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Conserved domains on  [gi|1182682416|emb|SMF04781|]
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DNA-binding transcriptional regulator GbsR, MarR family [Bacillus subtilis]

Protein Classification

GbsR/MarR family transcriptional regulator( domain architecture ID 10003936)

GbsR/MarR family transcriptional regulator containing a MarR family DNA-binding helix-turn-helix (HTH) domain, may act as a transcriptional activator or as a transcriptional repressor in controlling the expression of genes encoding metabolic enzymes

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  37630496|28670937|32044654|28694934|23428319|15808743|10473770|8831795
SCOP:  3000034

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
8-170 3.28e-38

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


:

Pssm-ID: 441119  Cd Length: 164  Bit Score: 128.51  E-value: 3.28e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182682416   8 AAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMRDE-MTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRK 86
Cdd:COG1510     3 EKLEEAKERFIEAFGEMGERWGLPRSAGRIYALLYLSDEpLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKPGDRK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182682416  87 HTFVAEKDFFKFFTNFFPPKWEREVQVNVAAIEEAQADLQkvlcKEDLDEDIKnealllyDQLESSKAYYDWLKRLAESV 166
Cdd:COG1510    83 DYFRAEKDVWELFRRVFRERLRREIDPTLELLREALEELE----DSEEAEEAR-------ERLEELRDFYEFLERLLEAL 151


                  ....
gi 1182682416 167 QTGE 170
Cdd:COG1510   152 LKRW 155
 
Name Accession Description Interval E-value
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
8-170 3.28e-38

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 128.51  E-value: 3.28e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182682416   8 AAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMRDE-MTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRK 86
Cdd:COG1510     3 EKLEEAKERFIEAFGEMGERWGLPRSAGRIYALLYLSDEpLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKPGDRK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182682416  87 HTFVAEKDFFKFFTNFFPPKWEREVQVNVAAIEEAQADLQkvlcKEDLDEDIKnealllyDQLESSKAYYDWLKRLAESV 166
Cdd:COG1510    83 DYFRAEKDVWELFRRVFRERLRREIDPTLELLREALEELE----DSEEAEEAR-------ERLEELRDFYEFLERLLEAL 151


                  ....
gi 1182682416 167 QTGE 170
Cdd:COG1510   152 LKRW 155
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-79 2.39e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.57  E-value: 2.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1182682416  28 YGITRSVGILYGTMYMRDEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKT 79
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
 
Name Accession Description Interval E-value
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
8-170 3.28e-38

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 128.51  E-value: 3.28e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182682416   8 AAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMRDE-MTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRK 86
Cdd:COG1510     3 EKLEEAKERFIEAFGEMGERWGLPRSAGRIYALLYLSDEpLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKPGDRK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182682416  87 HTFVAEKDFFKFFTNFFPPKWEREVQVNVAAIEEAQADLQkvlcKEDLDEDIKnealllyDQLESSKAYYDWLKRLAESV 166
Cdd:COG1510    83 DYFRAEKDVWELFRRVFRERLRREIDPTLELLREALEELE----DSEEAEEAR-------ERLEELRDFYEFLERLLEAL 151


                  ....
gi 1182682416 167 QTGE 170
Cdd:COG1510   152 LKRW 155
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-79 2.39e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.57  E-value: 2.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1182682416  28 YGITRSVGILYGTMYMRDEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKT 79
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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