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Conserved domains on  [gi|2327533383|gb|UZH24719|]
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bloodgroup CO protein [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-227 1.26e-102

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 298.08  E-value: 1.26e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383   4 EFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNqtAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSL--AVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  84 LLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRD 163
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2327533383 164 LGGS-APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:pfam00230 159 SLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-227 1.26e-102

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 298.08  E-value: 1.26e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383   4 EFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNqtAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSL--AVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  84 LLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRD 163
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2327533383 164 LGGS-APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:pfam00230 159 SLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-227 5.57e-88

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 260.69  E-value: 5.57e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  16 AEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRAL 95
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  96 MYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLA-DGVNSGQGLGIEIIGTLQLVLCVLATTD-RRRRDLGGSAPLAIG 173
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSAsAGVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2327533383 174 LSVALGHLLAIDYTGCGINPARSFGSAVITH--NFSNHWIFWVGPFIGGALAVLIY 227
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-230 1.68e-81

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 244.47  E-value: 1.68e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLG----IALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  92 FRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRN---------DLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRR 162
Cdd:cd00333    77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANnivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNG 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2327533383 163 -DLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFS---NHWIFWVGPFIGGALAVLIYDFI 230
Cdd:cd00333   157 pPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-232 8.16e-56

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 179.17  E-value: 8.16e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  10 FWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVqdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 89
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLG-----IALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  90 SIFRALMYIIAQCVGAIVATAILSGI------TSSLTGNSLGR--NDLADGVNSGQGLGIEIIGTLQLVLCVLATTDrRR 161
Cdd:COG0580    77 PWKDVLPYIIAQLLGAFLGAALVYLIygghfdATEDGGAKLGVfaTSPAIGYSLGAAFLTEIIGTFVLVFVILGITD-KR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2327533383 162 RDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVI------THNFSNHWIFWVGPFIGGALAVLIYDFILA 232
Cdd:COG0580   156 AAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PLN00166 PLN00166
aquaporin TIP2; Provisional
 12-227 1.02e-45

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 153.94  E-value: 1.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  92 FRALMYIIAQCVGAIVATAILSGITSsltGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLGGSAPL 170
Cdd:PLN00166   99 ITGFFYWIAQCLGSIVACLLLVFVTN---GESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAaDPKKGSLGTIAPI 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2327533383 171 AIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:PLN00166  176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIY 232
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-227 1.26e-102

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 298.08  E-value: 1.26e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383   4 EFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNqtAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSL--AVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  84 LLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRD 163
Cdd:pfam00230  79 LVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2327533383 164 LGGS-APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:pfam00230 159 SLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-227 5.57e-88

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 260.69  E-value: 5.57e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  16 AEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRAL 95
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  96 MYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLA-DGVNSGQGLGIEIIGTLQLVLCVLATTD-RRRRDLGGSAPLAIG 173
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSAsAGVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2327533383 174 LSVALGHLLAIDYTGCGINPARSFGSAVITH--NFSNHWIFWVGPFIGGALAVLIY 227
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-230 1.68e-81

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 244.47  E-value: 1.68e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLG----IALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  92 FRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRN---------DLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRR 162
Cdd:cd00333    77 IRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANnivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNG 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2327533383 163 -DLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFS---NHWIFWVGPFIGGALAVLIYDFI 230
Cdd:cd00333   157 pPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-232 8.16e-56

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 179.17  E-value: 8.16e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  10 FWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVqdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 89
Cdd:COG0580     2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLG-----IALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  90 SIFRALMYIIAQCVGAIVATAILSGI------TSSLTGNSLGR--NDLADGVNSGQGLGIEIIGTLQLVLCVLATTDrRR 161
Cdd:COG0580    77 PWKDVLPYIIAQLLGAFLGAALVYLIygghfdATEDGGAKLGVfaTSPAIGYSLGAAFLTEIIGTFVLVFVILGITD-KR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2327533383 162 RDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVI------THNFSNHWIFWVGPFIGGALAVLIYDFILA 232
Cdd:COG0580   156 AAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PLN00166 PLN00166
aquaporin TIP2; Provisional
 12-227 1.02e-45

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 153.94  E-value: 1.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  92 FRALMYIIAQCVGAIVATAILSGITSsltGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLGGSAPL 170
Cdd:PLN00166   99 ITGFFYWIAQCLGSIVACLLLVFVTN---GESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAaDPKKGSLGTIAPI 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2327533383 171 AIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:PLN00166  176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIY 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 12-230 1.74e-45

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 153.40  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSL--AFGLSIATlaqSVG-HISGAHLNPAVTLGLLLSCQ 88
Cdd:PLN00027   21 KAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALahAFALFVAV---SVGaNISGGHVNPAVTFGAFIGGN 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  89 ISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGrndLADGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLGGS 167
Cdd:PLN00027   98 ITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFS---LSSGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGII 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2327533383 168 APLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFI 230
Cdd:PLN00027  175 APIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
PRK05420 PRK05420
aquaporin Z; Provisional
 12-235 2.57e-40

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 139.33  E-value: 2.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIGSA----------LGFkypvgnnqtavqdnVKVSLAFGLSIATLAQSVGHISGAHLNPAVTL 81
Cdd:PRK05420    3 KKLAAEFFGTFWLVFGGCGSAvlaaafpelgIGF--------------LGVALAFGLTVLTMAYAVGHISGGHFNPAVSV 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  82 GLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLA---------DGVNSGQGLGIEIIGTLQLVLC 152
Cdd:PRK05420   69 GLWAGGRFPAKELVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFAsngygehspGGYSLLAALVCEVVLTAFFLLV 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383 153 VLATTDRRRRdlGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNF--SNHWIFWVGPFIGGALAVLIYDFI 230
Cdd:PRK05420  149 ILGATDKRAP--AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLL 226


                  ....*
gi 2327533383 231 LAPRS 235
Cdd:PRK05420  227 LEKDD 231
PLN00167 PLN00167
aquaporin TIP5; Provisional
 12-240 1.85e-34

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 124.63  E-value: 1.85e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISI 91
Cdd:PLN00167   23 RSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  92 FRALMYIIAQCVGAIVATAILSGITsslTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLA 171
Cdd:PLN00167  103 PTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRGLLGAIGPLA 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2327533383 172 IGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTD 240
Cdd:PLN00167  180 IGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFPTQDDRGS 248
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 8-233 5.39e-25

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 100.59  E-value: 5.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383   8 KLFWRAVVAEFLATtlFVFISIGSALgfkypVGNNQTAVQDNVKVSLAFGLSIAT---LAQSVGhISGAHLNPAVTLGll 84
Cdd:PTZ00016   47 RPNVREYVAEFLGT--FVLLFFGEGV-----VATTHTVGNNGDYLAITIGWGLGVtfgLLVSAG-ISGGHLNPAVTLG-- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  85 lSCQISIF---RALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGlGI---------------EIIGT 146
Cdd:PTZ00016  117 -NAVFGKFpwkKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETMANGFA-GVfatypregnfyaifsELILT 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383 147 LQLVLCVLATTDRRRRDLGGSAPLAIGLSV-ALGHLLAIDyTGCGINPARSF----------GSAVITHNFSNHWIFWVG 215
Cdd:PTZ00016  195 AILLLVILAITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLgprlfsailwGSEVFTKDNYYFWVPLVA 273

                         250
                  ....*....|....*...
gi 2327533383 216 PFIGGALAVLIYDFILAP 233
Cdd:PTZ00016  274 PFVGAVLGMFLYDKFIPP 291
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 14-230 6.84e-23

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 94.59  E-value: 6.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  14 VVAEFLATTLFVFISIGSALgfkypVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFR 93
Cdd:PLN00182   45 LIAEMIGTYFIIFSGCGVVV-----VNVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQ 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  94 ALMYIIAQCVGAIVATAILSgITSSLTGNSLGRNDLADgvNSGQGLGIEIIGT--LQLVLCVLATTDRRRRDLGGsapLA 171
Cdd:PLN00182  120 VPLYIGAQLTGSLLASLTLR-LMFNVTPEAFFGTTPTD--SSGQALVAEIIISflLMFVISGVATDSRAVGELAG---IA 193

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2327533383 172 IGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFI 230
Cdd:PLN00182  194 VGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLI 252
PLN00184 PLN00184
aquaporin NIP1; Provisional
 10-230 2.06e-22

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 93.93  E-value: 2.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  10 FWRAVVAEFLATTLFVFISIGSAlgfkypVGNNQtavQDNV----KVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLL 85
Cdd:PLN00184   53 FLQKLIAEVLGTYFLVFTGCASV------VVNMQ---NDNVvtlpGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFAS 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  86 SCQISIFRALMYIIAQCVGAIVATAIL-----------SGITSSLTGNSLGRNDLadgvnsgQGLGIEIIGTLQLVLcVL 154
Cdd:PLN00184  124 CGRFPLKQVPAYVISQVIGSTLAAATLrllfgldhdvcSGKHDVFIGSSPVGSDL-------QAFVMEFIVTFYLMF-II 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2327533383 155 ATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFI 230
Cdd:PLN00184  196 SGVATDNRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTV 271
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 12-230 1.88e-20

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 87.99  E-value: 1.88e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIG---SALGFKYPVGNNQTAVqdnvkvslAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQ 88
Cdd:PLN00183   46 RMVLAEMVGTFILMFCVCGiiaSTQLSGGEVGLLEYAA--------TAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGH 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  89 ISIFRALMYIIAQCVGAIVATaiLSGITSSLTGNSLGRNDLADGVNSgqGLGIEIIGTLQLVLCVLATTDrRRRDLGGSA 168
Cdd:PLN00183  118 FPWSKVPLYITAQTVGSVLAT--YVGVSVYGVKADLMTTKPAQGCSS--AFWVEFIATFIVMFLAASLTS-QPQSLGHLS 192

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2327533383 169 PLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFI 230
Cdd:PLN00183  193 GFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLL 254
PLN00026 PLN00026
aquaporin NIP; Provisional
 12-227 5.25e-20

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 87.22  E-value: 5.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  12 RAVVAEFLATTLFVFISIGSAL------GFKYPVGNNQTAvqdnvkvslafGLSIATLAQSVGHISGAHLNPAVTLGLLL 85
Cdd:PLN00026   72 RKLGAEFVGTFILIFAATAGPIvnqkydGAETLIGNAACA-----------GLAVMIVILSTGHISGAHLNPSLTIAFAA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327533383  86 SCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLgrndLADGVNSGQGLGIEIIGTLQLVLCVLAT-TDRRRrdL 164
Cdd:PLN00026  141 LRHFPWKHVPAYIAAQVSASICASFALKGVFHPFMSGGV----TVPSVSTGQAFALEFIITFNLLFVVTAVaTDTRA--V 214

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2327533383 165 GGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIY 227
Cdd:PLN00026  215 GELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTY 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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