NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2214449150|gb|UNY85606|]
View 

WD40-containting protein [Zea mays]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 224-534 1.69e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.87  E-value: 1.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWGVAQSEDCKIpmddpscvyLKAHRQSglgpvdadnekkckVKGVKQ 303
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT---------LKGHTGP--------------VRDVAA 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 304 SADSACVVIPTAVFQI------SKQPLHEFRGHSGDVLNLSWSNNKHLL-SASTDKTVRLWEIGSANCITVFP-HSNFVT 375
Cdd:cd00200    60 SADGTYLASGSSDKTIrlwdleTGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRgHTDWVN 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 376 CVQFNPTneNQFI-SGSIDGKIRVWDIPRCSVI-------DWVdirdiiTAVCYRPDGKGAVVGTITGNCRFYDasdnlL 447
Cdd:cd00200   140 SVAFSPD--GTFVaSSSQDGTIKLWDLRTGKCVatltghtGEV------NSVAFSPDGEKLLSSSSDGTIKLWD-----L 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 448 RFETQVAV-SGKKKSslkrITAFEFSPSNpsKLMVT-SADSKIKI--LEGTTVTQNYSGLRaGSCQSLAtFTPDGQHIVY 523
Cdd:cd00200   207 STGKCLGTlRGHENG----VNSVAFSPDG--YLLASgSEDGTIRVwdLRTGECVQTLSGHT-NSVTSLA-WSPDGKRLAS 278

                         330
                  ....*....|.
gi 2214449150 524 ASEDSNIYVWN 534
Cdd:cd00200   279 GSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 224-534 1.69e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.87  E-value: 1.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWGVAQSEDCKIpmddpscvyLKAHRQSglgpvdadnekkckVKGVKQ 303
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT---------LKGHTGP--------------VRDVAA 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 304 SADSACVVIPTAVFQI------SKQPLHEFRGHSGDVLNLSWSNNKHLL-SASTDKTVRLWEIGSANCITVFP-HSNFVT 375
Cdd:cd00200    60 SADGTYLASGSSDKTIrlwdleTGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRgHTDWVN 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 376 CVQFNPTneNQFI-SGSIDGKIRVWDIPRCSVI-------DWVdirdiiTAVCYRPDGKGAVVGTITGNCRFYDasdnlL 447
Cdd:cd00200   140 SVAFSPD--GTFVaSSSQDGTIKLWDLRTGKCVatltghtGEV------NSVAFSPDGEKLLSSSSDGTIKLWD-----L 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 448 RFETQVAV-SGKKKSslkrITAFEFSPSNpsKLMVT-SADSKIKI--LEGTTVTQNYSGLRaGSCQSLAtFTPDGQHIVY 523
Cdd:cd00200   207 STGKCLGTlRGHENG----VNSVAFSPDG--YLLASgSEDGTIRVwdLRTGECVQTLSGHT-NSVTSLA-WSPDGKRLAS 278

                         330
                  ....*....|.
gi 2214449150 524 ASEDSNIYVWN 534
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
224-534 7.53e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.52  E-value: 7.53e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWGVAQSEDCKIpmddpscvyLKAHRQSglgpvdadnekkckVKGVKQ 303
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT---------LTGHSGA--------------VTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 304 SADSACVVipTA-------VFQI-SKQPLHEFRGHSGDVLNLSWS-NNKHLLSASTDKTVRLWEIGSANCITVFP-HSNF 373
Cdd:COG2319   171 SPDGKLLA--SGsddgtvrLWDLaTGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 374 VTCVQFNPtNENQFISGSIDGKIRVWDIPRCSVIDWVD-IRDIITAVCYRPDGKGAVVGTITGNCRFYDASDNllrfETQ 452
Cdd:COG2319   249 VRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG----KLL 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 453 VAVSGKKksslKRITAFEFSPsNPSKLMVTSADSKIKI--LEGTTVTQNYSGlRAGSCQSLAtFTPDGQHIVYASEDSNI 530
Cdd:COG2319   324 RTLTGHT----GAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTG-HTGAVTSVA-FSPDGRTLASGSADGTV 396


                  ....
gi 2214449150 531 YVWN 534
Cdd:COG2319   397 RLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-257 8.10e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 8.10e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2214449150  224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVW 257
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
224-257 6.30e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 6.30e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVW 257
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 318-401 5.10e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 318 QISKQPLHEFRGHSGDVLNLSWSN--NKHLLSASTDKTVRLWEIGSAN----------CItVFPHSNFVTCVQFNPTNEN 385
Cdd:PTZ00420   61 QMRKPPVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI-LKGHKKKISIIDWNPMNYY 139

                          90
                  ....*....|....*.
gi 2214449150 386 QFISGSIDGKIRVWDI 401
Cdd:PTZ00420  140 IMCSSGFDSFVNIWDI 155
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 224-534 1.69e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.87  E-value: 1.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWGVAQSEDCKIpmddpscvyLKAHRQSglgpvdadnekkckVKGVKQ 303
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT---------LKGHTGP--------------VRDVAA 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 304 SADSACVVIPTAVFQI------SKQPLHEFRGHSGDVLNLSWSNNKHLL-SASTDKTVRLWEIGSANCITVFP-HSNFVT 375
Cdd:cd00200    60 SADGTYLASGSSDKTIrlwdleTGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRgHTDWVN 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 376 CVQFNPTneNQFI-SGSIDGKIRVWDIPRCSVI-------DWVdirdiiTAVCYRPDGKGAVVGTITGNCRFYDasdnlL 447
Cdd:cd00200   140 SVAFSPD--GTFVaSSSQDGTIKLWDLRTGKCVatltghtGEV------NSVAFSPDGEKLLSSSSDGTIKLWD-----L 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 448 RFETQVAV-SGKKKSslkrITAFEFSPSNpsKLMVT-SADSKIKI--LEGTTVTQNYSGLRaGSCQSLAtFTPDGQHIVY 523
Cdd:cd00200   207 STGKCLGTlRGHENG----VNSVAFSPDG--YLLASgSEDGTIRVwdLRTGECVQTLSGHT-NSVTSLA-WSPDGKRLAS 278

                         330
                  ....*....|.
gi 2214449150 524 ASEDSNIYVWN 534
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
224-534 7.53e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.52  E-value: 7.53e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWGVAQSEDCKIpmddpscvyLKAHRQSglgpvdadnekkckVKGVKQ 303
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT---------LTGHSGA--------------VTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 304 SADSACVVipTA-------VFQI-SKQPLHEFRGHSGDVLNLSWS-NNKHLLSASTDKTVRLWEIGSANCITVFP-HSNF 373
Cdd:COG2319   171 SPDGKLLA--SGsddgtvrLWDLaTGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 374 VTCVQFNPtNENQFISGSIDGKIRVWDIPRCSVIDWVD-IRDIITAVCYRPDGKGAVVGTITGNCRFYDASDNllrfETQ 452
Cdd:COG2319   249 VRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG----KLL 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 453 VAVSGKKksslKRITAFEFSPsNPSKLMVTSADSKIKI--LEGTTVTQNYSGlRAGSCQSLAtFTPDGQHIVYASEDSNI 530
Cdd:COG2319   324 RTLTGHT----GAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTG-HTGAVTSVA-FSPDGRTLASGSADGTV 396


                  ....
gi 2214449150 531 YVWN 534
Cdd:COG2319   397 RLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
224-534 3.40e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.48  E-value: 3.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWGVAqsedckipmddpscvylkahrqsglgpvdadnekkckvkgvkq 303
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA------------------------------------------- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 304 sadsacvviptavfqiSKQPLHEFRGHSGDVLNLSWS-NNKHLLSASTDKTVRLWEIGSANCITVFP-HSNFVTCVQFNP 381
Cdd:COG2319   109 ----------------TGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 382 tNENQFISGSIDGKIRVWDIPRCSVIDWVDI-RDIITAVCYRPDGKGAVVGTITGNCRFYDASDNLLRFETqvavsgkkK 460
Cdd:COG2319   173 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL--------T 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2214449150 461 SSLKRITAFEFSPSNpSKLMVTSADSKIKI--LEGTTVTQNYSGlRAGSCQSLAtFTPDGQHIVYASEDSNIYVWN 534
Cdd:COG2319   244 GHSGSVRSVAFSPDG-RLLASGSADGTVRLwdLATGELLRTLTG-HSGGVNSVA-FSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
224-444 5.60e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 5.60e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWGVAQSEdckipmddpsCVYLKAHRQSGlgpvdadnekkckVKGVKQ 303
Cdd:COG2319   198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK----------LLRTLTGHSGS-------------VRSVAF 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 304 SADSACVVIPTAVFQI------SKQPLHEFRGHSGDVLNLSWS-NNKHLLSASTDKTVRLWEIGSANCITVFP-HSNFVT 375
Cdd:COG2319   255 SPDGRLLASGSADGTVrlwdlaTGELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVR 334

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 376 CVQFNPtNENQFISGSIDGKIRVWDIPRCSVI-DWVDIRDIITAVCYRPDGKGAVVGTITGNCRFYDASD 444
Cdd:COG2319   335 SVAFSP-DGKTLASGSDDGTVRLWDLATGELLrTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 216-400 2.46e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 2.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 216 ELSAVYQGQVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWgvaqseDckipMDDPSCVY-LKAHRQSglgpvdadnek 294
Cdd:cd00200   121 DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW------D----LRTGKCVAtLTGHTGE----------- 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 295 kckVKGVKQSADSACVVIPTAVFQI------SKQPLHEFRGHSGDVLNLSWSNNKHLL-SASTDKTVRLWEIGSANCITV 367
Cdd:cd00200   180 ---VNSVAFSPDGEKLLSSSSDGTIklwdlsTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLRTGECVQT 256

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2214449150 368 FP-HSNFVTCVQFNPTNeNQFISGSIDGKIRVWD 400
Cdd:cd00200   257 LSgHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 323-551 5.47e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 5.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 323 PLHEFRGHSGDVLNLSWS-NNKHLLSASTDKTVRLWEIGSANCITVFP-HSNFVTCVQFNPtNENQFISGSIDGKIRVWD 400
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 401 IP-RCSVIDWVDIRDIITAVCYRPDGKGAVVGTITGNCRFYDASDNLLRFETQ--------VAVSGKKK----------- 460
Cdd:cd00200    80 LEtGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvnsVAFSPDGTfvasssqdgti 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 461 -----SSLKRITAFE----------FSPSNpSKLMVTSADSKIKI--LEGTTVTQNYSGLRAGSCqSLAtFTPDGQHIVY 523
Cdd:cd00200   160 klwdlRTGKCVATLTghtgevnsvaFSPDG-EKLLSSSSDGTIKLwdLSTGKCLGTLRGHENGVN-SVA-FSPDGYLLAS 236

                         250       260       270
                  ....*....|....*....|....*....|
gi 2214449150 524 ASEDSNIYVWNHVNQDE-ASLK-HAKTIWS 551
Cdd:cd00200   237 GSEDGTIRVWDLRTGECvQTLSgHTNSVTS 266
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-257 8.10e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 8.10e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2214449150  224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVW 257
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
224-257 6.30e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 6.30e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2214449150 224 QVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVW 257
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
222-260 6.93e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 6.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2214449150 222 QGQVIKGHDGAILTMKFSPDGQFLATGGEDGVVRVWGVA 260
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 320-358 5.31e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 5.31e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2214449150  320 SKQPLHEFRGHSGDVLNLSWS-NNKHLLSASTDKTVRLWE 358
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 361-400 8.59e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 8.59e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2214449150  361 SANCITVFP-HSNFVTCVQFNPtNENQFISGSIDGKIRVWD 400
Cdd:smart00320   1 SGELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
321-358 4.11e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 4.11e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2214449150 321 KQPLHEFRGHSGDVLNLSWS-NNKHLLSASTDKTVRLWE 358
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
363-400 8.83e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 8.83e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2214449150 363 NCITVFP-HSNFVTCVQFNPtNENQFISGSIDGKIRVWD 400
Cdd:pfam00400   2 KLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 318-401 5.10e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 318 QISKQPLHEFRGHSGDVLNLSWSN--NKHLLSASTDKTVRLWEIGSAN----------CItVFPHSNFVTCVQFNPTNEN 385
Cdd:PTZ00420   61 QMRKPPVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI-LKGHKKKISIIDWNPMNYY 139

                          90
                  ....*....|....*.
gi 2214449150 386 QFISGSIDGKIRVWDI 401
Cdd:PTZ00420  140 IMCSSGFDSFVNIWDI 155
PTZ00420 PTZ00420
coronin; Provisional
 226-282 2.09e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 2.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2214449150 226 IKGHDGAILTMKFSP-DGQFLATGGEDGVVRVWGVAQSEDCKIPMDDPSCVyLKAHRQ 282
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVKEIKDPQCI-LKGHKK 126
PTZ00421 PTZ00421
coronin; Provisional
 225-407 2.30e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 225 VIKGHDGAILTMKFSP-DGQFLATGGEDGVVRVWGvaqsedckIPMDdpscvylkahrqsglgpvdadnekkckvkGVKQ 303
Cdd:PTZ00421   70 ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWG--------IPEE-----------------------------GLTQ 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2214449150 304 SADSacvviptavfqiskqPLHEFRGHSGDV--LNLSWSNNKHLLSASTDKTVRLWEIGSANCITVFP-HSNFVTCVQFN 380
Cdd:PTZ00421  113 NISD---------------PIVHLQGHTKKVgiVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKcHSDQITSLEWN 177

                         170       180
                  ....*....|....*....|....*..
gi 2214449150 381 pTNENQFISGSIDGKIRVWDIPRCSVI 407
Cdd:PTZ00421  178 -LDGSLLCTTSKDKKLNIIDPRDGTIV 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH