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Conserved domains on  [gi|2209133507|gb|UNI83894|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Rhinoceros unicornis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-66 1.15e-39

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00110:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 459  Bit Score: 134.64  E-value: 1.15e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00110  319 HGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMS 384
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-66 1.15e-39

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 134.64  E-value: 1.15e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00110  319 HGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMS 384
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-66 1.31e-09

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 51.55  E-value: 1.31e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2209133507   1 HGLTSSVLFCLANS-NYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:pfam00361 208 HGLFSAGLFLCAGSvIYRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAA 274
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 1-66 1.48e-09

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 51.62  E-value: 1.48e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:COG1008   336 HGLITAALFLLVGVLYDRTHTRDIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLG 401
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 1-65 1.43e-08

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 48.78  E-value: 1.43e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVV 65
Cdd:TIGR01972 330 HGLITAALFLLVGVLYERAHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILL 394
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-66 1.15e-39

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 134.64  E-value: 1.15e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00110  319 HGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMS 384
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-66 5.94e-34

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 119.53  E-value: 5.94e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00124  319 HGLTSSMLFCLANTNYERTHSRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTS 384
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-66 3.40e-31

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 111.93  E-value: 3.40e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00068  319 HGLTSSALFCLANTNYERTHSRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVS 384
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-66 3.74e-24

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 92.71  E-value: 3.74e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00127  320 HGLTSSALFCLANTNYERTHSRTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMIITS 385
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 1-66 5.52e-24

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 92.31  E-value: 5.52e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00206  315 HGLVSSALFCLANLLYERSHTRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITS 380
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-66 1.30e-21

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 85.80  E-value: 1.30e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00044  321 HGLVSSALFCLANILYERSGTRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISS 386
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-66 2.27e-19

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 79.43  E-value: 2.27e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00163  307 HGLCSSGLFCLANIIYERLGSRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINS 372
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 1-66 3.28e-18

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 76.03  E-value: 3.28e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00150  278 HGFCSSGLFCLANYTYEKVHSRSLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPS 343
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 1-66 2.49e-16

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 70.78  E-value: 2.49e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00205  311 HGLCSSGMFALANVNYERTNSRSMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMS 376
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 1-66 1.04e-15

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 69.00  E-value: 1.04e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00014  313 HGLCSSALFALANMTYETTHTRSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTS 378
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-66 1.31e-09

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 51.55  E-value: 1.31e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2209133507   1 HGLTSSVLFCLANS-NYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:pfam00361 208 HGLFSAGLFLCAGSvIYRRVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAA 274
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 1-66 1.48e-09

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 51.62  E-value: 1.48e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:COG1008   336 HGLITAALFLLVGVLYDRTHTRDIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLG 401
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 1-66 4.92e-09

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 50.06  E-value: 4.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00204  336 HGFVSSALFIAVTFLYERHHTRLIKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFFSLLA 401
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 1-66 5.86e-09

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 49.92  E-value: 5.86e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:MTH00226  357 HGIVSSLLFILVTILYDRHHTRLIKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILS 422
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 1-65 1.43e-08

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 48.78  E-value: 1.43e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVV 65
Cdd:TIGR01972 330 HGLITAALFLLVGVLYERAHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILL 394
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 1-62 6.78e-08

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 46.97  E-value: 6.78e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELF 62
Cdd:MTH00217  333 HGLVSSALFIAVTFLYERHHTRLIKYYRGMVITMPLFGILMLLLVLANASIPLSCNFVGEFL 394
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 1-65 1.01e-07

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 46.35  E-value: 1.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVV 65
Cdd:PRK05846  338 HGLSSAALFLLVGVLYDRLHTRDIADYGGLAKVMPVLAAFFLFFAMASLGLPGTSGFVGEFLILL 402
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 1-65 8.31e-07

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 43.87  E-value: 8.31e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVV 65
Cdd:PRK12561  312 HGLIAAALFFLTGVTYERTHTLSIPNMGGLAKVMPKTFALFTASSMASLALPGMSGFVSELTVFL 376
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 1-65 2.29e-04

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 36.99  E-value: 2.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVV 65
Cdd:PRK02546  340 HGLIGASLFFLVGATYDRTHTLMLDEMGGVGQKMRKMFAMWTACSLASLALPGMSGFVAELMVFV 404
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 1-66 2.44e-04

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 36.66  E-value: 2.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2209133507   1 HGLTSSVLFCLANSNYERTHSRTMILARGLQTLLPLMAMWWLLASLTNLALPPTINLVGELFVVVS 66
Cdd:COG0651   333 HALAKALLFLAAGAIERATGTRDLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQA 398
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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