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Conserved domains on  [gi|2168430667|gb|UHH89862|]
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TLR5 [Eudyptes schlegeli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 2.43e-26

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  694 RYDAYLCYSKNDfeWVQNSLLKHLDSQYFDKNrftLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430667  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIQNFLQRsRYLLWPEDYQDVDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 3.69e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 274 NNLKNPDSDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKinqiqrqAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 354 yDYTFEGLHSVMYIDLQQNHIGMIGEkSFSNLVSLKIIDLRDNAIKKLPSF----PHLTSAFLGDNKLmsvvgTAIAATI 429
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQI-----TDLPEPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 430 LELErnwlaNLGDLYIlfqvpdvqyiflkqnrfsycvkhhnvtENNQLIYMDlgenmlqlvwerdlclDVFRALSKLQVL 509
Cdd:COG4886   202 GNLT-----NLEELDL---------------------------SGNQLTDLP----------------EPLANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168430667 510 HLNNNYLSALPReiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
97-159 4.68e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 4.68e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430667  97 PNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLgdSILEERYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 97-270 1.07e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.18  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  97 PNLHVLDLGFNKILQLDLDAFV----GLPSLTVLRLFHNYLGDSILEE--RYFQDLSSLEELDLSGNQIT---------- 160
Cdd:COG5238   208 TTVTTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIGaegaialaka 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 161 ---NLQPHPLFYNL------------------TVLKTVNLKFNKITNLCESNLTSFRGKHFLFFSLGSNNFYKTDEMAWA 219
Cdd:COG5238   288 lqgNTTLTSLDLSVnrigdegaialaeglqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIA 367

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2168430667 220 KCPNPFRNITFNSLDLSDNGWSTEKVQYFCTAIKGTQIGSLILGSHTMGSG 270
Cdd:COG5238   368 LAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 4.48e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 4.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLTFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430667  631 CDED 634
Cdd:TIGR00864   80 CDEE 83
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 2.43e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  694 RYDAYLCYSKNDfeWVQNSLLKHLDSQYFDKNrftLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430667  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIQNFLQRsRYLLWPEDYQDVDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 695-843 9.94e-23

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 95.51  E-value: 9.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 695 YDAYLCYSKND-FEWVQNSLLKHLDsqyfdKNRFTLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 774 FNFAQSRYFsDLKDVLIMVVVGSLSQYQL-------MKHKPIQNFLQRSRYLLWPEDYQDVD------------WFLNKL 834
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALNEVAniwhsksvsdesKFWKKI 154


                  ....*....
gi 2168430667 835 SCQMLKEKK 843
Cdd:pfam01582 155 AYDISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 3.69e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 274 NNLKNPDSDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKinqiqrqAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 354 yDYTFEGLHSVMYIDLQQNHIGMIGEkSFSNLVSLKIIDLRDNAIKKLPSF----PHLTSAFLGDNKLmsvvgTAIAATI 429
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQI-----TDLPEPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 430 LELErnwlaNLGDLYIlfqvpdvqyiflkqnrfsycvkhhnvtENNQLIYMDlgenmlqlvwerdlclDVFRALSKLQVL 509
Cdd:COG4886   202 GNLT-----NLEELDL---------------------------SGNQLTDLP----------------EPLANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168430667 510 HLNNNYLSALPReiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
504-562 5.35e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 5.35e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430667 504 SKLQVLHLNNNYLSALPREIFRGLTSLKRLNLASNLLSHLSPGLF--PQSLTNLNLSGNQL 562
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-159 4.68e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 4.68e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430667  97 PNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLgdSILEERYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-209 5.88e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 5.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  92 AFRNLPNLHVLDLGFNKILQLDlDAFVGLPSLTVLRLFHNYLGDsiLEEryFQDLSSLEELDLSGNQITNLqphPLFYNL 171
Cdd:COG4886   200 PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDL---PPLANL 271

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2168430667 172 TVLKTVNLKFNKITNLCESNLTSFRGKHFLFFSLGSNN 209
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-585 3.00e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 3.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  96 LPNLHVLDLGFNKI---LQLDLDAFvglPSLTVLRLFHNYLGDSIleERYFQDLSSLEELDLSGNQITNLQPHP------ 166
Cdd:PLN00113  139 IPNLETLDLSNNMLsgeIPNDIGSF---SSLKVLDLGGNVLVGKI--PNSLTNLTSLEFLTLASNQLVGQIPRElgqmks 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 167 -----LFYN------------LTVLKTVNLKFNKITNLCESNLTSFRGKHFLFfsLGSNNFykTDEMAwakcPNPFRNIT 229
Cdd:PLN00113  214 lkwiyLGYNnlsgeipyeiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLF--LYQNKL--SGPIP----PSIFSLQK 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 230 FNSLDLSDNGWSTEkvqyfctaikgtqIGSLILgshtmgsgfgfnNLKNPDSdtfaglassdLHLLdiSNGYIFSLNSLI 309
Cdd:PLN00113  286 LISLDLSDNSLSGE-------------IPELVI------------QLQNLEI----------LHLF--SNNFTGKIPVAL 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 310 fQSLGNLELLNLFKNKIN-QIQRQaffgLG---NLKTLNLSSN-LLGELYDYTFEGLHSVMYIDLQQNHIGMIgEKSFSN 384
Cdd:PLN00113  329 -TSLPRLQVLQLWSNKFSgEIPKN----LGkhnNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGEI-PKSLGA 402

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 385 LVSLKIIDLRDNAIK-KLPS-FPHLTSAF---LGDNKLMSVVGTAI----AATILELERNWLanLGDLYILFQVPDVQYI 455
Cdd:PLN00113  403 CRSLRRVRLQDNSFSgELPSeFTKLPLVYfldISNNNLQGRINSRKwdmpSLQMLSLARNKF--FGGLPDSFGSKRLENL 480

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 456 FLKQNRFSYCV--KHHNVTEnnqLIYMDLGENMLQLVWERDLcldvfRALSKLQVLHLNNNYLSALPREIFRGLTSLKRL 533
Cdd:PLN00113  481 DLSRNQFSGAVprKLGSLSE---LMQLKLSENKLSGEIPDEL-----SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQL 552

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 534 NLASNLLShlspGLFP------QSLTNLNLSGNQLFS--PEPEVFMTLSILDITHNKYVC 585
Cdd:PLN00113  553 DLSQNQLS----GEIPknlgnvESLVQVNISHNHLHGslPSTGAFLAINASAVAGNIDLC 608
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-417 9.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 9.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  87 TIGKGAFRNLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLGDSILEERYFQDLSSLEELDLSGNQitnlqphp 166
Cdd:COG4886    36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 167 LFYNLTVLKTVNLKFNKITNLCE--SNLTSFRgkhflffslgsnnfyktdemawakcpnpfrnitfnSLDLSDNgwstek 244
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEelANLTNLK-----------------------------------ELDLSNN------ 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 245 vqyfctaikgtQIGSLilgshtmgsGFGFNNLKNpdsdtfaglassdLHLLDISNGYIFSLNSLIFQsLGNLELLNLFKN 324
Cdd:COG4886   147 -----------QLTDL---------PEPLGNLTN-------------LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNN 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 325 KINQIQrQAFFGLGNLKTLNLSSNLLGELyDYTFEGLHSVMYIDLQQNHIGMIgeKSFSNLVSLKIIDLRDNAIKKLPS- 403
Cdd:COG4886   193 QITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPl 268

                         330
                  ....*....|....*.
gi 2168430667 404 --FPHLTSAFLGDNKL 417
Cdd:COG4886   269 anLTNLKTLDLSNNQL 284
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 125-400 7.92e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.05  E-value: 7.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 125 VLRLFHNYLGDsILEERYFQDLSSLEELDLSGNQITNLQPHPLFYNLTV---LKTVNLKFN------KITNLCESNLTSF 195
Cdd:cd00116     2 QLSLKGELLKT-ERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPqpsLKELCLSLNetgripRGLQSLLQGLTKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 196 RGKHFLffSLGSNNFYKTDEMAWAKCpnpFRNITFNSLDLSDNGWSTEKVQYFCTAIKGTQ--IGSLILGShtmgsgfgf 273
Cdd:cd00116    81 CGLQEL--DLSDNALGPDGCGVLESL---LRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpaLEKLVLGR--------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 274 NNLKNPDSDTFAGLASS--DLHLLDISNGYI----FSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFG----LGNLKTL 343
Cdd:cd00116   147 NRLEGASCEALAKALRAnrDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVL 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430667 344 NLSSNLLG-----ELYDYTFEGLHSVMYIDLQQNHIGMIGEKSFS----NLVSLKIIDLRDNAIKK 400
Cdd:cd00116   227 NLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGE 292
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 97-270 1.07e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.18  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  97 PNLHVLDLGFNKILQLDLDAFV----GLPSLTVLRLFHNYLGDSILEE--RYFQDLSSLEELDLSGNQIT---------- 160
Cdd:COG5238   208 TTVTTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIGaegaialaka 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 161 ---NLQPHPLFYNL------------------TVLKTVNLKFNKITNLCESNLTSFRGKHFLFFSLGSNNFYKTDEMAWA 219
Cdd:COG5238   288 lqgNTTLTSLDLSVnrigdegaialaeglqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIA 367

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2168430667 220 KCPNPFRNITFNSLDLSDNGWSTEKVQYFCTAIKGTQIGSLILGSHTMGSG 270
Cdd:COG5238   368 LAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-417 1.04e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  85 PVTIGKgafrnLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLGDSILEERYfqDLSSLEELDLSGNQITNLQP 164
Cdd:PLN00113  229 PYEIGG-----LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSLSGEIP 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 165 HpLFYNLTVLKTVNLKFNKITNLCESNLTSFRGKHFLffSLGSNNFYKTDEMAWAKCPNpfrnitFNSLDLSDNGWSTEK 244
Cdd:PLN00113  302 E-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--QLWSNKFSGEIPKNLGKHNN------LTVLDLSTNNLTGEI 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 245 VQYFCTAikgTQIGSLILGSHTMGSGF-----GFNNLKNP--DSDTFAGLASSD------LHLLDISNGYIFSLNSLIFQ 311
Cdd:PLN00113  373 PEGLCSS---GNLFKLILFSNSLEGEIpkslgACRSLRRVrlQDNSFSGELPSEftklplVYFLDISNNNLQGRINSRKW 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 312 SLGNLELLNLFKNKINQiQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI-GMIGEK--SFSNLVSL 388
Cdd:PLN00113  450 DMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsGEIPDElsSCKKLVSL 528

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2168430667 389 kiiDLRDNAIK-KLPS----FPHLTSAFLGDNKL 417
Cdd:PLN00113  529 ---DLSHNQLSgQIPAsfseMPVLSQLDLSQNQL 559
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-187 3.49e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  93 FRNLPNLHVLDLGFNKI-----LQldldafvGLPSLTVLRLFHNYLGDS---ILEERYFQDLS-SLEELDLSGNQITNLQ 163
Cdd:cd21340    64 LENLVNLKKLYLGGNRIsvvegLE-------NLTNLEELHIENQRLPPGeklTFDPRSLAALSnSLRVLNISGNNIDSLE 136

                          90       100
                  ....*....|....*....|....
gi 2168430667 164 PhplFYNLTVLKTVNLKFNKITNL 187
Cdd:cd21340   137 P---LAPLRNLEQLDASNNQISDL 157
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 4.48e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 4.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLTFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430667  631 CDED 634
Cdd:TIGR00864   80 CDEE 83
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 340-562 3.01e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 340 LKTLNLSSNLLGELYDytfeGLHSVM----------YIDLQQNHIGMIGEKSFSNL---VSLKIIDLRDNAIKK------ 400
Cdd:cd00116    53 LKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrglrll 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 401 ----LPSFPHLTSAFLGDNKLMSVVGTAIAATilelernwLANLGDLYIL------FQVPDVQYIFlkqnrfsycvkhHN 470
Cdd:cd00116   129 akglKDLPPALEKLVLGRNRLEGASCEALAKA--------LRANRDLKELnlanngIGDAGIRALA------------EG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 471 VTENNQLIYMDLGENMLQLVWERDLClDVFRALSKLQVLHLNNNYL-----SALPREIFRGLTSLKRLNLASNLLSHLSP 545
Cdd:cd00116   189 LKANCNLEVLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGA 267

                         250       260
                  ....*....|....*....|...
gi 2168430667 546 GLFPQ------SLTNLNLSGNQL 562
Cdd:cd00116   268 KDLAEvlaekeSLLELDLRGNKF 290
LRRCT smart00082
Leucine rich repeat C-terminal domain;
581-632 1.90e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.02  E-value: 1.90e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2168430667  581 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCVYPPAFAGvPLSSLT--FDGCD 632
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLELLhsEFKCP 51
LRR smart00370
Leucine-rich repeats, outliers;
503-526 2.95e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....
gi 2168430667  503 LSKLQVLHLNNNYLSALPREIFRG 526
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_8 pfam13855
Leucine rich repeat;
147-187 4.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 4.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2168430667 147 SSLEELDLSGNQITNLQPHpLFYNLTVLKTVNLKFNKITNL 187
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTL 40
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-263 6.73e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  91 GAFRNLPNLHVLDLGFNKILQLD---LDAFVGLPSLTVLRLFHNYLGDSILE--ERYFQDLS-SLEELDLSGNQITNLQP 164
Cdd:cd00116    75 QGLTKGCGLQELDLSDNALGPDGcgvLESLLRSSSLQELKLNNNGLGDRGLRllAKGLKDLPpALEKLVLGRNRLEGASC 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 165 HPL---FYNLTVLKTVNLKFNKITN-----LCESnLTSFRGKHFLffSLGSNNFykTDEMAWAKCPNPFRNITFNSLDLS 236
Cdd:cd00116   155 EALakaLRANRDLKELNLANNGIGDagiraLAEG-LKANCNLEVL--DLNNNGL--TDEGASALAETLASLKSLEVLNLG 229

                         170       180
                  ....*....|....*....|....*..
gi 2168430667 237 DNGWSTEKVQYFCTAIKGTQIGSLILG 263
Cdd:cd00116   230 DNNLTDAGAAALASALLSPNISLLTLS 256
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
694-829 2.43e-26

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 105.10  E-value: 2.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  694 RYDAYLCYSKNDfeWVQNSLLKHLDSQYFDKNrftLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYG---LCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430667  774 FNFAQSRYFSDLKDVLIMVVVGSLSQYQLMKHKPIQNFLQRsRYLLWPEDYQDVDW 829
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 695-843 9.94e-23

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 95.51  E-value: 9.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 695 YDAYLCYSKND-FEWVQNSLLKHLDsqyfdKNRFTLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEA 773
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 774 FNFAQSRYFsDLKDVLIMVVVGSLSQYQL-------MKHKPIQNFLQRSRYLLWPEDYQDVD------------WFLNKL 834
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALNEVAniwhsksvsdesKFWKKI 154


                  ....*....
gi 2168430667 835 SCQMLKEKK 843
Cdd:pfam01582 155 AYDISNKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-562 3.69e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 274 NNLKNPDSDTFAGLASSDLHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKinqiqrqAFFGLGNLKTLNLSSNLLGEL 353
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 354 yDYTFEGLHSVMYIDLQQNHIGMIGEkSFSNLVSLKIIDLRDNAIKKLPSF----PHLTSAFLGDNKLmsvvgTAIAATI 429
Cdd:COG4886   129 -PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEElgnlTNLKELDLSNNQI-----TDLPEPL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 430 LELErnwlaNLGDLYIlfqvpdvqyiflkqnrfsycvkhhnvtENNQLIYMDlgenmlqlvwerdlclDVFRALSKLQVL 509
Cdd:COG4886   202 GNLT-----NLEELDL---------------------------SGNQLTDLP----------------EPLANLTNLETL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2168430667 510 HLNNNYLSALPReiFRGLTSLKRLNLASNLLSHLSPGLFPQSLTNLNLSGNQL 562
Cdd:COG4886   234 DLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
504-562 5.35e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 5.35e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2168430667 504 SKLQVLHLNNNYLSALPREIFRGLTSLKRLNLASNLLSHLSPGLF--PQSLTNLNLSGNQL 562
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-159 4.68e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 4.68e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2168430667  97 PNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLgdSILEERYFQDLSSLEELDLSGNQI 159
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-209 5.88e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 5.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  92 AFRNLPNLHVLDLGFNKILQLDlDAFVGLPSLTVLRLFHNYLGDsiLEEryFQDLSSLEELDLSGNQITNLqphPLFYNL 171
Cdd:COG4886   200 PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDL---PPLANL 271

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2168430667 172 TVLKTVNLKFNKITNLCESNLTSFRGKHFLFFSLGSNN 209
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-440 8.81e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 8.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  87 TIGKGAFRNLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNylgdsileeRYFQDLSSLEELDLSGNQITNLQPHp 166
Cdd:COG4886    62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEE- 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 167 lFYNLTVLKTVNLKFNKITNLCE--SNLTSFRgkhflFFSLGSNNFyktdemawAKCPNPFRNIT-FNSLDLSDNgwste 243
Cdd:COG4886   132 -LANLTNLKELDLSNNQLTDLPEplGNLTNLK-----SLDLSNNQL--------TDLPEELGNLTnLKELDLSNN----- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 244 kvqyfctaikgtQIGSLilgshtmgsGFGFNNLKNpdsdtfaglassdLHLLDISNGYIFSLnSLIFQSLGNLELLNLFK 323
Cdd:COG4886   193 ------------QITDL---------PEPLGNLTN-------------LEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 324 NKINQIqrQAFFGLGNLKTLNLSSNLLGELYDytFEGLHSVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAIKKLPS 403
Cdd:COG4886   238 NQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2168430667 404 FPHLTSAFLGDNKLMSVVGTAIAATILELERNWLANL 440
Cdd:COG4886   314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR_8 pfam13855
Leucine rich repeat;
315-374 1.28e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 1.28e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 315 NLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI 374
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-585 3.00e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 3.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  96 LPNLHVLDLGFNKI---LQLDLDAFvglPSLTVLRLFHNYLGDSIleERYFQDLSSLEELDLSGNQITNLQPHP------ 166
Cdd:PLN00113  139 IPNLETLDLSNNMLsgeIPNDIGSF---SSLKVLDLGGNVLVGKI--PNSLTNLTSLEFLTLASNQLVGQIPRElgqmks 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 167 -----LFYN------------LTVLKTVNLKFNKITNLCESNLTSFRGKHFLFfsLGSNNFykTDEMAwakcPNPFRNIT 229
Cdd:PLN00113  214 lkwiyLGYNnlsgeipyeiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLF--LYQNKL--SGPIP----PSIFSLQK 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 230 FNSLDLSDNGWSTEkvqyfctaikgtqIGSLILgshtmgsgfgfnNLKNPDSdtfaglassdLHLLdiSNGYIFSLNSLI 309
Cdd:PLN00113  286 LISLDLSDNSLSGE-------------IPELVI------------QLQNLEI----------LHLF--SNNFTGKIPVAL 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 310 fQSLGNLELLNLFKNKIN-QIQRQaffgLG---NLKTLNLSSN-LLGELYDYTFEGLHSVMYIDLQQNHIGMIgEKSFSN 384
Cdd:PLN00113  329 -TSLPRLQVLQLWSNKFSgEIPKN----LGkhnNLTVLDLSTNnLTGEIPEGLCSSGNLFKLILFSNSLEGEI-PKSLGA 402

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 385 LVSLKIIDLRDNAIK-KLPS-FPHLTSAF---LGDNKLMSVVGTAI----AATILELERNWLanLGDLYILFQVPDVQYI 455
Cdd:PLN00113  403 CRSLRRVRLQDNSFSgELPSeFTKLPLVYfldISNNNLQGRINSRKwdmpSLQMLSLARNKF--FGGLPDSFGSKRLENL 480

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 456 FLKQNRFSYCV--KHHNVTEnnqLIYMDLGENMLQLVWERDLcldvfRALSKLQVLHLNNNYLSALPREIFRGLTSLKRL 533
Cdd:PLN00113  481 DLSRNQFSGAVprKLGSLSE---LMQLKLSENKLSGEIPDEL-----SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQL 552

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 534 NLASNLLShlspGLFP------QSLTNLNLSGNQLFS--PEPEVFMTLSILDITHNKYVC 585
Cdd:PLN00113  553 DLSQNQLS----GEIPknlgnvESLVQVNISHNHLHGslPSTGAFLAINASAVAGNIDLC 608
LRR_8 pfam13855
Leucine rich repeat;
339-398 5.49e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.49e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 339 NLKTLNLSSNLLGELYDYTFEGLHSVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAI 398
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
292-350 6.80e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 6.80e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2168430667 292 LHLLDISNGYIFSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLL 350
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 146-582 8.42e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 8.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 146 LSSLEELDLSGNQITNLQPHPLFYNLTVLKTVNLKFNKITNLCEsnltsfRGKHFLFFSLG-SNNfyktdeMAWAKCPNP 224
Cdd:PLN00113   92 LPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIP------RGSIPNLETLDlSNN------MLSGEIPND 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 225 ---FRNITFnsLDLSDNGWsTEKVQYFCTAIkgTQIGSLILGSHTMGSG---------------FGFNNLKNPDSDTFAG 286
Cdd:PLN00113  160 igsFSSLKV--LDLGGNVL-VGKIPNSLTNL--TSLEFLTLASNQLVGQiprelgqmkslkwiyLGYNNLSGEIPYEIGG 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 287 LASSDlHLLDISNgyifSLNSLIFQSLGN---LELLNLFKNKINQIQRQAFFGLGNLKTLNLSSNLL-GELYDytfeglh 362
Cdd:PLN00113  235 LTSLN-HLDLVYN----NLTGPIPSSLGNlknLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsGEIPE------- 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 363 svMYIDLQQNHIGMIgeksFSNLVSLKIidlrdnaIKKLPSFPHLTSAFLGDNKLMSVV----GTAIAATILELERNWLA 438
Cdd:PLN00113  303 --LVIQLQNLEILHL----FSNNFTGKI-------PVALTSLPRLQVLQLWSNKFSGEIpknlGKHNNLTVLDLSTNNLT 369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 439 --------NLGDLY--ILF------QVP-------DVQYIFLKQNRFSYCVKhHNVTENNQLIYMDLGENMLQ-----LV 490
Cdd:PLN00113  370 geipeglcSSGNLFklILFsnslegEIPkslgacrSLRRVRLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQgrinsRK 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 491 WErdlcldvfraLSKLQVLHLN-NNYLSALPReiFRGLTSLKRLNLASNLLSHLSP---GLFPQsLTNLNLSGNQLFSPE 566
Cdd:PLN00113  449 WD----------MPSLQMLSLArNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPrklGSLSE-LMQLKLSENKLSGEI 515

                         490
                  ....*....|....*....
gi 2168430667 567 PEVFMT---LSILDITHNK 582
Cdd:PLN00113  516 PDELSSckkLVSLDLSHNQ 534
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-417 9.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 9.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  87 TIGKGAFRNLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLGDSILEERYFQDLSSLEELDLSGNQitnlqphp 166
Cdd:COG4886    36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 167 LFYNLTVLKTVNLKFNKITNLCE--SNLTSFRgkhflffslgsnnfyktdemawakcpnpfrnitfnSLDLSDNgwstek 244
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDLPEelANLTNLK-----------------------------------ELDLSNN------ 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 245 vqyfctaikgtQIGSLilgshtmgsGFGFNNLKNpdsdtfaglassdLHLLDISNGYIFSLNSLIFQsLGNLELLNLFKN 324
Cdd:COG4886   147 -----------QLTDL---------PEPLGNLTN-------------LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNN 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 325 KINQIQrQAFFGLGNLKTLNLSSNLLGELyDYTFEGLHSVMYIDLQQNHIGMIgeKSFSNLVSLKIIDLRDNAIKKLPS- 403
Cdd:COG4886   193 QITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPl 268

                         330
                  ....*....|....*.
gi 2168430667 404 --FPHLTSAFLGDNKL 417
Cdd:COG4886   269 anLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
86-133 2.68e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.68e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2168430667  86 VTIGKGAFRNLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYL 133
Cdd:pfam13855  14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 125-400 7.92e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.05  E-value: 7.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 125 VLRLFHNYLGDsILEERYFQDLSSLEELDLSGNQITNLQPHPLFYNLTV---LKTVNLKFN------KITNLCESNLTSF 195
Cdd:cd00116     2 QLSLKGELLKT-ERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPqpsLKELCLSLNetgripRGLQSLLQGLTKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 196 RGKHFLffSLGSNNFYKTDEMAWAKCpnpFRNITFNSLDLSDNGWSTEKVQYFCTAIKGTQ--IGSLILGShtmgsgfgf 273
Cdd:cd00116    81 CGLQEL--DLSDNALGPDGCGVLESL---LRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpaLEKLVLGR--------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 274 NNLKNPDSDTFAGLASS--DLHLLDISNGYI----FSLNSLIFQSLGNLELLNLFKNKINQIQRQAFFG----LGNLKTL 343
Cdd:cd00116   147 NRLEGASCEALAKALRAnrDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVL 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2168430667 344 NLSSNLLG-----ELYDYTFEGLHSVMYIDLQQNHIGMIGEKSFS----NLVSLKIIDLRDNAIKK 400
Cdd:cd00116   227 NLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGAKDLAevlaEKESLLELDLRGNKFGE 292
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 97-270 1.07e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.18  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  97 PNLHVLDLGFNKILQLDLDAFV----GLPSLTVLRLFHNYLGDSILEE--RYFQDLSSLEELDLSGNQIT---------- 160
Cdd:COG5238   208 TTVTTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIGaegaialaka 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 161 ---NLQPHPLFYNL------------------TVLKTVNLKFNKITNLCESNLTSFRGKHFLFFSLGSNNFYKTDEMAWA 219
Cdd:COG5238   288 lqgNTTLTSLDLSVnrigdegaialaeglqgnKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIA 367

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2168430667 220 KCPNPFRNITFNSLDLSDNGWSTEKVQYFCTAIKGTQIGSLILGSHTMGSG 270
Cdd:COG5238   368 LAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAE 418
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 323-568 1.95e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 323 KNKINQIQrQAFFGLGNLKTLNLSSNLL-GELYDYTFEGLHSVMYIDLQQNHI-GMIGEKSFSNL--------------- 385
Cdd:PLN00113   79 KNISGKIS-SAIFRLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGSIPNLetldlsnnmlsgeip 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 386 ------VSLKIIDLRDNA--------IKKLPSFPHLTSA---------------------FLGDNKLMSVVGTAIAATI- 429
Cdd:PLN00113  158 ndigsfSSLKVLDLGGNVlvgkipnsLTNLTSLEFLTLAsnqlvgqiprelgqmkslkwiYLGYNNLSGEIPYEIGGLTs 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 430 ---LELERNWL-----ANLGDLyilfqvPDVQYIFLKQNRFSYCVKhHNVTENNQLIYMDLGENML-----QLVWErdlc 496
Cdd:PLN00113  238 lnhLDLVYNNLtgpipSSLGNL------KNLQYLFLYQNKLSGPIP-PSIFSLQKLISLDLSDNSLsgeipELVIQ---- 306

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2168430667 497 ldvfraLSKLQVLHLNNNYLSAlprEIFRGLTSLKR---LNLASNLLSHLSPGLFPQ--SLTNLNLSGNQLFSPEPE 568
Cdd:PLN00113  307 ------LQNLEILHLFSNNFTG---KIPVALTSLPRlqvLQLWSNKFSGEIPKNLGKhnNLTVLDLSTNNLTGEIPE 374
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 698-780 7.06e-07

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 48.85  E-value: 7.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 698 YLCYSKNDFEWVQNsLLKHLDsqyfdKNRFTLCFEERDFLPGEEHITNIRDAIWNSRKTICIVTRQFLKDGWCVEAFNFA 777
Cdd:pfam13676   2 FISYAGEDRAWAEW-LADALE-----AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA 75


                  ...
gi 2168430667 778 QSR 780
Cdd:pfam13676  76 LAD 78
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-417 1.04e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  85 PVTIGKgafrnLPNLHVLDLGFNKILQLDLDAFVGLPSLTVLRLFHNYLGDSILEERYfqDLSSLEELDLSGNQITNLQP 164
Cdd:PLN00113  229 PYEIGG-----LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSLSGEIP 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 165 HpLFYNLTVLKTVNLKFNKITNLCESNLTSFRGKHFLffSLGSNNFYKTDEMAWAKCPNpfrnitFNSLDLSDNGWSTEK 244
Cdd:PLN00113  302 E-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--QLWSNKFSGEIPKNLGKHNN------LTVLDLSTNNLTGEI 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 245 VQYFCTAikgTQIGSLILGSHTMGSGF-----GFNNLKNP--DSDTFAGLASSD------LHLLDISNGYIFSLNSLIFQ 311
Cdd:PLN00113  373 PEGLCSS---GNLFKLILFSNSLEGEIpkslgACRSLRRVrlQDNSFSGELPSEftklplVYFLDISNNNLQGRINSRKW 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 312 SLGNLELLNLFKNKINQiQRQAFFGLGNLKTLNLSSNLLGELYDYTFEGLHSVMYIDLQQNHI-GMIGEK--SFSNLVSL 388
Cdd:PLN00113  450 DMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLsGEIPDElsSCKKLVSL 528

                         330       340       350
                  ....*....|....*....|....*....|....
gi 2168430667 389 kiiDLRDNAIK-KLPS----FPHLTSAFLGDNKL 417
Cdd:PLN00113  529 ---DLSHNQLSgQIPAsfseMPVLSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
121-184 2.87e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.87e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2168430667 121 PSLTVLRLFHNYLGDsiLEERYFQDLSSLEELDLSGNQITNLQPHpLFYNLTVLKTVNLKFNKI 184
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
494-540 3.78e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.78e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2168430667 494 DLCLDVFRALSKLQVLHLNNNYLSALPREIFRGLTSLKRLNLASNLL 540
Cdd:pfam13855  15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-187 3.49e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  93 FRNLPNLHVLDLGFNKI-----LQldldafvGLPSLTVLRLFHNYLGDS---ILEERYFQDLS-SLEELDLSGNQITNLQ 163
Cdd:cd21340    64 LENLVNLKKLYLGGNRIsvvegLE-------NLTNLEELHIENQRLPPGeklTFDPRSLAALSnSLRVLNISGNNIDSLE 136

                          90       100
                  ....*....|....*....|....
gi 2168430667 164 PhplFYNLTVLKTVNLKFNKITNL 187
Cdd:cd21340   137 P---LAPLRNLEQLDASNNQISDL 157
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 556-634 4.48e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 4.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  556 NLSGNQLFSPEPEVF---MTLSILDITHNKYVCDCTLKSLLVWLNETNVTLAGSQSdRYCVYPPAFAGVPL--SSLTFDG 630
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEA-ALCAGPGALAGQPLlgIPLLDSG 79


                   ....
gi 2168430667  631 CDED 634
Cdd:TIGR00864   80 CDEE 83
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 68-375 1.18e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  68 PLLEHLLVLEIGTQYV-YPVTIGKGAFRNLPNLHVLDlgFNKILQLDLDAFVGLPSLTVLRLFHNYLGDSILEERYFQDL 146
Cdd:COG5238   102 PVALAETATAVATPPPdLRRIMAKTLEDSLILYLALP--RRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQN 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 147 SSLEELDLSGNQITNLQPHPLFYNL---TVLKTVNLKFNKITNLCESNLTS-FRGKHFLfFSLGSNNFYKTDE--MAWAK 220
Cdd:COG5238   180 NSVETVYLGCNQIGDEGIEELAEALtqnTTVTTLWLKRNPIGDEGAEILAEaLKGNKSL-TTLDLSNNQIGDEgvIALAE 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 221 CPNPFRNITfnSLDLSDNGWSTEKVQYFCTAIKG-TQIGSLILgshtmgsgfGFNNLKNPDSDTFA-GLA-SSDLHLLDI 297
Cdd:COG5238   259 ALKNNTTVE--TLYLSGNQIGAEGAIALAKALQGnTTLTSLDL---------SVNRIGDEGAIALAeGLQgNKTLHTLNL 327

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 298 S------NGYIFSLNSLifQSLGNLELLNLFKNKINQIQR----QAFFGLGNLKTLNLSSNLLGELydyTFEGL------ 361
Cdd:COG5238   328 AyngigaQGAIALAKAL--QENTTLHSLDLSDNQIGDEGAialaKYLEGNTTLRELNLGKNNIGKQ---GAEALidalqt 402

                         330
                  ....*....|....
gi 2168430667 362 HSVMYIDLQQNHIG 375
Cdd:COG5238   403 NRLHTLILDGNLIG 416
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 340-562 3.01e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 340 LKTLNLSSNLLGELYDytfeGLHSVM----------YIDLQQNHIGMIGEKSFSNL---VSLKIIDLRDNAIKK------ 400
Cdd:cd00116    53 LKELCLSLNETGRIPR----GLQSLLqgltkgcglqELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrglrll 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 401 ----LPSFPHLTSAFLGDNKLMSVVGTAIAATilelernwLANLGDLYIL------FQVPDVQYIFlkqnrfsycvkhHN 470
Cdd:cd00116   129 akglKDLPPALEKLVLGRNRLEGASCEALAKA--------LRANRDLKELnlanngIGDAGIRALA------------EG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 471 VTENNQLIYMDLGENMLQLVWERDLClDVFRALSKLQVLHLNNNYL-----SALPREIFRGLTSLKRLNLASNLLSHLSP 545
Cdd:cd00116   189 LKANCNLEVLDLNNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGA 267

                         250       260
                  ....*....|....*....|...
gi 2168430667 546 GLFPQ------SLTNLNLSGNQL 562
Cdd:cd00116   268 KDLAEvlaekeSLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 361-560 3.16e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 361 LHSVMYIDLQQNHIGMIGEksFSNLVSLKIIDLRDNAIKK---LPSFPHLTSAFLGDNKlmsvvgtaiaatILELErnwl 437
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKienLEFLTNLTHLYLQNNQ------------IEKIE---- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 438 aNLGDLYILfqvpdvQYIFLKQNRFSyCVKH----HNVTE----NNQLiymDLGENmlqlvwerdLCLDVF--RALSK-L 506
Cdd:cd21340    63 -NLENLVNL------KKLYLGGNRIS-VVEGlenlTNLEElhieNQRL---PPGEK---------LTFDPRslAALSNsL 122

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2168430667 507 QVLHLNNNYLSALprEIFRGLTSLKRLNLASNLLSHLSP--GLFPQ--SLTNLNLSGN 560
Cdd:cd21340   123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSwpSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
363-417 5.51e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 5.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 363 SVMYIDLQQNHIGMIGEKSFSNLVSLKIIDLRDNAIKKLP-----SFPHLTSAFLGDNKL 417
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 497-582 9.28e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 9.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 497 LDVFRALSKLQVLHLNNNYLSALprEIFRGLTSLKRLNLAS-------------NLLSHLSPglfpqSLTNLNLSGNQLF 563
Cdd:cd21340    61 IENLENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENqrlppgekltfdpRSLAALSN-----SLRVLNISGNNID 133

                          90       100
                  ....*....|....*....|
gi 2168430667 564 SPEPEVFMT-LSILDITHNK 582
Cdd:cd21340   134 SLEPLAPLRnLEQLDASNNQ 153
LRRCT smart00082
Leucine rich repeat C-terminal domain;
581-632 1.90e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.02  E-value: 1.90e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2168430667  581 NKYVCDCTLKSLLVWLNETNVTLagSQSDRYCVYPPAFAGvPLSSLT--FDGCD 632
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ--DPVDLRCASPSSLRG-PLLELLhsEFKCP 51
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 322-396 2.15e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 2.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2168430667 322 FKNKINQIQRQAFFGLGNLKTLNLSSNLLgELYDYTFEGLHSVmYIDLQQNhIGMIGEKSFSNLVSLKIIDLRDN 396
Cdd:pfam13306  18 IPSSLTSIGEYAFSNCTSLKSITLPSSLT-SIGSYAFYNCSLT-SITIPSS-LTSIGEYAFSNCSNLKSITLPSN 89
LRR smart00370
Leucine-rich repeats, outliers;
503-526 2.95e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....
gi 2168430667  503 LSKLQVLHLNNNYLSALPREIFRG 526
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
503-526 2.95e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.95e-03
                           10        20
                   ....*....|....*....|....
gi 2168430667  503 LSKLQVLHLNNNYLSALPREIFRG 526
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 295-404 4.09e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 295 LDISNGYIFSLNSLifQSLGNLELLNLFKNKIN--------------QIQRQ-------------AFFGLGN-LKTLNLS 346
Cdd:cd21340    51 LYLQNNQIEKIENL--ENLVNLKKLYLGGNRISvveglenltnleelHIENQrlppgekltfdprSLAALSNsLRVLNIS 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 347 SNLLGELYDytFEGLHSVMYIDLQQNHIGMIGE--KSFSNLVSLKIIDLRDNAIKKLPSF 404
Cdd:cd21340   129 GNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKY 186
LRR_8 pfam13855
Leucine rich repeat;
147-187 4.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 4.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2168430667 147 SSLEELDLSGNQITNLQPHpLFYNLTVLKTVNLKFNKITNL 187
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDG-AFKGLSNLKVLDLSNNLLTTL 40
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-185 5.13e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  91 GAFRNLPNLHVLDLGFNKIL----QLDLDAFVGLPSLTVLRLFHNYL---GDSILEErYFQDLSSLEELDLSGNQITN-- 161
Cdd:cd00116   159 KALRANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLtdeGASALAE-TLASLKSLEVLNLGDNNLTDag 237

                          90       100
                  ....*....|....*....|....*..
gi 2168430667 162 ---LQPHPLFYNLTvLKTVNLKFNKIT 185
Cdd:cd00116   238 aaaLASALLSPNIS-LLTLSLSCNDIT 263
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 91-263 6.73e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667  91 GAFRNLPNLHVLDLGFNKILQLD---LDAFVGLPSLTVLRLFHNYLGDSILE--ERYFQDLS-SLEELDLSGNQITNLQP 164
Cdd:cd00116    75 QGLTKGCGLQELDLSDNALGPDGcgvLESLLRSSSLQELKLNNNGLGDRGLRllAKGLKDLPpALEKLVLGRNRLEGASC 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2168430667 165 HPL---FYNLTVLKTVNLKFNKITN-----LCESnLTSFRGKHFLffSLGSNNFykTDEMAWAKCPNPFRNITFNSLDLS 236
Cdd:cd00116   155 EALakaLRANRDLKELNLANNGIGDagiraLAEG-LKANCNLEVL--DLNNNGL--TDEGASALAETLASLKSLEVLNLG 229

                         170       180
                  ....*....|....*....|....*..
gi 2168430667 237 DNGWSTEKVQYFCTAIKGTQIGSLILG 263
Cdd:cd00116   230 DNNLTDAGAAALASALLSPNISLLTLS 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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