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Conserved domains on  [gi|2478927741|emb|SMP52303|]
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AAA ATPase domain-containing protein [Fibrobacter sp. UWB10]

Protein Classification

ATP-binding protein( domain architecture ID 1002851)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase

Gene Ontology:  GO:0005524
PubMed:  15037234|18208389|16828312|18466635

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3950 super family cl34700
Predicted ATP-binding protein involved in virulence [General function prediction only];
1-367 2.73e-18

Predicted ATP-binding protein involved in virulence [General function prediction only];


The actual alignment was detected with superfamily member COG3950:

Pssm-ID: 443150 [Multi-domain]  Cd Length: 276  Bit Score: 83.89  E-value: 2.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741   1 MLEKMTVKGLLHQFSYELDFTNENGPAVkyITGPNGFGKTTILKLLVALYGADWKTMAALPFDSFECvmdgktlsvtkee 80
Cdd:COG3950     2 RIKSLTIENFRGFEDLEIDFDNPPRLTV--LVGENGSGKTTLLEAIALALSGLLSRLDDVKFRKLLI------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741  81 wqiiqnddsdeqddldvrldilfegqktlqvsvkgRDGKFYTPKKSgdhsvemilsqkkILYIPDTRVIEKNLPKRNRKS 160
Cdd:COG3950    67 -----------------------------------RNGEFGDSAKL-------------ILYYGTSRLLLDGPLKKLERL 98

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 161 pvktcNDSFIKYLSILSDKIGDflKSKLKnefpvnepieglkfplvdkmlgfglnsEFLTDVKKYGSIVENLLNDEYSik 240
Cdd:COG3950    99 -----KEEYFSRLDGYDSLLDE--DSNLR---------------------------EFLEWLREYLEDLENKLSDELD-- 142

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 241 hevDKLEKFMELINRYEFVNKKISISENDGFRFKLNDlFNSIIDLDDLSSGERQYLMLVYKMLFESNEH----------- 309
Cdd:COG3950   143 ---EKLEAVREALNKLLPDFKDIRIDRDPGRLVILDK-NGEELPLNQLSDGERSLLALVGDLARRLAELnpalenplege 218

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2478927741 310 TLVLVDEPENSMHMSWILEFPKVIKELCKwsDLQFIICTHNSNIFEQRWDMSQDLFEK 367
Cdd:COG3950   219 GIVLIDEIDLHLHPKWQRRILPDLRKIFP--NIQFIVTTHSPLILSSLEDEEVIVLER 274
 
Name Accession Description Interval E-value
COG3950 COG3950
Predicted ATP-binding protein involved in virulence [General function prediction only];
1-367 2.73e-18

Predicted ATP-binding protein involved in virulence [General function prediction only];


Pssm-ID: 443150 [Multi-domain]  Cd Length: 276  Bit Score: 83.89  E-value: 2.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741   1 MLEKMTVKGLLHQFSYELDFTNENGPAVkyITGPNGFGKTTILKLLVALYGADWKTMAALPFDSFECvmdgktlsvtkee 80
Cdd:COG3950     2 RIKSLTIENFRGFEDLEIDFDNPPRLTV--LVGENGSGKTTLLEAIALALSGLLSRLDDVKFRKLLI------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741  81 wqiiqnddsdeqddldvrldilfegqktlqvsvkgRDGKFYTPKKSgdhsvemilsqkkILYIPDTRVIEKNLPKRNRKS 160
Cdd:COG3950    67 -----------------------------------RNGEFGDSAKL-------------ILYYGTSRLLLDGPLKKLERL 98

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 161 pvktcNDSFIKYLSILSDKIGDflKSKLKnefpvnepieglkfplvdkmlgfglnsEFLTDVKKYGSIVENLLNDEYSik 240
Cdd:COG3950    99 -----KEEYFSRLDGYDSLLDE--DSNLR---------------------------EFLEWLREYLEDLENKLSDELD-- 142

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 241 hevDKLEKFMELINRYEFVNKKISISENDGFRFKLNDlFNSIIDLDDLSSGERQYLMLVYKMLFESNEH----------- 309
Cdd:COG3950   143 ---EKLEAVREALNKLLPDFKDIRIDRDPGRLVILDK-NGEELPLNQLSDGERSLLALVGDLARRLAELnpalenplege 218

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2478927741 310 TLVLVDEPENSMHMSWILEFPKVIKELCKwsDLQFIICTHNSNIFEQRWDMSQDLFEK 367
Cdd:COG3950   219 GIVLIDEIDLHLHPKWQRRILPDLRKIFP--NIQFIVTTHSPLILSSLEDEEVIVLER 274
AAA_21 pfam13304
AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being ...
 31-355 2.19e-11

AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.


Pssm-ID: 433102 [Multi-domain]  Cd Length: 303  Bit Score: 63.95  E-value: 2.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741  31 ITGPNGFGKTTILKLLVALygadwktmaalpFDSFECVMDGKTLSVTKEEWQIIQNDDSDEQDDLDVRLDILFEGQKtlq 110
Cdd:pfam13304   4 LIGPNGSGKSNLLEALRFL------------ADFDALVIGLTDERSRNGGIGGIPSLLNGIDPKEPIEFEISEFLED--- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 111 vsvkgrDGKFYTPKKSGDHSVEMILSQKKILYIPDTRVIEKNLPKRNRKSPVKTCNDSFIKYLSILSDKIGDFLKSKLkn 190
Cdd:pfam13304  69 ------GVRYRYGLDLEREDVEEKLSSKPTLLEKRLLLREDSEEREPKFPPEAEELRLGLDVEERIELSLSELSDLIS-- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 191 eFPVNEPIEGLKFPLVDKMLGFGlnsefltdvkKYGSIVENLLNDEYSIKHEVDKLEKFMELINRYEFVNKKISISENDG 270
Cdd:pfam13304 141 -GLLLLSIISPLSFLLLLDEGLL----------LEDWAVLDLAADLALFPDLKELLQRLVRGLKLADLNLSDLGEGIEKS 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 271 FRFKLNDLFNSII----------DLDDLSSGERQYLMLVYKMLFESNEHTLVLVDEPENSMHMSWILEFPKVIKElCKWS 340
Cdd:pfam13304 210 LLVDDRLRERGLIllenggggelPAFELSDGTKRLLALLAALLSALPKGGLLLIDEPESGLHPKLLRRLLELLKE-LSRN 288

                         330
                  ....*....|....*
gi 2478927741 341 DLQFIICTHNSNIFE 355
Cdd:pfam13304 289 GAQLILTTHSPLLLD 303
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 249-355 4.75e-05

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 43.00  E-value: 4.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 249 FMELINRYEFVNK-KISISENDGFRFKLNDLFNSIIDLDDLSSGERQYLMLVYKMLFESnehTLVLVDEPENSMHMSWIL 327
Cdd:cd00267    41 LLRAIAGLLKPTSgEILIDGKDIAKLPLEELRRRIGYVPQLSGGQRQRVALARALLLNP---DLLLLDEPTSGLDPASRE 117

                          90       100
                  ....*....|....*....|....*...
gi 2478927741 328 EFPKVIKELCKwSDLQFIICTHNSNIFE 355
Cdd:cd00267   118 RLLELLRELAE-EGRTVIIVTHDPELAE 144
ccmA TIGR01189
heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein ...
 18-82 3.17e-04

heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein encoded by ccmA in bacteria. An exception is, an arabidopsis protein. Quite likely this is encoded by an organelle. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other]


Pssm-ID: 273491 [Multi-domain]  Cd Length: 198  Bit Score: 41.58  E-value: 3.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2478927741  18 LDFTNENGPAVKyITGPNGFGKTTILKLLVALygadwktmaaLPFDSFECVMDGKTLSVTKEEWQ 82
Cdd:TIGR01189  19 LSFTLNAGEALQ-VTGPNGIGKTTLLRILAGL----------LRPDSGEVRWNGTPLAEQRDEPH 72
PRK00635 PRK00635
excinuclease ABC subunit A; Provisional
 285-353 8.45e-03

excinuclease ABC subunit A; Provisional


Pssm-ID: 234806 [Multi-domain]  Cd Length: 1809  Bit Score: 38.27  E-value: 8.45e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2478927741  285 LDDLSSGERQYLMLVYKMLFESNEHTLVLVDEPENSMHMSWILEFPKVIKELCKWSDLQFIIcTHNSNI 353
Cdd:PRK00635   807 LSSLSGGEIQRLKLAYELLAPSKKPTLYVLDEPTTGLHTHDIKALIYVLQSLTHQGHTVVII-EHNMHV 874
 
Name Accession Description Interval E-value
COG3950 COG3950
Predicted ATP-binding protein involved in virulence [General function prediction only];
1-367 2.73e-18

Predicted ATP-binding protein involved in virulence [General function prediction only];


Pssm-ID: 443150 [Multi-domain]  Cd Length: 276  Bit Score: 83.89  E-value: 2.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741   1 MLEKMTVKGLLHQFSYELDFTNENGPAVkyITGPNGFGKTTILKLLVALYGADWKTMAALPFDSFECvmdgktlsvtkee 80
Cdd:COG3950     2 RIKSLTIENFRGFEDLEIDFDNPPRLTV--LVGENGSGKTTLLEAIALALSGLLSRLDDVKFRKLLI------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741  81 wqiiqnddsdeqddldvrldilfegqktlqvsvkgRDGKFYTPKKSgdhsvemilsqkkILYIPDTRVIEKNLPKRNRKS 160
Cdd:COG3950    67 -----------------------------------RNGEFGDSAKL-------------ILYYGTSRLLLDGPLKKLERL 98

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 161 pvktcNDSFIKYLSILSDKIGDflKSKLKnefpvnepieglkfplvdkmlgfglnsEFLTDVKKYGSIVENLLNDEYSik 240
Cdd:COG3950    99 -----KEEYFSRLDGYDSLLDE--DSNLR---------------------------EFLEWLREYLEDLENKLSDELD-- 142

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 241 hevDKLEKFMELINRYEFVNKKISISENDGFRFKLNDlFNSIIDLDDLSSGERQYLMLVYKMLFESNEH----------- 309
Cdd:COG3950   143 ---EKLEAVREALNKLLPDFKDIRIDRDPGRLVILDK-NGEELPLNQLSDGERSLLALVGDLARRLAELnpalenplege 218

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2478927741 310 TLVLVDEPENSMHMSWILEFPKVIKELCKwsDLQFIICTHNSNIFEQRWDMSQDLFEK 367
Cdd:COG3950   219 GIVLIDEIDLHLHPKWQRRILPDLRKIFP--NIQFIVTTHSPLILSSLEDEEVIVLER 274
COG1106 COG1106
ATPase/GTPase, AAA15 family [General function prediction only];
231-370 1.90e-12

ATPase/GTPase, AAA15 family [General function prediction only];


Pssm-ID: 440723 [Multi-domain]  Cd Length: 330  Bit Score: 67.38  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 231 NLLNDEYSIKHEVDKLEKFMEL-INRYEFVNKKISISENDGFRFKLNDLfNSIIDLDDLSSGERQYLMLVYKMLFESNEH 309
Cdd:COG1106   146 LLLKEDESLKEELLELLKIADPgIEDIEVEEEEIEDLVERKLIFKHKGG-NVPLPLSEESDGTKRLLALAGALLDALAKG 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2478927741 310 TLVLVDEPENSMHMSWILEFPKVIKELCKWSDLQFIICTHNSNIfeqrWDMSQDLFEKSQL 370
Cdd:COG1106   225 GVLLIDEIEASLHPSLLRKLLKLFLDLANKNNAQLIFTTHSTEL----LDAFLELLRRDQI 281
AAA_21 pfam13304
AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being ...
 31-355 2.19e-11

AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.


Pssm-ID: 433102 [Multi-domain]  Cd Length: 303  Bit Score: 63.95  E-value: 2.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741  31 ITGPNGFGKTTILKLLVALygadwktmaalpFDSFECVMDGKTLSVTKEEWQIIQNDDSDEQDDLDVRLDILFEGQKtlq 110
Cdd:pfam13304   4 LIGPNGSGKSNLLEALRFL------------ADFDALVIGLTDERSRNGGIGGIPSLLNGIDPKEPIEFEISEFLED--- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 111 vsvkgrDGKFYTPKKSGDHSVEMILSQKKILYIPDTRVIEKNLPKRNRKSPVKTCNDSFIKYLSILSDKIGDFLKSKLkn 190
Cdd:pfam13304  69 ------GVRYRYGLDLEREDVEEKLSSKPTLLEKRLLLREDSEEREPKFPPEAEELRLGLDVEERIELSLSELSDLIS-- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 191 eFPVNEPIEGLKFPLVDKMLGFGlnsefltdvkKYGSIVENLLNDEYSIKHEVDKLEKFMELINRYEFVNKKISISENDG 270
Cdd:pfam13304 141 -GLLLLSIISPLSFLLLLDEGLL----------LEDWAVLDLAADLALFPDLKELLQRLVRGLKLADLNLSDLGEGIEKS 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 271 FRFKLNDLFNSII----------DLDDLSSGERQYLMLVYKMLFESNEHTLVLVDEPENSMHMSWILEFPKVIKElCKWS 340
Cdd:pfam13304 210 LLVDDRLRERGLIllenggggelPAFELSDGTKRLLALLAALLSALPKGGLLLIDEPESGLHPKLLRRLLELLKE-LSRN 288

                         330
                  ....*....|....*
gi 2478927741 341 DLQFIICTHNSNIFE 355
Cdd:pfam13304 289 GAQLILTTHSPLLLD 303
YbjD COG3593
Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM ...
 217-353 1.63e-08

Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains [Replication, recombination and repair];


Pssm-ID: 442812 [Multi-domain]  Cd Length: 359  Bit Score: 55.78  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 217 EFLTDVKKYGSIVENL--LNDEYSikhevDKLEKFMELINRY---EFVNKKISISENDGFRFKLNDLFN------SIIDL 285
Cdd:COG3593    86 RLLLKEEDKEELEEALeeLNEELK-----EALKALNELLSEYlkeLLDGLDLELELSLDELEDLLKSLSlriedgKELPL 160

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2478927741 286 DDLSSGERQ-YLMLVYKMLFE---SNEHTLVLVDEPENSMHMSWILEFPKVIKELCKWsDLQFIICTHNSNI 353
Cdd:COG3593   161 DRLGSGFQRlILLALLSALAElkrAPANPILLIEEPEAHLHPQAQRRLLKLLKELSEK-PNQVIITTHSPHL 231
COG4938 COG4938
Predicted ATPase [General function prediction only];
212-356 2.49e-05

Predicted ATPase [General function prediction only];


Pssm-ID: 443965 [Multi-domain]  Cd Length: 277  Bit Score: 45.34  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 212 FGLNSEFLTDvkkYGSIVENLLNDEYSIKHEVDKLEKFMElinryEFVNKKISISEN-DGFRFKLNDLFNSI-IDLDDLS 289
Cdd:COG4938    72 LGSRGEYTAD---FLAELENLEILDDKSKELLEQVEEWLE-----KIFPGKVEVDASsDLVRLVFRPSGNGKrIPLSNVG 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2478927741 290 SGERQYLMLVYKMLFESNEHTLVLVDEPENSMHMSWILEFPKVIKELCKwSDLQFIICTHNSNIFEQ 356
Cdd:COG4938   144 SGVSELLPILLALLSAAKPGSLLIIEEPEAHLHPKAQSALAELLAELAN-SGVQVIIETHSDYILNG 209
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 249-355 4.75e-05

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 43.00  E-value: 4.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 249 FMELINRYEFVNK-KISISENDGFRFKLNDLFNSIIDLDDLSSGERQYLMLVYKMLFESnehTLVLVDEPENSMHMSWIL 327
Cdd:cd00267    41 LLRAIAGLLKPTSgEILIDGKDIAKLPLEELRRRIGYVPQLSGGQRQRVALARALLLNP---DLLLLDEPTSGLDPASRE 117

                          90       100
                  ....*....|....*....|....*...
gi 2478927741 328 EFPKVIKELCKwSDLQFIICTHNSNIFE 355
Cdd:cd00267   118 RLLELLRELAE-EGRTVIIVTHDPELAE 144
COG4637 COG4637
Predicted ATPase [General function prediction only];
240-350 5.02e-05

Predicted ATPase [General function prediction only];


Pssm-ID: 443675 [Multi-domain]  Cd Length: 371  Bit Score: 44.92  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2478927741 240 KHEVDKLEKFMELINR-YEFVNKKISISENDG---FRFKLNDlFNSIIDLDDLSSGERQYLMLVYkMLFESNEHTLVLVD 315
Cdd:COG4637   208 ETHPERFERILEALRDaFPGFEDIEVEPDEDGrvlLEFREKG-LDRPFPARELSDGTLRFLALLA-ALLSPRPPPLLCIE 285

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2478927741 316 EPENSMHMSWILEFPKVIKELCKwsDLQFIICTHN 350
Cdd:COG4637   286 EPENGLHPDLLPALAELLREASE--RTQVIVTTHS 318
ABC_UvrA cd03238
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...
 288-336 2.21e-04

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.


Pssm-ID: 213205 [Multi-domain]  Cd Length: 176  Bit Score: 41.54  E-value: 2.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2478927741 288 LSSGERQYLMLVYKmLFESNEHTLVLVDEPENSMHMSWILEFPKVIKEL 336
Cdd:cd03238    88 LSGGELQRVKLASE-LFSEPPGTLFILDEPSTGLHQQDINQLLEVIKGL 135
ccmA TIGR01189
heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein ...
 18-82 3.17e-04

heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein encoded by ccmA in bacteria. An exception is, an arabidopsis protein. Quite likely this is encoded by an organelle. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other]


Pssm-ID: 273491 [Multi-domain]  Cd Length: 198  Bit Score: 41.58  E-value: 3.17e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2478927741  18 LDFTNENGPAVKyITGPNGFGKTTILKLLVALygadwktmaaLPFDSFECVMDGKTLSVTKEEWQ 82
Cdd:TIGR01189  19 LSFTLNAGEALQ-VTGPNGIGKTTLLRILAGL----------LRPDSGEVRWNGTPLAEQRDEPH 72
ABC_CcmA_heme_exporter cd03231
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ...
 18-82 2.18e-03

Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE.


Pssm-ID: 213198 [Multi-domain]  Cd Length: 201  Bit Score: 39.01  E-value: 2.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2478927741  18 LDFTNENGPAVKyITGPNGFGKTTILKLLVALygadwktmaaLPFDSFECVMDGKTLSVTKEEWQ 82
Cdd:cd03231    19 LSFTLAAGEALQ-VTGPNGSGKTTLLRILAGL----------SPPLAGRVLLNGGPLDFQRDSIA 72
ABC_NatA_like cd03267
ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; ...
 18-49 2.66e-03

ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.


Pssm-ID: 213234 [Multi-domain]  Cd Length: 236  Bit Score: 38.85  E-value: 2.66e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2478927741  18 LDFTNENGPAVKYItGPNGFGKTTILKLLVAL 49
Cdd:cd03267    40 ISFTIEKGEIVGFI-GPNGAGKTTTLKILSGL 70
ABC_Class2 cd03227
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ...
 282-355 2.88e-03

ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.


Pssm-ID: 213194 [Multi-domain]  Cd Length: 162  Bit Score: 38.11  E-value: 2.88e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2478927741 282 IIDLDDLSSGERQYLMLVYKM-LFESNEHTLVLVDEPENSMHMSWILEFPKVIKELCKwSDLQFIICTHNSNIFE 355
Cdd:cd03227    72 IFTRLQLSGGEKELSALALILaLASLKPRPLYILDEIDRGLDPRDGQALAEAILEHLV-KGAQVIVITHLPELAE 145
COG4586 COG4586
ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...
 6-46 4.28e-03

ABC-type uncharacterized transport system, ATPase component [General function prediction only];


Pssm-ID: 443643 [Multi-domain]  Cd Length: 323  Bit Score: 38.53  E-value: 4.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2478927741   6 TVKGLLHQfSYE-------LDFTNENGPAVKYItGPNGFGKTTILKLL 46
Cdd:COG4586    23 ALKGLFRR-EYReveavddISFTIEPGEIVGFI-GPNGAGKSTTIKML 68
CcmA COG4133
ABC-type transport system involved in cytochrome c biogenesis, ATPase component ...
 18-53 5.49e-03

ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443308 [Multi-domain]  Cd Length: 206  Bit Score: 37.84  E-value: 5.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2478927741  18 LDFTNENGPAVkYITGPNGFGKTTILKLLVALYGAD 53
Cdd:COG4133    21 LSFTLAAGEAL-ALTGPNGSGKTTLLRILAGLLPPS 55
PvdE COG4615
ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion ...
 30-50 6.04e-03

ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion transport and metabolism];


Pssm-ID: 443659 [Multi-domain]  Cd Length: 547  Bit Score: 38.63  E-value: 6.04e-03
                          10        20
                  ....*....|....*....|.
gi 2478927741  30 YITGPNGFGKTTILKLLVALY 50
Cdd:COG4615   362 FIVGGNGSGKSTLAKLLTGLY 382
PRK00635 PRK00635
excinuclease ABC subunit A; Provisional
 285-353 8.45e-03

excinuclease ABC subunit A; Provisional


Pssm-ID: 234806 [Multi-domain]  Cd Length: 1809  Bit Score: 38.27  E-value: 8.45e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2478927741  285 LDDLSSGERQYLMLVYKMLFESNEHTLVLVDEPENSMHMSWILEFPKVIKELCKWSDLQFIIcTHNSNI 353
Cdd:PRK00635   807 LSSLSGGEIQRLKLAYELLAPSKKPTLYVLDEPTTGLHTHDIKALIYVLQSLTHQGHTVVII-EHNMHV 874
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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