NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2290538542|gb|UVP69436|]
View 

S46 family peptidase [Bacteroides fragilis]

Protein Classification

S46 family peptidase( domain architecture ID 12106229)

S46 family peptidase is a serine protease similar to Capnocytophaga gingivalis dipeptidyl-peptidase 7 and Asp/Glu-specific dipeptidyl-peptidase, which catalyze the removal of dipeptides from the N-terminus of oligopeptides

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Peptidase_S46 pfam10459
Peptidase S46; Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. ...
 35-722 0e+00

Peptidase S46; Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.


:

Pssm-ID: 431297  Cd Length: 695  Bit Score: 1019.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542  35 DEGMWMLGNLNKETRKtMKELGLQMPADQLYSTRHPSlKDAVVSFGGFCSGVVVSEDGLVFTNHHCGFSSIQQHSSVDHD 114
Cdd:pfam10459   1 DEGMWTPQQLPEQADK-LKALGLEIDAEWLYNLRRSS-KDAVVRFGGGCTGSFVSPDGLVLTNHHCAYGAIQQHSSVEHD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 115 YLKDGFTAHSREEELPNPELYVRFLLRTENVTRRVLKATTPGMTESERSLAIDSMMVLLGDEVTKKDSTLVgIVDAYYGG 194
Cdd:pfam10459  79 YLKDGFLAKSRAEELPAPGLRVTVLVRITDVTDRVRAALKAGTDGEERSKAIEARLKALAKECEKEDGLRC-EVVAFYGG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 195 NEFWLSVYRDFNDVRLVFAPPSSIGKFGWDTDNWMWPRHTGDFCVFRIYAGKDNRPADYSPDNVPYRPEYVAPITLDGYK 274
Cdd:pfam10459 158 NEYYLYKYREYKDVRLVFAPPSSIGKFGGDTDNWMWPRHTGDFSFFRAYAGKDGKPADYSKDNVPYKPKHFLKISLKGVK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 275 EGSFCMTLGYPGSTERYLSSFGIEEMMNGMNQAMIDVRGVKQAIWKREMDRRDSIRIKYASKYDESSNYWKNSIGTNKAI 354
Cdd:pfam10459 238 EGDFVFVAGYPGSTSRYLTSAEVEERRDWVNPARIDRRGERQALLEREMLKDPEIRIKYASKLAGSANYWKNLIGMLEGL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 355 RKLKVLDKKRQAEEALRQWIQKTPAEREKLLHLMSSLELNYKDRKEVNRAMSYFGESFINGPELVQFALTILNFDFEAE- 433
Cdd:pfam10459 318 RDLDVLAKKQAREAALRAWLRKDPARRKKYGDALDELDALQAERRDLARRYYYFEEAFSGGSELLSAARTLVRLAKEREk 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 434 ----------QKQVVAQLQKLLDKYANYDVSIDKEVFVAMLKEYRSKVDKAYLPDLYQTIDTLYGGNEQMYVDTLYAHSE 503
Cdd:pfam10459 398 pdaerepgyqERALPTLKKSLERIDADYDPEVDKAVLAAMLEEYRELLGADRLPAVDKLLGKEFKGSPDAYADRLYAGSK 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 504 LTSPRGLKRFLERDT-TFHMIDDPAVSLGIDLIVKLFDMRSQMAEASDNIEKDEREFNAAMRRMYADRNFYPDANSTMRL 582
Cdd:pfam10459 478 LTDPANRLALLEGGKaAVEASKDPMIALAVALADARRALEKAEKELDGAIERARPLYAKARLAMYGSTPVYPDANSTLRL 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 583 SFGTIGSYSPYDGADYGYYTTVKGIFEkvKEHSGDPDFAVQPEVLSLLSSGDFGRYADTKGDMNVCFISNNDITGGNSGS 662
Cdd:pfam10459 558 TYGQVKGYSPRDGVYYPPFTTLDGVFE--KEDTGEEPFDVPEKLLDAIEAKDFGRYAAENGSVPVNFLSTNDITGGNSGS 635

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 663 AMFNGKGELLGLAFDGNWEAMSSDIVFEPDVQRCIGVDVRYMLFIIEKFGKASHLIQELK 722
Cdd:pfam10459 636 PVLNGKGELVGLAFDGNWESLSGDIGFDPDLQRAVAVDIRYILWALDKVYGADHLIDELT 695
 
Name Accession Description Interval E-value
Peptidase_S46 pfam10459
Peptidase S46; Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. ...
 35-722 0e+00

Peptidase S46; Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.


Pssm-ID: 431297  Cd Length: 695  Bit Score: 1019.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542  35 DEGMWMLGNLNKETRKtMKELGLQMPADQLYSTRHPSlKDAVVSFGGFCSGVVVSEDGLVFTNHHCGFSSIQQHSSVDHD 114
Cdd:pfam10459   1 DEGMWTPQQLPEQADK-LKALGLEIDAEWLYNLRRSS-KDAVVRFGGGCTGSFVSPDGLVLTNHHCAYGAIQQHSSVEHD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 115 YLKDGFTAHSREEELPNPELYVRFLLRTENVTRRVLKATTPGMTESERSLAIDSMMVLLGDEVTKKDSTLVgIVDAYYGG 194
Cdd:pfam10459  79 YLKDGFLAKSRAEELPAPGLRVTVLVRITDVTDRVRAALKAGTDGEERSKAIEARLKALAKECEKEDGLRC-EVVAFYGG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 195 NEFWLSVYRDFNDVRLVFAPPSSIGKFGWDTDNWMWPRHTGDFCVFRIYAGKDNRPADYSPDNVPYRPEYVAPITLDGYK 274
Cdd:pfam10459 158 NEYYLYKYREYKDVRLVFAPPSSIGKFGGDTDNWMWPRHTGDFSFFRAYAGKDGKPADYSKDNVPYKPKHFLKISLKGVK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 275 EGSFCMTLGYPGSTERYLSSFGIEEMMNGMNQAMIDVRGVKQAIWKREMDRRDSIRIKYASKYDESSNYWKNSIGTNKAI 354
Cdd:pfam10459 238 EGDFVFVAGYPGSTSRYLTSAEVEERRDWVNPARIDRRGERQALLEREMLKDPEIRIKYASKLAGSANYWKNLIGMLEGL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 355 RKLKVLDKKRQAEEALRQWIQKTPAEREKLLHLMSSLELNYKDRKEVNRAMSYFGESFINGPELVQFALTILNFDFEAE- 433
Cdd:pfam10459 318 RDLDVLAKKQAREAALRAWLRKDPARRKKYGDALDELDALQAERRDLARRYYYFEEAFSGGSELLSAARTLVRLAKEREk 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 434 ----------QKQVVAQLQKLLDKYANYDVSIDKEVFVAMLKEYRSKVDKAYLPDLYQTIDTLYGGNEQMYVDTLYAHSE 503
Cdd:pfam10459 398 pdaerepgyqERALPTLKKSLERIDADYDPEVDKAVLAAMLEEYRELLGADRLPAVDKLLGKEFKGSPDAYADRLYAGSK 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 504 LTSPRGLKRFLERDT-TFHMIDDPAVSLGIDLIVKLFDMRSQMAEASDNIEKDEREFNAAMRRMYADRNFYPDANSTMRL 582
Cdd:pfam10459 478 LTDPANRLALLEGGKaAVEASKDPMIALAVALADARRALEKAEKELDGAIERARPLYAKARLAMYGSTPVYPDANSTLRL 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 583 SFGTIGSYSPYDGADYGYYTTVKGIFEkvKEHSGDPDFAVQPEVLSLLSSGDFGRYADTKGDMNVCFISNNDITGGNSGS 662
Cdd:pfam10459 558 TYGQVKGYSPRDGVYYPPFTTLDGVFE--KEDTGEEPFDVPEKLLDAIEAKDFGRYAAENGSVPVNFLSTNDITGGNSGS 635

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 663 AMFNGKGELLGLAFDGNWEAMSSDIVFEPDVQRCIGVDVRYMLFIIEKFGKASHLIQELK 722
Cdd:pfam10459 636 PVLNGKGELVGLAFDGNWESLSGDIGFDPDLQRAVAVDIRYILWALDKVYGADHLIDELT 695
 
Name Accession Description Interval E-value
Peptidase_S46 pfam10459
Peptidase S46; Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. ...
 35-722 0e+00

Peptidase S46; Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.


Pssm-ID: 431297  Cd Length: 695  Bit Score: 1019.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542  35 DEGMWMLGNLNKETRKtMKELGLQMPADQLYSTRHPSlKDAVVSFGGFCSGVVVSEDGLVFTNHHCGFSSIQQHSSVDHD 114
Cdd:pfam10459   1 DEGMWTPQQLPEQADK-LKALGLEIDAEWLYNLRRSS-KDAVVRFGGGCTGSFVSPDGLVLTNHHCAYGAIQQHSSVEHD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 115 YLKDGFTAHSREEELPNPELYVRFLLRTENVTRRVLKATTPGMTESERSLAIDSMMVLLGDEVTKKDSTLVgIVDAYYGG 194
Cdd:pfam10459  79 YLKDGFLAKSRAEELPAPGLRVTVLVRITDVTDRVRAALKAGTDGEERSKAIEARLKALAKECEKEDGLRC-EVVAFYGG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 195 NEFWLSVYRDFNDVRLVFAPPSSIGKFGWDTDNWMWPRHTGDFCVFRIYAGKDNRPADYSPDNVPYRPEYVAPITLDGYK 274
Cdd:pfam10459 158 NEYYLYKYREYKDVRLVFAPPSSIGKFGGDTDNWMWPRHTGDFSFFRAYAGKDGKPADYSKDNVPYKPKHFLKISLKGVK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 275 EGSFCMTLGYPGSTERYLSSFGIEEMMNGMNQAMIDVRGVKQAIWKREMDRRDSIRIKYASKYDESSNYWKNSIGTNKAI 354
Cdd:pfam10459 238 EGDFVFVAGYPGSTSRYLTSAEVEERRDWVNPARIDRRGERQALLEREMLKDPEIRIKYASKLAGSANYWKNLIGMLEGL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 355 RKLKVLDKKRQAEEALRQWIQKTPAEREKLLHLMSSLELNYKDRKEVNRAMSYFGESFINGPELVQFALTILNFDFEAE- 433
Cdd:pfam10459 318 RDLDVLAKKQAREAALRAWLRKDPARRKKYGDALDELDALQAERRDLARRYYYFEEAFSGGSELLSAARTLVRLAKEREk 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 434 ----------QKQVVAQLQKLLDKYANYDVSIDKEVFVAMLKEYRSKVDKAYLPDLYQTIDTLYGGNEQMYVDTLYAHSE 503
Cdd:pfam10459 398 pdaerepgyqERALPTLKKSLERIDADYDPEVDKAVLAAMLEEYRELLGADRLPAVDKLLGKEFKGSPDAYADRLYAGSK 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 504 LTSPRGLKRFLERDT-TFHMIDDPAVSLGIDLIVKLFDMRSQMAEASDNIEKDEREFNAAMRRMYADRNFYPDANSTMRL 582
Cdd:pfam10459 478 LTDPANRLALLEGGKaAVEASKDPMIALAVALADARRALEKAEKELDGAIERARPLYAKARLAMYGSTPVYPDANSTLRL 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 583 SFGTIGSYSPYDGADYGYYTTVKGIFEkvKEHSGDPDFAVQPEVLSLLSSGDFGRYADTKGDMNVCFISNNDITGGNSGS 662
Cdd:pfam10459 558 TYGQVKGYSPRDGVYYPPFTTLDGVFE--KEDTGEEPFDVPEKLLDAIEAKDFGRYAAENGSVPVNFLSTNDITGGNSGS 635

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2290538542 663 AMFNGKGELLGLAFDGNWEAMSSDIVFEPDVQRCIGVDVRYMLFIIEKFGKASHLIQELK 722
Cdd:pfam10459 636 PVLNGKGELVGLAFDGNWESLSGDIGFDPDLQRAVAVDIRYILWALDKVYGADHLIDELT 695
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH