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Conserved domains on  [gi|1732943973|gb|TYS20789|]
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type III pantothenate kinase [Bacillus subtilis]

Protein Classification

type III pantothenate kinase( domain architecture ID 10014195)

type III pantothenate kinase catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis

CATH:  3.30.420.40
EC:  2.7.1.33
Gene Ontology:  GO:0005524|GO:0016310|GO:0004594|GO:0046872|GO:0015937
PubMed:  16905099|8800467|7781919
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-255 7.82e-168

type III pantothenate kinase;


:

Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 463.85  E-value: 7.82e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHSGLMFEQIDGIIISSVVPPIMFALERMCTKY 80
Cdd:PRK13318    1 MLLAIDVGNTNTVFGLYEGGKLVAHWRISTDSRRTADEYGVWLKQLLGLSGLDPEDITGIIISSVVPSVMHSLERMCRKY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  81 FHIEPQ-IVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTE 159
Cdd:PRK13318   81 FNIEPLvVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGINISAD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 160 ALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDP 239
Cdd:PRK13318  161 ALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEELGKDPKVIATGGLAPLFAEESDTIDIVDP 240

                         250
                  ....*....|....*.
gi 1732943973 240 FLTLKGLELIYERNRV 255
Cdd:PRK13318  241 DLTLKGLRLIYERNKE 256
 
Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-255 7.82e-168

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 463.85  E-value: 7.82e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHSGLMFEQIDGIIISSVVPPIMFALERMCTKY 80
Cdd:PRK13318    1 MLLAIDVGNTNTVFGLYEGGKLVAHWRISTDSRRTADEYGVWLKQLLGLSGLDPEDITGIIISSVVPSVMHSLERMCRKY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  81 FHIEPQ-IVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTE 159
Cdd:PRK13318   81 FNIEPLvVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGINISAD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 160 ALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDP 239
Cdd:PRK13318  161 ALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEELGKDPKVIATGGLAPLFAEESDTIDIVDP 240

                         250
                  ....*....|....*.
gi 1732943973 240 FLTLKGLELIYERNRV 255
Cdd:PRK13318  241 DLTLKGLRLIYERNKE 256
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
1-254 2.33e-143

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 401.46  E-value: 2.33e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHkTEDEFGMILRSLFEHsglMFEQIDGIIISSVVPPIMFALERMCTKY 80
Cdd:COG1521     1 MLLAIDIGNTRIKWGLFDGGELLASWRLATDRR-TADELAELLRQLLAA---LLPDIEGVIISSVVPPLTEALEELLRKY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  81 FHIEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA 160
Cdd:COG1521    77 FGVPPLVVGPGVKTGLKNAYDNPEELGADRIANAVAARELYGGPLLVVDFGTATTFDVVDADGEYLGGAIAPGLGLSLEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 161 LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDPF 240
Cdd:COG1521   157 LHQRTAKLPLVELEKPPSVIGKNTVEAIQSGVVYGYAGLIEGLIERIKEELGEDPKVIATGGDAPLLAPELKTIDIVDPD 236

                         250
                  ....*....|....
gi 1732943973 241 LTLKGLELIYERNR 254
Cdd:COG1521   237 LVLEGLRLIYERNK 250
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 3-249 1.22e-120

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 343.86  E-value: 1.22e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   3 LVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGmilrslFEHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFH 82
Cdd:cd24015     1 LVIDIGNTNIKLGLFDGGELVKIWRLSTDKELTEDELL------LLLAGIELEDISGVVISSVVPSLTEVLEEALKKYFG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  83 IEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEALY 162
Cdd:cd24015    75 ISPLVVGPGLKLGVKIAYDNPKELGADRLANAVAAAKLYGRPVIVVDFGTATTIDLVDAEGEFLGGAIAPGIELSLKALH 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 163 SRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDPFLT 242
Cdd:cd24015   155 QRTAKLPSVELIKPKKVIGKNTEEAIQSGVFYGYAGLIEGIIERLKKELGGDAKVILTGGDAKLVAPYLEPIDIYDPDLT 234


                  ....*..
gi 1732943973 243 LKGLELI 249
Cdd:cd24015   235 LKGLKLI 241
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 2-251 7.55e-116

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 331.74  E-value: 7.55e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   2 LLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHSglmfeqIDGIIISSVVPPIMFALERMCTKYF 81
Cdd:TIGR00671   1 LLLIDVGNTRIVFALNSGNKVYQFWRLATNLMKTYDEHSEFLKELFGKS------LNKAFISSVVPELTEAVRNMIPKIK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  82 HIEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEAL 161
Cdd:TIGR00671  75 NIKPEIFFPLVYDGLPNLYKSPKELGIDRVANALAAIKFYGFNVVVVDAGTALTIDLVDQEGKFLGGAIAPGLGISLHAL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 162 YSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGlAPLIANESDCIDIVDPFL 241
Cdd:TIGR00671 155 KDRAAALPKFEIARPDEVLGKSTREAVQSGAVYGVLGLIQGLLKDWKKYFKRKFAVVITGG-DGKYLSAFLPFSIYDPHL 233

                         250
                  ....*....|
gi 1732943973 242 TLKGLELIYE 251
Cdd:TIGR00671 234 TVEGMRNLLR 243
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 2-206 1.80e-115

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 329.14  E-value: 1.80e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   2 LLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHSGlmFEQIDGIIISSVVPPIMFALERMCTKYF 81
Cdd:pfam03309   1 LLAIDIGNTNIKWGLFDGDKLVAHWRISTDARRTADELGVLLRSLLRLAG--IDPIDGVIISSVVPPLNAALERACLKYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  82 HIEPQIVG-PGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGN-PLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTE 159
Cdd:pfam03309  79 KIEPLVVGaPGIKTGLRNRYDNPKELGADRWVNAVAARELYPGkPLIVVDFGTATTFDAVSADGEYLGGAIAPGIGLSLD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1732943973 160 ALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKR 206
Cdd:pfam03309 159 ALAQGTAKLPRVEITRPGSVIGKNTVEAIQSGILYGYAGLVEGIIRR 205
 
Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-255 7.82e-168

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 463.85  E-value: 7.82e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHSGLMFEQIDGIIISSVVPPIMFALERMCTKY 80
Cdd:PRK13318    1 MLLAIDVGNTNTVFGLYEGGKLVAHWRISTDSRRTADEYGVWLKQLLGLSGLDPEDITGIIISSVVPSVMHSLERMCRKY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  81 FHIEPQ-IVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTE 159
Cdd:PRK13318   81 FNIEPLvVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGINISAD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 160 ALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDP 239
Cdd:PRK13318  161 ALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEELGKDPKVIATGGLAPLFAEESDTIDIVDP 240

                         250
                  ....*....|....*.
gi 1732943973 240 FLTLKGLELIYERNRV 255
Cdd:PRK13318  241 DLTLKGLRLIYERNKE 256
PRK13321 PRK13321
type III pantothenate kinase;
1-254 2.99e-147

type III pantothenate kinase;


Pssm-ID: 237349 [Multi-domain]  Cd Length: 256  Bit Score: 411.57  E-value: 2.99e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHSGLMFEQIDGIIISSVVPPIMFALERMCTKY 80
Cdd:PRK13321    1 MLLLIDVGNTNIKLGVFDGDRLLRSFRLPTDKSRTSDELGILLLSLFRHAGLDPEDIRAVVISSVVPPLNYSLESACKRY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  81 FHIEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNP-LIVVDFGTATTYCYIDENKQYMGGAIAPGITISTE 159
Cdd:PRK13321   81 FGIKPLFVGPGIKTGLKIRYDNPREVGADRIVNAVAARRLYPDRnLIVVDFGTATTFDCVSGKGEYLGGAICPGILISME 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 160 ALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDP 239
Cdd:PRK13321  161 ALSQKTAKLPRVEIAKPPSAIGKSTVSSIQSGLYYGYAGLVEGIVARIKAELGGPPRVIATGGFASLIAKESRCFDHVDP 240

                         250
                  ....*....|....*
gi 1732943973 240 FLTLKGLELIYERNR 254
Cdd:PRK13321  241 DLLLEGLRILYQMNR 255
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
1-254 2.33e-143

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 401.46  E-value: 2.33e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHkTEDEFGMILRSLFEHsglMFEQIDGIIISSVVPPIMFALERMCTKY 80
Cdd:COG1521     1 MLLAIDIGNTRIKWGLFDGGELLASWRLATDRR-TADELAELLRQLLAA---LLPDIEGVIISSVVPPLTEALEELLRKY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  81 FHIEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA 160
Cdd:COG1521    77 FGVPPLVVGPGVKTGLKNAYDNPEELGADRIANAVAARELYGGPLLVVDFGTATTFDVVDADGEYLGGAIAPGLGLSLEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 161 LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDPF 240
Cdd:COG1521   157 LHQRTAKLPLVELEKPPSVIGKNTVEAIQSGVVYGYAGLIEGLIERIKEELGEDPKVIATGGDAPLLAPELKTIDIVDPD 236

                         250
                  ....*....|....
gi 1732943973 241 LTLKGLELIYERNR 254
Cdd:COG1521   237 LVLEGLRLIYERNK 250
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 3-249 1.22e-120

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 343.86  E-value: 1.22e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   3 LVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGmilrslFEHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFH 82
Cdd:cd24015     1 LVIDIGNTNIKLGLFDGGELVKIWRLSTDKELTEDELL------LLLAGIELEDISGVVISSVVPSLTEVLEEALKKYFG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  83 IEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEALY 162
Cdd:cd24015    75 ISPLVVGPGLKLGVKIAYDNPKELGADRLANAVAAAKLYGRPVIVVDFGTATTIDLVDAEGEFLGGAIAPGIELSLKALH 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 163 SRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDPFLT 242
Cdd:cd24015   155 QRTAKLPSVELIKPKKVIGKNTEEAIQSGVFYGYAGLIEGIIERLKKELGGDAKVILTGGDAKLVAPYLEPIDIYDPDLT 234


                  ....*..
gi 1732943973 243 LKGLELI 249
Cdd:cd24015   235 LKGLKLI 241
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 2-251 7.55e-116

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 331.74  E-value: 7.55e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   2 LLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHSglmfeqIDGIIISSVVPPIMFALERMCTKYF 81
Cdd:TIGR00671   1 LLLIDVGNTRIVFALNSGNKVYQFWRLATNLMKTYDEHSEFLKELFGKS------LNKAFISSVVPELTEAVRNMIPKIK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  82 HIEPQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEAL 161
Cdd:TIGR00671  75 NIKPEIFFPLVYDGLPNLYKSPKELGIDRVANALAAIKFYGFNVVVVDAGTALTIDLVDQEGKFLGGAIAPGLGISLHAL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 162 YSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGlAPLIANESDCIDIVDPFL 241
Cdd:TIGR00671 155 KDRAAALPKFEIARPDEVLGKSTREAVQSGAVYGVLGLIQGLLKDWKKYFKRKFAVVITGG-DGKYLSAFLPFSIYDPHL 233

                         250
                  ....*....|
gi 1732943973 242 TLKGLELIYE 251
Cdd:TIGR00671 234 TVEGMRNLLR 243
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 2-206 1.80e-115

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 329.14  E-value: 1.80e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   2 LLVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHSGlmFEQIDGIIISSVVPPIMFALERMCTKYF 81
Cdd:pfam03309   1 LLAIDIGNTNIKWGLFDGDKLVAHWRISTDARRTADELGVLLRSLLRLAG--IDPIDGVIISSVVPPLNAALERACLKYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  82 HIEPQIVG-PGMKTGLNIKYDNPKEVGADRIVNAVAAIHLYGN-PLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTE 159
Cdd:pfam03309  79 KIEPLVVGaPGIKTGLRNRYDNPKELGADRWVNAVAARELYPGkPLIVVDFGTATTFDAVSADGEYLGGAIAPGIGLSLD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1732943973 160 ALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKR 206
Cdd:pfam03309 159 ALAQGTAKLPRVEITRPGSVIGKNTVEAIQSGILYGYAGLVEGIIRR 205
PRK13320 PRK13320
type III pantothenate kinase;
1-254 3.28e-63

type III pantothenate kinase;


Pssm-ID: 237348 [Multi-domain]  Cd Length: 244  Bit Score: 198.16  E-value: 3.28e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLeyhwrIETSRHKTEdEFGMILRSLFEHsglmFEQIDGIIISSVVPPIMFALERMCTKY 80
Cdd:PRK13320    3 MNLVIDIGNTTTKLAVFEGDEL-----LEVFVVSTE-GVEESLEKLLAK----YPAIRDAIVSSVVPLAEEAFSALLKLL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  81 FHIepQIVGPGMKTGLNIKYDNPKEVGADRIVNAVAAIHLY-GNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTE 159
Cdd:PRK13320   73 FAV--LELDSETPLPFRNDYDTPETLGADRLALCAGARYLFpGKNVLAIDAGTAITYDVLDSEGVYLGGLISPGLEMRFK 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 160 ALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKwqAK-QEPKVIATGGLAPLIANESDCIDIVD 238
Cdd:PRK13320  151 ALHEFTARLPLVTIEGPIPLIGRSTEECIRSGVVWGCVAEIEGLIEAYK--SKlPELLVILTGGDAPFLASRLKNTIFAD 228

                         250
                  ....*....|....*.
gi 1732943973 239 PFLTLKGLELIYERNR 254
Cdd:PRK13320  229 EHAVLKGLNRILEYNK 244
PRK13324 PRK13324
type III pantothenate kinase;
1-256 9.48e-41

type III pantothenate kinase;


Pssm-ID: 106284 [Multi-domain]  Cd Length: 258  Bit Score: 140.92  E-value: 9.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLEYHWRIETSR-HKTEDEFGMILRSLFEHSGLMFEQIDGIIISSVVPPIMFALERMCTK 79
Cdd:PRK13324    1 MLLVMDMGNSHIHIGVFDGDRIVSQIRYATSSvDSTSDQMGVFLRQALRENSVDLGKIDGCGISSVVPHLNYSLGSAVIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  80 YFHIEPQIVGPGMkTGLNIKYDNPKEVGADRIVNAVAAIHLYGNP-LIVVDFGTATTYCYIDENKQYMGGAIAPGITIST 158
Cdd:PRK13324   81 YFNIKPFFISMDT-TDLDMSAVEAHQVGADRIASCISAIADHPNKdLLIIDLGTATTFDLVTKDKKYLSGSIMPGVKLSL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 159 EALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANEsDCIDIVD 238
Cdd:PRK13324  160 NALCQGASQLSSVTIVKPEVAIGYDTKTNIRSGLYYGHLGALKELKRRSVEEFGSPVYTIATGGFAGLFKEE-DIFNEIS 238

                         250
                  ....*....|....*....
gi 1732943973 239 PFLTLKGLELIY-ERNRVG 256
Cdd:PRK13324  239 PDLILRGIRIAFlENNKKG 257
PRK13322 PRK13322
pantothenate kinase; Reviewed
 1-246 2.12e-31

pantothenate kinase; Reviewed


Pssm-ID: 237350 [Multi-domain]  Cd Length: 246  Bit Score: 116.20  E-value: 2.12e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTvlgvyhegkleyHWRIeTSRHKTEDEFGMILRS---LFEH-SGLMFEQIDGIIISSVV-PPIMFALER 75
Cdd:PRK13322    1 MILELDCGNSRL------------KWRV-IDNGGQIIEHGAHLDSpaeLLLGlANLASLAPTRCRIVSVLsEEETARLVA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  76 MCTKYFHIEPQIVGP-----GMKTGlnikYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAI 150
Cdd:PRK13322   68 ILEKRLGIPVVFAKVaaelaGVRNG----YEDPEQLGIDRWLALLGAFHLAKNACLVIDCGTAVTIDLVDADGQHLGGYI 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 151 APGITISTEALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANE 230
Cdd:PRK13322  144 CPGLYLMRDALRTHTRRIRYDDGTADSLSPGRNTVDAVERGCLLMLRGFIESQLEQARELWGPDFEIFLTGGDAPLLADH 223

                         250
                  ....*....|....*.
gi 1732943973 231 SDCIdIVDPFLTLKGL 246
Cdd:PRK13322  224 LPQA-RVVPDLVFVGL 238
PRK13326 PRK13326
type III pantothenate kinase;
3-249 1.92e-22

type III pantothenate kinase;


Pssm-ID: 237351  Cd Length: 262  Bit Score: 92.93  E-value: 1.92e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   3 LVIDVGNTNTVLGVYHEGKLEYHWRIETSRHKTEDEFGMILRSLFEHsglmfeQIDGIIISSVVPPIMFALERMCTKYFH 82
Cdd:PRK13326    9 LIIDIGNTSISFALYKDNKMQIFCKLKTKLDLSFDELYSFLKEKFDF------KVNQVFVSSVVPVIDKVLINVIFSLYK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  83 IEPQIVGPGMKTGLNIK-YDNPKEV-GADRIVNAVAAIHLYG-NPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTE 159
Cdd:PRK13326   83 VKPLFIGFDLNYDLSFNpYNSNKFLlGSDVFANLVGAIEYYNiNDALVVDLGTACTIFAVSRQDGILGGLINGGPFTNLN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 160 ALYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIANESDCIDIVDP 239
Cdd:PRK13326  163 ALLDNAYLLKDFNLSVPKNLLGLSTSDSVNSGVIYQYKYLIEGVYHDLKRNYDREFNLIITGGNSNLILPLISVDFIFNL 242

                         250
                  ....*....|
gi 1732943973 240 FLTLKGLELI 249
Cdd:PRK13326  243 YLTLEGIRIL 252
PRK13329 PRK13329
pantothenate kinase; Reviewed
 1-228 1.26e-21

pantothenate kinase; Reviewed


Pssm-ID: 183979 [Multi-domain]  Cd Length: 249  Bit Score: 90.44  E-value: 1.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLVIDVGNTNTVLGVYHEGKLEYHWRIETSR-HKTEDEFGMILRSLFEHSGLMfeqidgiIISSVV-PPIMFALERMCT 78
Cdd:PRK13329    2 TFLAIDVGNTRLKWGLYDAAQPGAALLAHGAEfLAEIDRLAEGAWAGLPAPARV-------LGCNVAgDAVARRVAEQLE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  79 KyFHIEPQIVGPGM-KTGLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITIS 157
Cdd:PRK13329   75 L-WDVAPRWVVASAaECGVRNGYDHPARLGADRWVALIGARHGPARPCLVVMVGTAVTVDALDADGEFLGGLILPGHGLM 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1732943973 158 TEALYSRAAKLPrieitRPDNIIG---KNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVIATGGLAPLIA 228
Cdd:PRK13329  154 LRALESGTAGLH-----VPTGEVRefpTNTSDALTSGGTQAIAGAVERMFRHLAQHCGAEPECLLTGGAAWKLA 222
PRK13331 PRK13331
pantothenate kinase; Reviewed
 107-249 1.71e-20

pantothenate kinase; Reviewed


Pssm-ID: 237353 [Multi-domain]  Cd Length: 251  Bit Score: 87.41  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 107 GADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEALYSRAAKLPRIEI-TRPDNIIGKNTV 185
Cdd:PRK13331   97 GIDRALALWGAGQTYGFPCLVIDAGTALTFTGVDSDRTLVGGAILPGLGLQLRSLADKTAALPQVELpPPLPPRWATNTQ 176

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1732943973 186 SAMQSGILFGYVGQVEGIVKrmKWQaKQEP--KVIATGGLAPLIAN-------ESDCIDIVDPFLTLKGLELI 249
Cdd:PRK13331  177 EAIQSGVIYTILAGLRDFIE--DWL-SLFPdgKIVLTGGDGELLHNylqdldpELAQRLRVDPNLIFWGIAAI 246
PRK13328 PRK13328
type III pantothenate kinase;
100-228 2.64e-14

type III pantothenate kinase;


Pssm-ID: 237352 [Multi-domain]  Cd Length: 255  Bit Score: 70.43  E-value: 2.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 100 YDNPKEVGADRIVNAVAAIHLY-GNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEALYSRAAKLPRIEIT---- 174
Cdd:PRK13328   94 YREPAQLGSDRWAGLIGARAAFpGEHLLIATFGTATTLDALRADGRFAGGLILPGLALMMRALARHTAQLPTLDVDaasa 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1732943973 175 --RPDNIIGKNTVSAMQSGILFGYVGQVEgivkRMkWQA-----KQEPKVIATGGLAPLIA 228
Cdd:PRK13328  174 aaGAVAPFADDTPDAISAGCLAAQAGLIE----RA-WRDlaarwQAPVRLVLSGGAADAVA 229
PRK13325 PRK13325
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;
95-228 1.74e-10

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;


Pssm-ID: 183976 [Multi-domain]  Cd Length: 592  Bit Score: 60.88  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  95 GLNIKYDNPKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEALYSRAAKLPRIEIT 174
Cdd:PRK13325  421 GIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNRHAGK 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1732943973 175 RPDniIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQ--AKQEPKVIATGGLAPLIA 228
Cdd:PRK13325  501 RYP--FPTTTGNAVASGMMDAVCGSVMMMHGRLKEKtgAGKPVDVIITGGGAAKVA 554
PRK13327 PRK13327
type III pantothenate kinase;
95-169 1.02e-09

type III pantothenate kinase;


Pssm-ID: 183977 [Multi-domain]  Cd Length: 242  Bit Score: 57.15  E-value: 1.02e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1732943973  95 GLNIKYDNPKEVGADRIVNAVAAihlYGN-PLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEALYSRAAKLP 169
Cdd:PRK13327   86 GVRIAYADPSRFGVDRFLALLGA---RGDaPVLVVGVGTALTIDLLGADGLHHGGRIAASPTTMREALHARAVQLP 158
PRK13333 PRK13333
type III pantothenate kinase;
1-253 1.63e-07

type III pantothenate kinase;


Pssm-ID: 183981 [Multi-domain]  Cd Length: 206  Bit Score: 50.31  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973   1 MLLViDVGNTNtvLGVYHEGKLeYHWRIETSRHKTEDEfgmilrslfehsglmfeqidGIIISSVVPPIMFALERMCTKY 80
Cdd:PRK13333    1 MLLC-DIGNTN--AHFYQNGKI-FSLSIEEFKRFKIDQ--------------------EIYYISVNEELEKKLLKCYPNA 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973  81 FHIEPQIVgpgmktgLNIKYdnpKEVGADRIVnAVAAIhlygNPLIVVDFGTATTycyID--ENKQYMGGAIAPGITIST 158
Cdd:PRK13333   57 INLEPYFE-------LDTIY---QGLGIDRIA-ACYAI----EDGVVVDAGSAIT---VDimSNGIHLGGFILPGIAAYK 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732943973 159 EALYSRAAKL-----PRIEItrpdNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWqakqepkvIATGG----LAPLIAN 229
Cdd:PRK13333  119 KAYKKISPRLkqpfnAQISL----DALPQNTRDAISYGVIKSIILLIEKLAKNKKI--------YFTGGdgkfLSKFFPN 186

                         250       260
                  ....*....|....*....|....
gi 1732943973 230 EsdcidIVDPFLTLKGLELIYERN 253
Cdd:PRK13333  187 A-----IYDERLVFRGMKKIIKEN 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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