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Conserved domains on  [gi|1403730280|emb|SPT35702|]
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ARHGAP31, partial [Homo sapiens]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138166)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-211 4.48e-119

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 370.29  E-value: 4.48e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCK 96
Cdd:cd04384      1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   97 LYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Cdd:cd04384     81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1403730280  177 NLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNH 211
Cdd:cd04384    161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-211 4.48e-119

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 370.29  E-value: 4.48e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCK 96
Cdd:cd04384      1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   97 LYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Cdd:cd04384     81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1403730280  177 NLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNH 211
Cdd:cd04384    161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 32-212 3.61e-56

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 192.48  E-value: 3.61e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280    32 QDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYE 110
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAF--DSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYE 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   111 LYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEieatgcn 190
Cdd:smart00324   79 LYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD------- 151

                           170       180
                    ....*....|....*....|...
gi 1403730280   191 GDAAFLA-VRVQQVVIEFILNHV 212
Cdd:smart00324  152 GEVASLKdIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 35-182 6.70e-55

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 187.75  E-value: 6.70e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   35 PYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYE 113
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAF--DRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1403730280  114 KFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSK 182
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-211 4.48e-119

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 370.29  E-value: 4.48e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCK 96
Cdd:cd04384      1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   97 LYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Cdd:cd04384     81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1403730280  177 NLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNH 211
Cdd:cd04384    161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 32-212 3.61e-56

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 192.48  E-value: 3.61e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280    32 QDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYE 110
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAF--DSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYE 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   111 LYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEieatgcn 190
Cdd:smart00324   79 LYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD------- 151

                           170       180
                    ....*....|....*....|...
gi 1403730280   191 GDAAFLA-VRVQQVVIEFILNHV 212
Cdd:smart00324  152 GEVASLKdIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 35-182 6.70e-55

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 187.75  E-value: 6.70e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   35 PYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYE 113
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAF--DRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1403730280  114 KFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSK 182
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 35-211 5.64e-51

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 177.49  E-value: 5.64e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   35 PYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVylqDIHCVGSLCKLYFRELPNPLLTYELYE 113
Cdd:cd00159      1 PLIIEKCIEYLEKNGLnTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDY---DVHDVASLLKLYLRELPEPLIPFELYD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  114 KFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEatgcngDA 193
Cdd:cd00159     78 EFIELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSD------DE 151

                          170
                   ....*....|....*...
gi 1403730280  194 AFLAVRVQQVVIEFILNH 211
Cdd:cd00159    152 LLEDIKKLNEIVEFLIEN 169
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-216 1.34e-40

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 148.71  E-value: 1.34e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcPD----LTREVYLQDIHCVGS 93
Cdd:cd04398      1 FGVPLEDLILREGDNVPNIVYQCIQAIENFGLnLEGIYRLSGNVSRVNKLKELFDKD--PLnvllISPEDYESDIHSVAS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   94 LCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04398     79 LLKLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAII 158

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1403730280  174 WAPNLLRSkeieATGCNGDAAFlavrvQQVVIEFILNHVDQIF 216
Cdd:cd04398    159 WGPTLMNA----APDNAADMSF-----QSRVIETLLDNAYQIF 192
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-216 1.20e-38

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 143.04  E-value: 1.20e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEFGSD-QCPDLTREVYlQDIHCVGSLCK 96
Cdd:cd04372      1 YGCDLTTLVKAHNTQRPMVVDMCIREIEARGLQsEGLYRVSGFAEEIEDVKMAFDRDgEKADISATVY-PDINVITGALK 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   97 LYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Cdd:cd04372     80 LYFRDLPIPVITYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGP 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1403730280  177 NLLRSKEIEATGCNGDaaflaVRVQQVVIEFILNHVDQIF 216
Cdd:cd04372    160 TLMRPPEDSALTTLND-----MRYQILIVQLLITNEDVLF 194
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-220 1.26e-38

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 143.37  E-value: 1.26e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSdQCPDLTREVYLQDIHCVGSLC 95
Cdd:cd04386      3 PVFGTPLEEHLKRTGREIALPIEACVMCLLETGMNEeGLFRVGGGASKLKRLKAALDA-GTFSLPLDEFYSDPHAVASAL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04386     82 KSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLA 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1403730280  176 PNLLRSKEIEATGCNGDAAFLAVrvqQVVIEFILNHVDQIFNNGA 220
Cdd:cd04386    162 PNLLWAKNEGSLAEMAAGTSVHV---VAIVELIISHADWFFPGEV 203
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 19-209 1.68e-38

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 142.53  E-value: 1.68e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTrEVYLQDIHCVGSLCKL 97
Cdd:cd04403      1 FGCHLEALCQRENSTVPKFVRLCIEAVEKRGLdVDGIYRVSGNLAVIQKLRFAVDHDEKLDLD-DSKWEDIHVITGALKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   98 YFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPN 177
Cdd:cd04403     80 FFRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPT 159

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1403730280  178 LLRSkEIEatgcNGDAAFLAVRVQQVViEFIL 209
Cdd:cd04403    160 LLRP-EQE----TGNIAVHMVYQNQIV-ELIL 185
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-180 1.95e-32

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 124.86  E-value: 1.95e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEyLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcPDltrEVYLQD--IHCVGSLC 95
Cdd:cd04377      1 FGVSLSS-LTSEDRSVPLVLEKLLEHIEMHGLyTEGIYRKSGSANKIKELRQGLDTD--PD---SVNLEDypIHVITSVL 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04377     75 KQWLRELPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFA 154


                   ....*
gi 1403730280  176 PNLLR 180
Cdd:cd04377    155 PCILR 159
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 18-183 1.31e-31

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 122.89  E-value: 1.31e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   18 AFGCDLTEYLESSGQD-VPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEF--GSDQCpDLTREVYlQDIHCVGS 93
Cdd:cd04395      1 TFGVPLDDCPPSSENPyVPLIVEVCCNIVEARGLeTVGIYRVPGNNAAISALQEELnrGGFDI-DLQDPRW-RDVNVVSS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   94 LCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04395     79 LLKSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIV 158

                          170
                   ....*....|
gi 1403730280  174 WAPNLLRSKE 183
Cdd:cd04395    159 FGPTLVRTSD 168
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 30-183 2.05e-31

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 122.03  E-value: 2.05e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   30 SGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcpdlTREVYL----QDIHCVGSLCKLYFRELPN 104
Cdd:cd04385     11 TDNDIPVIVDKCIDFITQHGLmSEGIYRKNGKNSSVKKLLEAFRKD-----ARSVQLregeYTVHDVADVLKRFLRDLPD 85

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1403730280  105 PLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKE 183
Cdd:cd04385     86 PLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTDE 164
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-216 3.07e-29

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 116.28  E-value: 3.07e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESSGQD--VPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVylqDIHCVGSLC 95
Cdd:cd04404      6 FGVSLQFLKEKNPEQepIPPVVRETVEYLQAHALtTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYE---DVHLPAVIL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   96 KLYFRELPNPLLTYELYEKFTeAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04404     83 KTFLRELPEPLLTFDLYDDIV-GFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFG 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1403730280  176 PNLLRSKEIEATgcngdaaFLAVRVQQVVIEFILNHVDQIF 216
Cdd:cd04404    162 PNLLWAKDASMS-------LSAINPINTFTKFLLDHQDEIF 195
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-178 6.64e-29

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 114.84  E-value: 6.64e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESS----GQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLtrEVYlqDIHCVGS 93
Cdd:cd04381      1 FGASLSLAVERSrchdGIDLPLVFRECIDYVEKHGMkCEGIYKVSGIKSKVDELKAAYNRRESPNL--EEY--EPPTVAS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   94 LCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04381     77 LLKQYLRELPEPLLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIV 156


                   ....*
gi 1403730280  174 WAPNL 178
Cdd:cd04381    157 LSPTV 161
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 34-216 1.06e-27

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 112.15  E-value: 1.06e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   34 VPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsdQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELY 112
Cdd:cd04376      9 VPRLVESCCQHLEKHGLqTVGIFRVGSSKKRVRQLREEF---DRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELY 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  113 EKFTEAVSHCPEEgQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKT-----------NMHARNLALVWAPNLLRS 181
Cdd:cd04376     86 TAFIGTALLEPDE-QLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSidedgqevsgnKMTSLNLATIFGPNLLHK 164

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1403730280  182 KEIEATGCNGDAAFLAVRVQQV-VIEFILNHVDQIF 216
Cdd:cd04376    165 QKSGEREFVQASLRIEESTAIInVVQTMIDNYEELF 200
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-210 1.23e-27

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 111.36  E-value: 1.23e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEF--GSDQCPDLTREvylQDIHCVGSLC 95
Cdd:cd04383      3 FNGSLEEYIQDSGQAIPLVVESCIRFINLYGLQhQGIFRVSGSQVEVNDIKNAFerGEDPLADDQND---HDINSVAGVL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04383     80 KLYFRGLENPLFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFG 159

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1403730280  176 PNLLRSKEieatgcNGDAAFLAVRVQQVVIEFILN 210
Cdd:cd04383    160 PTLMPVPE------GQDQVSCQAHVNELIKTIIIH 188
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-211 2.91e-27

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 110.59  E-value: 2.91e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHG-IVDGIYRLSGVTSNIQRLRQEF--GSDQcpdltreVYLQDI--HCVGS 93
Cdd:cd04378      1 FGVDFSQVPRDFPDEVPFIIKKCTSEIENRAlGVQGIYRVSGSKARVEKLCQAFenGKDL-------VELSELspHDISS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   94 LCKLYFRELPNPLLTYELYEKF------------TEAVSHCPEEGQ--LARIQNVIQELPPSHYRTLEYLIRHLAHIASF 159
Cdd:cd04378     74 VLKLFLRQLPEPLILFRLYNDFialakeiqrdteEDKAPNTPIEVNriIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQ 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1403730280  160 SSKTNMHARNLALVWAPNLLRSKEIEAT---GCNGDAAFlavrvQQVVIEFILNH 211
Cdd:cd04378    154 FEENKMSPNNLGIVFGPTLIRPRPGDADvslSSLVDYGY-----QARLVEFLITN 203
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 38-211 2.97e-27

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 110.56  E-value: 2.97e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   38 LKSCAEFIETHGIVD-GIYRLSGVTSNIQRLrQEFGSDQ----CPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELY 112
Cdd:cd04374     32 VRKCIEAVETRGINEqGLYRVVGVNSKVQKL-LSLGLDPktstPGDVDLDNSEWEIKTITSALKTYLRNLPEPLMTYELH 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  113 EKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEiEATgcngd 192
Cdd:cd04374    111 NDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQE-ETV----- 184

                          170
                   ....*....|....*....
gi 1403730280  193 AAFLAVRVQQVVIEFILNH 211
Cdd:cd04374    185 AAIMDIKFQNIVVEILIEN 203
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 34-211 5.10e-27

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 109.63  E-value: 5.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   34 VPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSDQcPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELY 112
Cdd:cd04387     16 VPYIVRQCVEEVERRGMEEvGIYRISGVATDIQALKAAFDTNN-KDVSVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  113 EKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEA---TGC 189
Cdd:cd04387     95 PNFAEGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKESkipTNT 174

                          170       180
                   ....*....|....*....|..
gi 1403730280  190 NGDAAFLAVRVQQVVIEFILNH 211
Cdd:cd04387    175 MTDSWSLEVMSQVQVLLYFLQL 196
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 19-178 3.40e-26

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 107.06  E-value: 3.40e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESS-----GQDVPYVLKSCAEFIETHGIV--DGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCV 91
Cdd:cd04400      2 FGSPLEEAVELSshkynGRDLPSVVYRCIEYLDKNRAIyeEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHTV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   92 GSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARI-QNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNL 170
Cdd:cd04400     82 AGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALElKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161


                   ....*...
gi 1403730280  171 ALVWAPNL 178
Cdd:cd04400    162 CIVFSPTL 169
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-178 1.55e-25

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 105.24  E-value: 1.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEyLESSGQ---DVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEFGSDQCPDLTREvylQDIHCVGSL 94
Cdd:cd04393      3 FGVPLQE-LQQAGQpenGVPAVVRHIVEYLEQHGLEqEGLFRVNGNAETVEWLRQRLDSGEEVDLSKE---ADVCSAASL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   95 CKLYFRELPNPLLTYELYEKFTEAVSHCPEEG-QLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04393     79 LRLFLQELPEGLIPASLQIRLMQLYQDYNGEDeFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAV 158


                   ....*
gi 1403730280  174 WAPNL 178
Cdd:cd04393    159 FGPDV 163
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 27-180 4.42e-25

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 103.92  E-value: 4.42e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   27 LESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcPDltrEVYLQD--IHCVGSLCKLYFRELP 103
Cdd:cd04407      8 LTSNKTSVPIVLEKLLEHVEMHGLyTEGIYRKSGSANRMKELHQLLQAD--PE---NVKLENypIHAITGLLKQWLRELP 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1403730280  104 NPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180
Cdd:cd04407     83 EPLMTFAQYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLLR 159
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 34-211 4.62e-25

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 104.06  E-value: 4.62e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   34 VPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSDQCPDLTREVylqDIHCVGSLCKLYFRELPNPLLTYELY 112
Cdd:cd04390     22 VPILVEQCVDFIREHGLKEeGLFRLPGQANLVKQLQDAFDAGERPSFDSDT---DVHTVASLLKLYLRELPEPVIPWAQY 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  113 EKF---TEAVSHCPEEGqLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSK-EIEATG 188
Cdd:cd04390     99 EDFlscAQLLSKDEEKG-LGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRPKvEDPATI 177

                          170       180
                   ....*....|....*....|...
gi 1403730280  189 CNGdaaflAVRVQQVVIEFILNH 211
Cdd:cd04390    178 MEG-----TPQIQQLMTVMISKH 195
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-180 6.78e-25

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 103.54  E-value: 6.78e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEyLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcpdlTREVYLQD--IHCVGSLC 95
Cdd:cd04406      1 FGVELSR-LTSEDRSVPLVVEKLINYIEMHGLyTEGIYRKSGSTNKIKELRQGLDTD-----ANSVNLDDynIHVIASVF 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04406     75 KQWLRDLPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFA 154


                   ....*
gi 1403730280  176 PNLLR 180
Cdd:cd04406    155 PCILR 159
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-210 6.42e-23

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 97.53  E-value: 6.42e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEyLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYlqDIHCVGSLCKL 97
Cdd:cd04373      1 FGVPLAN-VVTSEKPIPIFLEKCVEFIEATGLeTEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDF--TVNAVAGALKS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   98 YFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPN 177
Cdd:cd04373     78 FFSELPDPLIPYSMHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPT 157

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1403730280  178 LLRSkEIEATGcngdaAFLAVRVQQVVIE-FILN 210
Cdd:cd04373    158 LMRP-DFTSME-----ALSATRIYQTIIEtFIQQ 185
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-187 7.29e-23

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 98.34  E-value: 7.29e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHG-IVDGIYRLSGVTSNIQRLRQEFGSDQcpDLtreVYLQDI--HCVGSLC 95
Cdd:cd04409      1 FGADFAQVAKKSPDGIPFIIKKCTSEIESRAlCLKGIYRVNGAKSRVEKLCQAFENGK--DL---VELSELspHDISNVL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   96 KLYFRELPNPLLTYELYEKF---TEAVSHCPEEGQ-------------------LARIQNVIQELPPSHYRTLEYLIRHL 153
Cdd:cd04409     76 KLYLRQLPEPLILFRLYNEFiglAKESQHVNETQEakknsdkkwpnmctelnriLLKSKDLLRQLPAPNYNTLQFLIVHL 155

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1403730280  154 AHIASFSSKTNMHARNLALVWAPNLLRSKEIEAT 187
Cdd:cd04409    156 HRVSEQAEENKMSASNLGIIFGPTLIRPRPTDAT 189
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-178 1.33e-22

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 97.87  E-value: 1.33e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIvD--GIYRLSGVTSNIQRLRQEfgSDQCPDLTreVY-LQDIHCVGS 93
Cdd:cd04375      3 NVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNAL-DqvGLFRKSGVKSRIQKLRSM--IESSTDNV--NYdGQQAYDVAD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   94 LCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04375     78 MLKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVC 157


                   ....*
gi 1403730280  174 WAPNL 178
Cdd:cd04375    158 LAPSL 162
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 19-211 1.40e-21

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 94.11  E-value: 1.40e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEF--GSDQcpdltreVYLQDI--HCVGS 93
Cdd:cd04408      1 FGVDFSQLPRDFPEEVPFVVVRCTAEIENRALgVQGIYRISGSKARVEKLCQAFenGRDL-------VDLSGHspHDITS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   94 LCKLYFRELPNPLLTYELYEKF----------TEAVSHCPEEGQ--LARIQNVIQELPPSHYRTLEYLIRHLAHIASFSS 161
Cdd:cd04408     74 VLKHFLKELPEPVLPFQLYDDFialakelqrdSEKAAESPSIVEniIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFE 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1403730280  162 KTNMHARNLALVWAPNLLRSKEIEATGCNgdaAFLAVRVQQVVIEFILNH 211
Cdd:cd04408    154 DNKMSPNNLGIVFGPTLLRPLVGGDVSMI---CLLDTGYQAQLVEFLISN 200
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 51-206 9.47e-21

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 92.04  E-value: 9.47e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   51 VDGIYRLSGvtsNIQRLRQ-----EFGSDQCPDLTREVYLQdihcVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEE 125
Cdd:cd04397     45 VEGVFRKNG---NIRRLKElteeiDKNPTEVPDLSKENPVQ----LAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEE 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  126 GQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFS-----SKTNMHARNLALVWAPNLLRSKEIEATGcnGDAAFLAVRV 200
Cdd:cd04397    118 ERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFShideeTGSKMDIHNLATVITPNILYSKTDNPNT--GDEYFLAIEA 195


                   ....*.
gi 1403730280  201 QQVVIE 206
Cdd:cd04397    196 VNYLIE 201
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 19-179 1.76e-20

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 91.37  E-value: 1.76e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYL--ESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCP-DLTREVYlQDIHCVGSL 94
Cdd:cd04379      1 FGVPLSRLVerEGESRDVPIVLQKCVQEIERRGLdVIGLYRLCGSAAKKKELRDAFERNSAAvELSEELY-PDINVITGV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   95 CKLYFRELPNPLLTYELYEKFTEAVSHCPE---EGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLA 171
Cdd:cd04379     80 LKDYLRELPEPLITPQLYEMVLEALAVALPndvQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLA 159


                   ....*...
gi 1403730280  172 LVWAPNLL 179
Cdd:cd04379    160 VCFGPVLM 167
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 52-216 3.06e-20

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 90.05  E-value: 3.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   52 DGIYRLSGVTSNIQRLRQEFGSDQCPDLTREvylqDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARI 131
Cdd:cd04402     34 EGIFRRSANAKACKELKEKLNSGVEVDLKAE----PVLLLASVLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKIAEL 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  132 QNVIQELPPSHYRTLEYLIRHLAHIaSFSSKTN-MHARNLALVWAPNLLRSKeieaTGCNGDAAFLavRVQQVVIEFILN 210
Cdd:cd04402    110 QRLLDKLPRPNVLLLKHLICVLHNI-SQNSETNkMDAFNLAVCIAPSLLWPP----ASSELQNEDL--KKVTSLVQFLIE 182


                   ....*.
gi 1403730280  211 HVDQIF 216
Cdd:cd04402    183 NCQEIF 188
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 34-178 1.72e-19

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 88.12  E-value: 1.72e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   34 VPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEF-GSDQCPDLTrevyLQDIHCVGSLCKLYFRELPNPLLTYEL 111
Cdd:cd04382     17 IPALIVHCVNEIEARGLTEeGLYRVSGSEREVKALKEKFlRGKTVPNLS----KVDIHVICGCLKDFLRSLKEPLITFAL 92

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1403730280  112 YEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASfSSKTNMHARNLALVWAPNL 178
Cdd:cd04382     93 WKEFMEAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQ-SPECKMDINNLARVFGPTI 158
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 19-180 8.07e-16

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 77.05  E-value: 8.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLESS-----GQDVPYVLKSCAEFIETHG--IVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTrevyLQDIHCV 91
Cdd:cd04389      1 FGSSLEEIMDRQkekypELKLPWILTFLSEKVLALGgfQTEGIFRVPGDIDEVNELKLRVDQWDYPLSG----LEDPHVP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   92 GSLCKLYFRELPNPLLTYELYEKFTEAvSHCPEEgqlarIQNVIQELPPSHYRTLEYLIRHLAHIASFS--SKTNMHARN 169
Cdd:cd04389     77 ASLLKLWLRELEEPLIPDALYQQCISA-SEDPDK-----AVEIVQKLPIINRLVLCYLINFLQVFAQPEnvAHTKMDVSN 150

                          170
                   ....*....|.
gi 1403730280  170 LALVWAPNLLR 180
Cdd:cd04389    151 LAMVFAPNILR 161
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-216 1.87e-15

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 77.00  E-value: 1.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   19 FGCDLTEYLE-----SSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEfgsdqcpdLTREVYLQD----- 87
Cdd:cd04391      2 FGVPLSTLLErdqkkVPGSKVPLIFQKLINKLEERGLeTEGILRIPGSAQRVKFLCQE--------LEAKFYEGTflwdq 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   88 --IHCVGSLCKLYFRELPNPLLTYELYEKFTeAVSHCPE-EGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTN 164
Cdd:cd04391     74 vkQHDAASLLKLFIRELPQPLLTVEYLPAFY-SVQGLPSkKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNK 152

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1403730280  165 MHARNLALVWAPNLLRSKEIEATGCNGDAA--FLAVRVQQvVIEFILNHVDQIF 216
Cdd:cd04391    153 MNLWNVAMIMAPNLFPPRGKHSKDNESLQEevNMAAGCAN-IMRLLIRYQDLLW 205
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-183 1.56e-14

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 74.05  E-value: 1.56e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   21 CDLTEYlessgQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDltrEVYLqdIHCVGSLCKLYFR 100
Cdd:cd04394     12 STVPEY-----GNVPKFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACL---SSAL--PCDVAGLLKQFFR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  101 ELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180
Cdd:cd04394     82 ELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLFQ 161


                   ...
gi 1403730280  181 SKE 183
Cdd:cd04394    162 SEE 164
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 34-215 3.41e-14

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 73.60  E-value: 3.41e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   34 VPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQD--IHCVGSLCKLYFRELPNPLLTYE 110
Cdd:cd04396     32 IPVVVAKCGVYLKENATeVEGIFRVAGSSKRIRELQLIF--STPPDYGKSFDWDGytVHDAASVLRRYLNNLPEPLVPLD 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  111 LYEKFTEAVSHCPE-----------------EGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04396    110 LYEEFRNPLRKRPRilqymkgrineplntdiDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAI 189

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1403730280  174 WAPNLLrSKEIEATgCNGDaaflaVRVQQVVIEFILNHVDQI 215
Cdd:cd04396    190 FQPGIL-SHPDHEM-DPKE-----YKLSRLVVEFLIEHQDKF 224
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 43-203 3.27e-11

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 64.40  E-value: 3.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   43 EFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYlqDIHCVGSLCKLYFRELPNPLLTYELYE--------- 113
Cdd:cd04392     18 EYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGF--HAHDCATVLKGFLGELPEPLLTHAHYPahlqiadlc 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  114 KFTEAVSHCP---EEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEI------ 184
Cdd:cd04392     96 QFDEKGNKTSapdKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLtpedlh 175

                          170       180
                   ....*....|....*....|
gi 1403730280  185 -EATGCNGDAAFLAVRVQQV 203
Cdd:cd04392    176 eNAQKLNSIVTFMIKHSQKL 195
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 12-183 5.18e-08

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 55.04  E-value: 5.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   12 RKGAASAFGCDLTEYLESSGQDVPY----VLKSCAEFIETHGIVD-GIYRLSGVTSN----IQRLRQEFGSDQcPDLTRE 82
Cdd:cd04380     24 PDPGIRNLIDQLELGDNPDYSEVPLsipkEIWRLVDYLYTRGLAQeGLFEEPGLPSEpgelLAEIRDALDTGS-PFNSPG 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   83 vylqDIHCVGSlCKLYF-RELPNPLLTYELYEKFTEAVSHCPEE-GQLARIQnviqeLPPSHYRTLEYLIRHLAHIASFS 160
Cdd:cd04380    103 ----SAESVAE-ALLLFlESLPDPIIPYSLYERLLEAVANNEEDkRQVIRIS-----LPPVHRNVFVYLCSFLRELLSES 172

                          170       180
                   ....*....|....*....|...
gi 1403730280  161 SKTNMHARNLALVWAPNLLRSKE 183
Cdd:cd04380    173 ADRGLDENTLATIFGRVLLRDPP 195
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 22-180 3.71e-07

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 52.18  E-value: 3.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   22 DLTEylESSGQDV-PYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQefgSDQCPDLTREVYLQDIHCVGSLCKLYFR 100
Cdd:cd04388      4 DLTE--QFSPPDVaPPLLIKLVEAIEKKGLESSTLYRTQSSSSLTELRQ---ILDCDAASVDLEQFDVAALADALKRYLL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280  101 ELPNPLLTYELYE---KFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPN 177
Cdd:cd04388     79 DLPNPVIPAPVYSemiSRAQEVQSSDEYAQLLRKLIRSPNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPL 158


                   ...
gi 1403730280  178 LLR 180
Cdd:cd04388    159 LFR 161
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 91-216 3.75e-06

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 49.64  E-value: 3.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1403730280   91 VGSLCKLYFRELPNPLLTYELYEKFTEAVSHCP------EEGQLARIQNVIQELPPSHYRTLEYLIRHLA---HIASFSS 161
Cdd:cd04399     81 VASVLKLYLLELPDSLIPHDIYDLIRSLYSAYPpsqedsDTARIQGLQSTLSQLPKSHIATLDAIITHFYrliEITKMGE 160

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1403730280  162 KTNMHARNLALVWAPNLLRSKeIEATGCNGDaaflavRVQQVVIEFILNHVDQIF 216
Cdd:cd04399    161 SEEEYADKLATSLSREILRPI-IESLLTIGD------KHGYKFFRDLLTHKDQIF 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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