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A.superbus venom factor 1-like [Platysternon megacephalum]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
TFP_LU_ECD_PLIG | cd23588 | extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ... |
73-154 | 1.73e-31 | |||
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit (gamma-PLI) family; The gamma-PLI family includes gamma-PLI A and gamma-PLI B. Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. Gamma-PLI A and gamma-PLI B form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). : Pssm-ID: 467117 Cd Length: 82 Bit Score: 113.18 E-value: 1.73e-31
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TFP_LU_ECD_PINLYP_rpt2 | cd23572 | second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ... |
168-245 | 1.04e-21 | |||
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD. : Pssm-ID: 467102 Cd Length: 80 Bit Score: 87.48 E-value: 1.04e-21
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Name | Accession | Description | Interval | E-value | |||
TFP_LU_ECD_PLIG | cd23588 | extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ... |
73-154 | 1.73e-31 | |||
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit (gamma-PLI) family; The gamma-PLI family includes gamma-PLI A and gamma-PLI B. Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. Gamma-PLI A and gamma-PLI B form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467117 Cd Length: 82 Bit Score: 113.18 E-value: 1.73e-31
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TFP_LU_ECD_PINLYP_rpt2 | cd23572 | second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ... |
168-245 | 1.04e-21 | |||
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD. Pssm-ID: 467102 Cd Length: 80 Bit Score: 87.48 E-value: 1.04e-21
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PLA2_inh | pfam02988 | Phospholipase A2 inhibitor; |
73-155 | 6.10e-08 | |||
Phospholipase A2 inhibitor; Pssm-ID: 190495 Cd Length: 83 Bit Score: 49.41 E-value: 6.10e-08
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UPAR_LY6 | pfam00021 | u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087. |
172-245 | 6.67e-04 | |||
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087. Pssm-ID: 394978 Cd Length: 77 Bit Score: 37.90 E-value: 6.67e-04
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Name | Accession | Description | Interval | E-value | |||
TFP_LU_ECD_PLIG | cd23588 | extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ... |
73-154 | 1.73e-31 | |||
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit (gamma-PLI) family; The gamma-PLI family includes gamma-PLI A and gamma-PLI B. Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. Gamma-PLI A and gamma-PLI B form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467117 Cd Length: 82 Bit Score: 113.18 E-value: 1.73e-31
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TFP_LU_ECD_PINLYP_rpt2 | cd23572 | second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ... |
168-245 | 1.04e-21 | |||
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD. Pssm-ID: 467102 Cd Length: 80 Bit Score: 87.48 E-value: 1.04e-21
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TFP_LU_ECD_PINLYP_rpt1 | cd23571 | first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ... |
70-158 | 4.12e-15 | |||
first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. Pssm-ID: 467101 Cd Length: 89 Bit Score: 69.75 E-value: 4.12e-15
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TFP_LU_ECD_PLIGB | cd23630 | extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ... |
73-153 | 9.36e-09 | |||
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit B (gamma-PLI B) and similar proteins; Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. There are two gamma-PLI subunits, subunit A and subunit B, which form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467150 Cd Length: 82 Bit Score: 51.77 E-value: 9.36e-09
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TFP_LU_ECD_PLIGA | cd23629 | extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ... |
75-153 | 2.00e-08 | |||
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit A (gamma-PLI A) and similar proteins; Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. There are two gamma-PLI subunits, subunit A and subunit B, which form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467149 Cd Length: 83 Bit Score: 50.96 E-value: 2.00e-08
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PLA2_inh | pfam02988 | Phospholipase A2 inhibitor; |
73-155 | 6.10e-08 | |||
Phospholipase A2 inhibitor; Pssm-ID: 190495 Cd Length: 83 Bit Score: 49.41 E-value: 6.10e-08
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TFP_LU_ECD_uPAR_rpt3 | cd23558 | third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ... |
163-224 | 1.26e-04 | |||
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD. Pssm-ID: 467088 Cd Length: 93 Bit Score: 40.46 E-value: 1.26e-04
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UPAR_LY6 | pfam00021 | u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087. |
172-245 | 6.67e-04 | |||
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087. Pssm-ID: 394978 Cd Length: 77 Bit Score: 37.90 E-value: 6.67e-04
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TFP | cd00117 | three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ... |
73-153 | 8.67e-04 | |||
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances. Pssm-ID: 467060 Cd Length: 81 Bit Score: 37.85 E-value: 8.67e-04
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TFP_LU_ECD_CD59 | cd23554 | extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ... |
73-153 | 1.57e-03 | |||
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467084 Cd Length: 70 Bit Score: 36.53 E-value: 1.57e-03
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TFP_LU_ECD_LYPD3_rpt2 | cd23563 | second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ... |
167-246 | 2.22e-03 | |||
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD. Pssm-ID: 467093 Cd Length: 88 Bit Score: 36.67 E-value: 2.22e-03
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TFP_LU_ECD_uPAR_rpt1 | cd23556 | first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ... |
73-153 | 4.14e-03 | |||
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. Pssm-ID: 467086 Cd Length: 79 Bit Score: 35.51 E-value: 4.14e-03
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TFP_LU_ECD_LYPD9 | cd23570 | extracellular domain (ECD) found in Mus musculus Ly6/PLAUR domain-containing protein 9 (LYPD9) ... |
168-248 | 9.99e-03 | |||
extracellular domain (ECD) found in Mus musculus Ly6/PLAUR domain-containing protein 9 (LYPD9) and similar proteins; LYPD9 is a testis-specific secreted protein dispensable for spermatogenesis in mouse. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467100 Cd Length: 86 Bit Score: 34.85 E-value: 9.99e-03
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Blast search parameters | ||||
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