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Conserved domains on  [gi|1437703019|emb|STX33285|]
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astacin protease [Legionella birminghamensis]

Protein Classification

M12 family metallopeptidase( domain architecture ID 10136691)

M12 family metallopeptidase such as astacin, a digestive enzyme isolated from crayfish, belongs to a group of zinc-dependent proteolytic enzymes with an HExxH zinc-binding site/active site

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_astacin_like cd04280
Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of ...
 81-262 1.03e-72

Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to yield the active protease domain, which is consequently always found at the N-terminus in multi-domain architectures. This family includes: astacin, a digestive enzyme from Crayfish; meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain, proteins involved in (bone) morphogenesis, tolloid from drosophila, and the sea urchin SPAN protein, which may also play a role in development.


:

Pssm-ID: 239807 [Multi-domain]  Cd Length: 180  Bit Score: 220.14  E-value: 1.03e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  81 GVIPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFVEltsknRAEYKDYIYFIPAAGttCSSYVGKMGGRQEINLSPRCTT 160
Cdd:cd04280     2 GTVPYVIDGSFDESDRSLILRAMREIESNTCIRFVP-----RTTEKDYIRIVKGSG--CWSYVGRVGGRQVVSLGSGCFS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 161 MNT-VHEIGHALGLWHEQSRADRANYIRIVWENIDEDHRYNFDQQLTD-GKDFGE-YDYQSIMHYGAYAFSKNGQRTIIP 237
Cdd:cd04280    75 LGTiVHELMHALGFYHEQSRPDRDDYVTINWENIQPGYEHNFDKYSPDtVTTYGVpYDYGSVMHYGPTAFSKNGKPTIVP 154

                         170       180
                  ....*....|....*....|....*.
gi 1437703019 238 LMD-DVEIGQRVRLSDRDIAAVKAMY 262
Cdd:cd04280   155 KDPgYQIIGQREGLSFLDIKKINKMY 180
 
Name Accession Description Interval E-value
ZnMc_astacin_like cd04280
Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of ...
 81-262 1.03e-72

Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to yield the active protease domain, which is consequently always found at the N-terminus in multi-domain architectures. This family includes: astacin, a digestive enzyme from Crayfish; meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain, proteins involved in (bone) morphogenesis, tolloid from drosophila, and the sea urchin SPAN protein, which may also play a role in development.


Pssm-ID: 239807 [Multi-domain]  Cd Length: 180  Bit Score: 220.14  E-value: 1.03e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  81 GVIPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFVEltsknRAEYKDYIYFIPAAGttCSSYVGKMGGRQEINLSPRCTT 160
Cdd:cd04280     2 GTVPYVIDGSFDESDRSLILRAMREIESNTCIRFVP-----RTTEKDYIRIVKGSG--CWSYVGRVGGRQVVSLGSGCFS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 161 MNT-VHEIGHALGLWHEQSRADRANYIRIVWENIDEDHRYNFDQQLTD-GKDFGE-YDYQSIMHYGAYAFSKNGQRTIIP 237
Cdd:cd04280    75 LGTiVHELMHALGFYHEQSRPDRDDYVTINWENIQPGYEHNFDKYSPDtVTTYGVpYDYGSVMHYGPTAFSKNGKPTIVP 154

                         170       180
                  ....*....|....*....|....*.
gi 1437703019 238 LMD-DVEIGQRVRLSDRDIAAVKAMY 262
Cdd:cd04280   155 KDPgYQIIGQREGLSFLDIKKINKMY 180
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
 76-262 4.19e-66

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 204.05  E-value: 4.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  76 NRWQHGVIPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFVELTSKNRAeykDYIYFIPAAGttCSSYVGKMGGRQEINLS 155
Cdd:pfam01400   1 KKWPNGPIPYVIDGSLTGLARALIRQAMRHWENKTCIRFVERTPAPDN---NYLFFFKGDG--CYSYVGRVGGRQPVSIG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 156 PRCTTMNTV-HEIGHALGLWHEQSRADRANYIRIVWENIDEDHRYNFDQQ---LTDgkDFGE-YDYQSIMHYGAYAFSKN 230
Cdd:pfam01400  76 DGCDKFGIIvHELGHALGFFHEQSRPDRDDYVSINWDNIDPGQEGNFDKYdpsEVD--SYGVpYDYGSIMHYGPNAFSKN 153

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1437703019 231 G-QRTIIPLMDDV--EIGQRVRLSDRDIAAVKAMY 262
Cdd:pfam01400 154 GsLPTIVPKDNDYqaTIGQRVKLSFYDIKKINKLY 188
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 74-218 4.17e-31

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 112.44  E-value: 4.17e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019   74 GGNRWQHGVIPFE-MSEDLPLMNKLAVLQAIAHWQQYTALEFVELTSknraEYKDYIYFIPAAGTTCSSYVGKMGGRQEI 152
Cdd:smart00235   1 GSKKWPKGTVPYViDSSSLSPEEREAIAKALAEWSDVTCIRFVERTG----TADIYISFGSGDSGCTLSHAGRPGGDQHL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1437703019  153 NLSPRCTTMNT-VHEIGHALGLWHEQSRADRANYIRIVWENIDEdhrYNFDQQLTDGKDFGeYDYQS 218
Cdd:smart00235  77 SLGNGCINTGVaAHELGHALGLYHEQSRSDRDNYMYINYTNIDT---RNFDLSEDDSLGIP-YDYGS 139
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 98-181 6.92e-08

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 51.99  E-value: 6.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  98 AVLQAIAHWQQYtaLEFVELTSKNRAEYKdyIYFIPAAGTTC-----------SSYVGKMGGRQ-----EINLSP----R 157
Cdd:COG5549   105 AVLQAIAEWNAY--LPLEVVENPENADII--IVRSNPPLTASpnpetgarsaeTTYEFYDTGNIlshrfTILLSPnqtgK 180

                          90       100
                  ....*....|....*....|....*
gi 1437703019 158 CTTMNTVHEIGHALGLW-HEQSRAD 181
Cdd:COG5549   181 YLLATARHELGHALGIWgHSPSPTD 205
 
Name Accession Description Interval E-value
ZnMc_astacin_like cd04280
Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of ...
 81-262 1.03e-72

Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to yield the active protease domain, which is consequently always found at the N-terminus in multi-domain architectures. This family includes: astacin, a digestive enzyme from Crayfish; meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain, proteins involved in (bone) morphogenesis, tolloid from drosophila, and the sea urchin SPAN protein, which may also play a role in development.


Pssm-ID: 239807 [Multi-domain]  Cd Length: 180  Bit Score: 220.14  E-value: 1.03e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  81 GVIPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFVEltsknRAEYKDYIYFIPAAGttCSSYVGKMGGRQEINLSPRCTT 160
Cdd:cd04280     2 GTVPYVIDGSFDESDRSLILRAMREIESNTCIRFVP-----RTTEKDYIRIVKGSG--CWSYVGRVGGRQVVSLGSGCFS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 161 MNT-VHEIGHALGLWHEQSRADRANYIRIVWENIDEDHRYNFDQQLTD-GKDFGE-YDYQSIMHYGAYAFSKNGQRTIIP 237
Cdd:cd04280    75 LGTiVHELMHALGFYHEQSRPDRDDYVTINWENIQPGYEHNFDKYSPDtVTTYGVpYDYGSVMHYGPTAFSKNGKPTIVP 154

                         170       180
                  ....*....|....*....|....*.
gi 1437703019 238 LMD-DVEIGQRVRLSDRDIAAVKAMY 262
Cdd:cd04280   155 KDPgYQIIGQREGLSFLDIKKINKMY 180
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
 76-262 4.19e-66

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 204.05  E-value: 4.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  76 NRWQHGVIPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFVELTSKNRAeykDYIYFIPAAGttCSSYVGKMGGRQEINLS 155
Cdd:pfam01400   1 KKWPNGPIPYVIDGSLTGLARALIRQAMRHWENKTCIRFVERTPAPDN---NYLFFFKGDG--CYSYVGRVGGRQPVSIG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 156 PRCTTMNTV-HEIGHALGLWHEQSRADRANYIRIVWENIDEDHRYNFDQQ---LTDgkDFGE-YDYQSIMHYGAYAFSKN 230
Cdd:pfam01400  76 DGCDKFGIIvHELGHALGFFHEQSRPDRDDYVSINWDNIDPGQEGNFDKYdpsEVD--SYGVpYDYGSIMHYGPNAFSKN 153

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1437703019 231 G-QRTIIPLMDDV--EIGQRVRLSDRDIAAVKAMY 262
Cdd:pfam01400 154 GsLPTIVPKDNDYqaTIGQRVKLSFYDIKKINKLY 188
ZnMc_hatching_enzyme cd04283
Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted ...
 83-262 2.91e-51

Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related metalloproteases, high choriolytic enzyme and low choriolytic enzyme (HCE and LCE), which may have different substrate specificities and cooperatively digest the chorion.


Pssm-ID: 239810 [Multi-domain]  Cd Length: 182  Bit Score: 165.51  E-value: 2.91e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  83 IPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFVELTSKNraeykDYIYFIPAAGttCSSYVGKMGGRQEINLS-PRCTTM 161
Cdd:cd04283     6 VPYVISPQYSENERAVIEKAMQEFETLTCVRFVPRTTER-----DYLNIESRSG--CWSYIGRQGGRQTVSLQkQGCMYK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 162 NTV-HEIGHALGLWHEQSRADRANYIRIVWENIDEDHRYNFDQQLTDGKDFgEYDYQSIMHYGAYAFSKNGQRTIIPLMD 240
Cdd:cd04283    79 GIIqHELLHALGFYHEQTRSDRDKYVRINWENIIPDQLYNFDKQDTNNLGT-PYDYSSVMHYGRYAFSINGKPTIVPIPD 157

                         170       180
                  ....*....|....*....|...
gi 1437703019 241 -DVEIGQRVRLSDRDIAAVKAMY 262
Cdd:cd04283   158 pNVPIGQRQGMSNLDILRINKLY 180
ZnMc_BMP1_TLD cd04281
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) ...
 77-262 1.18e-48

Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.


Pssm-ID: 239808 [Multi-domain]  Cd Length: 200  Bit Score: 159.53  E-value: 1.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  77 RWQHGVIPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFVEltsknRAEYKDYIYF-IPAAGttCSSYVGKMG-GRQEINL 154
Cdd:cd04281     9 IWPGGVIPYVIDGNFTGSQRAMFKQAMRHWENFTCVTFVE-----RTPEENYIVFtYRPCG--CCSYVGRRGnGPQAISI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 155 SPRCTTMN-TVHEIGHALGLWHEQSRADRANYIRIVWENIDEDHRYNFDQ-QLTDGKDFGE-YDYQSIMHYGAYAFSKNG 231
Cdd:cd04281    82 GKNCDKFGiVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKmEPEEVDSLGEpYDFDSIMHYARNTFSRGM 161

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1437703019 232 -QRTIIPLMDDV----EIGQRVRLSDRDIAAVKAMY 262
Cdd:cd04281   162 fLDTILPKRDPNgvrpEIGQRTRLSEGDIIQANKLY 197
ZnMc_meprin cd04282
Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted ...
 51-262 5.28e-36

Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as osteopontin, and proteins such as collagen IV, fibronectin, casein and gelatin. Meprins may also be able to release proteins from the cell surface. Closely related meprin alpha- and beta-subunits form homo- and hetero-oligomers; these complexes are found on epithelial cells of the intestine, for example, and are also expressed in certain cancer cells.


Pssm-ID: 239809 [Multi-domain]  Cd Length: 230  Bit Score: 127.97  E-value: 5.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  51 EGDILLAKTREldkagavfRPKIGGN--RWQHgVIPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFveltsKNRAEYKDY 128
Cdd:cd04282    25 EGDILLDEGQS--------RNGLIGDtyRWPF-PIPYILDDSLDLNAKGVILKAFEMYRLKSCVDF-----KPYEGESNY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 129 IYFIPAAGttCSSYVGKMGGRQEINLSPRCTTMNTV-HEIGHALGLWHEQSRADRANYIRIVWENIDEDHRYNF----DQ 203
Cdd:cd04282    91 IFFFKGSG--CWSMVGDQQGGQNLSIGAGCDYKATVeHEFLHALGFYHEQSRSDRDDYVKIWWDQILSGREHNFnkydDS 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1437703019 204 QLTDGKDfgEYDYQSIMHYGAYAFSKNGQR----TIIPLMDDVeIGQRVRLSDRDIAAVKAMY 262
Cdd:cd04282   169 FSTDLNT--PYDYESVMHYSPFSFNKGASEptitTKIPEFNDI-IGQRLDFSDIDLERLNRMY 228
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 74-218 4.17e-31

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 112.44  E-value: 4.17e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019   74 GGNRWQHGVIPFE-MSEDLPLMNKLAVLQAIAHWQQYTALEFVELTSknraEYKDYIYFIPAAGTTCSSYVGKMGGRQEI 152
Cdd:smart00235   1 GSKKWPKGTVPYViDSSSLSPEEREAIAKALAEWSDVTCIRFVERTG----TADIYISFGSGDSGCTLSHAGRPGGDQHL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1437703019  153 NLSPRCTTMNT-VHEIGHALGLWHEQSRADRANYIRIVWENIDEdhrYNFDQQLTDGKDFGeYDYQS 218
Cdd:smart00235  77 SLGNGCINTGVaAHELGHALGLYHEQSRSDRDNYMYINYTNIDT---RNFDLSEDDSLGIP-YDYGS 139
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 98-262 1.37e-16

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 74.87  E-value: 1.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  98 AVLQAIAHWQQYTALEFVEltsKNRAEYKDYIYFIPAA-----GTTCSSYVGKM--GGRQEINLSPRCTTMN-----TVH 165
Cdd:cd00203    26 LILIAMQIWRDYLNIRFVL---VGVEIDKADIAILVTRqdfdgGTGGWAYLGRVcdSLRGVGVLQDNQSGTKegaqtIAH 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 166 EIGHALGLWHEQSRADRANYIRIVWENIDEDhrynfdqqltdgkdfgeYDYQSIMHYGAYAFSkngqrtiiplmddveIG 245
Cdd:cd00203   103 ELGHALGFYHDHDRKDRDDYPTIDDTLNAED-----------------DDYYSVMSYTKGSFS---------------DG 150

                         170
                  ....*....|....*..
gi 1437703019 246 QRVRLSDRDIAAVKAMY 262
Cdd:cd00203   151 QRKDFSQCDIDQINKLY 167
ZnMc_MMP_like_3 cd04327
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
 96-263 8.98e-15

Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239819 [Multi-domain]  Cd Length: 198  Bit Score: 70.87  E-value: 8.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  96 KLAVLQAIAHWQQYTALEFVELTsknRAEYKDYIYFIPAAGTtcSSYVGK--MGGRQE---INLSPRCTTM-------NT 163
Cdd:cd04327    22 KDKVRAAAREWLPYANLKFKFVT---DADADIRISFTPGDGY--WSYVGTdaLLIGADaptMNLGWFTDDTpdpefsrVV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 164 VHEIGHALGLWHEQSRAD----------RANYIRI-VWENIDEDHRYNFDQQLTDGKDFGEYDYQSIMHygaYAFSKngq 232
Cdd:cd04327    97 LHEFGHALGFIHEHQSPAanipwdkeavYAYFSGPpNWDRETVINHNVFAKLDDGDVAYSPYDPDSIMH---YPFPG--- 170

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1437703019 233 rTIIplMDDVEIGQRVRLSDRDIAAVKAMYP 263
Cdd:cd04327   171 -SLT--LDGEEVPPNRTLSDKDKAFMRLLYP 198
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 81-262 1.63e-14

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 69.45  E-value: 1.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  81 GVIPFEMSEDLPLMNKLAVLQAIAHWQQYTALEFVELTSKNRAeykdYIYFI----PAAGTTCSSYVGKM--GGRQEINL 154
Cdd:cd04268     2 KPITYYIDDSVPDKLRAAILDAIEAWNKAFAIGFKNANDVDPA----DIRYSvirwIPYNDGTWSYGPSQvdPLTGEILL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019 155 SPRCTTMN------------TVHEIGHALGLWHEQSRADRANYIRIVwenidedhrynfdqqltdgkdFGEYDYQSIMHY 222
Cdd:cd04268    78 ARVYLYSSfveysgarlrntAEHELGHALGLRHNFAASDRDDNVDLL---------------------AEKGDTSSVMDY 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1437703019 223 GAYAFSKNGqrtiiplmddvEIGQRVRLSDRDIAAVKAMY 262
Cdd:cd04268   137 APSNFSIQL-----------GDGQKYTIGPYDIAAIKKLY 165
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 98-181 6.92e-08

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 51.99  E-value: 6.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  98 AVLQAIAHWQQYtaLEFVELTSKNRAEYKdyIYFIPAAGTTC-----------SSYVGKMGGRQ-----EINLSP----R 157
Cdd:COG5549   105 AVLQAIAEWNAY--LPLEVVENPENADII--IVRSNPPLTASpnpetgarsaeTTYEFYDTGNIlshrfTILLSPnqtgK 180

                          90       100
                  ....*....|....*....|....*
gi 1437703019 158 CTTMNTVHEIGHALGLW-HEQSRAD 181
Cdd:COG5549   181 YLLATARHELGHALGIWgHSPSPTD 205
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 98-185 1.47e-07

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 49.76  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1437703019  98 AVLQAIAHWQQYTALEFVElTSKNRAEYKDYIYF-----IPAAGTTCSSYVGKMGGRQEINLSPRcTTMN---------- 162
Cdd:cd04279    25 AVKQAAAEWENVGPLKFVY-NPEEDNDADIVIFFdrpppVGGAGGGLARAGFPLISDGNRKLFNR-TDINlgpgqprgae 102

                          90       100
                  ....*....|....*....|....*...
gi 1437703019 163 -----TVHEIGHALGLWHEQSRADRANY 185
Cdd:cd04279   103 nlqaiALHELGHALGLWHHSDRPEDAMY 130
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 164-175 8.66e-03

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 36.03  E-value: 8.66e-03
                          10
                  ....*....|..
gi 1437703019 164 VHEIGHALGLWH 175
Cdd:cd04278   112 AHEIGHALGLGH 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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