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Conserved domains on  [gi|2250083697|gb|URW97254|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Crocidura baluensis]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.86e-37

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.19  E-value: 1.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  1 MSLVYMNAALAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2250083697 81 VSNTYGADFVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.86e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.19  E-value: 1.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  1 MSLVYMNAALAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2250083697 81 VSNTYGADFVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 8.55e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 53.34  E-value: 8.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  3 LVYMNAALAFSISTLGLLmYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 2250083697 83 NTYGADFVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.86e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 121.19  E-value: 1.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  1 MSLVYMNAALAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2250083697 81 VSNTYGADFVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.44e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 83.36  E-value: 1.44e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  1 MSLVYMNAALAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVM 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 2250083697 81 VSNTYGADFVQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.88e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 79.24  E-value: 6.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  1 MSLVYMNAALAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVM 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 2250083697 81 VSNTYGADFVQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.03e-17

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 71.17  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  1 MSLVYMNAALAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVM 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 2250083697 81 VSNTYGADFVQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 2.81e-11

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 54.56  E-value: 2.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  9 ALAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVMVSNTYGAD 88
Cdd:MTH00181   6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                 ....*...
gi 2250083697 89 FVQNLNLL 96
Cdd:MTH00181  86 HLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 8.55e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 53.34  E-value: 8.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  3 LVYMNAALAFSISTLGLLmYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 2250083697 83 NTYGADFVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 12-97 7.43e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 51.07  E-value: 7.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697 12 FSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVMVSNTYGADFVQ 91
Cdd:MTH00043  12 FFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVLLSRNHNSDLVA 91


                 ....*.
gi 2250083697 92 NLNLLQ 97
Cdd:MTH00043  92 SLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 12-98 1.13e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 43.04  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697 12 FSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHFTLasMLPIVLLVFAACEAAVGLSLLVMVSNTYGADFVQ 91
Cdd:MTH00188  13 VVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKEL--YLSLVLLTFAACEASVGLALLVSLIRSHGSDYVS 90


                 ....*..
gi 2250083697 92 NLNLLQC 98
Cdd:MTH00188  91 SLNLIKC 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 1.21e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 42.45  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697 12 FSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLgtMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVMVSNTYGADFVQ 91
Cdd:MTH00162  11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                 .
gi 2250083697 92 N 92
Cdd:MTH00162  89 S 89
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.00e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 40.21  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697  1 MSLVYMNAALAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFtlGTMTILITHFTLASMLPIVLLVFAACEAAVGLSLLVM 80
Cdd:MTH00149   2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLL--VMMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVS 79

                         90
                 ....*....|....*...
gi 2250083697 81 VSNTYGADFVQNLNLLQC 98
Cdd:MTH00149  80 LIRLHGNDYVSSLSSLKF 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 10-98 2.69e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 39.35  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250083697 10 LAFSISTLGLLMYRMHLMSSLLCLEGMMLSLFTLGTMTILITHfTLASMLPIVLLVFAACEAAVGLSLLVMVSNTYGADF 89
Cdd:MTH00013  10 ISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFAN-QVNGMLAIVLLTFGACEASLGLSLLVLMTRSYGNDM 88


                 ....*....
gi 2250083697 90 VQNLNLLQC 98
Cdd:MTH00013  89 LKSLTSNKC 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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