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Conserved domains on  [gi|1605342042|gb|TFJ98654|]
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A.superbus venom factor 1-like [Platysternon megacephalum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_PLIG cd23588
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ...
 73-154 1.73e-31

extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit (gamma-PLI) family; The gamma-PLI family includes gamma-PLI A and gamma-PLI B. Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. Gamma-PLI A and gamma-PLI B form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467117  Cd Length: 82  Bit Score: 113.18  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCSEFGRNCRGSMETCSSGDDSCAITVFQTLIVGIHTQVVTKSCMASSECRASPVVARFGEGMAIRKSTTCCVWDA 152
Cdd:cd23588     1 LECEVCSGTGTNCTGPMETCSPGEDTCGIILTESTLGGKKTQTVEKGCVSSSVCTLGPVSFNFGKGRTIRTSVSCCTGDA 80


                  ..
gi 1605342042 153 CS 154
Cdd:cd23588    81 CK 82
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 168-245 1.04e-21

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467102  Cd Length: 80  Bit Score: 87.48  E-value: 1.04e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1605342042 168 NGRRCPACSSVFNFPC-SEETFDCTGSETHCIALAGSIAMGSYPLQATLKGCATESACTQLKRDSRTFGDNLKITTATC 245
Cdd:cd23572     1 NGLQCPACYSEGSDSCkSEETVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSLPFGGTSVNITTATC 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_PLIG cd23588
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ...
 73-154 1.73e-31

extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit (gamma-PLI) family; The gamma-PLI family includes gamma-PLI A and gamma-PLI B. Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. Gamma-PLI A and gamma-PLI B form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467117  Cd Length: 82  Bit Score: 113.18  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCSEFGRNCRGSMETCSSGDDSCAITVFQTLIVGIHTQVVTKSCMASSECRASPVVARFGEGMAIRKSTTCCVWDA 152
Cdd:cd23588     1 LECEVCSGTGTNCTGPMETCSPGEDTCGIILTESTLGGKKTQTVEKGCVSSSVCTLGPVSFNFGKGRTIRTSVSCCTGDA 80


                  ..
gi 1605342042 153 CS 154
Cdd:cd23588    81 CK 82
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 168-245 1.04e-21

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 87.48  E-value: 1.04e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1605342042 168 NGRRCPACSSVFNFPC-SEETFDCTGSETHCIALAGSIAMGSYPLQATLKGCATESACTQLKRDSRTFGDNLKITTATC 245
Cdd:cd23572     1 NGLQCPACYSEGSDSCkSEETVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSLPFGGTSVNITTATC 79
PLA2_inh pfam02988
Phospholipase A2 inhibitor;
73-155 6.10e-08

Phospholipase A2 inhibitor;


Pssm-ID: 190495  Cd Length: 83  Bit Score: 49.41  E-value: 6.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCSEFGRNCRGSMETCSSGDDSCAITVFQTLIVGIHTQVVTKSCMASSECRASPVVARFGEGMAIRKSTTCCVWDA 152
Cdd:pfam02988   1 RSCEICHNLGKDCNGWTEECDSPEDQCGTVLTEVSSAPLSIRTIHKNCFSSSTCKLEYFDVNPGHELYLRGRIHCCTGEE 80


                  ...
gi 1605342042 153 CST 155
Cdd:pfam02988  81 CET 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 172-245 6.67e-04

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 37.90  E-value: 6.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1605342042 172 CPACSSVFNFPCSEETfDCTGSETHCIALAGSIAMGSYPLQATLKGCATESaCTQLKRDSRTFGdNLKITTATC 245
Cdd:pfam00021   1 CYSCLGVSNEDCLSEV-TCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSS-CPRLLSDFINGG-IISVSESCC 71
 
Name Accession Description Interval E-value
TFP_LU_ECD_PLIG cd23588
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ...
 73-154 1.73e-31

extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit (gamma-PLI) family; The gamma-PLI family includes gamma-PLI A and gamma-PLI B. Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. Gamma-PLI A and gamma-PLI B form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467117  Cd Length: 82  Bit Score: 113.18  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCSEFGRNCRGSMETCSSGDDSCAITVFQTLIVGIHTQVVTKSCMASSECRASPVVARFGEGMAIRKSTTCCVWDA 152
Cdd:cd23588     1 LECEVCSGTGTNCTGPMETCSPGEDTCGIILTESTLGGKKTQTVEKGCVSSSVCTLGPVSFNFGKGRTIRTSVSCCTGDA 80


                  ..
gi 1605342042 153 CS 154
Cdd:cd23588    81 CK 82
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 168-245 1.04e-21

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 87.48  E-value: 1.04e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1605342042 168 NGRRCPACSSVFNFPC-SEETFDCTGSETHCIALAGSIAMGSYPLQATLKGCATESACTQLKRDSRTFGDNLKITTATC 245
Cdd:cd23572     1 NGLQCPACYSEGSDSCkSEETVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSLPFGGTSVNITTATC 79
TFP_LU_ECD_PINLYP_rpt1 cd23571
first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 70-158 4.12e-15

first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467101  Cd Length: 89  Bit Score: 69.75  E-value: 4.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  70 GACLQCEVCSEFGRNCRGSMETCSSGDDSCAITVFQTLIVGIHTQVVTKSCMASSECRASPVVARFGEGMAIRKSTTCCV 149
Cdd:cd23571     1 GSPLSCEVCKSKGSLCSGPLQTCAPGEDACLTLTGETTLGGNGLVRTFKGCLKPSDCPSGPFSFTFFPKIRMRRNSKCCQ 80


                  ....*....
gi 1605342042 150 WDACSTASV 158
Cdd:cd23571    81 TDGCNSGAV 89
TFP_LU_ECD_PLIGB cd23630
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ...
 73-153 9.36e-09

extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit B (gamma-PLI B) and similar proteins; Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. There are two gamma-PLI subunits, subunit A and subunit B, which form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467150  Cd Length: 82  Bit Score: 51.77  E-value: 9.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCSEFGRNCRGSMETCSSGDDSCaiTVFQTLIVG--IHTQVVTKSCMASSECRASPVVARFGEGMAIRKSTTCCVW 150
Cdd:cd23630     1 LECEVCIGLGKKCNGWTKTCKANEDTC--VTFQTEVIRapVSLTFTAKHCGTSDTCHLDYLETTLHDELTVRLKRTCCTG 78


                  ...
gi 1605342042 151 DAC 153
Cdd:cd23630    79 EEC 81
TFP_LU_ECD_PLIGA cd23629
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ...
 75-153 2.00e-08

extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit A (gamma-PLI A) and similar proteins; Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. There are two gamma-PLI subunits, subunit A and subunit B, which form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467149  Cd Length: 83  Bit Score: 50.96  E-value: 2.00e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1605342042  75 CEVCSEFGRNCRGSMETCSSGDDSCAITVFQTLIVGIHTQVVTKSCMASSECRASPVVARFGEGMAIRKSTTCCVWDAC 153
Cdd:cd23629     3 CEICHNIGKDCDGYEEECSSPEDVCGKVLLEISSAPLSVRTVHKNCFSSSICKLGHFDVNIGHHSYIRGRINCCDKEPC 81
PLA2_inh pfam02988
Phospholipase A2 inhibitor;
73-155 6.10e-08

Phospholipase A2 inhibitor;


Pssm-ID: 190495  Cd Length: 83  Bit Score: 49.41  E-value: 6.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCSEFGRNCRGSMETCSSGDDSCAITVFQTLIVGIHTQVVTKSCMASSECRASPVVARFGEGMAIRKSTTCCVWDA 152
Cdd:pfam02988   1 RSCEICHNLGKDCNGWTEECDSPEDQCGTVLTEVSSAPLSIRTIHKNCFSSSTCKLEYFDVNPGHELYLRGRIHCCTGEE 80


                  ...
gi 1605342042 153 CST 155
Cdd:pfam02988  81 CET 83
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 163-224 1.26e-04

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 40.46  E-value: 1.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1605342042 163 ANTTPNGRRCPACSSVFNFPCSEE---TFDCTGSETHCIALAGSIAMGSYPLQATLKGCATESAC 224
Cdd:cd23558     1 PDLPPNGIQCYSCNGNSTHGCSSEetsKVRCRGPQTQCLEATGTTAHGGKNQSYMVKGCATPSMC 65
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 172-245 6.67e-04

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 37.90  E-value: 6.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1605342042 172 CPACSSVFNFPCSEETfDCTGSETHCIALAGSIAMGSYPLQATLKGCATESaCTQLKRDSRTFGdNLKITTATC 245
Cdd:pfam00021   1 CYSCLGVSNEDCLSEV-TCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSS-CPRLLSDFINGG-IISVSESCC 71
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 73-153 8.67e-04

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 37.85  E-value: 8.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCS----EFGRNCRGSMETCSSGDDSCAITVFQtliVGIHTQVVTKSCMASSECRASPVVARFGEGmaIRKSTTCC 148
Cdd:cd00117     1 LKCYQCNssndPNCCNSSPTLVTCSSPETFCRKIVGK---VGGGETLVIRGCATECECGCTECCSGTGTS--GTTCTSCC 75


                  ....*
gi 1605342042 149 VWDAC 153
Cdd:cd00117    76 DTDLC 80
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 73-153 1.57e-03

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 36.53  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCSEFGRNCRgSMETCSSGDDSCAITVFQTLIvgihtqvvTKSCMASSECRASPVVARFGEGmairKST-TCCVWD 151
Cdd:cd23554     1 LKCYNCPNPTSNCN-TNVTCSSNLDACLIVKAGNRI--------YRQCWKYSDCNFDFISERFGES----NFKyRCCQKD 67


                  ..
gi 1605342042 152 AC 153
Cdd:cd23554    68 LC 69
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 167-246 2.22e-03

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 36.67  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042 167 PNGRRCPACSSVFNFPCSEET---FDCTGSETHCIALAGSIAMGSYPLQATLKGCATESACTqlkRDSRTfGDNLKITTA 243
Cdd:cd23563     1 PNGVECYSCVGNSRGACSPSNapvVRCYGAYSGCFDGNVTLTIGNVTLSLPVKGCVQDGDCT---RESKG-GASVTLKGS 76


                  ...
gi 1605342042 244 TCR 246
Cdd:cd23563    77 CCS 79
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 73-153 4.14e-03

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 35.51  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042  73 LQCEVCSEfGRNCRGSmETCSSGDDSCAITVFQTLIVGIHTQVVTKSCmASSECRASPVVARFGeGMAIRKSTTCCVWDA 152
Cdd:cd23556     1 LRCYSCKS-NGDCRVE-EVCALGQDLCRTTVMTLWEEGEELELVVKGC-DVSGKTNASSSYRTG-LNINSLQETVCSSDL 76


                  .
gi 1605342042 153 C 153
Cdd:cd23556    77 C 77
TFP_LU_ECD_LYPD9 cd23570
extracellular domain (ECD) found in Mus musculus Ly6/PLAUR domain-containing protein 9 (LYPD9) ...
 168-248 9.99e-03

extracellular domain (ECD) found in Mus musculus Ly6/PLAUR domain-containing protein 9 (LYPD9) and similar proteins; LYPD9 is a testis-specific secreted protein dispensable for spermatogenesis in mouse. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467100  Cd Length: 86  Bit Score: 34.85  E-value: 9.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605342042 168 NGRRCPACSSVFNFPCSEETFDCTGSETHCIALAGSIAMGSYPLQATLKGCATESACtqlkRDSRTF-GDNLKITTATCR 246
Cdd:cd23570     8 NGLKCPTCFAVMGRKCNPELKWCSADKIKCVEFSGIINTGLKDIAIELKKCIQAELC----KETTTYmGFPIANKSKICR 83


                  ..
gi 1605342042 247 PA 248
Cdd:cd23570    84 SA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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