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Conserved domains on  [gi|2258869593|gb|USN92708|]
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MAG: type II secretion system protein [Candidatus Nomurabacteria bacterium]

Protein Classification

type II secretion system protein( domain architecture ID 11450365)

type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0005886|GO:0015628|GO:0015627
PubMed:  30767847|1365398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 14-74 8.99e-17

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 71.87  E-value: 8.99e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIELDYGMTGTY 74
Cdd:COG2165     9 RQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGRY 69
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 14-74 8.99e-17

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 71.87  E-value: 8.99e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIELDYGMTGTY 74
Cdd:COG2165     9 RQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGRY 69
PRK10574 PRK10574
putative major pilin subunit; Provisional
 14-66 1.43e-07

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 48.49  E-value: 1.43e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIEL 66
Cdd:PRK10574    3 KQRGFTLIELMVVIAIIAILSAIGIPAYQNYLQKAALTDMLQTFVPYKTAVEL 55
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 14-38 2.46e-07

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 45.06  E-value: 2.46e-07
                          10        20
                  ....*....|....*....|....*
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVL 38
Cdd:pfam07963   3 KQRGFTLIELLVALAILAILLAAAL 27
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 17-90 7.17e-07

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 46.65  E-value: 7.17e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2258869593  17 GFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIELDYGMTGTYAHND--LQWFRLPPTTSP 90
Cdd:TIGR01710   2 GFTLLEIMVVLVILGLLAALVAPKLFSQADKAKAQVAKAQIKALKNALDMYRLDNGRYPTEEqgLAALVTKPSGEP 77
T4P_ComGE NF041013
competence type IV pilus minor pilin ComGE;
17-65 8.20e-04

competence type IV pilus minor pilin ComGE;


Pssm-ID: 468942 [Multi-domain]  Cd Length: 83  Bit Score: 36.79  E-value: 8.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2258869593  17 GFTLIELLVVITIVGILSAVVLSSLkdMRMTAKDTLIKQQIRSIVTAIE 65
Cdd:NF041013    5 GFILLESLVALALLALIVSLLLPSL--TQIQKEREEIKQKEEALQVLYE 51
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 14-74 8.99e-17

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 71.87  E-value: 8.99e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIELDYGMTGTY 74
Cdd:COG2165     9 RQRGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALERYRLDNGRY 69
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
14-89 7.21e-15

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 67.79  E-value: 7.21e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIELDYGMTGTYAhNDLQWFRLPPTTS 89
Cdd:COG4968     8 RQRGFTLIELMIVVAIIGILAAIAIPSYQDYVERARRAEAKAALLELAQAQERYYADNGSYP-SALADLGLPASTS 82
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
14-66 1.42e-11

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 57.55  E-value: 1.42e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKdtlIKQQIRSIVTAIEL 66
Cdd:COG4970     7 RQRGFTLIELLVVLAILAILAAIAVPSFSSLIARQR---LRAAANELAAALRL 56
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
13-78 1.58e-11

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 58.95  E-value: 1.58e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2258869593  13 LRQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIELDYGMTGTYAHND 78
Cdd:COG4969     3 KKQKGFTLIELMIVVAIIGILAAIAIPAYQDYVARARVSEALALASPLKTAVEECALENGSLPNCN 68
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
14-74 6.46e-10

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 54.16  E-value: 6.46e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIELDYGMTGTY 74
Cdd:COG4537    10 KEKGFTLIEMLIVLLIISILLLIAVPNLTKQRETAQEKGCEANIKMVQSQVELYELDHGTY 70
PRK10574 PRK10574
putative major pilin subunit; Provisional
 14-66 1.43e-07

putative major pilin subunit; Provisional


Pssm-ID: 236718 [Multi-domain]  Cd Length: 146  Bit Score: 48.49  E-value: 1.43e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIEL 66
Cdd:PRK10574    3 KQRGFTLIELMVVIAIIAILSAIGIPAYQNYLQKAALTDMLQTFVPYKTAVEL 55
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 14-38 2.46e-07

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 45.06  E-value: 2.46e-07
                          10        20
                  ....*....|....*....|....*
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVL 38
Cdd:pfam07963   3 KQRGFTLIELLVALAILAILLAAAL 27
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 17-90 7.17e-07

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 46.65  E-value: 7.17e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2258869593  17 GFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTLIKQQIRSIVTAIELDYGMTGTYAHND--LQWFRLPPTTSP 90
Cdd:TIGR01710   2 GFTLLEIMVVLVILGLLAALVAPKLFSQADKAKAQVAKAQIKALKNALDMYRLDNGRYPTEEqgLAALVTKPSGEP 77
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 15-38 1.06e-06

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 43.45  E-value: 1.06e-06
                          10        20
                  ....*....|....*....|....
gi 2258869593  15 QDGFTLIELLVVITIVGILSAVVL 38
Cdd:TIGR02532   1 QRGFTLIELLVVLAILGILALIAL 24
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 12-67 1.21e-06

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 45.39  E-value: 1.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2258869593  12 HLRQDGFTLIELLVVITIVGILSAVVLSSLKDM-----RMTAKDTLIkQQIRSIVTAIELD 67
Cdd:COG4795     5 RRRQRGFTLLELLVALAIFALLLLAAYRGLDSVlrsreRLEQQAERL-QELQRALALLERD 64
typeII_sec_gspH TIGR01708
type II secretion system protein H; This model represents GspH, protein H of the main terminal ...
 14-73 1.82e-06

type II secretion system protein H; This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130769 [Multi-domain]  Cd Length: 143  Bit Score: 45.63  E-value: 1.82e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRmtaKDTLIKQQIRSIVTAIELDYG---MTGT 73
Cdd:TIGR01708   2 RQSGFTLIELLVVLAIMGLVAAAAALSLVSHY---GTKSLDQVAGRLAARLRLAQTsarATGR 61
PilW COG4966
Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];
14-96 1.07e-05

Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];


Pssm-ID: 443992 [Multi-domain]  Cd Length: 158  Bit Score: 43.63  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2258869593  14 RQDGFTLIELLVVITIVGILSAVVLSSLKDMRMTAKDTL----IKQQIRSIVTAIELDYGMTGTYAHNDLQWFRLPPTTS 89
Cdd:COG4966     3 RQRGFTLVELMVALAIGLIVLAAVLQLFLSSRRSYRTQEalarLQENGRFALDLLSRDLRQAGYFGCASGNGNPNGGASV 82


                  ....*..
gi 2258869593  90 PGESCAD 96
Cdd:COG4966    83 DIADDVS 89
PRK10506 PRK10506
prepilin peptidase-dependent protein;
14-35 1.58e-05

prepilin peptidase-dependent protein;


Pssm-ID: 236704 [Multi-domain]  Cd Length: 162  Bit Score: 43.06  E-value: 1.58e-05
                          10        20
                  ....*....|....*....|..
gi 2258869593  14 RQDGFTLIELLVVITIVGILSA 35
Cdd:PRK10506    7 KQRGYTLIELLVVMTIVSILSA 28
T4P_ComGE NF041013
competence type IV pilus minor pilin ComGE;
17-65 8.20e-04

competence type IV pilus minor pilin ComGE;


Pssm-ID: 468942 [Multi-domain]  Cd Length: 83  Bit Score: 36.79  E-value: 8.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2258869593  17 GFTLIELLVVITIVGILSAVVLSSLkdMRMTAKDTLIKQQIRSIVTAIE 65
Cdd:NF041013    5 GFILLESLVALALLALIVSLLLPSL--TQIQKEREEIKQKEEALQVLYE 51
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
14-38 7.61e-03

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 34.19  E-value: 7.61e-03
                          10        20
                  ....*....|....*....|....*..
gi 2258869593  14 RQDGFTLIELLV--VITIVGILSAVVL 38
Cdd:COG4967     9 RQRGFTLIEVLValVILSIGLLGLAGL 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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