GSSGIA-GWA 173
Cdd:smart00434 161 GSSGIAvGMA 170
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 25-173 4.33e-108

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 316.43  E-value: 4.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  25 VGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQDFSMRYMLVDGQGNF 104
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411 105 GSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLINGSSGIA-GWA 173
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAvGMA 150
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
27-173 7.38e-99

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 292.15  E-value: 7.38e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  27 RALPDVRDGLKPVHRRVLYAMNELGNDwNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQDFSMRYMLVDGQGNFGS 106
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFELLNL-DKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1173202411 107 V-DGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLINGSSGIA-GWA 173
Cdd:pfam00521  80 RiDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAvGMA 148
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 2-170 1.89e-149

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 433.30  E-value: 1.89e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   2 EITPVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVY 81
Cdd:PRK05560    4 RIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  82 DTIVRMAQDFSMRYMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTL 161
Cdd:PRK05560   84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163


                  ....*....
gi 1173202411 162 LINGSSGIA 170
Cdd:PRK05560  164 LVNGSSGIA 172
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
2-170 5.08e-145

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 422.14  E-value: 5.08e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   2 EITPVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVY 81
Cdd:COG0188     9 RIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDSAVY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  82 DTIVRMAQDFSMRYMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTL 161
Cdd:COG0188    89 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNL 168


                  ....*....
gi 1173202411 162 LINGSSGIA 170
Cdd:COG0188   169 LVNGSSGIA 177
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 3-170 1.11e-125

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 372.03  E-value: 1.11e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   3 ITPVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYD 82
Cdd:TIGR01063   1 IVPVNIEEEMKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  83 TIVRMAQDFSMRYMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLL 162
Cdd:TIGR01063  81 TLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLL 160


                  ....*...
gi 1173202411 163 INGSSGIA 170
Cdd:TIGR01063 161 VNGSSGIA 168
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
3-170 4.81e-118

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 350.95  E-value: 4.81e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   3 ITPVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYD 82
Cdd:PRK05561   10 IEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDSSIYD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  83 TIVRMAQDFSMRYMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLL 162
Cdd:PRK05561   90 AMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNLL 169


                  ....*...
gi 1173202411 163 INGSSGIA 170
Cdd:PRK05561  170 LNGATGIA 177
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 6-173 2.14e-112

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 327.21  E-value: 2.14e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411    6 VNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIV 85
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   86 RMAQDFSMRYMLVDGQGNFGSV-DGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLIN 164
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160

                          170
                   ....*....|
gi 1173202411  165 GSSGIA-GWA 173
Cdd:smart00434 161 GSSGIAvGMA 170
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 25-173 4.33e-108

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 316.43  E-value: 4.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  25 VGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQDFSMRYMLVDGQGNF 104
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411 105 GSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLINGSSGIA-GWA 173
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAvGMA 150
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
27-173 7.38e-99

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 292.15  E-value: 7.38e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  27 RALPDVRDGLKPVHRRVLYAMNELGNDwNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQDFSMRYMLVDGQGNFGS 106
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFELLNL-DKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1173202411 107 V-DGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLINGSSGIA-GWA 173
Cdd:pfam00521  80 RiDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAvGMA 148
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 12-170 1.91e-82

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 258.30  E-value: 1.91e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  12 LTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQDF 91
Cdd:TIGR01062  10 TEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  92 SMRYMLVDGQGNFGSVDG-DNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLINGSSGIA 170
Cdd:TIGR01062  90 SYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNILLNGTTGIA 169
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 16-170 1.39e-76

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 246.55  E-value: 1.39e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  16 YLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQDFSMRY 95
Cdd:PRK13979   26 YLPYAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQDFTTRM 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1173202411  96 MLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLINGSSGIA 170
Cdd:PRK13979  106 PLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIA 180
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 15-173 1.39e-76

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 242.79  E-value: 1.39e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  15 SYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQDFSMR 94
Cdd:TIGR01061  13 SFGKYAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRMSQDWKNN 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  95 YMLVDGQGNFGSVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPTLLINGSSGI-AGWA 173
Cdd:TIGR01061  93 WTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGATGIaAGYA 172
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 5-170 7.80e-41

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 145.62  E-value: 7.80e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   5 PVNIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELgNDWNkpYKKSARVVGDVIgKYHPHGDSAVYDTI 84
Cdd:PRK09631    1 MMDIKTLFKDNFLQYASYVIKDRAIPDVIDGLKPVQRRILHSLFEM-HDGK--FHKVANVVGNTM-KYHPHGDASIYEAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  85 VRMA-QDFsmrymLVDGQGNFGSV-DGDNAAAMRYTEVRMARISHELLadLDKETVDWVPNYDGTEMIPAVMPTKVPTLL 162
Cdd:PRK09631   77 VNLAnKDL-----FIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPVIL 149


                  ....*...
gi 1173202411 163 INGSSGIA 170
Cdd:PRK09631  150 IQGAEGIA 157
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
16-170 2.49e-40

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 145.15  E-value: 2.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  16 YLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDwnkPYKKSARVVGDVIgKYHPHGDSAVYDTIVRMAQdfsmRY 95
Cdd:PRK12758   31 FLDYASYVILERAVPHIEDGLKPVQRRILHSMKEMDDG---RYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ----KD 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1173202411  96 MLVDGQGNFGSV-DGDNAAAMRYTEVRMARISHELLadLDKETVDWVPNYDGTEMIPAVMPTKVPTLLINGSSGIA 170
Cdd:PRK12758  103 LLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIA 176
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 17-185 1.24e-28

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 110.15  E-value: 1.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  17 LDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDV--IGkYHpHGDSAVYDTIVRMAQDFSMR 94
Cdd:PHA02592   17 LEYAMYTVEERAIPNLIDGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVadLG-YH-HGETSAQDAGALMANTWNNN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  95 YMLVDGQGNFGSVDGDNAAAMRYTEVRMarisHELLADLDKETvDWVPNYDGTEMIPAV--MPTkVPTLLINGSSGIA-G 171
Cdd:PHA02592   95 IPLLDGQGNFGSRLVQKAAAARYIFARV----HDNFRKIYKDE-DLAPVHEDPEHIPPAfyLPI-IPMVLLNGVSGIAtG 168

                         170
                  ....*....|....
gi 1173202411 172 WAwpTQHFPPQPTS 185
Cdd:PHA02592  169 YA--TNILPHSPKS 180
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 7-170 3.93e-27

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 106.52  E-value: 3.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   7 NIAAELTSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELgnDWNKPYKksarvVGDVIGK---YHPHGDSAVYDT 83
Cdd:PRK09630    3 DVSDLFKTHFMHYASYVILERAIPHILDGLKPVQRRLLWTLFRM--DDGKMHK-----VANIAGRtmaLHPHGDAPIVEA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  84 IVRMAQdfsmRYMLVDGQGNFGS-VDGDNAAAMRYTEVRMARISHELLADLDkeTVDWVPNYDGTEMIPAVMPTKVPTLL 162
Cdd:PRK09630   76 LVVLAN----KGYLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVLFNTD--LMTFHDSYDGREKEPDILPAKLPLLL 149


                  ....*...
gi 1173202411 163 INGSSGIA 170
Cdd:PRK09630  150 LHGVDGIA 157
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 27-173 2.79e-18

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 81.63  E-value: 2.79e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   27 RALPDVRDGLKPVHRRVLYAM------NELgndwnkpykKSARVVGDVIGK--YHpHGDSAVYDTIVRMAQDF----SMR 94
Cdd:PTZ00108   680 RSIPSLVDGLKPGQRKILFACfkrnlkNEI---------KVAQLSGYVSEHsaYH-HGEQSLQQTIVGMAQNFvgsnNIN 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   95 YMLVDGQgnFGS--VDGDNAAAMRYTEVRMARISHELLADLDKETVDWVpNYDGTEMIPA-VMPTkVPTLLINGSSGIA- 170
Cdd:PTZ00108   750 LLYPCGQ--FGSrlQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYL-EDDGQSVEPFyYVPI-IPMVLVNGAEGIGt 825


                   ...
gi 1173202411  171 GWA 173
Cdd:PTZ00108   826 GFS 828
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 27-172 3.23e-17

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 78.60  E-value: 3.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   27 RALPDVRDGLKPVHRRVLYAMneLGNDWnKPYKKSARVVGDVI--GKYHpHGDSAVYDTIVRMAQDF--SMRYMLVDGQG 102
Cdd:PLN03128   673 RSIPSMVDGLKPSQRKVLFAC--FKRNL-KSEIKVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgSNNINLLTPSG 748

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1173202411  103 NFGS--VDGDNAAAMRYTEVRMARISHELLADLDKETVDWVpNYDGTEMIPA-VMPTkVPTLLINGSSGIA-GW 172
Cdd:PLN03128   749 QFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYL-NEDGQSIEPEwYCPI-IPMVLVNGSEGIGtGW 820
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 27-176 3.92e-16

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 75.67  E-value: 3.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411   27 RALPDVRDGLKPVHRRVLYAmnelgnDWNKPYKKSARV---VGDV--IGKYHpHGDSAVYDTIVRMAQDF--SMRYMLVD 99
Cdd:PLN03237   698 RSIPSMVDGLKPGQRKILFC------SFKRNFVKEAKVaqlSGYVseHSAYH-HGEQSLASTIIGMAQDFvgSNNINLLL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1173202411  100 GQGNFG--SVDGDNAAAMRYTEVRMARISHELLADLDKETVDWVpNYDGTEMIPA-VMPTkVPTLLINGSSGIaGWAWPT 176
Cdd:PLN03237   771 PNGQFGtrLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYL-NEDGQSIEPTwYMPI-IPTVLVNGAEGI-GTGWST 847
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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