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Conserved domains on  [gi|2168430639|gb|UHH89848|]
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TLR5 [Aptenodytes patagonicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 2.58e-26

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.58e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  694 RYDAYLCYSKNDfeWVQNSLLKRLDSQYFDKNrftLCFEERDFLPGEEHINNIHDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430639  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIRNFLQRsRYLLWPEDYQDIDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 1.76e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 1.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 274 NNLKNPDNDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 354 YDYTFEGLRSVMYIDLQQNhigmigeKSFSNLVSLKIIDLRDNAIKKLP----SFPHLTSAFLGDNKLmSVVGTAIAA-- 427
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQL-TDLPEPLGNlt 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 428 --THLELERNWLANLGDlyILFQVPDVQYIFLKQNRFSYcvKSDNVTENNQLIYMDLGENMLqlvweRDLcLDVFRALSK 505
Cdd:COG4886   160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2168430639 506 LQVLHLNNNYLSALPQeiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
97-159 7.27e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 7.27e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430639  97 PNLRVLDLGFNKILQLDLDAFVGLLSLTVLHLFQNYLgdSILEERYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-270 2.59e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  92 AFRNLPNLRVLDLGFNKILQLDLDAFVGLL----SLTVLHLFQNYLGD--SILEERYFQDLSSLEELDLSGNQITK---- 161
Cdd:COG5238   231 ALKGNKSLTTLDLSNNQIGDEGVIALAEALknntTVETLYLSGNQIGAegAIALAKALQGNTTLTSLDLSVNRIGDegai 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 162 -LQPHpLFYNLTvLKTVNLKFNKITNLCESNLTSFRGKH--FLFFSLSSNNLykTDEMAWAKCPNPFRNMMFNSLDLSDN 238
Cdd:COG5238   311 aLAEG-LQGNKT-LHTLNLAYNGIGAQGAIALAKALQENttLHSLDLSDNQI--GDEGAIALAKYLEGNTTLRELNLGKN 386

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2168430639 239 GWSTEEVQYFCTAIKGTQIGSLILSSHTMGSG 270
Cdd:COG5238   387 NIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 6.73e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 6.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLIFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430639  631 CNED 634
Cdd:TIGR00864   80 CDEE 83
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 2.58e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.58e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  694 RYDAYLCYSKNDfeWVQNSLLKRLDSQYFDKNrftLCFEERDFLPGEEHINNIHDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430639  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIRNFLQRsRYLLWPEDYQDIDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 695-843 8.31e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 98.59  E-value: 8.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 695 YDAYLCYSKND-FEWVQNSLLKRLDsqyfdKNRFTLCFEERDFLPGEEHINNIHDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 774 FNFAQSRYFsDLKDVLIMVVVGSLSQYQL-------MKHKPIRNFLQRSRYLLWPEDYQDID------------WFLNKL 834
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALNEVAniwhsksvsdesKFWKKI 154


                  ....*....
gi 2168430639 835 SCQMLKEKK 843
Cdd:pfam01582 155 AYDISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 1.76e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 1.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 274 NNLKNPDNDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 354 YDYTFEGLRSVMYIDLQQNhigmigeKSFSNLVSLKIIDLRDNAIKKLP----SFPHLTSAFLGDNKLmSVVGTAIAA-- 427
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQL-TDLPEPLGNlt 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 428 --THLELERNWLANLGDlyILFQVPDVQYIFLKQNRFSYcvKSDNVTENNQLIYMDLGENMLqlvweRDLcLDVFRALSK 505
Cdd:COG4886   160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2168430639 506 LQVLHLNNNYLSALPQeiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
504-562 2.40e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 2.40e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430639 504 SKLQVLHLNNNYLSALPQEIFRGLTSLKRLNLASNLLSHLSPGLF--PQSLTNLNLSGNQL 562
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-159 7.27e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 7.27e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430639  97 PNLRVLDLGFNKILQLDLDAFVGLLSLTVLHLFQNYLgdSILEERYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-585 2.31e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  96 LPNLRVLDLGfNKILQLDLDAFVGLLS-LTVLHLFQNYLGDSIleERYFQDLSSLEELDLSGNQITKLQPHP-------- 166
Cdd:PLN00113  139 IPNLETLDLS-NNMLSGEIPNDIGSFSsLKVLDLGGNVLVGKI--PNSLTNLTSLEFLTLASNQLVGQIPRElgqmkslk 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 167 ---LFYN------------LTVLKTVNLKFNKITNLCESNLTSFRGKHFLFfslssnnLYKTdemawaKCPNPFRNMMFN 231
Cdd:PLN00113  216 wiyLGYNnlsgeipyeiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLF-------LYQN------KLSGPIPPSIFS 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 232 -----SLDLSDNGWSTEevqyfctaikgtqIGSLILSSHTMgsgfgfnnlknpdndtfaglasSDLHLLdiSNGYIFSLN 306
Cdd:PLN00113  283 lqkliSLDLSDNSLSGE-------------IPELVIQLQNL----------------------EILHLF--SNNFTGKIP 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 307 SLIfQSLGNLELLNLFKNKIN-QIQRQaffgLG---NLKTLNLSSN-LLGELYDYTFEGLRSVMYIDLQQNHIGMIgEKS 381
Cdd:PLN00113  326 VAL-TSLPRLQVLQLWSNKFSgEIPKN----LGkhnNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGEI-PKS 399

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 382 FSNLVSLKIIDLRDNAIK-KLPS-FPHLTSAF---LGDNKLMSVVGTAI----AATHLELERNWLanLGDLYILFQVPDV 452
Cdd:PLN00113  400 LGACRSLRRVRLQDNSFSgELPSeFTKLPLVYfldISNNNLQGRINSRKwdmpSLQMLSLARNKF--FGGLPDSFGSKRL 477

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 453 QYIFLKQNRFSYCVKSdNVTENNQLIYMDLGENMLQLVWERDLcldvfRALSKLQVLHLNNNYLSALPQEIFRGLTSLKR 532
Cdd:PLN00113  478 ENLDLSRNQFSGAVPR-KLGSLSELMQLKLSENKLSGEIPDEL-----SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQ 551

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430639 533 LNLASNLLShlspGLFP------QSLTNLNLSGNQLFS--PEPEVFMTLSILDITHNKYVC 585
Cdd:PLN00113  552 LDLSQNQLS----GEIPknlgnvESLVQVNISHNHLHGslPSTGAFLAINASAVAGNIDLC 608
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-417 3.92e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.08  E-value: 3.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  85 PVTIGKgafrnLPNLRVLDLGFNKILQLDLDAFVGLLSLTVLHLFQNYLGDSILEERYfqDLSSLEELDLSGNQITKLQP 164
Cdd:PLN00113  229 PYEIGG-----LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSLSGEIP 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 165 HpLFYNLTVLKTVNLKFNKITNLCESNLTSFRGKHFLffSLSSNNLYKTDEMAWAKCPNpfrnmmFNSLDLSDNGWSTEE 244
Cdd:PLN00113  302 E-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--QLWSNKFSGEIPKNLGKHNN------LTVLDLSTNNLTGEI 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 245 VQYFCTAikgTQIGSLILSSHTM--------GSGFGFNNLKNPDNdTFAGLASSD------LHLLDISNGYIFSLNSLIF 310
Cdd:PLN00113  373 PEGLCSS---GNLFKLILFSNSLegeipkslGACRSLRRVRLQDN-SFSGELPSEftklplVYFLDISNNNLQGRINSRK 448

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 311 QSLGNLELLNLFKNKINQiQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLRSVMYIDLQQNHI-GMIGEK--SFSNLVS 387
Cdd:PLN00113  449 WDMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsGEIPDElsSCKKLVS 527

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2168430639 388 LkiiDLRDNAIK-KLPS----FPHLTSAFLGDNKL 417
Cdd:PLN00113  528 L---DLSHNQLSgQIPAsfseMPVLSQLDLSQNQL 559
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-270 2.59e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  92 AFRNLPNLRVLDLGFNKILQLDLDAFVGLL----SLTVLHLFQNYLGD--SILEERYFQDLSSLEELDLSGNQITK---- 161
Cdd:COG5238   231 ALKGNKSLTTLDLSNNQIGDEGVIALAEALknntTVETLYLSGNQIGAegAIALAKALQGNTTLTSLDLSVNRIGDegai 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 162 -LQPHpLFYNLTvLKTVNLKFNKITNLCESNLTSFRGKH--FLFFSLSSNNLykTDEMAWAKCPNPFRNMMFNSLDLSDN 238
Cdd:COG5238   311 aLAEG-LQGNKT-LHTLNLAYNGIGAQGAIALAKALQENttLHSLDLSDNQI--GDEGAIALAKYLEGNTTLRELNLGKN 386

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2168430639 239 GWSTEEVQYFCTAIKGTQIGSLILSSHTMGSG 270
Cdd:COG5238   387 NIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 146-400 6.25e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 6.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 146 LSSLEELDLSGNQITKLQPHPLFYNLTV---LKTVNLKFN------KITNLCESNLTSFRGKHFLffSLSSNNLYKTDEM 216
Cdd:cd00116    22 LLCLQVLRLEGNTLGEEAAKALASALRPqpsLKELCLSLNetgripRGLQSLLQGLTKGCGLQEL--DLSDNALGPDGCG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 217 AWAKCpnpFRNMMFNSLDLSDNGWSTEEVQYFCTAIKGTQ--IGSLILsshtmgsgfGFNNLKNPDNDTFAGLASS--DL 292
Cdd:cd00116   100 VLESL---LRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpaLEKLVL---------GRNRLEGASCEALAKALRAnrDL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 293 HLLDISNGYI----FSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFG----LGNLKTLNLSSNLLG-----ELYDYTFE 359
Cdd:cd00116   168 KELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTdagaaALASALLS 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2168430639 360 GLRSVMYIDLQQNHIGMIGEKSFS----NLVSLKIIDLRDNAIKK 400
Cdd:cd00116   248 PNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGE 292
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-187 5.09e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 5.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  93 FRNLPNLRVLDLGFNKI-----LQldldafvGLLSLTVLHLFQNYLGDS---ILEERYFQDLS-SLEELDLSGNQITKLQ 163
Cdd:cd21340    64 LENLVNLKKLYLGGNRIsvvegLE-------NLTNLEELHIENQRLPPGeklTFDPRSLAALSnSLRVLNISGNNIDSLE 136

                          90       100
                  ....*....|....*....|....
gi 2168430639 164 PhplFYNLTVLKTVNLKFNKITNL 187
Cdd:cd21340   137 P---LAPLRNLEQLDASNNQISDL 157
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 6.73e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 6.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLIFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430639  631 CNED 634
Cdd:TIGR00864   80 CDEE 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 361-560 2.44e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 361 LRSVMYIDLQQNHIGMIGEksFSNLVSLKIIDLRDNAIKK---LPSFPHLTSAFLGDNKL--MSVVGTAIAATHLELERN 435
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKienLEFLTNLTHLYLQNNQIekIENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 436 WLA---------NLGDLYIlfqvpdvqyiflkqnrfsycvksdnvtENNQLiymDLGENmlqlvwerdLCLDVF--RALS 504
Cdd:cd21340    79 RISvveglenltNLEELHI---------------------------ENQRL---PPGEK---------LTFDPRslAALS 119

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430639 505 K-LQVLHLNNNYLSALpqEIFRGLTSLKRLNLASNLLSHLSP--GLFPQ--SLTNLNLSGN 560
Cdd:cd21340   120 NsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSwpSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
147-210 8.01e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2168430639 147 SSLEELDLSGNQITKLQPHpLFYNLTVLKTVNLKFNKITNLcesNLTSFRGKHFLFF-SLSSNNL 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTL---SPGAFSGLPSLRYlDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-263 2.52e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  91 GAFRNLPNLRVLDLgFNKILQLDLDAFVGLL----SLTVLHLFQNYLGDSILE--ERYFQDLS-SLEELDLSGNQITKLQ 163
Cdd:cd00116    75 QGLTKGCGLQELDL-SDNALGPDGCGVLESLlrssSLQELKLNNNGLGDRGLRllAKGLKDLPpALEKLVLGRNRLEGAS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 164 PHPL---FYNLTVLKTVNLKFNKITN-----LCESnLTSFRGKHFLffSLSSNNLykTDEMAWAKCPNPFRNMMFNSLDL 235
Cdd:cd00116   154 CEALakaLRANRDLKELNLANNGIGDagiraLAEG-LKANCNLEVL--DLNNNGL--TDEGASALAETLASLKSLEVLNL 228

                         170       180
                  ....*....|....*....|....*...
gi 2168430639 236 SDNGWSTEEVQYFCTAIKGTQIGSLILS 263
Cdd:cd00116   229 GDNNLTDAGAAALASALLSPNISLLTLS 256
LRRCT smart00082
Leucine rich repeat C-terminal domain;
581-626 3.61e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 3.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2168430639  581 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCVYPPAFAGvPLSSL 626
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLEL 43
LRR smart00370
Leucine-rich repeats, outliers;
503-526 4.24e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.24e-03
                           10        20
                   ....*....|....*....|....
gi 2168430639  503 LSKLQVLHLNNNYLSALPQEIFRG 526
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 2.58e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.58e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  694 RYDAYLCYSKNDfeWVQNSLLKRLDSQYFDKNrftLCFEERDFLPGEEHINNIHDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430639  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIRNFLQRsRYLLWPEDYQDIDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 695-843 8.31e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 98.59  E-value: 8.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 695 YDAYLCYSKND-FEWVQNSLLKRLDsqyfdKNRFTLCFEERDFLPGEEHINNIHDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 774 FNFAQSRYFsDLKDVLIMVVVGSLSQYQL-------MKHKPIRNFLQRSRYLLWPEDYQDID------------WFLNKL 834
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALNEVAniwhsksvsdesKFWKKI 154


                  ....*....
gi 2168430639 835 SCQMLKEKK 843
Cdd:pfam01582 155 AYDISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 1.76e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 1.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 274 NNLKNPDNDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 354 YDYTFEGLRSVMYIDLQQNhigmigeKSFSNLVSLKIIDLRDNAIKKLP----SFPHLTSAFLGDNKLmSVVGTAIAA-- 427
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPeelaNLTNLKELDLSNNQL-TDLPEPLGNlt 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 428 --THLELERNWLANLGDlyILFQVPDVQYIFLKQNRFSYcvKSDNVTENNQLIYMDLGENMLqlvweRDLcLDVFRALSK 505
Cdd:COG4886   160 nlKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQL-----TDL-PEPLANLTN 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2168430639 506 LQVLHLNNNYLSALPQeiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-654 4.85e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 4.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 274 NNLKNPDNDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKinqiqrqAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 354 yDYTFEGLRSVMYIDLQQNHIGMIGEkSFSNLVSLKIIDLRDNAIKKLPSF----PHLTSAFLGDNKLmSVVGTAIAA-- 427
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQI-TDLPEPLGNlt 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 428 --THLELERNWLANLgdlyilfqvpdvqyiflkqnrfsycvkSDNVTENNQLIYMDLGENMLQlvwerdlCLDVFRALSK 505
Cdd:COG4886   206 nlEELDLSGNQLTDL---------------------------PEPLANLTNLETLDLSNNQLT-------DLPELGNLTN 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 506 LQVLHLNNNYLSALPQEIfrGLTSLKRLNLASNLLSHLS-----PGLFPQSLTNLNLSGNQLFSPEPEVFMTLSILDITH 580
Cdd:COG4886   252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlkeleLLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2168430639 581 NKYVCDCTLKSLLVWLNETNVTLAGSQSDRYCVYPPAFAGVPLSSLIFDGCNEDELQQTLRFSVFLFTSITLLT 654
Cdd:COG4886   330 LKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
LRR_8 pfam13855
Leucine rich repeat;
504-562 2.40e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 2.40e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430639 504 SKLQVLHLNNNYLSALPQEIFRGLTSLKRLNLASNLLSHLSPGLF--PQSLTNLNLSGNQL 562
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-159 7.27e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 7.27e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430639  97 PNLRVLDLGFNKILQLDLDAFVGLLSLTVLHLFQNYLgdSILEERYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-440 1.55e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  87 TIGKGAFRNLPNLRVLDLGFNKILQLDLDAFVGLLSLTVLHLFQNylgdsileeRYFQDLSSLEELDLSGNQITKLQPHp 166
Cdd:COG4886    62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEE- 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 167 lFYNLTVLKTVNLKFNKITNLCE--SNLTSFRgkhflFFSLSSNNLyktdemawAKCPNPFRNM-MFNSLDLSDNgwste 243
Cdd:COG4886   132 -LANLTNLKELDLSNNQLTDLPEplGNLTNLK-----SLDLSNNQL--------TDLPEELGNLtNLKELDLSNN----- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 244 evqyfctaikgtQIGSLilsshtmgsGFGFNNLKNpdndtfaglassdLHLLDISNGYIFSLnSLIFQSLGNLELLNLFK 323
Cdd:COG4886   193 ------------QITDL---------PEPLGNLTN-------------LEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 324 NKINQIqrQAFFGLGNLKTLNLSSNLLGELYDytFEGLRSVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAIKKLPS 403
Cdd:COG4886   238 NQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2168430639 404 FPHLTSAFLGDNKLMSVVGTAIAATHLELERNWLANL 440
Cdd:COG4886   314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR_8 pfam13855
Leucine rich repeat;
315-374 1.41e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.41e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 315 NLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLRSVMYIDLQQNHI 374
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-585 2.31e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  96 LPNLRVLDLGfNKILQLDLDAFVGLLS-LTVLHLFQNYLGDSIleERYFQDLSSLEELDLSGNQITKLQPHP-------- 166
Cdd:PLN00113  139 IPNLETLDLS-NNMLSGEIPNDIGSFSsLKVLDLGGNVLVGKI--PNSLTNLTSLEFLTLASNQLVGQIPRElgqmkslk 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 167 ---LFYN------------LTVLKTVNLKFNKITNLCESNLTSFRGKHFLFfslssnnLYKTdemawaKCPNPFRNMMFN 231
Cdd:PLN00113  216 wiyLGYNnlsgeipyeiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLF-------LYQN------KLSGPIPPSIFS 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 232 -----SLDLSDNGWSTEevqyfctaikgtqIGSLILSSHTMgsgfgfnnlknpdndtfaglasSDLHLLdiSNGYIFSLN 306
Cdd:PLN00113  283 lqkliSLDLSDNSLSGE-------------IPELVIQLQNL----------------------EILHLF--SNNFTGKIP 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 307 SLIfQSLGNLELLNLFKNKIN-QIQRQaffgLG---NLKTLNLSSN-LLGELYDYTFEGLRSVMYIDLQQNHIGMIgEKS 381
Cdd:PLN00113  326 VAL-TSLPRLQVLQLWSNKFSgEIPKN----LGkhnNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGEI-PKS 399

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 382 FSNLVSLKIIDLRDNAIK-KLPS-FPHLTSAF---LGDNKLMSVVGTAI----AATHLELERNWLanLGDLYILFQVPDV 452
Cdd:PLN00113  400 LGACRSLRRVRLQDNSFSgELPSeFTKLPLVYfldISNNNLQGRINSRKwdmpSLQMLSLARNKF--FGGLPDSFGSKRL 477

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 453 QYIFLKQNRFSYCVKSdNVTENNQLIYMDLGENMLQLVWERDLcldvfRALSKLQVLHLNNNYLSALPQEIFRGLTSLKR 532
Cdd:PLN00113  478 ENLDLSRNQFSGAVPR-KLGSLSELMQLKLSENKLSGEIPDEL-----SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQ 551

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430639 533 LNLASNLLShlspGLFP------QSLTNLNLSGNQLFS--PEPEVFMTLSILDITHNKYVC 585
Cdd:PLN00113  552 LDLSQNQLS----GEIPknlgnvESLVQVNISHNHLHGslPSTGAFLAINASAVAGNIDLC 608
LRR_8 pfam13855
Leucine rich repeat;
292-350 7.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 7.58e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2168430639 292 LHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLL 350
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
339-398 7.73e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 7.73e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 339 NLKTLNLSSNLLGELYDYTFEGLRSVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAI 398
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-540 1.56e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  87 TIGKGAFRNLPNLRVLDLGFNKILQLDLDAFVGLLSLTVLHLFQNYLGDSILEERYFQDLSSLEELDLSGNQitklqphp 166
Cdd:COG4886    36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 167 LFYNLTVLKTVNLKFNKITNLCE--SNLTSFRgkhflffslssnnlyktdemawakcpnpfrnmmfnSLDLSDNgwstee 244
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEelANLTNLK-----------------------------------ELDLSNN------ 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 245 vqyfctaikgtQIGSLilsshtmgsGFGFNNLKNpdndtfaglassdLHLLDISNGYIFSLNSLIFQsLGNLELLNLFKN 324
Cdd:COG4886   147 -----------QLTDL---------PEPLGNLTN-------------LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNN 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 325 KINQIQrQAFFGLGNLKTLNLSSNLLGELyDYTFEGLRSVMYIDLQQNHIGMIgeKSFSNLVSLKIIDLRDNAIKKLPS- 403
Cdd:COG4886   193 QITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPl 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 404 --FPHLTSAFLGDNKLMSVVGTAIAATHLELERNWLANLGDLYILFQVPDVQYIFLKQNRFSYCVKSDNVTENNQLIYMD 481
Cdd:COG4886   269 anLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2168430639 482 LGENMLQLVWERDLCLDVFRALSKLQVLHLNNNYLSALPQEIFRGLTSLKRLNLASNLL 540
Cdd:COG4886   349 LLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 323-568 1.87e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 323 KNKINQIQrQAFFGLGNLKTLNLSSNLL-GELYDYTFEGLRSVMYIDLQQNHI-GMIGEKSFSNL--------------- 385
Cdd:PLN00113   79 KNISGKIS-SAIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLetldlsnnmlsgeip 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 386 ------VSLKIIDLRDNA--------IKKLPSFPHLTSA---------------------FLGDNKLMS----VVGTAIA 426
Cdd:PLN00113  158 ndigsfSSLKVLDLGGNVlvgkipnsLTNLTSLEFLTLAsnqlvgqiprelgqmkslkwiYLGYNNLSGeipyEIGGLTS 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 427 ATHLELERNWL-----ANLGDLyilfqvPDVQYIFLKQNRFSYCVKSdNVTENNQLIYMDLGENML-----QLVWErdlc 496
Cdd:PLN00113  238 LNHLDLVYNNLtgpipSSLGNL------KNLQYLFLYQNKLSGPIPP-SIFSLQKLISLDLSDNSLsgeipELVIQ---- 306

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2168430639 497 ldvfraLSKLQVLHLNNNYLSAlpqEIFRGLTSLKR---LNLASNLLSHLSPGLFPQ--SLTNLNLSGNQLFSPEPE 568
Cdd:PLN00113  307 ------LQNLEILHLFSNNFTG---KIPVALTSLPRlqvLQLWSNKFSGEIPKNLGKhnNLTVLDLSTNNLTGEIPE 374
LRR_8 pfam13855
Leucine rich repeat;
78-133 1.27e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430639  78 IGIQYVYPVTIGKGAFRNLPNLRVLDLGFNKILQLDLDAFVGLLSLTVLHLFQNYL 133
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-417 3.92e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.08  E-value: 3.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  85 PVTIGKgafrnLPNLRVLDLGFNKILQLDLDAFVGLLSLTVLHLFQNYLGDSILEERYfqDLSSLEELDLSGNQITKLQP 164
Cdd:PLN00113  229 PYEIGG-----LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSLSGEIP 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 165 HpLFYNLTVLKTVNLKFNKITNLCESNLTSFRGKHFLffSLSSNNLYKTDEMAWAKCPNpfrnmmFNSLDLSDNGWSTEE 244
Cdd:PLN00113  302 E-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--QLWSNKFSGEIPKNLGKHNN------LTVLDLSTNNLTGEI 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 245 VQYFCTAikgTQIGSLILSSHTM--------GSGFGFNNLKNPDNdTFAGLASSD------LHLLDISNGYIFSLNSLIF 310
Cdd:PLN00113  373 PEGLCSS---GNLFKLILFSNSLegeipkslGACRSLRRVRLQDN-SFSGELPSEftklplVYFLDISNNNLQGRINSRK 448

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 311 QSLGNLELLNLFKNKINQiQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLRSVMYIDLQQNHI-GMIGEK--SFSNLVS 387
Cdd:PLN00113  449 WDMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsGEIPDElsSCKKLVS 527

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2168430639 388 LkiiDLRDNAIK-KLPS----FPHLTSAFLGDNKL 417
Cdd:PLN00113  528 L---DLSHNQLSgQIPAsfseMPVLSQLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 147-633 7.05e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 7.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 147 SSLEELDLSGNQITKlQPHPLFYNLTVLKTVNLKFNKITNLCESNLtSFRGKHFLFFSLSSNNLykTDEMAWAKCPNpfr 226
Cdd:PLN00113   69 SRVVSIDLSGKNISG-KISSAIFRLPYIQTINLSNNQLSGPIPDDI-FTTSSSLRYLNLSNNNF--TGSIPRGSIPN--- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 227 nmmFNSLDLSDNGWSTEEVQyfctaikgtQIGSlilsshtmgsgfgFNNLKnpdndtfaglassdlhLLDISNGYifsLN 306
Cdd:PLN00113  142 ---LETLDLSNNMLSGEIPN---------DIGS-------------FSSLK----------------VLDLGGNV---LV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 307 SLIFQSLGNLELLNLFKNKINQIQRQAFFGLGNLKTLNL----SSNLLGELyDYTFEGLRSVMYIDLQQNHIGMIGEKSF 382
Cdd:PLN00113  178 GKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWiylgYNNLSGEI-PYEIGGLTSLNHLDLVYNNLTGPIPSSL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 383 SNLVSLKIIDLRDNAI-----KKLPSFPHLTSAFLGDNKLMSVVGTAIAA-THLELERNWLANL-GDLYI-LFQVPDVQY 454
Cdd:PLN00113  257 GNLKNLQYLFLYQNKLsgpipPSIFSLQKLISLDLSDNSLSGEIPELVIQlQNLEILHLFSNNFtGKIPVaLTSLPRLQV 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 455 IFLKQNRFSYCVKSdNVTENNQLIYMDLGENMLQLVWERDLC-------LDVFR------------ALSKLQVLHLNNNY 515
Cdd:PLN00113  337 LQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCssgnlfkLILFSnslegeipkslgACRSLRRVRLQDNS 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 516 LSA-LPQEI---------------FRG--------LTSLKRLNLASNLLSHLSPGLF-PQSLTNLNLSGNQLFSPEPEVF 570
Cdd:PLN00113  416 FSGeLPSEFtklplvyfldisnnnLQGrinsrkwdMPSLQMLSLARNKFFGGLPDSFgSKRLENLDLSRNQFSGAVPRKL 495

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 571 MTLS---ILDITHNKYVCDC--TLKSL--LVWLNETNVTLAGSqsdrycvYPPAFAGVPLSSLIFDGCNE 633
Cdd:PLN00113  496 GSLSelmQLKLSENKLSGEIpdELSSCkkLVSLDLSHNQLSGQ-------IPASFSEMPVLSQLDLSQNQ 558
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 698-780 1.24e-06

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 48.08  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 698 YLCYSKNDFEWVQNsLLKRLDsqyfdKNRFTLCFEERDFLPGEEHINNIHDAIWNSRKTICIVTRQFLKDGWCVEAFNFA 777
Cdd:pfam13676   2 FISYAGEDRAWAEW-LADALE-----AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA 75


                  ...
gi 2168430639 778 QSR 780
Cdd:pfam13676  76 LAD 78
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-270 2.59e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  92 AFRNLPNLRVLDLGFNKILQLDLDAFVGLL----SLTVLHLFQNYLGD--SILEERYFQDLSSLEELDLSGNQITK---- 161
Cdd:COG5238   231 ALKGNKSLTTLDLSNNQIGDEGVIALAEALknntTVETLYLSGNQIGAegAIALAKALQGNTTLTSLDLSVNRIGDegai 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 162 -LQPHpLFYNLTvLKTVNLKFNKITNLCESNLTSFRGKH--FLFFSLSSNNLykTDEMAWAKCPNPFRNMMFNSLDLSDN 238
Cdd:COG5238   311 aLAEG-LQGNKT-LHTLNLAYNGIGAQGAIALAKALQENttLHSLDLSDNQI--GDEGAIALAKYLEGNTTLRELNLGKN 386

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2168430639 239 GWSTEEVQYFCTAIKGTQIGSLILSSHTMGSG 270
Cdd:COG5238   387 NIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
LRR_8 pfam13855
Leucine rich repeat;
494-540 5.08e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2168430639 494 DLCLDVFRALSKLQVLHLNNNYLSALPQEIFRGLTSLKRLNLASNLL 540
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 146-400 6.25e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 6.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 146 LSSLEELDLSGNQITKLQPHPLFYNLTV---LKTVNLKFN------KITNLCESNLTSFRGKHFLffSLSSNNLYKTDEM 216
Cdd:cd00116    22 LLCLQVLRLEGNTLGEEAAKALASALRPqpsLKELCLSLNetgripRGLQSLLQGLTKGCGLQEL--DLSDNALGPDGCG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 217 AWAKCpnpFRNMMFNSLDLSDNGWSTEEVQYFCTAIKGTQ--IGSLILsshtmgsgfGFNNLKNPDNDTFAGLASS--DL 292
Cdd:cd00116   100 VLESL---LRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpaLEKLVL---------GRNRLEGASCEALAKALRAnrDL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 293 HLLDISNGYI----FSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFG----LGNLKTLNLSSNLLG-----ELYDYTFE 359
Cdd:cd00116   168 KELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTdagaaALASALLS 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2168430639 360 GLRSVMYIDLQQNHIGMIGEKSFS----NLVSLKIIDLRDNAIKK 400
Cdd:cd00116   248 PNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGE 292
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-187 5.09e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 5.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  93 FRNLPNLRVLDLGFNKI-----LQldldafvGLLSLTVLHLFQNYLGDS---ILEERYFQDLS-SLEELDLSGNQITKLQ 163
Cdd:cd21340    64 LENLVNLKKLYLGGNRIsvvegLE-------NLTNLEELHIENQRLPPGeklTFDPRSLAALSnSLRVLNISGNNIDSLE 136

                          90       100
                  ....*....|....*....|....
gi 2168430639 164 PhplFYNLTVLKTVNLKFNKITNL 187
Cdd:cd21340   137 P---LAPLRNLEQLDASNNQISDL 157
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 6.73e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 6.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLIFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430639  631 CNED 634
Cdd:TIGR00864   80 CDEE 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 361-560 2.44e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 361 LRSVMYIDLQQNHIGMIGEksFSNLVSLKIIDLRDNAIKK---LPSFPHLTSAFLGDNKL--MSVVGTAIAATHLELERN 435
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKienLEFLTNLTHLYLQNNQIekIENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 436 WLA---------NLGDLYIlfqvpdvqyiflkqnrfsycvksdnvtENNQLiymDLGENmlqlvwerdLCLDVF--RALS 504
Cdd:cd21340    79 RISvveglenltNLEELHI---------------------------ENQRL---PPGEK---------LTFDPRslAALS 119

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430639 505 K-LQVLHLNNNYLSALpqEIFRGLTSLKRLNLASNLLSHLSP--GLFPQ--SLTNLNLSGN 560
Cdd:cd21340   120 NsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSwpSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
362-417 2.51e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430639 362 RSVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAIKKLP-----SFPHLTSAFLGDNKL 417
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
147-210 8.01e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2168430639 147 SSLEELDLSGNQITKLQPHpLFYNLTVLKTVNLKFNKITNLcesNLTSFRGKHFLFF-SLSSNNL 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTL---SPGAFSGLPSLRYlDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 340-562 9.12e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 9.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 340 LKTLNLSSNLLGELYDytfeGLRSVM----------YIDLQQNHIGMIGEKSFSNL---VSLKIIDLRDNAIKK------ 400
Cdd:cd00116    53 LKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrglrll 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 401 ----LPSFPHLTSAFLGDNKLMSVVGTAIAAThlelernwLANLGDLYIL------FQVPDVQYIFLkqnrfsycvksdN 470
Cdd:cd00116   129 akglKDLPPALEKLVLGRNRLEGASCEALAKA--------LRANRDLKELnlanngIGDAGIRALAE------------G 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 471 VTENNQLIYMDLGENMLQLVWERDLClDVFRALSKLQVLHLNNNYL-----SALPQEIFRGLTSLKRLNLASNLLSHLSP 545
Cdd:cd00116   189 LKANCNLEVLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGA 267

                         250       260
                  ....*....|....*....|...
gi 2168430639 546 GLFPQ------SLTNLNLSGNQL 562
Cdd:cd00116   268 KDLAEvlaekeSLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 497-582 1.03e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 497 LDVFRALSKLQVLHLNNNYLSALpqEIFRGLTSLKRLNLAS-------------NLLSHLSPglfpqSLTNLNLSGNQLF 563
Cdd:cd21340    61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                          90       100
                  ....*....|....*....|
gi 2168430639 564 SPEPEVFMT-LSILDITHNK 582
Cdd:cd21340   134 SLEPLAPLRnLEQLDASNNQ 153
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 322-396 2.38e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.68  E-value: 2.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2168430639 322 FKNKINQIQRQAFFGLGNLKTLNLSSNLLgELYDYTFEG--LRSvmyIDLQQNhIGMIGEKSFSNLVSLKIIDLRDN 396
Cdd:pfam13306  18 IPSSLTSIGEYAFSNCTSLKSITLPSSLT-SIGSYAFYNcsLTS---ITIPSS-LTSIGEYAFSNCSNLKSITLPSN 89
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-263 2.52e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639  91 GAFRNLPNLRVLDLgFNKILQLDLDAFVGLL----SLTVLHLFQNYLGDSILE--ERYFQDLS-SLEELDLSGNQITKLQ 163
Cdd:cd00116    75 QGLTKGCGLQELDL-SDNALGPDGCGVLESLlrssSLQELKLNNNGLGDRGLRllAKGLKDLPpALEKLVLGRNRLEGAS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 164 PHPL---FYNLTVLKTVNLKFNKITN-----LCESnLTSFRGKHFLffSLSSNNLykTDEMAWAKCPNPFRNMMFNSLDL 235
Cdd:cd00116   154 CEALakaLRANRDLKELNLANNGIGDagiraLAEG-LKANCNLEVL--DLNNNGL--TDEGASALAETLASLKSLEVLNL 228

                         170       180
                  ....*....|....*....|....*...
gi 2168430639 236 SDNGWSTEEVQYFCTAIKGTQIGSLILS 263
Cdd:cd00116   229 GDNNLTDAGAAALASALLSPNISLLTLS 256
LRRCT smart00082
Leucine rich repeat C-terminal domain;
581-626 3.61e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 3.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2168430639  581 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCVYPPAFAGvPLSSL 626
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLEL 43
LRR smart00370
Leucine-rich repeats, outliers;
503-526 4.24e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.24e-03
                           10        20
                   ....*....|....*....|....
gi 2168430639  503 LSKLQVLHLNNNYLSALPQEIFRG 526
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
503-526 4.24e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.24e-03
                           10        20
                   ....*....|....*....|....
gi 2168430639  503 LSKLQVLHLNNNYLSALPQEIFRG 526
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 295-404 4.56e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 295 LDISNGYIFSLNSLifQSLGNLELLNLFKNKIN--------------QIQRQ-------------AFFGLGN-LKTLNLS 346
Cdd:cd21340    51 LYLQNNQIEKIENL--ENLVNLKKLYLGGNRISvveglenltnleelHIENQrlppgekltfdprSLAALSNsLRVLNIS 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430639 347 SNLLGELYDytFEGLRSVMYIDLQQNHIGMIGE--KSFSNLVSLKIIDLRDNAIKKLPSF 404
Cdd:cd21340   129 GNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKY 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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