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Conserved domains on  [gi|2221379269|gb|UOO01118|]
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C1 [Tomato curly stunt virus]

Protein Classification

replication-associated protein( domain architecture ID 10466662)

replication-associated protein is essential for the replication of viral ssDNA by initiating the rolling-circle replication

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gemini_AL1 pfam00799
Geminivirus Rep catalytic domain; The AL1 proteins encodes the replication initiator protein ...
 7-119 3.31e-62

Geminivirus Rep catalytic domain; The AL1 proteins encodes the replication initiator protein (Rep) of geminiviruses, which is a replicon-specific initiator enzyme and is an essential component of the replisome. For geminivirus Rep protein, this N-terminal region is crucial for origin recognition and DNA cleavage and nucleotidyl transfer.


:

Pssm-ID: 366313  Cd Length: 113  Bit Score: 194.30  E-value: 3.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221379269   7 FQINSKNYFVTYPKCSLTKEESLSQLLNLETPTNKKYIKICRELHENGEPHLHVLIQFEGKFNCKNHRFFDLVSPNRSAH 86
Cdd:pfam00799   1 FRIQAKNIFLTYPQCSLSKEEALTQIQKLQTNTNKKYIKIARELHEDGEPHLHVLLQLEKKFRITDLRFFDIVSPTRSAH 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2221379269  87 FHPNIQGAKSSSDVKSYIDKDGDTLEWGEFQVD 119
Cdd:pfam00799  81 FHPNIQGAKSSSDVRSYVDKDGDTIEWGTFQID 113
Gemini_AL1_M super family cl07042
Geminivirus rep protein central domain; This is the cetral domain of the geminivirus rep ...
 126-230 1.87e-35

Geminivirus rep protein central domain; This is the cetral domain of the geminivirus rep proteins.


The actual alignment was detected with superfamily member pfam08283:

Pssm-ID: 285483  Cd Length: 107  Bit Score: 125.02  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221379269 126 GCQNANDACADAL-NADSAEAAMAIIREKLPKDFIFQYHNLKTNLDRIFQAPPEPYISPFSSSSFDQVPEELEEWVSENV 204
Cdd:pfam08283   1 GQKTAKDEYAKAIiNATSKEEYLQIIQEELPKDWVLQHHNIENNADKIFPEAPEPFVPPFPLSSFTNLPEEMQDWVDDYF 80

                          90       100
                  ....*....|....*....|....*..
gi 2221379269 205 -CGAAARPWRPNSIVIEGDSRSGKTIW 230
Cdd:pfam08283  81 gVVSAARPMRPKSIIVEGESRTGKTMW 107
 
Name Accession Description Interval E-value
Gemini_AL1 pfam00799
Geminivirus Rep catalytic domain; The AL1 proteins encodes the replication initiator protein ...
 7-119 3.31e-62

Geminivirus Rep catalytic domain; The AL1 proteins encodes the replication initiator protein (Rep) of geminiviruses, which is a replicon-specific initiator enzyme and is an essential component of the replisome. For geminivirus Rep protein, this N-terminal region is crucial for origin recognition and DNA cleavage and nucleotidyl transfer.


Pssm-ID: 366313  Cd Length: 113  Bit Score: 194.30  E-value: 3.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221379269   7 FQINSKNYFVTYPKCSLTKEESLSQLLNLETPTNKKYIKICRELHENGEPHLHVLIQFEGKFNCKNHRFFDLVSPNRSAH 86
Cdd:pfam00799   1 FRIQAKNIFLTYPQCSLSKEEALTQIQKLQTNTNKKYIKIARELHEDGEPHLHVLLQLEKKFRITDLRFFDIVSPTRSAH 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2221379269  87 FHPNIQGAKSSSDVKSYIDKDGDTLEWGEFQVD 119
Cdd:pfam00799  81 FHPNIQGAKSSSDVRSYVDKDGDTIEWGTFQID 113
Gemini_AL1_M pfam08283
Geminivirus rep protein central domain; This is the cetral domain of the geminivirus rep ...
 126-230 1.87e-35

Geminivirus rep protein central domain; This is the cetral domain of the geminivirus rep proteins.


Pssm-ID: 285483  Cd Length: 107  Bit Score: 125.02  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221379269 126 GCQNANDACADAL-NADSAEAAMAIIREKLPKDFIFQYHNLKTNLDRIFQAPPEPYISPFSSSSFDQVPEELEEWVSENV 204
Cdd:pfam08283   1 GQKTAKDEYAKAIiNATSKEEYLQIIQEELPKDWVLQHHNIENNADKIFPEAPEPFVPPFPLSSFTNLPEEMQDWVDDYF 80

                          90       100
                  ....*....|....*....|....*..
gi 2221379269 205 -CGAAARPWRPNSIVIEGDSRSGKTIW 230
Cdd:pfam08283  81 gVVSAARPMRPKSIIVEGESRTGKTMW 107
 
Name Accession Description Interval E-value
Gemini_AL1 pfam00799
Geminivirus Rep catalytic domain; The AL1 proteins encodes the replication initiator protein ...
 7-119 3.31e-62

Geminivirus Rep catalytic domain; The AL1 proteins encodes the replication initiator protein (Rep) of geminiviruses, which is a replicon-specific initiator enzyme and is an essential component of the replisome. For geminivirus Rep protein, this N-terminal region is crucial for origin recognition and DNA cleavage and nucleotidyl transfer.


Pssm-ID: 366313  Cd Length: 113  Bit Score: 194.30  E-value: 3.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221379269   7 FQINSKNYFVTYPKCSLTKEESLSQLLNLETPTNKKYIKICRELHENGEPHLHVLIQFEGKFNCKNHRFFDLVSPNRSAH 86
Cdd:pfam00799   1 FRIQAKNIFLTYPQCSLSKEEALTQIQKLQTNTNKKYIKIARELHEDGEPHLHVLLQLEKKFRITDLRFFDIVSPTRSAH 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2221379269  87 FHPNIQGAKSSSDVKSYIDKDGDTLEWGEFQVD 119
Cdd:pfam00799  81 FHPNIQGAKSSSDVRSYVDKDGDTIEWGTFQID 113
Gemini_AL1_M pfam08283
Geminivirus rep protein central domain; This is the cetral domain of the geminivirus rep ...
 126-230 1.87e-35

Geminivirus rep protein central domain; This is the cetral domain of the geminivirus rep proteins.


Pssm-ID: 285483  Cd Length: 107  Bit Score: 125.02  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2221379269 126 GCQNANDACADAL-NADSAEAAMAIIREKLPKDFIFQYHNLKTNLDRIFQAPPEPYISPFSSSSFDQVPEELEEWVSENV 204
Cdd:pfam08283   1 GQKTAKDEYAKAIiNATSKEEYLQIIQEELPKDWVLQHHNIENNADKIFPEAPEPFVPPFPLSSFTNLPEEMQDWVDDYF 80

                          90       100
                  ....*....|....*....|....*..
gi 2221379269 205 -CGAAARPWRPNSIVIEGDSRSGKTIW 230
Cdd:pfam08283  81 gVVSAARPMRPKSIIVEGESRTGKTMW 107
DUF6525 pfam20135
Family of unknown function (DUF6525); This family of proteins is functionally uncharacterized. ...
 189-234 9.54e-04

Family of unknown function (DUF6525); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 69 and 100 amino acids in length. There are two conserved sequence motifs: AALPWSP and RAE.


Pssm-ID: 466300  Cd Length: 78  Bit Score: 37.48  E-value: 9.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2221379269 189 FDQVPEELEEWVSEnvcgaAARPWRPnsiviegdsRSGKTIWARSL 234
Cdd:pfam20135  22 YDRLPPPLRRWLAQ-----AALPWSP---------ASALRLWRRAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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