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Conserved domains on  [gi|1594797171|gb|TDI57033|]
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TIR domain-containing protein [Acidobacteria bacterium]

Protein Classification

toll/interleukin-1 receptor domain-containing protein( domain architecture ID 12153331)

toll/interleukin-1 receptor (TIR) domain-containing protein with WD40 repeats; the TIR domain is responsible for signal transduction in all toll-like receptors (TLR)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
436-904 2.68e-42

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 2.68e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 436 AVSSDGRGVAWAGARGGVWRWIVGSDPQYLLDTDDLINAIQFVPESEALVVALSDGGIHYLPSEADPEffdPEADFEPDP 515
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG---ALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 516 GSEALDISIIPRADQmplVATAHLDGTVQVWELDTTFGLAfadpsRLLGHRDEATAIALSPNGERVMSAGFDGDVIWWDR 595
Cdd:COG2319    78 TAAVLSVAFSPDGRL---LASASADGTVRLWDLATGLLLR-----TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 596 FPNTRIGSaLAQHGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVtETGdaslaEEVEIFPIDDDEATALAIARDGSGFAVG 675
Cdd:COG2319   150 ATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL-ATG-----KLLRTLTGHTGAVRSVAFSPDGKLLASG 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 676 TLSGAIVLIDAA-GAERGRWQAHEVPVAGLVFNPDdsaepallsiddsgrlhswdrsdlaspgsaepdlisetadhvpgf 754
Cdd:COG2319   223 SADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPD--------------------------------------------- 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 755 apdGSQIAWTDDDG-LHLWTAET-DVATVLLEPPDLVTTVEFSGDGRLLAWAEANRRIGLWDLEDEEELGEDlTGHSEFI 832
Cdd:COG2319   258 ---GRLLASGSADGtVRLWDLATgELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAV 333

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1594797171 833 SDMEFLeRDGQSVAliSVSNDWSIRMWDVSEQRLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWEAD 904
Cdd:COG2319   334 RSVAFS-PDGKTLA--SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
192-639 1.16e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 192 LASEDQRQYRRGVLVRRAFQVGLAVLTIIAGGLAIFARNRQVAAEDQARLANSRAAASEAVAEVVTEPDQAALFALESLR 271
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 272 IepTLEARLALLSILSTPSNFVQRVSLEGDPTLLDAAWSPDGSSVAVIGADGVVRVWpvDAASGRPDGdpVSIEPAPGAW 351
Cdd:COG2319    93 L--ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLR--TLTGHSGAVT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 352 KIAFSADGAALRTMADSGVVETWDPVDGTRLdeitvdpvaLALSRHGDFVvtfdfafmvlWSVdgsivdqveleeplpee 431
Cdd:COG2319   167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLL---------RTLTGHTGAV----------RSV----------------- 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 432 eevvAVSSDGRGVAWAGARGGVWRW-IVGSDPQYLLDT-DDLINAIQFVPESEALVVALSDGGIHylpseadpeFFDPEA 509
Cdd:COG2319   211 ----AFSPDGKLLASGSADGTVRLWdLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVR---------LWDLAT 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 510 D----FEPDPGSEALDISIIPRADqmpLVATAHLDGTVQVWELDTTfglafADPSRLLGHRDEATAIALSPNGERVMSAG 585
Cdd:COG2319   278 GellrTLTGHSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATG-----KLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1594797171 586 FDGDVIWWDRFPNTRIGSaLAQHGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVT 639
Cdd:COG2319   350 DDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 20-115 3.86e-10

TIR domain; This is a family of Toll-like receptors.


:

Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 58.10  E-value: 3.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  20 FISYNHgAEEGFAAPFQEALEklakpwrkRRGRRVMLDEKAMSAGSSLSDTIEAKLASSEWLVMLASPQAADSPWCNDEL 99
Cdd:pfam13676   2 FISYAG-EDRAWAEWLADALE--------AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEW 72

                          90
                  ....*....|....*.
gi 1594797171 100 EYWDEHKSMDKVIIAL 115
Cdd:pfam13676  73 EAALADPEGRKRLIPV 88
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
436-904 2.68e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 2.68e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 436 AVSSDGRGVAWAGARGGVWRWIVGSDPQYLLDTDDLINAIQFVPESEALVVALSDGGIHYLPSEADPEffdPEADFEPDP 515
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG---ALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 516 GSEALDISIIPRADQmplVATAHLDGTVQVWELDTTFGLAfadpsRLLGHRDEATAIALSPNGERVMSAGFDGDVIWWDR 595
Cdd:COG2319    78 TAAVLSVAFSPDGRL---LASASADGTVRLWDLATGLLLR-----TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 596 FPNTRIGSaLAQHGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVtETGdaslaEEVEIFPIDDDEATALAIARDGSGFAVG 675
Cdd:COG2319   150 ATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL-ATG-----KLLRTLTGHTGAVRSVAFSPDGKLLASG 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 676 TLSGAIVLIDAA-GAERGRWQAHEVPVAGLVFNPDdsaepallsiddsgrlhswdrsdlaspgsaepdlisetadhvpgf 754
Cdd:COG2319   223 SADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPD--------------------------------------------- 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 755 apdGSQIAWTDDDG-LHLWTAET-DVATVLLEPPDLVTTVEFSGDGRLLAWAEANRRIGLWDLEDEEELGEDlTGHSEFI 832
Cdd:COG2319   258 ---GRLLASGSADGtVRLWDLATgELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAV 333

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1594797171 833 SDMEFLeRDGQSVAliSVSNDWSIRMWDVSEQRLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWEAD 904
Cdd:COG2319   334 RSVAFS-PDGKTLA--SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
192-639 1.16e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 192 LASEDQRQYRRGVLVRRAFQVGLAVLTIIAGGLAIFARNRQVAAEDQARLANSRAAASEAVAEVVTEPDQAALFALESLR 271
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 272 IepTLEARLALLSILSTPSNFVQRVSLEGDPTLLDAAWSPDGSSVAVIGADGVVRVWpvDAASGRPDGdpVSIEPAPGAW 351
Cdd:COG2319    93 L--ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLR--TLTGHSGAVT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 352 KIAFSADGAALRTMADSGVVETWDPVDGTRLdeitvdpvaLALSRHGDFVvtfdfafmvlWSVdgsivdqveleeplpee 431
Cdd:COG2319   167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLL---------RTLTGHTGAV----------RSV----------------- 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 432 eevvAVSSDGRGVAWAGARGGVWRW-IVGSDPQYLLDT-DDLINAIQFVPESEALVVALSDGGIHylpseadpeFFDPEA 509
Cdd:COG2319   211 ----AFSPDGKLLASGSADGTVRLWdLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVR---------LWDLAT 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 510 D----FEPDPGSEALDISIIPRADqmpLVATAHLDGTVQVWELDTTfglafADPSRLLGHRDEATAIALSPNGERVMSAG 585
Cdd:COG2319   278 GellrTLTGHSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATG-----KLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1594797171 586 FDGDVIWWDRFPNTRIGSaLAQHGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVT 639
Cdd:COG2319   350 DDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 532-902 3.95e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 3.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 532 PLVATAHLDGTVQVWELDTTFGLafadpSRLLGHRDEATAIALSPNGERVMSAGFDGDVIWWDrFPNTRIGSALAQHGDD 611
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELL-----RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD-LETGECVRTLTGHTSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 612 VLGVAFLDDGSRLVSVDAQGLAAFWDVTetgdaslaeeveifpidddeatalaiardgSGFAVGTLSGaivlidaagaer 691
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVWDVE------------------------------TGKCLTTLRG------------ 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 692 grwqaHEVPVAGLVFNPDDSaepaLLSiddSGrlhSWDRSdlaspgsaepdlisetadhvpgfapdgsqiawtdddgLHL 771
Cdd:cd00200   134 -----HTDWVNSVAFSPDGT----FVA---SS---SQDGT-------------------------------------IKL 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 772 WTAETD-VATVLLEPPDLVTTVEFSGDGRLLAWAEANRRIGLWDLEDEEELGEDlTGHSEFISDMEFlerDGQSVALISV 850
Cdd:cd00200   162 WDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAF---SPDGYLLASG 237

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1594797171 851 SNDWSIRMWDVSEQRLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWE 902
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 20-115 3.86e-10

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 58.10  E-value: 3.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  20 FISYNHgAEEGFAAPFQEALEklakpwrkRRGRRVMLDEKAMSAGSSLSDTIEAKLASSEWLVMLASPQAADSPWCNDEL 99
Cdd:pfam13676   2 FISYAG-EDRAWAEWLADALE--------AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEW 72

                          90
                  ....*....|....*.
gi 1594797171 100 EYWDEHKSMDKVIIAL 115
Cdd:pfam13676  73 EAALADPEGRKRLIPV 88
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 662-901 7.77e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.17  E-value: 7.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 662 ALAIARDGSGFAVGTLSGAIVLIDAAGAERGRWQAHeVPV---------AGLVFNPDDSAEPALLSIDdsGRLHSWD--R 730
Cdd:PLN00181  488 AIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIH-YPVvelasrsklSGICWNSYIKSQVASSNFE--GVVQVWDvaR 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 731 SDLASP-------------GSAEPDLISETADhvpgfapDGSQIAWTDDDGLHLWTAETDVAtvlleppdlVTTVEFSGD 797
Cdd:PLN00181  565 SQLVTEmkehekrvwsidySSADPTLLASGSD-------DGSVKLWSINQGVSIGTIKTKAN---------ICCVQFPSE 628

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 798 -GRLLAWAEANRRIGLWDLEDEEELGEDLTGHSEFISDMEFLErdgqSVALISVSNDWSIRMWDVS-------EQRLLGV 869
Cdd:PLN00181  629 sGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVD----SSTLVSSSTDNTLKLWDLSmsisginETPLHSF 704

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1594797171 870 LGwHANDVNSLAVNPNGTLIATAGDDDVVWLW 901
Cdd:PLN00181  705 MG-HTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 865-902 1.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1594797171  865 RLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWE 902
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
865-902 2.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.15e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1594797171 865 RLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWE 902
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
TIR smart00255
Toll - interleukin 1 - resistance;
17-159 2.52e-04

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 42.31  E-value: 2.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171   17 YKAFISYnHGAEEgfaapFQEALEKLAKPWRKRRGRRVMLDEKamSAGSSLSDTIEAKLASSEWLVMLASPQAADSPWCN 96
Cdd:smart00255   2 YDVFISY-SGKED-----VRNEFLSHLLEKLRGYGLCVFIDDF--EPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1594797171   97 DELEYWDEHKSMDKVIIALTGGEIVIDAEAEQIDWEATTALSDTFRGLVGEDAVPLYEDLRSF 159
Cdd:smart00255  74 DELVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYA 136
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
436-904 2.68e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 159.69  E-value: 2.68e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 436 AVSSDGRGVAWAGARGGVWRWIVGSDPQYLLDTDDLINAIQFVPESEALVVALSDGGIHYLPSEADPEffdPEADFEPDP 515
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG---ALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 516 GSEALDISIIPRADQmplVATAHLDGTVQVWELDTTFGLAfadpsRLLGHRDEATAIALSPNGERVMSAGFDGDVIWWDR 595
Cdd:COG2319    78 TAAVLSVAFSPDGRL---LASASADGTVRLWDLATGLLLR-----TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 596 FPNTRIGSaLAQHGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVtETGdaslaEEVEIFPIDDDEATALAIARDGSGFAVG 675
Cdd:COG2319   150 ATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL-ATG-----KLLRTLTGHTGAVRSVAFSPDGKLLASG 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 676 TLSGAIVLIDAA-GAERGRWQAHEVPVAGLVFNPDdsaepallsiddsgrlhswdrsdlaspgsaepdlisetadhvpgf 754
Cdd:COG2319   223 SADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPD--------------------------------------------- 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 755 apdGSQIAWTDDDG-LHLWTAET-DVATVLLEPPDLVTTVEFSGDGRLLAWAEANRRIGLWDLEDEEELGEDlTGHSEFI 832
Cdd:COG2319   258 ---GRLLASGSADGtVRLWDLATgELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAV 333

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1594797171 833 SDMEFLeRDGQSVAliSVSNDWSIRMWDVSEQRLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWEAD 904
Cdd:COG2319   334 RSVAFS-PDGKTLA--SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
410-813 4.82e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 4.82e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 410 VLWSVDGSIVDQVELEEPLPEEEEVVAVSSDGRGVAWAGARGGVWRWIV--GSDPQYLLDTDDLINAIQFVPESEALVVA 487
Cdd:COG2319    17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAaaGALLATLLGHTAAVLSVAFSPDGRLLASA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 488 LSDGGIHYLPSEADPEFFDPEADFEPdpgSEALDISiiprADQmPLVATAHLDGTVQVWELDTTFGLAfadpsRLLGHRD 567
Cdd:COG2319    97 SADGTVRLWDLATGLLLRTLTGHTGA---VRSVAFS----PDG-KTLASGSADGTVRLWDLATGKLLR-----TLTGHSG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 568 EATAIALSPNGERVMSAGFDGDVIWWDRFPNTRIGSaLAQHGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVtETGdasla 647
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-ATG----- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 648 EEVEIFPIDDDEATALAIARDGSGFAVGTLSGAIVLIDAA-GAERGRWQAHEVPVAGLVFNPDDSAepaLLSIDDSGRLH 726
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKL---LASGSDDGTVR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 727 SWDRSD--LASPGSAEPDLISETAdhvpgFAPDGSQIAWTDDDG-LHLWTAETD-VATVLLEPPDLVTTVEFSGDGRLLA 802
Cdd:COG2319   314 LWDLATgkLLRTLTGHTGAVRSVA-----FSPDGKTLASGSDDGtVRLWDLATGeLLRTLTGHTGAVTSVAFSPDGRTLA 388

                         410
                  ....*....|.
gi 1594797171 803 WAEANRRIGLW 813
Cdd:COG2319   389 SGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
228-732 1.09e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 1.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 228 ARNRQVAAEDQARLANSRAAASEAVAEVVTEPDQAALFALESLRIEPTLEARLALLSILSTPSnfVQRVSLEGDPTLLDA 307
Cdd:COG2319     7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 308 AWSPDGSSVAVIGADGVVRVWpvDAASGRPdgDPVSIEPAPGAWKIAFSADGAALRTMADSGVVETWDPVDGTRLDEitv 387
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLW--DLATGLL--LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 388 dpvalaLSRHGDFVvtfdfafmvlWSVdgsivdqveleeplpeeeevvAVSSDGRGVAWAGARGGV--WRWIVGSDPQYL 465
Cdd:COG2319   158 ------LTGHSGAV----------TSV---------------------AFSPDGKLLASGSDDGTVrlWDLATGKLLRTL 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 466 LDTDDLINAIQFVPesealvvalsDGGihylpseadpeffdpeadfepdpgsealdisiipradqmpLVATAHLDGTVQV 545
Cdd:COG2319   201 TGHTGAVRSVAFSP----------DGK----------------------------------------LLASGSADGTVRL 230

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 546 WELDTTFGLAfadpsRLLGHRDEATAIALSPNGERVMSAGFDGDVIWWDRfPNTRIGSALAQHGDDVLGVAFLDDGSRLV 625
Cdd:COG2319   231 WDLATGKLLR-----TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 626 SVDAQGLAAFWDVtETGdaslaEEVEIFPIDDDEATALAIARDGSGFAVGTLSGAIVLIDAA-GAERGRWQAHEVPVAGL 704
Cdd:COG2319   305 SGSDDGTVRLWDL-ATG-----KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSV 378

                         490       500
                  ....*....|....*....|....*...
gi 1594797171 705 VFNPDDSaepALLSIDDSGRLHSWDRSD 732
Cdd:COG2319   379 AFSPDGR---TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
192-639 1.16e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 192 LASEDQRQYRRGVLVRRAFQVGLAVLTIIAGGLAIFARNRQVAAEDQARLANSRAAASEAVAEVVTEPDQAALFALESLR 271
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 272 IepTLEARLALLSILSTPSNFVQRVSLEGDPTLLDAAWSPDGSSVAVIGADGVVRVWpvDAASGRPDGdpVSIEPAPGAW 351
Cdd:COG2319    93 L--ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLR--TLTGHSGAVT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 352 KIAFSADGAALRTMADSGVVETWDPVDGTRLdeitvdpvaLALSRHGDFVvtfdfafmvlWSVdgsivdqveleeplpee 431
Cdd:COG2319   167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLL---------RTLTGHTGAV----------RSV----------------- 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 432 eevvAVSSDGRGVAWAGARGGVWRW-IVGSDPQYLLDT-DDLINAIQFVPESEALVVALSDGGIHylpseadpeFFDPEA 509
Cdd:COG2319   211 ----AFSPDGKLLASGSADGTVRLWdLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVR---------LWDLAT 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 510 D----FEPDPGSEALDISIIPRADqmpLVATAHLDGTVQVWELDTTfglafADPSRLLGHRDEATAIALSPNGERVMSAG 585
Cdd:COG2319   278 GellrTLTGHSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATG-----KLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1594797171 586 FDGDVIWWDRFPNTRIGSaLAQHGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVT 639
Cdd:COG2319   350 DDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
616-911 2.57e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 2.57e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 616 AFLDDGSRLVSVDAQGLAAFWDVTETGDASLAEEVeifpidDDEATALAIARDGSGFAVGTLSGAIVLIDAA-GAERGRW 694
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGL------AAAVASLAASPDGARLAAGAGDLTLLLLDAAaGALLATL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 695 QAHEVPVAGLVFNPDDsaePALLSIDDSGRLHSWDRSdlaspGSAEPDLISETADHVPG--FAPDGSQIAWTDDDG-LHL 771
Cdd:COG2319    75 LGHTAAVLSVAFSPDG---RLLASASADGTVRLWDLA-----TGLLLRTLTGHTGAVRSvaFSPDGKTLASGSADGtVRL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 772 WTAET-DVATVLLEPPDLVTTVEFSGDGRLLAWAEANRRIGLWDLEDEEELGEDlTGHSEFISDMEFLeRDGQSVAliSV 850
Cdd:COG2319   147 WDLATgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFS-PDGKLLA--SG 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1594797171 851 SNDWSIRMWDVSEQRLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWEADEEKWVEL 911
Cdd:COG2319   223 SADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 532-902 3.95e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 3.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 532 PLVATAHLDGTVQVWELDTTFGLafadpSRLLGHRDEATAIALSPNGERVMSAGFDGDVIWWDrFPNTRIGSALAQHGDD 611
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELL-----RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD-LETGECVRTLTGHTSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 612 VLGVAFLDDGSRLVSVDAQGLAAFWDVTetgdaslaeeveifpidddeatalaiardgSGFAVGTLSGaivlidaagaer 691
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVWDVE------------------------------TGKCLTTLRG------------ 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 692 grwqaHEVPVAGLVFNPDDSaepaLLSiddSGrlhSWDRSdlaspgsaepdlisetadhvpgfapdgsqiawtdddgLHL 771
Cdd:cd00200   134 -----HTDWVNSVAFSPDGT----FVA---SS---SQDGT-------------------------------------IKL 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 772 WTAETD-VATVLLEPPDLVTTVEFSGDGRLLAWAEANRRIGLWDLEDEEELGEDlTGHSEFISDMEFlerDGQSVALISV 850
Cdd:cd00200   162 WDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAF---SPDGYLLASG 237

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1594797171 851 SNDWSIRMWDVSEQRLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWE 902
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 562-913 5.71e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 5.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 562 LLGHRDEATAIALSPNGERVMSAGFDGDVIWWDRFPNTRIgSALAQHGDDVLGVAFLDDGSRLVSvdaqglaAFWDVTet 641
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLAS-------GSSDKT-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 642 gdaslaeeVEIFPIDDDEAtalaiardgsgfaVGTLSGaivlidaagaergrwqaHEVPVAGLVFNPDDSaepaLLSidd 721
Cdd:cd00200    75 --------IRLWDLETGEC-------------VRTLTG-----------------HTSYVSSVAFSPDGR----ILS--- 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 722 SGrlhSWDRSdlaspgsaepdlisetadhvpgfapdgsqiawtdddgLHLWTAETDVA-TVLLEPPDLVTTVEFSGDGRL 800
Cdd:cd00200   110 SS---SRDKT-------------------------------------IKVWDVETGKClTTLRGHTDWVNSVAFSPDGTF 149

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 801 LAWAEANRRIGLWDLEDEEELGEDlTGHSEFISDMEFLErDGQSvaLISVSNDWSIRMWDVSEQRLLGVLGWHANDVNSL 880
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSP-DGEK--LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1594797171 881 AVNPNGTLIATAGDDDVVWLWeaDEEKWVELAC 913
Cdd:cd00200   226 AFSPDGYLLASGSEDGTIRVW--DLRTGECVQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 472-729 1.11e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 1.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 472 INAIQFVPESEALVVALSDGGIHylpsEADPEFFDPEADFEpDPGSEALDISIIPRADQMplvATAHLDGTVQVWELDTT 551
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIK----VWDLETGELLRTLK-GHTGPVRDVAASADGTYL---ASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 552 fglafADPSRLLGHRDEATAIALSPNGERVMSAGFDGDVIWWDrFPNTRIGSALAQHGDDVLGVAFLDDGSRLVSVDAQG 631
Cdd:cd00200    84 -----ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 632 LAAFWDVTEtgdaslAEEVEIFPIDDDEATALAIARDGSGFAVGTLSGAIVLID-AAGAERGRWQAHEVPVAGLVFNPDD 710
Cdd:cd00200   158 TIKLWDLRT------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDlSTGKCLGTLRGHENGVNSVAFSPDG 231

                         250
                  ....*....|....*....
gi 1594797171 711 SaepALLSIDDSGRLHSWD 729
Cdd:cd00200   232 Y---LLASGSEDGTIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 690-909 2.06e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 2.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 690 ERGRWQAHEVPVAGLVFNPDdsaEPALLSIDDSGRLHSWDRSDlaspgsaePDLISETADHvPGFAPDGSQIAWT----- 764
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWDLET--------GELLRTLKGH-TGPVRDVAASADGtylas 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 765 --DDDGLHLWTAETD-VATVLLEPPDLVTTVEFSGDGRLLAWAEANRRIGLWDLEDEEELGEDlTGHSEFISDMEFLErD 841
Cdd:cd00200    69 gsSDKTIRLWDLETGeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSP-D 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1594797171 842 GQSVAliSVSNDWSIRMWDVSEQRLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWEADEEKWV 909
Cdd:cd00200   147 GTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 529-709 9.41e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 9.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 529 DQMPLVATAHLDGTVQVWELDTTFGLAfadpsRLLGHRDEATAIALSPNGERVMSAGFDGDVIWWDrfpnTRIGSALAQ- 607
Cdd:cd00200   103 PDGRILSSSSRDKTIKVWDVETGKCLT-----TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD----LRTGKCVATl 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 608 --HGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVTETgdaslaEEVEIFPIDDDEATALAIARDGSGFAVGTLSGAIVLID 685
Cdd:cd00200   174 tgHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG------KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                         170       180
                  ....*....|....*....|....*
gi 1594797171 686 -AAGAERGRWQAHEVPVAGLVFNPD 709
Cdd:cd00200   248 lRTGECVQTLSGHTNSVTSLAWSPD 272
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 20-115 3.86e-10

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 58.10  E-value: 3.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  20 FISYNHgAEEGFAAPFQEALEklakpwrkRRGRRVMLDEKAMSAGSSLSDTIEAKLASSEWLVMLASPQAADSPWCNDEL 99
Cdd:pfam13676   2 FISYAG-EDRAWAEWLADALE--------AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEW 72

                          90
                  ....*....|....*.
gi 1594797171 100 EYWDEHKSMDKVIIAL 115
Cdd:pfam13676  73 EAALADPEGRKRLIPV 88
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 307-594 2.02e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 307 AAWSPDGSSVAVIGADGVVRVWpvDAASGRPDGDPVsiEPAPGAWKIAFSADGAALRTMADSGVVETWDPVDGTRLDEIT 386
Cdd:cd00200    15 VAFSPDGKLLATGSGDGTIKVW--DLETGELLRTLK--GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 387 --VDPV-ALALSRHGDFVVT--FDfAFMVLWSVDgsIVDQVELEEPLPEEEEVVAVSSDGRGVAWAGARG--GVWRwIVG 459
Cdd:cd00200    91 ghTSYVsSVAFSPDGRILSSssRD-KTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGtiKLWD-LRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 460 SDPQYLLDT-DDLINAIQFVPESEALVVALSDGGIH-YlpseaDPEFFDPEADFEPDPGSeALDISIIPRADqmpLVATA 537
Cdd:cd00200   167 GKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKlW-----DLSTGKCLGTLRGHENG-VNSVAFSPDGY---LLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1594797171 538 HLDGTVQVWELDTtfglafADPSRLL-GHRDEATAIALSPNGERVMSAGFDGDVIWWD 594
Cdd:cd00200   238 SEDGTIRVWDLRT------GECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 662-901 7.77e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.17  E-value: 7.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 662 ALAIARDGSGFAVGTLSGAIVLIDAAGAERGRWQAHeVPV---------AGLVFNPDDSAEPALLSIDdsGRLHSWD--R 730
Cdd:PLN00181  488 AIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIH-YPVvelasrsklSGICWNSYIKSQVASSNFE--GVVQVWDvaR 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 731 SDLASP-------------GSAEPDLISETADhvpgfapDGSQIAWTDDDGLHLWTAETDVAtvlleppdlVTTVEFSGD 797
Cdd:PLN00181  565 SQLVTEmkehekrvwsidySSADPTLLASGSD-------DGSVKLWSINQGVSIGTIKTKAN---------ICCVQFPSE 628

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171 798 -GRLLAWAEANRRIGLWDLEDEEELGEDLTGHSEFISDMEFLErdgqSVALISVSNDWSIRMWDVS-------EQRLLGV 869
Cdd:PLN00181  629 sGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVD----SSTLVSSSTDNTLKLWDLSmsisginETPLHSF 704

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1594797171 870 LGwHANDVNSLAVNPNGTLIATAGDDDVVWLW 901
Cdd:PLN00181  705 MG-HTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 865-902 1.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1594797171  865 RLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWE 902
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 198-717 3.90e-05

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 47.94  E-value: 3.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  198 RQYRRGVLVRRAFQ---VGLAVLTIIAGGLAIFARNRQVAAEDQARLANSRAAASEAVAEVVTEPDQAALFALESLRIEP 274
Cdd:COG3321    856 RGRRRVPLPTYPFQredAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVAL 935

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  275 TLEARLALLSILSTPSNFVQRVSLEGDPTLLDAAWSPDGSSVAVIGADGVVRVWPVDAASGRPDG-DPVSIEPAPGAWKI 353
Cdd:COG3321    936 AAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAaLALLAAAALLLAAA 1015

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  354 AFSADGAALRTMADSGVVETWDPVDGTRLDEITVDPVALALSRHGDFVVTFDFAFMVLWSVDGSIVDQVELEEPLPEEEE 433
Cdd:COG3321   1016 AAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAAL 1095

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  434 VVAVSSDGRGVAWAGARGGVWRWIVGSDPQYLLDTDDLINAIQFVPESEALVVALSDGGIHYLPSEADPEFFDPEADFEP 513
Cdd:COG3321   1096 ALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLL 1175

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  514 DPGSEALDISIIPRADQMPLVATAHLDGTVQVWELDTTFGLAFADPSRLLGHRDEATAIALSPNGERVMSAGFDGDVIWW 593
Cdd:COG3321   1176 ALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAAL 1255

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  594 DRFPNTRIGSALAQHGDDVLGVAFLDDGSRLVSVDAQGLAAFWDVTETGDASLAEEVEIFPIDDDEATALAIAR-DGSGF 672
Cdd:COG3321   1256 LAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAAlAALAA 1335

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 1594797171  673 AVGTLSGAIVLIDAAGAERGRWQAHEVPVAGLVFNPDDSAEPALL 717
Cdd:COG3321   1336 AVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAA 1380
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 564-594 1.76e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.76e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1594797171  564 GHRDEATAIALSPNGERVMSAGFDGDVIWWD 594
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
865-902 2.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.15e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1594797171 865 RLLGVLGWHANDVNSLAVNPNGTLIATAGDDDVVWLWE 902
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
TIR smart00255
Toll - interleukin 1 - resistance;
17-159 2.52e-04

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 42.31  E-value: 2.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171   17 YKAFISYnHGAEEgfaapFQEALEKLAKPWRKRRGRRVMLDEKamSAGSSLSDTIEAKLASSEWLVMLASPQAADSPWCN 96
Cdd:smart00255   2 YDVFISY-SGKED-----VRNEFLSHLLEKLRGYGLCVFIDDF--EPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1594797171   97 DELEYWDEHKSMDKVIIALTGGEIVIDAEAEQIDWEATTALSDTFRGLVGEDAVPLYEDLRSF 159
Cdd:smart00255  74 DELVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYA 136
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 754-813 2.79e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.56  E-value: 2.79e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1594797171  754 FAPDGSQIAWTDDDGlHLWTaeTDVAT----VLLEPP--DLVTTVEFSGDGRLLAWA----EANRRIGLW 813
Cdd:COG4946    396 WSPDGKKIAFTDNRG-RLWV--VDLASgkvrKVDTDGygDGISDLAWSPDSKWLAYSkpgpNQLSQIFLY 462
WD40 pfam00400
WD domain, G-beta repeat;
562-594 3.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.35e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1594797171 562 LLGHRDEATAIALSPNGERVMSAGFDGDVIWWD 594
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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