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Conserved domains on  [gi|2168430657|gb|UHH89857|]
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TLR5 [Eudyptes sclateri]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 1.54e-26

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.87  E-value: 1.54e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  694 RYDAYLCYSKNDfeWVQNALLKHLDSQYFDKNrftLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430657  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIRNFLQRsRYLLWPEDYQDVDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 4.04e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 274 NNLKNPDSDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKinqiqrqAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 354 yDYTFEGLHSVMYIDLQQNHIGMIGEkSFSNLVSLKIIDLRDNAIKKLPSF----PHLTSAFLGDNKLmsvvgTAIAATL 429
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQI-----TDLPEPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 430 LELErnwlaNLGDLYIlfqvpdvqyiflkqnrfsycvkrdnvtENNQLIYMDlgenmlqlvwerdlclDVFRALSKLQVL 509
Cdd:COG4886   202 GNLT-----NLEELDL---------------------------SGNQLTDLP----------------EPLANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168430657 510 HLNNNYLSALPReiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
97-159 3.53e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 3.53e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430657  97 PNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLgdSILEEHYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 98-270 7.69e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 7.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  98 NLHVLDLGFNKI----LQLDLDAFVGLPSLTVLRLFHNYLGDS---ILEEHyFQDLSSLEELDLSGNQITKLQPHPLFYN 170
Cdd:COG5238   265 TVETLYLSGNQIgaegAIALAKALQGNTTLTSLDLSVNRIGDEgaiALAEG-LQGNKTLHTLNLAYNGIGAQGAIALAKA 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 171 L---TVLKTVNLKFNKITnlcesnltsfrgkhflffslssnnfykiDEMAWAKCPNPFRNITFNSLDLSDNGWSTEEVQY 247
Cdd:COG5238   344 LqenTTLHSLDLSDNQIG----------------------------DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEA 395

                         170       180
                  ....*....|....*....|...
gi 2168430657 248 FCTAIKGTQIGSLILSSHTMGSG 270
Cdd:COG5238   396 LIDALQTNRLHTLILDGNLIGAE 418
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 4.48e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 4.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLTFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430657  631 CDED 634
Cdd:TIGR00864   80 CDEE 83
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 1.54e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.87  E-value: 1.54e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  694 RYDAYLCYSKNDfeWVQNALLKHLDSQYFDKNrftLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430657  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIRNFLQRsRYLLWPEDYQDVDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 695-843 2.70e-23

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 97.44  E-value: 2.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 695 YDAYLCYSKND-FEWVQNALLKHLDsqyfdKNRFTLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 774 FNFAQSRYFsDLKDVLIMVVVGSLSQYQL-------MKHKPIRNFLQRSRYLLWPEDYQDVD------------WFLNKL 834
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALNEVAniwhsksvsdesKFWKKI 154


                  ....*....
gi 2168430657 835 SCQMLKEKK 843
Cdd:pfam01582 155 AYDISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 4.04e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 274 NNLKNPDSDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKinqiqrqAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 354 yDYTFEGLHSVMYIDLQQNHIGMIGEkSFSNLVSLKIIDLRDNAIKKLPSF----PHLTSAFLGDNKLmsvvgTAIAATL 429
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQI-----TDLPEPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 430 LELErnwlaNLGDLYIlfqvpdvqyiflkqnrfsycvkrdnvtENNQLIYMDlgenmlqlvwerdlclDVFRALSKLQVL 509
Cdd:COG4886   202 GNLT-----NLEELDL---------------------------SGNQLTDLP----------------EPLANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168430657 510 HLNNNYLSALPReiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
504-562 5.62e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 5.62e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430657 504 SKLQVLHLNNNYLSALPREIFRGLTSLKRLNLASNLLSHLSPGLF--PQSLTNLNLSGNQL 562
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-159 3.53e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 3.53e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430657  97 PNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLgdSILEEHYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-353 6.37e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 6.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  92 AFRNLPNLHVLDLGFNKILQLDlDAFVGLPSLTVLRLFHNYLGDsiLEEHyFQDLSSLEELDLSGNQITKLqPHPLfYNL 171
Cdd:COG4886   131 ELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTD--LPEE-LGNLTNLKELDLSNNQITDL-PEPL-GNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 172 TVLKTVNLKFNKITNLCES--NLTSFRgkhflFFSLSSNNFYKIDEMawAKCPNpfrnitFNSLDLSDNGWSTEEVQYFC 249
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPlaNLTNLE-----TLDLSNNQLTDLPEL--GNLTN------LEELDLSNNQLTDLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 250 TAIKGTQIGSLILSSHTMGSGFGFNNLKNPDSDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKINQI 329
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260
                  ....*....|....*....|....
gi 2168430657 330 QRQAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLL 375
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-585 1.19e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  96 LPNLHVLDLGfNKILQLDLDAFVGL-PSLTVLRLFHNYLGDSIleEHYFQDLSSLEELDLSGNQITKLQPHP-------- 166
Cdd:PLN00113  139 IPNLETLDLS-NNMLSGEIPNDIGSfSSLKVLDLGGNVLVGKI--PNSLTNLTSLEFLTLASNQLVGQIPRElgqmkslk 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 167 ---LFYN------------LTVLKTVNLKFNKITNLCESNLTSFRGKHFLFfsLSSNNFYkidemawAKCPNPFRNIT-F 230
Cdd:PLN00113  216 wiyLGYNnlsgeipyeiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLF--LYQNKLS-------GPIPPSIFSLQkL 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 231 NSLDLSDNGWSTEevqyfctaikgtqIGSLILsshtmgsgfgfnNLKNPDSdtfaglassdLHLLdiSNGYIFSLNSLIf 310
Cdd:PLN00113  287 ISLDLSDNSLSGE-------------IPELVI------------QLQNLEI----------LHLF--SNNFTGKIPVAL- 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 311 QSLGNLELLNLFKNKIN-QIQRQaffgLG---NLKTLNLSSN-LLGELYDYTFEGLHSVMYIDLQQNHIGMIgEKSFSNL 385
Cdd:PLN00113  329 TSLPRLQVLQLWSNKFSgEIPKN----LGkhnNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGEI-PKSLGAC 403

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 386 VSLKIIDLRDNAIK-KLPS-FPHLTSAF---LGDNKLMSVVGTAI----AATLLELERNWLanLGDLYILFQVPDVQYIF 456
Cdd:PLN00113  404 RSLRRVRLQDNSFSgELPSeFTKLPLVYfldISNNNLQGRINSRKwdmpSLQMLSLARNKF--FGGLPDSFGSKRLENLD 481

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 457 LKQNRFSYCVKRdNVTENNQLIYMDLGENMLQLVWERDLcldvfRALSKLQVLHLNNNYLSALPREIFRGLTSLKRLNLA 536
Cdd:PLN00113  482 LSRNQFSGAVPR-KLGSLSELMQLKLSENKLSGEIPDEL-----SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2168430657 537 SNLLShlspGLFP------QSLTNLNLSGNQLFS--PEPEVFMTLSILDITHNKYVC 585
Cdd:PLN00113  556 QNQLS----GEIPknlgnvESLVQVNISHNHLHGslPSTGAFLAINASAVAGNIDLC 608
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 125-400 3.16e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.13  E-value: 3.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 125 VLRLFHNYLGDSILEEHyFQDLSSLEELDLSGNQITKLQPHPLFYNLTV---LKTVNLKFN------KITNLCESNLTSF 195
Cdd:cd00116     2 QLSLKGELLKTERATEL-LPKLLCLQVLRLEGNTLGEEAAKALASALRPqpsLKELCLSLNetgripRGLQSLLQGLTKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 196 RGKHFLffSLSSNNFYKIDEMAWAKCpnpFRNITFNSLDLSDNGWSTEEVQYFCTAIKGTQ--IGSLILsshtmgsgfGF 273
Cdd:cd00116    81 CGLQEL--DLSDNALGPDGCGVLESL---LRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpaLEKLVL---------GR 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 274 NNLKNPDSDTFAGLASS--DLHLLDISNGYI----FSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFG----LGNLKTL 343
Cdd:cd00116   147 NRLEGASCEALAKALRAnrDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVL 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430657 344 NLSSNLLG-----ELYDYTFEGLHSVMYIDLQQNHIGMIGEKSFS----NLVSLKIIDLRDNAIKK 400
Cdd:cd00116   227 NLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGE 292
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 98-270 7.69e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 7.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  98 NLHVLDLGFNKI----LQLDLDAFVGLPSLTVLRLFHNYLGDS---ILEEHyFQDLSSLEELDLSGNQITKLQPHPLFYN 170
Cdd:COG5238   265 TVETLYLSGNQIgaegAIALAKALQGNTTLTSLDLSVNRIGDEgaiALAEG-LQGNKTLHTLNLAYNGIGAQGAIALAKA 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 171 L---TVLKTVNLKFNKITnlcesnltsfrgkhflffslssnnfykiDEMAWAKCPNPFRNITFNSLDLSDNGWSTEEVQY 247
Cdd:COG5238   344 LqenTTLHSLDLSDNQIG----------------------------DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEA 395

                         170       180
                  ....*....|....*....|...
gi 2168430657 248 FCTAIKGTQIGSLILSSHTMGSG 270
Cdd:COG5238   396 LIDALQTNRLHTLILDGNLIGAE 418
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-449 2.55e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  85 PVTIGKgafrnLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLGDSILEEHYfqDLSSLEELDLSGNQITKLQP 164
Cdd:PLN00113  229 PYEIGG-----LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSLSGEIP 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 165 HpLFYNLTVLKTVNLKFNKITNLCESNLTSFRGKHFLffSLSSNNFYKIDEMAWAKCPNpfrnitFNSLDLSDNGWSTEE 244
Cdd:PLN00113  302 E-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--QLWSNKFSGEIPKNLGKHNN------LTVLDLSTNNLTGEI 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 245 VQYFCTAikgTQIGSLILSSHTMGSGF-----GFNNLKNP--DSDTFAGLASSD------LHLLDISNGYIFSLNSLIFQ 311
Cdd:PLN00113  373 PEGLCSS---GNLFKLILFSNSLEGEIpkslgACRSLRRVrlQDNSFSGELPSEftklplVYFLDISNNNLQGRINSRKW 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 312 SLGNLELLNLFKNKINQiQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI-GMIGEK--SFSNLVSL 388
Cdd:PLN00113  450 DMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsGEIPDElsSCKKLVSL 528

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430657 389 kiiDLRDNAIKKlpsfpHLTSAFlgdnKLMSVVGtaiaatLLELERNWL-----ANLGDLYILFQV 449
Cdd:PLN00113  529 ---DLSHNQLSG-----QIPASF----SEMPVLS------QLDLSQNQLsgeipKNLGNVESLVQV 576
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 4.48e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 4.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLTFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430657  631 CDED 634
Cdd:TIGR00864   80 CDEE 83
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 340-562 5.77e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 5.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 340 LKTLNLSSNLLGELYDytfeGLHSVM----------YIDLQQNHIGMIGEKSFSNL---VSLKIIDLRDNAIKK------ 400
Cdd:cd00116    53 LKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrglrll 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 401 ----LPSFPHLTSAFLGDNKLMSVVGTAIAATLLELernwlanlGDLYIL------FQVPDVQYIFLkqnrfsycvkrdN 470
Cdd:cd00116   129 akglKDLPPALEKLVLGRNRLEGASCEALAKALRAN--------RDLKELnlanngIGDAGIRALAE------------G 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 471 VTENNQLIYMDLGENMLQLVWERDLClDVFRALSKLQVLHLNNNYL-----SALPREIFRGLTSLKRLNLASNLLSHLSP 545
Cdd:cd00116   189 LKANCNLEVLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGA 267

                         250       260
                  ....*....|....*....|...
gi 2168430657 546 GLFPQ------SLTNLNLSGNQL 562
Cdd:cd00116   268 KDLAEvlaekeSLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-187 7.18e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 7.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  93 FRNLPNLHVLDLGFNKI-----LQldldafvGLPSLTVLRLFHNYL--GDSILeehyFQDLS------SLEELDLSGNQI 159
Cdd:cd21340    64 LENLVNLKKLYLGGNRIsvvegLE-------NLTNLEELHIENQRLppGEKLT----FDPRSlaalsnSLRVLNISGNNI 132

                          90       100
                  ....*....|....*....|....*...
gi 2168430657 160 TKLQPhplFYNLTVLKTVNLKFNKITNL 187
Cdd:cd21340   133 DSLEP---LAPLRNLEQLDASNNQISDL 157
LRR_8 pfam13855
Leucine rich repeat;
147-210 1.83e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2168430657 147 SSLEELDLSGNQITKLQPHpLFYNLTVLKTVNLKFNKITNLcesNLTSFRGKHFLFF-SLSSNNF 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTL---SPGAFSGLPSLRYlDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
581-632 1.92e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.02  E-value: 1.92e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2168430657  581 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCVYPPAFAGvPLSSLT--FDGCD 632
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLELLhsEFKCP 51
LRR smart00370
Leucine-rich repeats, outliers;
503-526 2.98e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.98e-03
                           10        20
                   ....*....|....*....|....
gi 2168430657  503 LSKLQVLHLNNNYLSALPREIFRG 526
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 1.54e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.87  E-value: 1.54e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  694 RYDAYLCYSKNDfeWVQNALLKHLDSQYFDKNrftLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430657  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIRNFLQRsRYLLWPEDYQDVDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 695-843 2.70e-23

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 97.44  E-value: 2.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 695 YDAYLCYSKND-FEWVQNALLKHLDsqyfdKNRFTLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 774 FNFAQSRYFsDLKDVLIMVVVGSLSQYQL-------MKHKPIRNFLQRSRYLLWPEDYQDVD------------WFLNKL 834
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALNEVAniwhsksvsdesKFWKKI 154


                  ....*....
gi 2168430657 835 SCQMLKEKK 843
Cdd:pfam01582 155 AYDISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 4.04e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 274 NNLKNPDSDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKinqiqrqAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 354 yDYTFEGLHSVMYIDLQQNHIGMIGEkSFSNLVSLKIIDLRDNAIKKLPSF----PHLTSAFLGDNKLmsvvgTAIAATL 429
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQI-----TDLPEPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 430 LELErnwlaNLGDLYIlfqvpdvqyiflkqnrfsycvkrdnvtENNQLIYMDlgenmlqlvwerdlclDVFRALSKLQVL 509
Cdd:COG4886   202 GNLT-----NLEELDL---------------------------SGNQLTDLP----------------EPLANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168430657 510 HLNNNYLSALPReiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
504-562 5.62e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 5.62e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430657 504 SKLQVLHLNNNYLSALPREIFRGLTSLKRLNLASNLLSHLSPGLF--PQSLTNLNLSGNQL 562
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-159 3.53e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 3.53e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430657  97 PNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLgdSILEEHYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-440 5.88e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 5.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  87 TIGKGAFRNLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNylgdsileeHYFQDLSSLEELDLSGNQITKLQPHp 166
Cdd:COG4886    62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEE- 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 167 lFYNLTVLKTVNLKFNKITNLCE--SNLTSFRgkhflFFSLSSNNFYKIdemawakcPNPFRNIT-FNSLDLSDNgwste 243
Cdd:COG4886   132 -LANLTNLKELDLSNNQLTDLPEplGNLTNLK-----SLDLSNNQLTDL--------PEELGNLTnLKELDLSNN----- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 244 evqyfctaikgtQIGSLilsshtmgsGFGFNNLKNpdsdtfaglassdLHLLDISNGYIFSLnSLIFQSLGNLELLNLFK 323
Cdd:COG4886   193 ------------QITDL---------PEPLGNLTN-------------LEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 324 NKINQIqrQAFFGLGNLKTLNLSSNLLGELYDytFEGLHSVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAIKKLPS 403
Cdd:COG4886   238 NQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2168430657 404 FPHLTSAFLGDNKLMSVVGTAIAATLLELERNWLANL 440
Cdd:COG4886   314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-353 6.37e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 6.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  92 AFRNLPNLHVLDLGFNKILQLDlDAFVGLPSLTVLRLFHNYLGDsiLEEHyFQDLSSLEELDLSGNQITKLqPHPLfYNL 171
Cdd:COG4886   131 ELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTD--LPEE-LGNLTNLKELDLSNNQITDL-PEPL-GNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 172 TVLKTVNLKFNKITNLCES--NLTSFRgkhflFFSLSSNNFYKIDEMawAKCPNpfrnitFNSLDLSDNGWSTEEVQYFC 249
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPlaNLTNLE-----TLDLSNNQLTDLPEL--GNLTN------LEELDLSNNQLTDLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 250 TAIKGTQIGSLILSSHTMGSGFGFNNLKNPDSDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKINQI 329
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260
                  ....*....|....*....|....
gi 2168430657 330 QRQAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLL 375
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-585 1.19e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  96 LPNLHVLDLGfNKILQLDLDAFVGL-PSLTVLRLFHNYLGDSIleEHYFQDLSSLEELDLSGNQITKLQPHP-------- 166
Cdd:PLN00113  139 IPNLETLDLS-NNMLSGEIPNDIGSfSSLKVLDLGGNVLVGKI--PNSLTNLTSLEFLTLASNQLVGQIPRElgqmkslk 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 167 ---LFYN------------LTVLKTVNLKFNKITNLCESNLTSFRGKHFLFfsLSSNNFYkidemawAKCPNPFRNIT-F 230
Cdd:PLN00113  216 wiyLGYNnlsgeipyeiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLF--LYQNKLS-------GPIPPSIFSLQkL 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 231 NSLDLSDNGWSTEevqyfctaikgtqIGSLILsshtmgsgfgfnNLKNPDSdtfaglassdLHLLdiSNGYIFSLNSLIf 310
Cdd:PLN00113  287 ISLDLSDNSLSGE-------------IPELVI------------QLQNLEI----------LHLF--SNNFTGKIPVAL- 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 311 QSLGNLELLNLFKNKIN-QIQRQaffgLG---NLKTLNLSSN-LLGELYDYTFEGLHSVMYIDLQQNHIGMIgEKSFSNL 385
Cdd:PLN00113  329 TSLPRLQVLQLWSNKFSgEIPKN----LGkhnNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGEI-PKSLGAC 403

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 386 VSLKIIDLRDNAIK-KLPS-FPHLTSAF---LGDNKLMSVVGTAI----AATLLELERNWLanLGDLYILFQVPDVQYIF 456
Cdd:PLN00113  404 RSLRRVRLQDNSFSgELPSeFTKLPLVYfldISNNNLQGRINSRKwdmpSLQMLSLARNKF--FGGLPDSFGSKRLENLD 481

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 457 LKQNRFSYCVKRdNVTENNQLIYMDLGENMLQLVWERDLcldvfRALSKLQVLHLNNNYLSALPREIFRGLTSLKRLNLA 536
Cdd:PLN00113  482 LSRNQFSGAVPR-KLGSLSELMQLKLSENKLSGEIPDEL-----SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2168430657 537 SNLLShlspGLFP------QSLTNLNLSGNQLFS--PEPEVFMTLSILDITHNKYVC 585
Cdd:PLN00113  556 QNQLS----GEIPknlgnvESLVQVNISHNHLHGslPSTGAFLAINASAVAGNIDLC 608
LRR_8 pfam13855
Leucine rich repeat;
315-374 1.34e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 1.34e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 315 NLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI 374
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-499 2.61e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  87 TIGKGAFRNLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLGDSILEEHYFQDLSSLEELDLSGNQitklqphp 166
Cdd:COG4886    36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 167 LFYNLTVLKTVNLKFNKITNLCESnLTSFRGKHFLFfsLSSNNFYKIDEmAWAKCPNpfrnitFNSLDLSDNgwsteevq 246
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELD--LSNNQLTDLPE-PLGNLTN------LKSLDLSNN-------- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 247 yfctaikgtQIGSLilsshtmgsGFGFNNLKNpdsdtfaglassdLHLLDISNGYIFSLnSLIFQSLGNLELLNLFKNKI 326
Cdd:COG4886   170 ---------QLTDL---------PEELGNLTN-------------LKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 327 NQIQrQAFFGLGNLKTLNLSSNLLGELYDytFEGLHSVMYIDLQQNHIGMIGEksFSNLVSLKIIDLRDNAIKKLpSFPH 406
Cdd:COG4886   218 TDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDL-KLKE 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 407 LTSAFLGDNKLMSVVGTAIAATLLELERNWLANLGDLYILFQVPDVQYIFLKQNRFSYCVKRDNVTENNQLIYMDLGENM 486
Cdd:COG4886   292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371

                         410
                  ....*....|...
gi 2168430657 487 LQLVWERDLCLDV 499
Cdd:COG4886   372 LGLLEATLLTLAL 384
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 146-582 5.18e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 5.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 146 LSSLEELDLSGNQITKLQPHPLFYNLTVLKTVNLKFNKITNLCEsnltsfRGKHFLFFSLS-SNNfykideMAWAKCPNP 224
Cdd:PLN00113   92 LPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIP------RGSIPNLETLDlSNN------MLSGEIPND 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 225 ---FRNITFnsLDLSDNGWsTEEVQYFCTAIkgTQIGSLILSSHTMGSG---------------FGFNNLKNPDSDTFAG 286
Cdd:PLN00113  160 igsFSSLKV--LDLGGNVL-VGKIPNSLTNL--TSLEFLTLASNQLVGQiprelgqmkslkwiyLGYNNLSGEIPYEIGG 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 287 LASSDlHLLDISNgyifSLNSLIFQSLGNL---ELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLL-GELYDytfeglh 362
Cdd:PLN00113  235 LTSLN-HLDLVYN----NLTGPIPSSLGNLknlQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPE------- 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 363 svMYIDLQQNHIGMIgeksFSNLVSLKIIdlrdnaiKKLPSFPHLTSAFLGDNKLMSVV----GTAIAATLLELERNWLA 438
Cdd:PLN00113  303 --LVIQLQNLEILHL----FSNNFTGKIP-------VALTSLPRLQVLQLWSNKFSGEIpknlGKHNNLTVLDLSTNNLT 369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 439 --------NLGDLY--ILF------QVP-------DVQYIFLKQNRFSYCVKRDnVTENNQLIYMDLGENMLQ-----LV 490
Cdd:PLN00113  370 geipeglcSSGNLFklILFsnslegEIPkslgacrSLRRVRLQDNSFSGELPSE-FTKLPLVYFLDISNNNLQgrinsRK 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 491 WER------DLCL--------DVFRAlSKLQVLHLNNNYLS-ALPREiFRGLTSLKRLNLASNLLSHLSPGLFP--QSLT 553
Cdd:PLN00113  449 WDMpslqmlSLARnkffgglpDSFGS-KRLENLDLSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSscKKLV 526

                         490       500       510
                  ....*....|....*....|....*....|..
gi 2168430657 554 NLNLSGNQLFSPEPEVFM---TLSILDITHNK 582
Cdd:PLN00113  527 SLDLSHNQLSGQIPASFSempVLSQLDLSQNQ 558
LRR_8 pfam13855
Leucine rich repeat;
339-398 5.82e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.82e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 339 NLKTLNLSSNLLGELYDYTFEGLHSVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAI 398
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
292-350 7.08e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 7.08e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2168430657 292 LHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLL 350
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-133 2.76e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.76e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2168430657  86 VTIGKGAFRNLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYL 133
Cdd:pfam13855  14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 323-578 2.52e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 323 KNKINQIQrQAFFGLGNLKTLNLSSNLL-GELYDYTFEGLHSVMYIDLQQNHI-GMIGEKSFSNLVSLkiiDLRDNAIK- 399
Cdd:PLN00113   79 KNISGKIS-SAIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLETL---DLSNNMLSg 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 400 KLP----SFPHLTSAFLGDNKLMSVVGTAIaATLLELERNWLAN---LGDLYI-LFQVPDVQYIFLKQNRFSYCVKrdnv 471
Cdd:PLN00113  155 EIPndigSFSSLKVLDLGGNVLVGKIPNSL-TNLTSLEFLTLASnqlVGQIPReLGQMKSLKWIYLGYNNLSGEIP---- 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 472 TENNQLIYMdlgeNMLQLVWErDLCLDV---FRALSKLQVLHLNNNYLSA-LPREIFrGLTSLKRLNLASNLLSHLSPGL 547
Cdd:PLN00113  230 YEIGGLTSL----NHLDLVYN-NLTGPIpssLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEIPEL 303

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2168430657 548 FPQ--SLTNLNLSGNQLFSPEPEVFMTLSILDI 578
Cdd:PLN00113  304 VIQlqNLEILHLFSNNFTGKIPVALTSLPRLQV 336
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 125-400 3.16e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.13  E-value: 3.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 125 VLRLFHNYLGDSILEEHyFQDLSSLEELDLSGNQITKLQPHPLFYNLTV---LKTVNLKFN------KITNLCESNLTSF 195
Cdd:cd00116     2 QLSLKGELLKTERATEL-LPKLLCLQVLRLEGNTLGEEAAKALASALRPqpsLKELCLSLNetgripRGLQSLLQGLTKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 196 RGKHFLffSLSSNNFYKIDEMAWAKCpnpFRNITFNSLDLSDNGWSTEEVQYFCTAIKGTQ--IGSLILsshtmgsgfGF 273
Cdd:cd00116    81 CGLQEL--DLSDNALGPDGCGVLESL---LRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpaLEKLVL---------GR 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 274 NNLKNPDSDTFAGLASS--DLHLLDISNGYI----FSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFG----LGNLKTL 343
Cdd:cd00116   147 NRLEGASCEALAKALRAnrDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVL 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430657 344 NLSSNLLG-----ELYDYTFEGLHSVMYIDLQQNHIGMIGEKSFS----NLVSLKIIDLRDNAIKK 400
Cdd:cd00116   227 NLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGE 292
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 698-780 4.22e-07

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 49.24  E-value: 4.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 698 YLCYSKNDFEWVQnALLKHLDsqyfdKNRFTLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEAFNFA 777
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALE-----AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA 75


                  ...
gi 2168430657 778 QSR 780
Cdd:pfam13676  76 LAD 78
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 147-582 5.32e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 5.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 147 SSLEELDLSGNQITKlQPHPLFYNLTVLKTVNLKFNKITNLCESNLtSFRGKHFLFFSLSSNNFykIDEMAWAKCPNpfr 226
Cdd:PLN00113   69 SRVVSIDLSGKNISG-KISSAIFRLPYIQTINLSNNQLSGPIPDDI-FTTSSSLRYLNLSNNNF--TGSIPRGSIPN--- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 227 nitFNSLDLSDNGWSTEEVQyfctaikgtQIGSlilsshtmgsgfgFNNLKnpdsdtfaglassdlhLLDISNGYifsLN 306
Cdd:PLN00113  142 ---LETLDLSNNMLSGEIPN---------DIGS-------------FSSLK----------------VLDLGGNV---LV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 307 SLIFQSLGNLELLNLFKNKINQIQRQAFFGLGNLKTLNL----SSNLLGELyDYTFEGLHSVMYIDLQQNHIGMIGEKSF 382
Cdd:PLN00113  178 GKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWiylgYNNLSGEI-PYEIGGLTSLNHLDLVYNNLTGPIPSSL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 383 SNLVSLKIIDLRDNAI-----KKLPSFPHLTSAFLGDNKLMSVVGTAIAA----TLLELERNWLAnlGDLYI-LFQVPDV 452
Cdd:PLN00113  257 GNLKNLQYLFLYQNKLsgpipPSIFSLQKLISLDLSDNSLSGEIPELVIQlqnlEILHLFSNNFT--GKIPVaLTSLPRL 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 453 QYIFLKQNRFSYCVKRdNVTENNQLIYMDLGENMLQLVWERDLC-------LDVFR------------ALSKLQVLHLNN 513
Cdd:PLN00113  335 QVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCssgnlfkLILFSnslegeipkslgACRSLRRVRLQD 413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 514 NYLSA-LPREI---------------FRG--------LTSLKRLNLASNLLSHLSPGLF-PQSLTNLNLSGNQLFSPEPE 568
Cdd:PLN00113  414 NSFSGeLPSEFtklplvyfldisnnnLQGrinsrkwdMPSLQMLSLARNKFFGGLPDSFgSKRLENLDLSRNQFSGAVPR 493

                         490
                  ....*....|....*..
gi 2168430657 569 VFMTLS---ILDITHNK 582
Cdd:PLN00113  494 KLGSLSelmQLKLSENK 510
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 98-270 7.69e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 7.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  98 NLHVLDLGFNKI----LQLDLDAFVGLPSLTVLRLFHNYLGDS---ILEEHyFQDLSSLEELDLSGNQITKLQPHPLFYN 170
Cdd:COG5238   265 TVETLYLSGNQIgaegAIALAKALQGNTTLTSLDLSVNRIGDEgaiALAEG-LQGNKTLHTLNLAYNGIGAQGAIALAKA 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 171 L---TVLKTVNLKFNKITnlcesnltsfrgkhflffslssnnfykiDEMAWAKCPNPFRNITFNSLDLSDNGWSTEEVQY 247
Cdd:COG5238   344 LqenTTLHSLDLSDNQIG----------------------------DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEA 395

                         170       180
                  ....*....|....*....|...
gi 2168430657 248 FCTAIKGTQIGSLILSSHTMGSG 270
Cdd:COG5238   396 LIDALQTNRLHTLILDGNLIGAE 418
LRR_8 pfam13855
Leucine rich repeat;
121-184 1.31e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.31e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2168430657 121 PSLTVLRLFHNYLGDsiLEEHYFQDLSSLEELDLSGNQITKLQPHpLFYNLTVLKTVNLKFNKI 184
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-449 2.55e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  85 PVTIGKgafrnLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLGDSILEEHYfqDLSSLEELDLSGNQITKLQP 164
Cdd:PLN00113  229 PYEIGG-----LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSLSGEIP 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 165 HpLFYNLTVLKTVNLKFNKITNLCESNLTSFRGKHFLffSLSSNNFYKIDEMAWAKCPNpfrnitFNSLDLSDNGWSTEE 244
Cdd:PLN00113  302 E-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--QLWSNKFSGEIPKNLGKHNN------LTVLDLSTNNLTGEI 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 245 VQYFCTAikgTQIGSLILSSHTMGSGF-----GFNNLKNP--DSDTFAGLASSD------LHLLDISNGYIFSLNSLIFQ 311
Cdd:PLN00113  373 PEGLCSS---GNLFKLILFSNSLEGEIpkslgACRSLRRVrlQDNSFSGELPSEftklplVYFLDISNNNLQGRINSRKW 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 312 SLGNLELLNLFKNKINQiQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI-GMIGEK--SFSNLVSL 388
Cdd:PLN00113  450 DMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsGEIPDElsSCKKLVSL 528

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430657 389 kiiDLRDNAIKKlpsfpHLTSAFlgdnKLMSVVGtaiaatLLELERNWL-----ANLGDLYILFQV 449
Cdd:PLN00113  529 ---DLSHNQLSG-----QIPASF----SEMPVLS------QLDLSQNQLsgeipKNLGNVESLVQV 576
LRR_8 pfam13855
Leucine rich repeat;
494-540 3.90e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2168430657 494 DLCLDVFRALSKLQVLHLNNNYLSALPREIFRGLTSLKRLNLASNLL 540
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 66-375 1.82e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  66 SFPLLEHLLVLEIGTQYVYPVTIGKgAFRNLPNLHVLDLgfnkiLQLDLDAFVGL-PSLTVLRLFHNYLGDSILE---EH 141
Cdd:COG5238   130 SLILYLALPRRINLIQVLKDPLGGN-AVHLLGLAARLGL-----LAAISMAKALQnNSVETVYLGCNQIGDEGIEelaEA 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 142 YFQDlSSLEELDLSGNQITKLQPHPLFYNL---TVLKTVNLKFNKITNlcesnltsfRGKHFLFFSLSSNnfykidemaw 218
Cdd:COG5238   204 LTQN-TTVTTLWLKRNPIGDEGAEILAEALkgnKSLTTLDLSNNQIGD---------EGVIALAEALKNN---------- 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 219 akcpnpfRNITfnSLDLSDNGWSTEEVQYFCTAIKG-TQIGSLILSshtmgsgfgFNNLKNPDSDTFA-GLA-SSDLHLL 295
Cdd:COG5238   264 -------TTVE--TLYLSGNQIGAEGAIALAKALQGnTTLTSLDLS---------VNRIGDEGAIALAeGLQgNKTLHTL 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 296 DIS------NGYIFSLNSLifQSLGNLELLNLFKNKINQIQR----QAFFGLGNLKTLNLSSNLLGELydyTFEGL---- 361
Cdd:COG5238   326 NLAyngigaQGAIALAKAL--QENTTLHSLDLSDNQIGDEGAialaKYLEGNTTLRELNLGKNNIGKQ---GAEALidal 400

                         330
                  ....*....|....*.
gi 2168430657 362 --HSVMYIDLQQNHIG 375
Cdd:COG5238   401 qtNRLHTLILDGNLIG 416
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 4.48e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 4.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLTFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430657  631 CDED 634
Cdd:TIGR00864   80 CDEE 83
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 340-562 5.77e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 5.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 340 LKTLNLSSNLLGELYDytfeGLHSVM----------YIDLQQNHIGMIGEKSFSNL---VSLKIIDLRDNAIKK------ 400
Cdd:cd00116    53 LKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrglrll 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 401 ----LPSFPHLTSAFLGDNKLMSVVGTAIAATLLELernwlanlGDLYIL------FQVPDVQYIFLkqnrfsycvkrdN 470
Cdd:cd00116   129 akglKDLPPALEKLVLGRNRLEGASCEALAKALRAN--------RDLKELnlanngIGDAGIRALAE------------G 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 471 VTENNQLIYMDLGENMLQLVWERDLClDVFRALSKLQVLHLNNNYL-----SALPREIFRGLTSLKRLNLASNLLSHLSP 545
Cdd:cd00116   189 LKANCNLEVLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGA 267

                         250       260
                  ....*....|....*....|...
gi 2168430657 546 GLFPQ------SLTNLNLSGNQL 562
Cdd:cd00116   268 KDLAEvlaekeSLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
363-417 5.84e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 363 SVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAIKKLP-----SFPHLTSAFLGDNKL 417
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-187 7.18e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 7.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  93 FRNLPNLHVLDLGFNKI-----LQldldafvGLPSLTVLRLFHNYL--GDSILeehyFQDLS------SLEELDLSGNQI 159
Cdd:cd21340    64 LENLVNLKKLYLGGNRIsvvegLE-------NLTNLEELHIENQRLppGEKLT----FDPRSlaalsnSLRVLNISGNNI 132

                          90       100
                  ....*....|....*....|....*...
gi 2168430657 160 TKLQPhplFYNLTVLKTVNLKFNKITNL 187
Cdd:cd21340   133 DSLEP---LAPLRNLEQLDASNNQISDL 157
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 497-582 9.62e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 9.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 497 LDVFRALSKLQVLHLNNNYLSALprEIFRGLTSLKRLNLAS-------------NLLSHLSPglfpqSLTNLNLSGNQLF 563
Cdd:cd21340    61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                          90       100
                  ....*....|....*....|
gi 2168430657 564 SPEPEVFMT-LSILDITHNK 582
Cdd:cd21340   134 SLEPLAPLRnLEQLDASNNQ 153
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 361-560 1.04e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 361 LHSVMYIDLQQNHIGMIGEksFSNLVSLKIIDLRDNAIKK---LPSFPHLTSAFLGDNKL--MSVVGTAIAATLLELERN 435
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKienLEFLTNLTHLYLQNNQIekIENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 436 WLA---------NLGDLYIlfqvpdvqyiflkqnrfsycvkrdnvtENNQLiymDLGENmlqlvwerdLCLDVF--RALS 504
Cdd:cd21340    79 RISvveglenltNLEELHI---------------------------ENQRL---PPGEK---------LTFDPRslAALS 119

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430657 505 K-LQVLHLNNNYLSALprEIFRGLTSLKRLNLASNLLSHLSP--GLFPQ--SLTNLNLSGN 560
Cdd:cd21340   120 NsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSwpSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
147-210 1.83e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2168430657 147 SSLEELDLSGNQITKLQPHpLFYNLTVLKTVNLKFNKITNLcesNLTSFRGKHFLFF-SLSSNNF 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTL---SPGAFSGLPSLRYlDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
581-632 1.92e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.02  E-value: 1.92e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2168430657  581 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCVYPPAFAGvPLSSLT--FDGCD 632
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLELLhsEFKCP 51
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 322-396 2.10e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 2.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2168430657 322 FKNKINQIQRQAFFGLGNLKTLNLSSNLLgELYDYTFEGLHSVmYIDLQQNhIGMIGEKSFSNLVSLKIIDLRDN 396
Cdd:pfam13306  18 IPSSLTSIGEYAFSNCTSLKSITLPSSLT-SIGSYAFYNCSLT-SITIPSS-LTSIGEYAFSNCSNLKSITLPSN 89
LRR smart00370
Leucine-rich repeats, outliers;
503-526 2.98e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.98e-03
                           10        20
                   ....*....|....*....|....
gi 2168430657  503 LSKLQVLHLNNNYLSALPREIFRG 526
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
503-526 2.98e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.98e-03
                           10        20
                   ....*....|....*....|....
gi 2168430657  503 LSKLQVLHLNNNYLSALPREIFRG 526
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-163 3.32e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2168430657  97 PNLHVLDLGFNKILqlDLDAFVGLPSLTVLRLFHNYLGDsiLEE--HYFQDLSSLEELDLSGNQITKLQ 163
Cdd:cd21340   120 NSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISD--LEEllDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 295-404 4.24e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 295 LDISNGYIFSLNSLifQSLGNLELLNLFKNKIN--------------QIQRQ-------------AFFGLGN-LKTLNLS 346
Cdd:cd21340    51 LYLQNNQIEKIENL--ENLVNLKKLYLGGNRISvveglenltnleelHIENQrlppgekltfdprSLAALSNsLRVLNIS 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 347 SNLLGELYDytFEGLHSVMYIDLQQNHIGMIGE--KSFSNLVSLKIIDLRDNAIKKLPSF 404
Cdd:cd21340   129 GNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKY 186
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 388-562 5.90e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 5.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 388 LKIIDLRDNAI---------KKLPSFPHLTSAFLGDNKL-MSVVGTAIAA---------TLLELERNWL--ANLGDLYIL 446
Cdd:cd00116    25 LQVLRLEGNTLgeeaakalaSALRPQPSLKELCLSLNETgRIPRGLQSLLqgltkgcglQELDLSDNALgpDGCGVLESL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657 447 FQVPDVQYIFLKQN-------RFSYCVKRDNVTennQLIYMDLGENMLQLVWERDLcLDVFRALSKLQVLHL-NNNYLSA 518
Cdd:cd00116   105 LRSSSLQELKLNNNglgdrglRLLAKGLKDLPP---ALEKLVLGRNRLEGASCEAL-AKALRANRDLKELNLaNNGIGDA 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168430657 519 LPREIFRGL---TSLKRLNLASNLLSHLSPGLF------PQSLTNLNLSGNQL 562
Cdd:cd00116   181 GIRALAEGLkanCNLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGDNNL 233
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-185 7.16e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 7.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430657  91 GAFRNLPNLHVLDLGFNKIL----QLDLDAFVGLPSLTVLRLFHNYL---GDSILEEhYFQDLSSLEELDLSGNQIT--- 160
Cdd:cd00116   159 KALRANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLtdeGASALAE-TLASLKSLEVLNLGDNNLTdag 237

                          90       100
                  ....*....|....*....|....*..
gi 2168430657 161 --KLQPHPLFYNLTvLKTVNLKFNKIT 185
Cdd:cd00116   238 aaALASALLSPNIS-LLTLSLSCNDIT 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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