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Conserved domains on  [gi|1631787914|gb|TKA60999|]
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Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, partial [Cryomyces minteri]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 94-280 1.36e-128

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 365.97  E-value: 1.36e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  94 PRYFGILKTRRGLPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHFQNKMVACTQPRRVAAMSVAQRV 173
Cdd:cd17973     1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKLVACTQPRRVAAMSVAQRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 174 AQEMDVTLGEEVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPD 253
Cdd:cd17973    81 AEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160

                         170       180
                  ....*....|....*....|....*..
gi 1631787914 254 LKIVIMSATLDAQKFQRYFNDAPLLAV 280
Cdd:cd17973   161 LKLIVMSATLDAGKFQKYFDNAPLLKV 187
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 285-336 1.18e-18

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd18791:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 171  Bit Score: 82.20  E-value: 1.18e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1631787914 285 HPVEIFYTPEP-----------ERDYVEAALRTVLQIHATEPEGDILLFLTGEEEIEDACRKI 336
Cdd:cd18791     1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL 63
 
Name Accession Description Interval E-value
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 94-280 1.36e-128

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 365.97  E-value: 1.36e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  94 PRYFGILKTRRGLPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHFQNKMVACTQPRRVAAMSVAQRV 173
Cdd:cd17973     1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKLVACTQPRRVAAMSVAQRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 174 AQEMDVTLGEEVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPD 253
Cdd:cd17973    81 AEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160

                         170       180
                  ....*....|....*....|....*..
gi 1631787914 254 LKIVIMSATLDAQKFQRYFNDAPLLAV 280
Cdd:cd17973   161 LKLIVMSATLDAGKFQKYFDNAPLLKV 187
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
106-334 4.41e-95

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 300.46  E-value: 4.41e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:COG1643    10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALL--ELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEV-AIRRPDLKIVIMSATLD 264
Cdd:COG1643    88 GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLqPALRPDLKLLVMSATLD 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631787914 265 AQKFQRYFNDAPLLAVPGRTHPVEIFYTP--EPERDYVEAALRTVLQIHAtEPEGDILLFLTGEEEIEDACR 334
Cdd:COG1643   168 AERFARLLGDAPVIESSGRTYPVEVRYRPlpADERDLEDAVADAVREALA-EEPGDILVFLPGEREIRRTAE 238
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 106-331 1.16e-77

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 259.22  E-value: 1.16e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:PRK11131    73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL--ELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCV 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDA 265
Cdd:PRK11131   151 GYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDP 230

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631787914  266 QKFQRYFNDAPLLAVPGRTHPVEIFYTP------EPERDYVEAALRTVLQIHAtEPEGDILLFLTGEEEIED 331
Cdd:PRK11131   231 ERFSRHFNNAPIIEVSGRTYPVEVRYRPiveeadDTERDQLQAIFDAVDELGR-EGPGDILIFMSGEREIRD 301
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 106-332 4.18e-77

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 257.39  E-value: 4.18e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:TIGR01967   66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICL--ELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKV 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDA 265
Cdd:TIGR01967  144 GYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDP 223

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1631787914  266 QKFQRYFNDAPLLAVPGRTHPVEIFYTP------EPERDYVEAALRTVLQIHATEPeGDILLFLTGEEEIEDA 332
Cdd:TIGR01967  224 ERFSRHFNNAPIIEVSGRTYPVEVRYRPlveeqeDDDLDQLEAILDAVDELFAEGP-GDILIFLPGEREIRDA 295
DEXDc smart00487
DEAD-like helicases superfamily;
111-290 2.38e-28

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 109.12  E-value: 2.38e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  111 QRDEFLQMYQKTQILVFVGETGSGKTTQIPQFvLFDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMD----VTLGEEVG 186
Cdd:smart00487  13 QKEAIEALLSGLRDVILAAPTGSGKTLAALLP-ALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPslglKVVGLYGG 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  187 YSIR--FEDKTSQKTMLKYMTDGMLLREAMNDH-NLQRYSTIILDEAHERT--LATDILMGLLKEVairRPDLKIVIMSA 261
Cdd:smart00487  92 DSKReqLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL---PKNVQLLLLSA 168

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1631787914  262 TL--DAQKFQRYFNDAPLLAVPGRT--HPVEIF 290
Cdd:smart00487 169 TPpeEIENLLELFLNDPVFIDVGFTplEPIEQF 201
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 285-336 1.18e-18

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 82.20  E-value: 1.18e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1631787914 285 HPVEIFYTPEP-----------ERDYVEAALRTVLQIHATEPEGDILLFLTGEEEIEDACRKI 336
Cdd:cd18791     1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL 63
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 111-264 1.12e-08

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 53.79  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 111 QRDEFLQMYQKTQILVfVGETGSGKTT--QIPQFVLFDDLPHfqNKMVACTQPRRVAA---MSVAQRVAQEMDVTLGEEV 185
Cdd:pfam00270   4 QAEAIPAILEGRDVLV-QAPTGSGKTLafLLPALEALDKLDN--GPQALVLAPTRELAeqiYEELKKLGKGLGLKVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 -GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHErtLATDILMGLLKEVAIR-RPDLKIVIMSATL 263
Cdd:pfam00270  81 gGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR--LLDMGFGPDLEEILRRlPKKRQILLLSATL 158


                  .
gi 1631787914 264 D 264
Cdd:pfam00270 159 P 159
 
Name Accession Description Interval E-value
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 94-280 1.36e-128

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 365.97  E-value: 1.36e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  94 PRYFGILKTRRGLPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHFQNKMVACTQPRRVAAMSVAQRV 173
Cdd:cd17973     1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKLVACTQPRRVAAMSVAQRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 174 AQEMDVTLGEEVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPD 253
Cdd:cd17973    81 AEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160

                         170       180
                  ....*....|....*....|....*..
gi 1631787914 254 LKIVIMSATLDAQKFQRYFNDAPLLAV 280
Cdd:cd17973   161 LKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 123-280 2.75e-95

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 280.11  E-value: 2.75e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 123 QILVFVGETGSGKTTQIPQFVLFDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEVGYSIRFEDKTSQKTMLK 202
Cdd:cd17917     2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIK 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631787914 203 YMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDAQKFQRYFNDAPLLAV 280
Cdd:cd17917    82 FCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
106-334 4.41e-95

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 300.46  E-value: 4.41e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:COG1643    10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALL--ELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEV-AIRRPDLKIVIMSATLD 264
Cdd:COG1643    88 GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLqPALRPDLKLLVMSATLD 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631787914 265 AQKFQRYFNDAPLLAVPGRTHPVEIFYTP--EPERDYVEAALRTVLQIHAtEPEGDILLFLTGEEEIEDACR 334
Cdd:COG1643   168 AERFARLLGDAPVIESSGRTYPVEVRYRPlpADERDLEDAVADAVREALA-EEPGDILVFLPGEREIRRTAE 238
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 106-278 3.12e-85

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 255.36  E-value: 3.12e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFvLFDDLPHfQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17978     1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQY-LYEAGFA-RGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRR-----PDLKIVIMS 260
Cdd:cd17978    79 GYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMS 158

                         170
                  ....*....|....*...
gi 1631787914 261 ATLDAQKFQRYFNDAPLL 278
Cdd:cd17978   159 ATLDADLFSEYFNGAPVL 176
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 103-281 1.72e-84

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 253.56  E-value: 1.72e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 103 RRGLPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVlfDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLG 182
Cdd:cd17971     3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYL--AEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 183 EEVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSAT 262
Cdd:cd17971    81 QEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSAT 160

                         170
                  ....*....|....*....
gi 1631787914 263 LDAQKFQRYFNDAPLLAVP 281
Cdd:cd17971   161 LDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 106-280 6.04e-84

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 252.04  E-value: 6.04e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFvLFDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17974     1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQY-LHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDA 265
Cdd:cd17974    80 GYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDA 159

                         170
                  ....*....|....*
gi 1631787914 266 QKFQRYFNDAPLLAV 280
Cdd:cd17974   160 EKFSAFFDDAPIFRI 174
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 106-280 8.27e-83

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 248.92  E-value: 8.27e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDlpHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17983     1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDG--YTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDA 265
Cdd:cd17983    79 GYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDA 158

                         170
                  ....*....|....*
gi 1631787914 266 QKFQRYFNDAPLLAV 280
Cdd:cd17983   159 DKFADFFGNVPIFTI 173
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 106-331 1.16e-77

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 259.22  E-value: 1.16e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:PRK11131    73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL--ELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCV 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDA 265
Cdd:PRK11131   151 GYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDP 230

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631787914  266 QKFQRYFNDAPLLAVPGRTHPVEIFYTP------EPERDYVEAALRTVLQIHAtEPEGDILLFLTGEEEIED 331
Cdd:PRK11131   231 ERFSRHFNNAPIIEVSGRTYPVEVRYRPiveeadDTERDQLQAIFDAVDELGR-EGPGDILIFMSGEREIRD 301
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 106-332 4.18e-77

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 257.39  E-value: 4.18e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:TIGR01967   66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICL--ELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKV 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDA 265
Cdd:TIGR01967  144 GYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDP 223

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1631787914  266 QKFQRYFNDAPLLAVPGRTHPVEIFYTP------EPERDYVEAALRTVLQIHATEPeGDILLFLTGEEEIEDA 332
Cdd:TIGR01967  224 ERFSRHFNNAPIIEVSGRTYPVEVRYRPlveeqeDDDLDQLEAILDAVDELFAEGP-GDILIFLPGEREIRDA 295
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 106-273 2.47e-73

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 225.43  E-value: 2.47e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFvLFDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17980     1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQY-LAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTS-QKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLD 264
Cdd:cd17980    80 GYCIRFDDCTDpQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLD 159


                  ....*....
gi 1631787914 265 AQKFQRYFN 273
Cdd:cd17980   160 AEKFRDFFN 168
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 106-280 2.94e-68

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 211.93  E-value: 2.94e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17989     1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICL--ELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDA 265
Cdd:cd17989    79 GYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDA 158

                         170
                  ....*....|....*
gi 1631787914 266 QKFQRYFNDAPLLAV 280
Cdd:cd17989   159 ERFSRHFNNAPIIEV 173
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 106-280 3.07e-66

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 207.01  E-value: 3.07e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPhfQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17984     1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFS--QHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAI-----RRPDLKIVIMS 260
Cdd:cd17984    79 GYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQekspnRKEHLKVVVMS 158

                         170       180
                  ....*....|....*....|
gi 1631787914 261 ATLDAQKFQRYFNDAPLLAV 280
Cdd:cd17984   159 ATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 106-276 3.78e-59

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 189.10  E-value: 3.78e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVL---FDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVtLG 182
Cdd:cd17982     1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYeagFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 183 EEVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPD--------- 253
Cdd:cd17982    80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159

                         170       180
                  ....*....|....*....|....*..
gi 1631787914 254 -LKIVIMSATLDAQKF---QRYFNDAP 276
Cdd:cd17982   160 pLKLVIMSATLRVEDFtenKLLFPRPP 186
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 106-280 3.43e-58

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 186.11  E-value: 3.43e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHfqnkmVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17979     1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH-----IACTQPRRIACISLAKRVAFESLNQYGSKV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLDA 265
Cdd:cd17979    76 AYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINI 155

                         170
                  ....*....|....*
gi 1631787914 266 QKFQRYFNDAPLLAV 280
Cdd:cd17979   156 ELFSGYFEGAPVVQV 170
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 106-280 9.20e-57

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 182.73  E-value: 9.20e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHFQNKM--VACTQPRRVAAMSVAQRVAQEMDVTLGE 183
Cdd:cd17985     1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVanIICTQPRRISAISVAERVAQERAERVGQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 184 EVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATL 263
Cdd:cd17985    81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160

                         170
                  ....*....|....*..
gi 1631787914 264 DAQKFQRYFNDAPLLAV 280
Cdd:cd17985   161 NAELFSDYFNSCPVIHI 177
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 106-280 6.22e-55

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 177.71  E-value: 6.22e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQ----FVLFDdlpHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTL 181
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeYCLSA---HYQHGVVVCTQVHKQTAVWLALRVADEMDVNI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 182 GEEVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSA 261
Cdd:cd17977    78 GHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITC 157

                         170
                  ....*....|....*....
gi 1631787914 262 TLDAQKFQRYFNDAPLLAV 280
Cdd:cd17977   158 PHLSSKLLSYYGNVPLIEV 176
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 106-280 9.54e-53

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 172.33  E-value: 9.54e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHFQNK--MVACTQPRRVAAMSVAQRVAQEM--DVTL 181
Cdd:cd17981     1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSscRIVCTQPRRISAISVAERVAAERaeSCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 182 GEEVGYSIRFEDKTSQK-TMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMS 260
Cdd:cd17981    81 GNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                         170       180
                  ....*....|....*....|
gi 1631787914 261 ATLDAQKFQRYFNDAPLLAV 280
Cdd:cd17981   161 ATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 106-280 2.98e-52

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 171.25  E-value: 2.98e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPH---FQNKMVACTQPRRVAAMSVAQRVAQEMDVTLG 182
Cdd:cd17975     1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNggtAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 183 -----EEVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIV 257
Cdd:cd17975    81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160

                         170       180
                  ....*....|....*....|...
gi 1631787914 258 IMSATLDAQKFQRYFNDAPLLAV 280
Cdd:cd17975   161 LMSATVDCEKFSSYFTHCPILRI 183
DEAH_box_HrpB TIGR01970
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ...
 106-329 8.74e-52

ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273901 [Multi-domain]  Cd Length: 819  Bit Score: 183.81  E-value: 8.74e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVAcTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:TIGR01970   1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALL--DAPGIGGKIIM-LEPRRLAARSAAQRLASQLGEAVGQTV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEV-AIRRPDLKIVIMSATLD 264
Cdd:TIGR01970  78 GYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVqSSLREDLKILAMSATLD 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1631787914 265 AQKFQRYFNDAPLLAVPGRTHPVEIFYTPEPERDYVEAAL-RTVLQIHATEPeGDILLFLTGEEEI 329
Cdd:TIGR01970 158 GERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVsRAVEHALASET-GSILVFLPGQAEI 222
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 106-280 1.12e-50

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 166.93  E-value: 1.12e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17987     1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMN-DHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATLD 264
Cdd:cd17987    81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160

                         170
                  ....*....|....*.
gi 1631787914 265 AQKFQRYFNDAPLLAV 280
Cdd:cd17987   161 VNLFIRYFGSCPVIYI 176
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 106-280 2.40e-48

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 161.11  E-value: 2.40e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHFQNKM--VACTQPRRVAAMSVAQRVAQEMDVTLGE 183
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARcnVVITQPRRISAVSVAQRVAHELGPNLRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 184 EVGYSIRFEDK-TSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSAT 262
Cdd:cd17976    81 NVGYQVRLESRpPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                         170
                  ....*....|....*...
gi 1631787914 263 LDAQKFQRYFNDAPLLAV 280
Cdd:cd17976   161 GDNQRLSRYFGGCPVVRV 178
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 106-280 3.74e-47

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 157.49  E-value: 3.74e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfdDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGEEV 185
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALL--AELWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVA-IRRPDLKIVIMSATLD 264
Cdd:cd17990    79 GYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQqLLRDDLRLLAMSATLD 158

                         170
                  ....*....|....*.
gi 1631787914 265 AQKFQRYFNDAPLLAV 280
Cdd:cd17990   159 GDGLAALLPEAPVVES 174
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 106-280 4.39e-47

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 157.75  E-value: 4.39e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFV-GETGSGKTTQIPQFVL-FDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMDVTLGE 183
Cdd:cd17986     1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQWCAeFALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 184 EVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLKIVIMSATL 263
Cdd:cd17986    81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPA 160

                         170
                  ....*....|....*..
gi 1631787914 264 DAQKFQRYFNDAPLLAV 280
Cdd:cd17986   161 LEPKLRAFWGNPPVVHV 177
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 94-280 1.00e-41

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 145.75  E-value: 1.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  94 PRYFGILKTRRGLPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLFDDLPHFQ----NKMVacTQPRRVAAMSV 169
Cdd:cd17972    47 HNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRaaecNIVV--TQPRRISAVSV 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 170 AQRVAQEMDVTLGEEVGYSIRFEDKTSQK--TMLkYMTDGMLLReaMNDHNLQRYSTIILDEAHERTLATDILMGLLKEV 247
Cdd:cd17972   125 AERVAFERGEEVGKSCGYSVRFESVLPRPhaSIL-FCTVGVLLR--KLEAGIRGISHVIVDEIHERDINTDFLLVVLRDV 201

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1631787914 248 AIRRPDLKIVIMSATLDAQKFQRYFNDAPLLAV 280
Cdd:cd17972   202 VQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 106-280 1.27e-41

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 143.41  E-value: 1.27e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIPQFVLfddlPHFQNKMVAC----TQPRRVAAMSVAQRVAQEMDVTL 181
Cdd:cd17988     1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFIL----DHYYKRGKYCnivvTQPRRIAAISIARRVSQEREWTL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 182 GEEVGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKE-VAIRRPDLKIVIMS 260
Cdd:cd17988    77 GSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRlLRTNSRHVKIILMS 156

                         170       180
                  ....*....|....*....|....
gi 1631787914 261 ATLDAQKFQRYF----NDAPLLAV 280
Cdd:cd17988   157 ATISCKEFADYFttpnNPAYVFEV 180
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 106-330 4.06e-41

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 153.54  E-value: 4.06e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 106 LPVHAQRDEFLQMYQKTQILVFVGETGSGKTTQIP-QFVLfddLPHFQNKMVAcTQPRRVAAMSVAQRVAQEMDVTLGEE 184
Cdd:PRK11664    4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQ---HGGINGKIIM-LEPRRLAARNVAQRLAEQLGEKPGET 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 185 VGYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLKEV-AIRRPDLKIVIMSATL 263
Cdd:PRK11664   80 VGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVqQGLRDDLKLLIMSATL 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631787914 264 DAQKFQRYFNDAPLLAVPGRTHPVEIFYTPEPERDYVEAAL-RTVLQIHATEPeGDILLFLTGEEEIE 330
Cdd:PRK11664  160 DNDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVaRATAELLRQES-GSLLLFLPGVGEIQ 226
DEXDc smart00487
DEAD-like helicases superfamily;
111-290 2.38e-28

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 109.12  E-value: 2.38e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  111 QRDEFLQMYQKTQILVFVGETGSGKTTQIPQFvLFDDLPHFQNKMVACTQPRRVAAMSVAQRVAQEMD----VTLGEEVG 186
Cdd:smart00487  13 QKEAIEALLSGLRDVILAAPTGSGKTLAALLP-ALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPslglKVVGLYGG 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914  187 YSIR--FEDKTSQKTMLKYMTDGMLLREAMNDH-NLQRYSTIILDEAHERT--LATDILMGLLKEVairRPDLKIVIMSA 261
Cdd:smart00487  92 DSKReqLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL---PKNVQLLLLSA 168

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1631787914  262 TL--DAQKFQRYFNDAPLLAVPGRT--HPVEIF 290
Cdd:smart00487 169 TPpeEIENLLELFLNDPVFIDVGFTplEPIEQF 201
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 285-336 1.18e-18

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 82.20  E-value: 1.18e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1631787914 285 HPVEIFYTPEP-----------ERDYVEAALRTVLQIHATEPEGDILLFLTGEEEIEDACRKI 336
Cdd:cd18791     1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL 63
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 126-310 1.64e-12

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 68.47  E-value: 1.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 126 VFVGETGSGKTTQIPQFVL--------FDDL----PHFQNKMVACTQPRR--VAAMSVAQRVAQEMDVTLGEEVgySIRF 191
Cdd:PHA02653  183 VLTGGTGVGKTSQVPKLLLwfnylfggFDNLdkidPNFIERPIVLSLPRValVRLHSITLLKSLGFDEIDGSPI--SLKY 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 192 EDKTSQKTMLKYMTDGMLL---REAMNdhNLQRYSTIILDEAHERTLATDILMGLLKEVAIRRPDLkiVIMSATL--DAQ 266
Cdd:PHA02653  261 GSIPDELINTNPKPYGLVFsthKLTLN--KLFDYGTVIIDEVHEHDQIGDIIIAVARKHIDKIRSL--FLMTATLedDRD 336

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1631787914 267 KFQRYFNDAPLLAVPGRT-HPV-EIF----YTPEPERDYVEAALRTVLQI 310
Cdd:PHA02653  337 RIKEFFPNPAFVHIPGGTlFPIsEVYvknkYNPKNKRAYIEEEKKNIVTA 386
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 111-264 1.12e-08

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 53.79  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 111 QRDEFLQMYQKTQILVfVGETGSGKTT--QIPQFVLFDDLPHfqNKMVACTQPRRVAA---MSVAQRVAQEMDVTLGEEV 185
Cdd:pfam00270   4 QAEAIPAILEGRDVLV-QAPTGSGKTLafLLPALEALDKLDN--GPQALVLAPTRELAeqiYEELKKLGKGLGLKVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 186 -GYSIRFEDKTSQKTMLKYMTDGMLLREAMNDHNLQRYSTIILDEAHErtLATDILMGLLKEVAIR-RPDLKIVIMSATL 263
Cdd:pfam00270  81 gGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR--LLDMGFGPDLEEILRRlPKKRQILLLSATL 158


                  .
gi 1631787914 264 D 264
Cdd:pfam00270 159 P 159
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 128-262 2.20e-08

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 52.41  E-value: 2.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 128 VGETGSGKTTQIPQFVLFDDLPhfQNKMVACTQPRRVAAMSVAQRVAQEMDvtLGEEVGYSIRFEDKTSQKTM------L 201
Cdd:cd00046     7 TAPTGSGKTLAALLAALLLLLK--KGKKVLVLVPTKALALQTAERLRELFG--PGIRVAVLVGGSSAEEREKNklgdadI 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1631787914 202 KYMTDGMLLR--EAMNDHNLQRYSTIILDEAHERTLATD-ILMGLLKEVAIRRPDLKIVIMSAT 262
Cdd:cd00046    83 IIATPDMLLNllLREDRLFLKDLKLIIVDEAHALLIDSRgALILDLAVRKAGLKNAQVILLSAT 146
DEXHc_viral_Ns3 cd17931
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ...
 123-262 9.08e-06

DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350689 [Multi-domain]  Cd Length: 151  Bit Score: 45.23  E-value: 9.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 123 QILVFVGETGSGKTTQIPQFVLFDDLPhfQNKMVACTQPRRVAAMSVAQRVAqemdvtlGEEVGYSI-RFEDKTSQKTML 201
Cdd:cd17931     2 QLTVLDLHPGAGKTTRVLPQIIREAIK--KRLRTLVLAPTRVVAAEMYEALR-------GLPIRYRTgAVKEEHGGNEIV 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631787914 202 KYMTDGMLLREAMNDHNLQRYSTIILDEAHERTLATDILMGLLkEVAIRRPDLKIVIMSAT 262
Cdd:cd17931    73 DYMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYI-HTRVEMGEAAVIFMTAT 132
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 109-278 9.34e-05

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 42.63  E-value: 9.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 109 HAQRDEFLQMYQKTQILVFVGETGSGKTTqIPQFVLFDDLPHFQNKMVAcTQPRRvaAMsVAQRVA--QEMDVTLGEEVG 186
Cdd:cd17921     4 PIQREALRALYLSGDSVLVSAPTSSGKTL-IAELAILRALATSGGKAVY-IAPTR--AL-VNQKEAdlRERFGPLGKNVG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 187 YSIrFEDKTSQKTMLKY----MT----DGMLLREAmnDHNLQRYSTIILDEAH-----ERtlaTDILMGLLKEVAIRRPD 253
Cdd:cd17921    79 LLT-GDPSVNKLLLAEAdilvATpeklDLLLRNGG--ERLIQDVRLVVVDEAHligdgER---GVVLELLLSRLLRINKN 152

                         170       180
                  ....*....|....*....|....*.
gi 1631787914 254 LKIVIMSATLD-AQKFQRYFNDAPLL 278
Cdd:cd17921   153 ARFVGLSATLPnAEDLAEWLGVEDLI 178
SRP_G_like cd03115
GTPase domain similar to the signal recognition particle subunit 54; The signal recognition ...
 124-279 3.33e-04

GTPase domain similar to the signal recognition particle subunit 54; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognate receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.


Pssm-ID: 349769 [Multi-domain]  Cd Length: 193  Bit Score: 41.20  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 124 ILVFVGETGSGKTTQIPQFVLFDDLPHFQnKMVACTQPRRVAAMsvaqrvaqEMDVTLGEEVGYSIrFEDKTSQKTMlky 203
Cdd:cd03115     2 VILLVGLQGSGKTTTLAKLARYYQEKGKK-VLLIAADTFRAAAV--------EQLKTLAEKLGVPV-FESYTGTDPA--- 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1631787914 204 mtdgMLLREAMNDHNLQRYSTIILDEAHeRTLATDILMGLLKEV-AIRRPDLKIVIMSATL--DAQKFQRYFNDAPLLA 279
Cdd:cd03115    69 ----SIAQEAVEKAKLEGYDVLLVDTAG-RLQKDEPLMEELKKVkEVESPDEVLLVLDATTgqEALSQAKAFNEAVGLT 142
AAA_22 pfam13401
AAA domain;
123-231 4.73e-04

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 39.63  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 123 QILVFVGETGSGKTTQIPQFVLFDDLPHFQNKMVACTQPRrvAAMSVAQRVAQEMDVTLGEEvgysirfedkTSQKTMLK 202
Cdd:pfam13401   6 GILVLTGESGTGKTTLLRRLLEQLPEVRDSVVFVDLPSGT--SPKDLLRALLRALGLPLSGR----------LSKEELLA 73

                          90       100
                  ....*....|....*....|....*....
gi 1631787914 203 YMTDGMllreamndHNLQRYSTIILDEAH 231
Cdd:pfam13401  74 ALQQLL--------LALAVAVVLIIDEAQ 94
Cas3 COG1203
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ...
 217-297 5.15e-04

CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 440816 [Multi-domain]  Cd Length: 535  Bit Score: 41.99  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631787914 217 HNLQrYSTIILDEAH---ERTLAtdILMGLLKEvaIRRPDLKIVIMSATLDAqkFQRYFNDAPLLAVPGRTHPVEIFYTP 293
Cdd:COG1203   265 HNLA-NSVIILDEVQaypPYMLA--LLLRLLEW--LKNLGGSVILMTATLPP--LLREELLEAYELIPDEPEELPEYFRA 337


                  ....
gi 1631787914 294 EPER 297
Cdd:COG1203   338 FVRK 341
FlhF TIGR03499
flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility]
 103-137 5.07e-03

flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility]


Pssm-ID: 274609 [Multi-domain]  Cd Length: 282  Bit Score: 38.08  E-value: 5.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1631787914 103 RRGLPVHAQRDEFLQmyqKTQILVFVGETGSGKTT 137
Cdd:TIGR03499 178 EGMLPVKPEEDPILE---QGGVIALVGPTGVGKTT 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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