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Conserved domains on  [gi|2431123074|gb|WCB27189|]
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chaperone protein DnaJ, partial [Lelliottia nimipressuralis]

Protein Classification

molecular chaperone DnaJ( domain architecture ID 11484931)

molecular chaperone DnaJ, part of the DnaK-DnaJ-GrpE system, prevents the aggregation of unfolded substrate and acts primarily by stimulating the ATPase activity of Hsp70

CATH:  2.10.230.10
Gene Ontology:  GO:0051082|GO:0009408|GO:0005524|GO:0006457
PubMed:  8016869|15063739|19060069

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 2-234 1.04e-175

chaperone protein DnaJ; Provisional


:

Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 486.96  E-value: 1.04e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKT 81
Cdd:PRK10767  133 VTKEIRIPTLVTCDTCHGSGAKPGTSPKTCPTCHGAGQVRMQQGFFTVQQTCPTCHGRGKIIKDPCKKCHGQGRVEKEKT 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNL 161
Cdd:PRK10767  213 LSVKIPAGVDTGDRIRLSGEGEAGERGGPAGDLYVQIHVKEHPIFERDGNDLYCEVPISFTTAALGGEIEVPTLDGRVKL 292

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFGGptGENNSPRSKSFF 234
Cdd:PRK10767  293 KIPEGTQTGKLFRLRGKGVKSVRSGARGDLYCQVVVETPVNLTKRQKELLEEFEESFES--GEKHSPKSKGFF 363
 
Name Accession Description Interval E-value
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 2-234 1.04e-175

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 486.96  E-value: 1.04e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKT 81
Cdd:PRK10767  133 VTKEIRIPTLVTCDTCHGSGAKPGTSPKTCPTCHGAGQVRMQQGFFTVQQTCPTCHGRGKIIKDPCKKCHGQGRVEKEKT 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNL 161
Cdd:PRK10767  213 LSVKIPAGVDTGDRIRLSGEGEAGERGGPAGDLYVQIHVKEHPIFERDGNDLYCEVPISFTTAALGGEIEVPTLDGRVKL 292

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFGGptGENNSPRSKSFF 234
Cdd:PRK10767  293 KIPEGTQTGKLFRLRGKGVKSVRSGARGDLYCQVVVETPVNLTKRQKELLEEFEESFES--GEKHSPKSKGFF 363
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 2-218 3.70e-117

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 338.04  E-value: 3.70e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:TIGR02349 134 VEKEIEIPRKESCETCHGTGAKPGTDPKTCPTCGGTGQVRRQQgtpfGFFQQQQTCPTCGGEGKIIKEPCSTCKGKGRVK 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:TIGR02349 214 ERKTITVKIPAGVDTGQRLRVSGKGNAGENGGPNGDLYVVIRVKPHKIFERDGNDLYIEVPISFTQAILGGEIEVPTLDG 293

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESF 218
Cdd:TIGR02349 294 DVKLKIPAGTQSGTVFRLKGKGVPRLRGNGRGDLLVTVKVETPKNLSKEQKELLEELAEAS 354
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 2-200 1.16e-91

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 268.35  E-value: 1.16e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKtKT 81
Cdd:pfam01556  16 CTKKIKITRNVICDTCGGSGAKPGTSPKTCPCCGGGGQVRRQFGFFSTCTCCPCCGGGGKIIDKCCKCCGGGGVVEK-KT 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNL 161
Cdd:pfam01556  95 LEVKIPAGVDDGQRIRLRGEGDAGENGGPPGDLYVVIRVKPHPVFRRDGDDLYCTVPISLTEALLGGTIEVPTLDGKVKL 174

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETP 200
Cdd:pfam01556 175 KIPAGTQPGTVLRLKGKGMPRLKGGGRGDLYVTVKVEVP 213
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 75-203 1.05e-65

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 200.34  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  75 RVEKTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPT 154
Cdd:cd10747    30 RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGPNGGPPGDLYVVIRVKPHPVFRRDGNDLYCEVPISLTEALLGGEIEVPT 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2431123074 155 LDGRVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGL 203
Cdd:cd10747   110 LGGKVKLKIPPGTQPGTVLRLKGKGMPRLRGGGRGDLYVEVKVEFPKKL 158
 
Name Accession Description Interval E-value
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 2-234 1.04e-175

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 486.96  E-value: 1.04e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKT 81
Cdd:PRK10767  133 VTKEIRIPTLVTCDTCHGSGAKPGTSPKTCPTCHGAGQVRMQQGFFTVQQTCPTCHGRGKIIKDPCKKCHGQGRVEKEKT 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNL 161
Cdd:PRK10767  213 LSVKIPAGVDTGDRIRLSGEGEAGERGGPAGDLYVQIHVKEHPIFERDGNDLYCEVPISFTTAALGGEIEVPTLDGRVKL 292

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFGGptGENNSPRSKSFF 234
Cdd:PRK10767  293 KIPEGTQTGKLFRLRGKGVKSVRSGARGDLYCQVVVETPVNLTKRQKELLEEFEESFES--GEKHSPKSKGFF 363
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 2-218 3.70e-117

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 338.04  E-value: 3.70e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:TIGR02349 134 VEKEIEIPRKESCETCHGTGAKPGTDPKTCPTCGGTGQVRRQQgtpfGFFQQQQTCPTCGGEGKIIKEPCSTCKGKGRVK 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:TIGR02349 214 ERKTITVKIPAGVDTGQRLRVSGKGNAGENGGPNGDLYVVIRVKPHKIFERDGNDLYIEVPISFTQAILGGEIEVPTLDG 293

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESF 218
Cdd:TIGR02349 294 DVKLKIPAGTQSGTVFRLKGKGVPRLRGNGRGDLLVTVKVETPKNLSKEQKELLEELAEAS 354
PRK14280 PRK14280
molecular chaperone DnaJ;
3-234 5.46e-106

molecular chaperone DnaJ;


Pssm-ID: 237656 [Multi-domain]  Cd Length: 376  Bit Score: 310.50  E-value: 5.46e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   3 TKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEK 78
Cdd:PRK14280  135 EKEIEIPKEETCDTCHGSGAKPGTSKETCSHCGGSGQVSVEQntpfGRVVNRQTCPHCNGTGQEIKEKCPTCHGKGKVRK 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  79 TKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGR 158
Cdd:PRK14280  215 RKKINVKIPAGVDNGQQIRVSGEGEPGVNGGPAGDLYVVFRVRPHEFFERDGDDIYCEMPLTFAQAALGDEIEVPTLHGK 294

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2431123074 159 VNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKElqesFGGPTGENNSPRSKSFF 234
Cdd:PRK14280  295 VKLKIPAGTQTGTQFRLKGKGVPNVRGYGQGDQYVVVRVVTPTKLTDRQKELLRE----FAELSGEEIDEQPSSFF 366
PRK14277 PRK14277
chaperone protein DnaJ; Provisional
 2-234 2.45e-96

chaperone protein DnaJ; Provisional


Pssm-ID: 184599 [Multi-domain]  Cd Length: 386  Bit Score: 286.31  E-value: 2.45e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14277  146 TEKEIEVERFEKCDVCKGSGAKPGSKPVTCPVCHGTGQVRTRQntpfGRIVNIRTCDRCHGEGKIITDPCNKCGGTGRIR 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:PRK14277  226 RRRKIKVNIPAGIDDGQMITLRGEGEPGIKGGPNGDLYIVIKVKPHPLFKREGYNVYLEMPITFTDAALGGEIEIPTLDG 305

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESfggpTGENNSPRSKSFF 234
Cdd:PRK14277  306 KVKFTIPEGTQTGTKFRLRGKGIPHLRGRGRGDQIVKVYIEVPKKLTEKQKELLREFEKL----SGEEGTESRKSFF 378
PRK14294 PRK14294
chaperone protein DnaJ; Provisional
 2-213 2.15e-95

chaperone protein DnaJ; Provisional


Pssm-ID: 237664 [Multi-domain]  Cd Length: 366  Bit Score: 283.19  E-value: 2.15e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKT 81
Cdd:PRK14294  135 TEKEIRIQKLETCEECHGSGCEPGTSPTTCPQCGGSGQVTQSQGFFSIRTTCPRCRGMGKVIVSPCKTCHGQGRVRVSKT 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNL 161
Cdd:PRK14294  215 VQVKIPAGVDTGSRLRLRGEGEAGVRGGPPGDLYVFLTVEPHEFFERDGNDVHCKVPISFVQAALGAQIEVPTLEGEREL 294

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKE 213
Cdd:PRK14294  295 KIPKGTQPGDIFRFKGKGIPSLRGGGRGDQIIEVEVKVPTRLTKKQEELLTE 346
PRK14298 PRK14298
chaperone protein DnaJ; Provisional
 2-234 6.83e-94

chaperone protein DnaJ; Provisional


Pssm-ID: 184612 [Multi-domain]  Cd Length: 377  Bit Score: 279.81  E-value: 6.83e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQV-QIRQ---GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14298  132 VRKDIDVPRAERCSTCSGTGAKPGTSPKRCPTCGGTGQVtTTRStplGQFVTTTTCSTCHGRGQVIESPCPVCSGTGKVR 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:PRK14298  212 KTRKITVNVPAGADSGLRLKLSGEGEAGSPGAPSGDLYIVLHVKEHDYFERVGDDIISEIPISFTQAALGADIMVPTLYG 291

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFGGPTGENNSPRSKSFF 234
Cdd:PRK14298  292 KVKMNIPPGTQTHSVFRLKDKGMPRLHGHGKGDQLVKVIVKTPTKLTQEQKELLREFDELSNGKNPSKAGKKKKGIF 368
PRK14276 PRK14276
chaperone protein DnaJ; Provisional
 2-234 2.19e-92

chaperone protein DnaJ; Provisional


Pssm-ID: 237653 [Multi-domain]  Cd Length: 380  Bit Score: 276.20  E-value: 2.19e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14276  137 KEKEVSYNREATCHTCNGSGAKPGTSPVTCGKCHGSGVITVDTqtplGMMRRQVTCDVCHGTGKEIKEPCQTCHGTGHEK 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:PRK14276  217 QAHTVSVKIPAGVETGQQIRLQGQGEAGFNGGPYGDLYVVFRVEPSKKFERDGSTIYYTLPISFVQAALGDTVEVPTVHG 296

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFGgptGENNSPRSKSFF 234
Cdd:PRK14276  297 DVELKIPAGTQTGKKFRLRGKGAPKLRGGGNGDQHVTVNIVTPTKLNDAQKEALKAFAKASG---EKDVNPKKKGFF 370
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 2-200 1.16e-91

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 268.35  E-value: 1.16e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKtKT 81
Cdd:pfam01556  16 CTKKIKITRNVICDTCGGSGAKPGTSPKTCPCCGGGGQVRRQFGFFSTCTCCPCCGGGGKIIDKCCKCCGGGGVVEK-KT 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNL 161
Cdd:pfam01556  95 LEVKIPAGVDDGQRIRLRGEGDAGENGGPPGDLYVVIRVKPHPVFRRDGDDLYCTVPISLTEALLGGTIEVPTLDGKVKL 174

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETP 200
Cdd:pfam01556 175 KIPAGTQPGTVLRLKGKGMPRLKGGGRGDLYVTVKVEVP 213
PRK14283 PRK14283
chaperone protein DnaJ; Provisional
 2-234 1.83e-87

chaperone protein DnaJ; Provisional


Pssm-ID: 184604 [Multi-domain]  Cd Length: 378  Bit Score: 263.61  E-value: 1.83e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQV-QIRQ---GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14283  137 VEKDIKVRHTKKCPVCNGSRAEPGSEVKTCPTCGGTGQVkQVRNtilGQMMNVTTCPDCQGEGKIVEKPCSNCHGKGVVR 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:PRK14283  217 ETKTISVKIPAGVETGSRLRVSGEGEMGDRGGEPGDLYVVIKVKPHKIFRREGANLYYEKPISFVQAALGDTVDVPTIDG 296

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKElqesFGGPTGENNSPRSKSFF 234
Cdd:PRK14283  297 PVELKIPAGTQSGTTFRLKGHGMPSLRWSGKGNLYVKVKVVVPKKLSPKQKELLRE----FASISGDEIHHVKKGLF 369
PRK14297 PRK14297
molecular chaperone DnaJ;
2-219 1.46e-85

molecular chaperone DnaJ;


Pssm-ID: 184611 [Multi-domain]  Cd Length: 380  Bit Score: 258.94  E-value: 1.46e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14297  139 VEKEISVTRNENCETCNGTGAKPGTSPKTCDKCGGTGQIRVQRntplGSFVSTTTCDKCGGSGKVIEDPCNKCHGKGKVR 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:PRK14297  219 KNRKIKVNVPAGVDTGNVIPLRGQGEHGKNGGPTGDLYINIRVAPHKTFKRKGFDIYIDKHISFAKAALGTEIKVPTVDG 298

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFG 219
Cdd:PRK14297  299 EVKYEVPAGTQPGTVFRLKGKGVPRVNSTGRGNQYVTVIVDIPKKLNSKQKEALTMFMEASG 360
PRK14301 PRK14301
chaperone protein DnaJ; Provisional
 5-216 4.43e-84

chaperone protein DnaJ; Provisional


Pssm-ID: 237668 [Multi-domain]  Cd Length: 373  Bit Score: 254.67  E-value: 4.43e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   5 EIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKTLSV 84
Cdd:PRK14301  138 TLRIPKNVTCDDCGGSGAAPGTSPETCRHCGGSGQVRQSQGFFQIAVPCPVCRGEGRVITHPCPKCKGSGIVQQTRELKV 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  85 KIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNLKVP 164
Cdd:PRK14301  218 RIPAGVDTGSRLRLRGEGEPGVHGGPPGDLYVVITVEDDKIFQRQGQDLVVTQEISFVQAALGDRIEVPTLDDPVTLDIP 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2431123074 165 GETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQE 216
Cdd:PRK14301  298 KGTQSGEVFRLRGKGLPYLGSSQKGDLLVEVSVVTPTKLTKRQEELLREFEA 349
PRK14287 PRK14287
chaperone protein DnaJ; Provisional
 5-226 1.78e-81

chaperone protein DnaJ; Provisional


Pssm-ID: 237659 [Multi-domain]  Cd Length: 371  Bit Score: 248.00  E-value: 1.78e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   5 EIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTK 80
Cdd:PRK14287  132 EIEIPREETCGTCHGSGAKPGTKPETCSHCGGSGQLNVEQntpfGRVVNRRVCHHCEGTGKIIKQKCATCGGKGKVRKRK 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  81 TLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVN 160
Cdd:PRK14287  212 KINVKVPAGIDHGQQLRVSGQGEAGVNGGPPGDLYVVFNVKPHEFFERDGDDIYCEMPLTFPQVALGDEIEVPTLNGKVK 291

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2431123074 161 LKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFGGPTGENN 226
Cdd:PRK14287  292 LKIPAGTQTGTSFRLRGKGVPNVHGRGQGDQHVQVRVVTPKNLTEKEKELMREFAGMSGGRPDEQN 357
PRK14295 PRK14295
molecular chaperone DnaJ;
2-233 1.11e-78

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 241.29  E-value: 1.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKT 81
Cdd:PRK14295  157 ATVPLRLTSQAPCPACSGTGAKNGTTPRVCPTCSGTGQVSRNSGGFSLSEPCPDCKGRGLIADDPCLVCKGSGRAKSSRT 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGR-VN 160
Cdd:PRK14295  237 MQVRIPAGVSDGQRIRLRGKGAPGERGGPAGDLYVVVHVDPHPVFGRSGDNLTVTVPVTFPEAALGAEVRVPTLGGPpVT 316

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2431123074 161 LKVPGETQTGKLFRMRGKGVKSvRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESfggpTGENNsPRSKSF 233
Cdd:PRK14295  317 VKLPPGTPNGRVLRVRGKGAVR-KDGTRGDLLVTVEVAVPKDLSGKAREALEAFREA----TADED-PRAELF 383
PRK14286 PRK14286
chaperone protein DnaJ; Provisional
 5-234 1.84e-78

chaperone protein DnaJ; Provisional


Pssm-ID: 172774 [Multi-domain]  Cd Length: 372  Bit Score: 240.28  E-value: 1.84e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   5 EIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKTLSV 84
Cdd:PRK14286  144 KIEIPRLESCVDCNGSGASKGSSPTTCPDCGGSGQIRRTQGFFSVATTCPTCRGKGTVISNPCKTCGGQGLQEKRRTINI 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  85 KIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGR-VNLKV 163
Cdd:PRK14286  224 KIPPGVETGSRLKVSGEGEAGPNGGPHGDLYVVTHIKKHELFERQGNDLILVRKISLAQAILGAEIEVPTIDGKkAKMKI 303

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2431123074 164 PGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKElqesFGGPTGENNS-PRSKSFF 234
Cdd:PRK14286  304 PEGTESGQVFRLKGHGMPYLGAYGKGDQHVIVKIEIPKKITRRQRELIEE----FARESGENIPgSKGKIFT 371
PRK14293 PRK14293
molecular chaperone DnaJ;
4-225 1.52e-77

molecular chaperone DnaJ;


Pssm-ID: 237663 [Multi-domain]  Cd Length: 374  Bit Score: 237.97  E-value: 1.52e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   4 KEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVqiRQ------GFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14293  136 KEIRIPHLETCETCRGSGAKPGTGPTTCSTCGGAGQV--RRatrtpfGSFTQVSECPTCNGTGQVIEDPCDACGGQGVKQ 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:PRK14293  214 VTKKLKINIPAGVDTGTRLRVSGEGDAGLRGGPPGDLYVYLFVKNDPEFRRDGINILSEIKISYLQAILGDTLEVDTVDG 293

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKsvRGG---AQGDLLCRVVVETPVGLNDKQKQLLKELQESFGGPTGEN 225
Cdd:PRK14293  294 PVELTIPAGTQPNTVLTLENKGVP--RLGnpvARGDHLITVKVKIPTRISDEERELLEKLAKIKGERQGKG 362
PRK14300 PRK14300
chaperone protein DnaJ; Provisional
 2-234 6.19e-77

chaperone protein DnaJ; Provisional


Pssm-ID: 172788 [Multi-domain]  Cd Length: 372  Bit Score: 236.45  E-value: 6.19e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKT 81
Cdd:PRK14300  136 IEKNISFSSEVKCDTCHGSGSEKGETVTTCDACSGVGATRMQQGFFTIEQACHKCQGNGQIIKNPCKKCHGMGRYHKQRN 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLD-GRVN 160
Cdd:PRK14300  216 LSVNIPAGVENGTRIRHTGEGEAGIRGGNSGDLYVDIAIKPHDIYKVDGANLHCKLPISFVNAALGGEIEVPVIEgGKVN 295

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2431123074 161 LKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESfggptGENNSPRSKSFF 234
Cdd:PRK14300  296 LTIPAGTQNGDQLRLRSKGMSKMRSTIRGDMLTHIHVEVPKNLSKRQRELLEEFKKE-----SINEKENDGSFF 364
PRK14279 PRK14279
molecular chaperone DnaJ;
2-217 7.91e-77

molecular chaperone DnaJ;


Pssm-ID: 237655 [Multi-domain]  Cd Length: 392  Bit Score: 236.94  E-value: 7.91e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKT 81
Cdd:PRK14279  164 VTMPLRLTSPAPCTTCHGSGARPGTSPKVCPTCNGSGVISRNQGAFGFSEPCTDCRGTGSIIEDPCEECKGTGVTTRTRT 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNL 161
Cdd:PRK14279  244 INVRIPPGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKVFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGPVGV 323

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSvRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQES 217
Cdd:PRK14279  324 KVPAGTADGRILRVRGRGVPK-RSGGAGDLLVTVKVAVPPNLDGAAAEALEAYAEA 378
PRK14284 PRK14284
chaperone protein DnaJ; Provisional
 2-233 4.21e-74

chaperone protein DnaJ; Provisional


Pssm-ID: 237658 [Multi-domain]  Cd Length: 391  Bit Score: 229.73  E-value: 4.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKT 81
Cdd:PRK14284  149 VEKELLVSGYKSCDACSGSGANSSQGIKVCDRCKGSGQVVQSRGFFSMASTCPECGGEGRVITDPCSVCRGQGRIKDKRS 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTL--DGRV 159
Cdd:PRK14284  229 VHVHIPAGVDSGMRLKMEGYGDAGQNGAPAGDLYVFIDVEPHPVFERRGDDLILELPIGFVDAALGMKKEIPTLlkEGTC 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2431123074 160 NLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKElqesFGGPTGENNSPRSKSF 233
Cdd:PRK14284  309 RLTIPEGIQSGTILKVRGQGFPNVHGKGRGDLLVRISVETPQNLSEEQKELLRQ----FAATEKAENFPKKRSF 378
PRK14278 PRK14278
chaperone protein DnaJ; Provisional
 2-216 1.87e-72

chaperone protein DnaJ; Provisional


Pssm-ID: 237654 [Multi-domain]  Cd Length: 378  Bit Score: 225.32  E-value: 1.87e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQ----QACPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14278  130 VTKQVTVDTAVLCDRCHGKGTAGDSKPVTCDTCGGRGEVQTVQRSFLGQvmtsRPCPTCRGVGEVIPDPCHECAGDGRVR 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTL-D 156
Cdd:PRK14278  210 ARREITVKIPAGVGDGMRIRLAAQGEVGPGGGPAGDLYVEVHEQPHDVFVRDGDDLHCTVSVPMVDAALGTTVTVEAIlD 289

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074 157 GRVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQE 216
Cdd:PRK14278  290 GPSEITIPPGTQPGSVITLRGRGMPHLRSGGRGDLHAHVEVVVPTRLDHEDIELLRELKA 349
PRK14291 PRK14291
chaperone protein DnaJ; Provisional
 3-216 1.81e-67

chaperone protein DnaJ; Provisional


Pssm-ID: 237661 [Multi-domain]  Cd Length: 382  Bit Score: 212.32  E-value: 1.81e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   3 TKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGtLIKDPCNKCHGHGRVEKTKTL 82
Cdd:PRK14291  148 TVSLEVPRYVPCEACGGTGYDPGSGEKVCPTCGGSGEIYQRGGFFRISQTCPTCGGEG-VLREPCSKCNGRGLVIKKETI 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  83 SVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG-RVNL 161
Cdd:PRK14291  227 KVRIPPGVDNGSKLRVPGKGHAGRFGGPPGDLYIIVKVKPHPLFERRGDNLYLDVNITVAEAVLGTELEVPLLDGkKEKV 306

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETP--------VGLNDKQKQLLKELQE 216
Cdd:PRK14291  307 KIPPGTKEGDKIRVPGKGMPRLKGSGYGDLVVRVHIDVPkismlsklMGDGKKAKKLLKELDK 369
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 75-203 1.05e-65

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 200.34  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  75 RVEKTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPT 154
Cdd:cd10747    30 RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGPNGGPPGDLYVVIRVKPHPVFRRDGNDLYCEVPISLTEALLGGEIEVPT 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2431123074 155 LDGRVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGL 203
Cdd:cd10747   110 LGGKVKLKIPPGTQPGTVLRLKGKGMPRLRGGGRGDLYVEVKVEFPKKL 158
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
 2-234 2.58e-62

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 199.65  E-value: 2.58e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGtKPQTCPTCHGSGQVqiRQ------GFFAVQQACPHCHGRGTLIKDPCNKCHGHGR 75
Cdd:PRK14281  154 VEKTLKIKKQVPCKECNGTGSKTG-ATETCPTCHGSGEV--RQasktmfGQFVNITACPTCGGEGRVVKDRCPACYGEGI 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  76 VEKTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTL 155
Cdd:PRK14281  231 KQGEVTVKVTVPAGVQDGNYLTLRGQGNAGPRGGAPGDLIVVIEEKPHELFVRNGDDVIYNLAVSYPDLVLGTKVEVPTL 310

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2431123074 156 DGRVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFGGPTGENNSPRSKSFF 234
Cdd:PRK14281  311 DGAVKLTIPAGTQPETMLRIPGKGIGHLRGSGRGDQYVRVNVFVPKEVSHQDKELLKELKKSSHISPNAHNDKEEKSFF 389
PRK14282 PRK14282
chaperone protein DnaJ; Provisional
 12-214 6.72e-61

chaperone protein DnaJ; Provisional


Pssm-ID: 184603 [Multi-domain]  Cd Length: 369  Bit Score: 195.40  E-value: 6.72e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  12 EECDICHGSGAKAGTKPQTCPTCHGSGQV-QIRQGFFAV---QQACPHCHGRGTLIKDPCNKCHGHGRVEKTKTLSVKIP 87
Cdd:PRK14282  153 ETCPHCGGTGVEPGSGYVTCPKCHGTGRIrEERRSFFGVfvsERTCERCGGTGKIPGEYCHECGGSGRIRRRVRTTVKIP 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  88 AGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVN-LKVPGE 166
Cdd:PRK14282  233 AGVEDGTVLRITGGGNAGYYGGPYGDLYVIVRVRPDPRFKRSGSDLIYDVTIDYLQAILGTTVEVPLPEGGTTmLKIPPG 312

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2431123074 167 TQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKEL 214
Cdd:PRK14282  313 TQPETVFRLKGKGLPNMRYGRRGDLIVNVHVEIPKRLSREERKLLKEL 360
PRK14289 PRK14289
molecular chaperone DnaJ;
2-217 2.43e-59

molecular chaperone DnaJ;


Pssm-ID: 237660 [Multi-domain]  Cd Length: 386  Bit Score: 191.58  E-value: 2.43e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQV-QIRQGFFAVQQA---CPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14289  145 VEKKFKVKKYVPCSHCHGTGAEGNNGSETCPTCKGSGSVtRVQNTILGTMQTqstCPTCNGEGKIIKKKCKKCGGEGIVY 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG 157
Cdd:PRK14289  225 GEEVITVKIPAGVAEGMQLSMNGKGNAGKHGGVNGDLLVVIEEEPHPELIRDENDLIYNLLLSVPTAALGGAVEVPTIDG 304

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074 158 RVNLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQES 217
Cdd:PRK14289  305 KAKVKIEAGTQPGKVLRLRNKGLPSVNGYGTGDLLVNVSVYIPETLSKEEKQTLEKMENS 364
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 5-234 7.91e-58

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 187.40  E-value: 7.91e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   5 EIRIPTLEECDICHGSGAKAGTKP-QTCPTCHGSGQVQIR-QGFFAV---QQACPHCHGRGTLIKDPCNKCHGHGRVEKT 79
Cdd:PRK14292  133 EVEVDRLTECEHCHGSRTEPGGKPpKTCPTCRGAGAVRAQaRTIFGVvetQQPCPTCRGEGQIITDPCTVCRGRGRTLKA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  80 KTLSVKIPAGVDTGDRIRLSGEGEAGEHGApaGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRV 159
Cdd:PRK14292  213 ETVKVKLPRGIDEGYRIRVAGMGNEGPGGN--GDLYVHIEMEPHPELRREQEHLIYEARIGFAKAALGGQITVPTLDGPQ 290

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2431123074 160 NLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLkelqESFGGPTGENNSPRSKSFF 234
Cdd:PRK14292  291 VIEVKPGTQHGDLHRLRGQGMPRLQGAGTGDLIVEYEIAVPKQLSPEAREAL----EAYARAVGDEVPEPHEGLF 361
PRK14290 PRK14290
chaperone protein DnaJ; Provisional
 14-214 8.60e-55

chaperone protein DnaJ; Provisional


Pssm-ID: 172778 [Multi-domain]  Cd Length: 365  Bit Score: 179.36  E-value: 8.60e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  14 CDICHGSGAKAGtKPQTCPTCHGSGQVQIR--QGFF--AVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKTLSVKIPAG 89
Cdd:PRK14290  152 CPDCSGTGAKNG-KLITCPTCHGTGQQRIVrgQGFFrmVTVTTCRTCGGRGRIPEEKCPRCNGTGTVVVNEDISVKIPKG 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  90 VDTGDRIRLSGEGEAgeHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNLKVPGETQT 169
Cdd:PRK14290  231 ATDNLRLRVKGKGQS--YGGRTGDLYVVLRVNNDPNIQRINDDLYVDQKINFPQAALGGEIEIKLFREKYNLKIPEGTQP 308

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2431123074 170 GKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKEL 214
Cdd:PRK14290  309 GEVLKIKGAGMPHLNGHGSGDLLVRINVEVPKRLTSKQKELIREF 353
PRK14285 PRK14285
chaperone protein DnaJ; Provisional
 14-214 2.94e-47

chaperone protein DnaJ; Provisional


Pssm-ID: 172773 [Multi-domain]  Cd Length: 365  Bit Score: 159.77  E-value: 2.94e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  14 CDICHGSGAKAGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKTLSVKIPAGVDTG 93
Cdd:PRK14285  149 CESCLGKKSEKGTSPSICNMCNGSGRVMQGGGFFRVTTTCPKCYGNGKIISNPCKSCKGKGSLKKKETIELKIPAGIDDN 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  94 DRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGR-VNLKVPGETQTGKL 172
Cdd:PRK14285  229 QQIKMRGKGSVNPDNQQYGDLYIKILIKPHKIFKRNGKDLYATLPISFTQAALGKEIKIQTIASKkIKIKIPKGTENDEQ 308

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2431123074 173 FRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKEL 214
Cdd:PRK14285  309 IIIKNEGMPILHTEKFGNLILIIKIKTPKNLNSNAIKLLENL 350
PRK14296 PRK14296
chaperone protein DnaJ; Provisional
 2-216 3.82e-45

chaperone protein DnaJ; Provisional


Pssm-ID: 237666 [Multi-domain]  Cd Length: 372  Bit Score: 154.72  E-value: 3.82e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   2 VTKEIRIPTLEECDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ--GFFAVQQA--CPHCHGRGTLIKDPCNKCHGHGRVE 77
Cdd:PRK14296  140 VDKIIELDLLTNCSKCFGSGAESNSDIHICNNCHGTGEVLVQKnmGFFQFQQSakCNVCNGAGKIIKNKCKNCKGKGKYL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  78 KTKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNN-LYCEVPINFAMAALGGEIEVPTLD 156
Cdd:PRK14296  220 ERKKIEVNIPKGIRPNQQIKLSQKGHASLNNGVNGDLIIDIYLKESKVFEIINNNdILMTYNISYLDAILGNEIIIKTLD 299

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2431123074 157 GRVNLKVPGETQTGKLFRMRGKGV-KSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQE 216
Cdd:PRK14296  300 GDIKYKLPKSINSNELIIINNKGLyKSINKDKRGDLIIKVNIVVPKNLSKKEKELIEQIYE 360
PRK14288 PRK14288
molecular chaperone DnaJ;
4-219 6.46e-43

molecular chaperone DnaJ;


Pssm-ID: 172776 [Multi-domain]  Cd Length: 369  Bit Score: 148.68  E-value: 6.46e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074   4 KEIRIPTLEECDICHGSGAKaGTKPQTCPTCHGSGQVQIRQGFFAVQQACPHCHGRGTLIKDPCNKCHGHGRVEKTKTLS 83
Cdd:PRK14288  133 KTIKVQYQSVCESCDGTGAK-DKALETCKQCNGQGQVFMRQGFMSFAQTCGACQGKGKIIKTPCQACKGKTYILKDEEID 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  84 VKIPAGVDTGDRIRLSGEGEAGEHGApAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDG-RVNLK 162
Cdd:PRK14288  212 AIIPEGIDDQNRMVLKNKGNEYEKGK-RGDLYLEARVKEDEHFKREGCDLFIEAPVFFTTIALGHTIKVPSLKGdELELK 290

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2431123074 163 VPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESFG 219
Cdd:PRK14288  291 IPRNARDRQTFAFRNEGVKHPESSYRGSLIVELQVIYPKSLNKEQQELLEKLHASFG 347
PRK10266 PRK10266
curved DNA-binding protein;
74-217 6.13e-35

curved DNA-binding protein;


Pssm-ID: 182347 [Multi-domain]  Cd Length: 306  Bit Score: 126.09  E-value: 6.13e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  74 GRVEK--TKTLSVKIPAGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIE 151
Cdd:PRK10266  150 GMIEQeiPKTLNVKIPAGVGNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVGQDLEIVVPLAPWEAALGAKVT 229

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2431123074 152 VPTLDGRVNLKVPGETQTGKLFRMRGKGVKSVRGgaQGDLLCRVVVETPVGLNDKQKQLLKELQES 217
Cdd:PRK10266  230 VPTLKESILLTIPPGSQAGQRLRVKGKGLVSKKQ--TGDLYAVLKIVMPPKPDEKTAALWQQLADA 293
DnaJ_CXXCXGXG pfam00684
DnaJ central domain; The central cysteine-rich (CR) domain of DnaJ proteins contains four ...
 14-74 1.04e-27

DnaJ central domain; The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found.


Pssm-ID: 459904 [Multi-domain]  Cd Length: 65  Bit Score: 100.33  E-value: 1.04e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2431123074  14 CDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHG 74
Cdd:pfam00684   1 CPTCNGSGAKPGTKPTTCPTCGGTGQVRRVQqtgpGFFQMQSTCPTCGGTGKIIKDPCKKCKGKG 65
PRK14299 PRK14299
chaperone protein DnaJ; Provisional
 82-218 5.10e-27

chaperone protein DnaJ; Provisional


Pssm-ID: 237667 [Multi-domain]  Cd Length: 291  Bit Score: 105.02  E-value: 5.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  82 LSVKIPAGVDTGDRIRLSGEGEAGehgapaGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVNL 161
Cdd:PRK14299  158 LSVRIPPGVREGQVIRLAGKGRQG------GDLYLVVRLLPHPVFRLEGDDLYATVDVPAPIAVVGGKVRVMTLDGPVEV 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2431123074 162 KVPGETQTGKLFRMRGKGVKSvRGGAQGDLLCRVVVETPVGLNDKQKQLLKELQESF 218
Cdd:PRK14299  232 TIPPRTQAGRKLRLKGKGWPR-GPAGRGDQYAEVRITIPTRPTPEEERLYKQLAELY 287
DnaJ_zf cd10719
Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of ...
 14-74 7.35e-26

Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding.


Pssm-ID: 199908 [Multi-domain]  Cd Length: 65  Bit Score: 95.40  E-value: 7.35e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2431123074  14 CDICHGSGAKAGTKPQTCPTCHGSGQVQIRQ----GFFAVQQACPHCHGRGTLIKDPCNKCHGHG 74
Cdd:cd10719     1 CPTCNGSGAKPGTKPKTCPTCGGSGQVRQVQgtgfGFFQTQTTCPTCGGTGKIIKDPCPKCKGKG 65
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 14-214 9.03e-22

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 92.58  E-value: 9.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  14 CDICHGSGAKAGTKpQTCPTCHGSG-QVQIRQGFFAVQQA---CPHCHGRGTLI--KDPCNKCHGHGRVEKTKTLSVKIP 87
Cdd:PTZ00037  153 CANCEGHGGPKDAF-VDCKLCNGQGiRVQIRQMGSMIHQTqstCNSCNGQGKIIpeSKKCKNCSGKGVKKTRKILEVNID 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2431123074  88 AGVDTGDRIRLSGEGEAGEHGAPaGDLYVQVQVKQHAIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVnLKV---P 164
Cdd:PTZ00037  232 KGVPNQHKITFHGEADEKPNEIP-GNVVFILNEKPHDTFKREGGDLFITKKISLYEALTGFVFYITHLDGRK-LLVntpP 309

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2431123074 165 GE-TQTGKLFRMRGKGVKSVRGG-AQGDLLCRVVVETPVG--LNDKQKQLLKEL 214
Cdd:PTZ00037  310 GEvVKPGDIKVINNEGMPTYKSPfKKGNLYVTFEVIFPVDrkFTNEEKEILKSL 363
phage_xxxx TIGR02642
uncharacterized phage protein; This uncharacterized protein is found in prophage regions of ...
 51-94 2.54e-04

uncharacterized phage protein; This uncharacterized protein is found in prophage regions of Shewanella oneidensis MR-1, Vibrio vulnificus YJ016, Yersinia pseudotuberculosis IP 32953, and Aeromonas hydrophila ATCC7966. It appears to have regions of sequence similarity to phage lambda antitermination protein Q. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 274243 [Multi-domain]  Cd Length: 186  Bit Score: 40.63  E-value: 2.54e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2431123074  51 QACPHCHGRGTLIK--DPCNKCHGHGRVEKT-----KTLSVKIPAGVDTGD 94
Cdd:TIGR02642 100 CKCPRCRGTGLIQRrqRECDTCAGTGRFRPTvedllKSFGVDSGAAIVLKD 150
phage_xxxx TIGR02642
uncharacterized phage protein; This uncharacterized protein is found in prophage regions of ...
 29-64 2.90e-03

uncharacterized phage protein; This uncharacterized protein is found in prophage regions of Shewanella oneidensis MR-1, Vibrio vulnificus YJ016, Yersinia pseudotuberculosis IP 32953, and Aeromonas hydrophila ATCC7966. It appears to have regions of sequence similarity to phage lambda antitermination protein Q. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 274243 [Multi-domain]  Cd Length: 186  Bit Score: 37.55  E-value: 2.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2431123074  29 QTCPTCHGSGQVQIRQGffavqqACPHCHGRGTLIK 64
Cdd:TIGR02642 100 CKCPRCRGTGLIQRRQR------ECDTCAGTGRFRP 129
Cytochrom_C3 cd08168
Heme-binding domain of the class III cytochrome C family and related proteins; This alignment ...
 12-71 7.52e-03

Heme-binding domain of the class III cytochrome C family and related proteins; This alignment models heme binding core motifs as encountered in the cytochrome C3 family and related proteins. Cytochrome C3 is a tetraheme protein found in sulfate-reducing bacteria which use either thiosulfate or sulfate as the ultimate electron acceptors. C3 is an integral part of a complex electron transfer chain. The model also contains triheme cytochromes C7 which function in electron transfer during Fe(III) respiration by Geobacter sulfurreducens (PpcA, PpcB, PpcC, PpcD, and PpcE) and four repeated core motifs as found in the 16-heme cytochrome C HmcA of Desulfovibrio vulgaris Hildenborough which plays a role in electron transfer through the membrane following periplasmic oxidation of hydrogen (resulting in sulfate reduction in the cytoplasm).


Pssm-ID: 173979 [Multi-domain]  Cd Length: 85  Bit Score: 34.52  E-value: 7.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2431123074  12 EECDICHGSGAKAGTKPQTCPTCHG--SGQVQIRQGFF-AVQQACPHCHGRGTLIKDP-----CNKCH 71
Cdd:cd08168    17 IDCRTCHHKYEGGKGEPQKCAECHShdGTDDPDFVSLKdAFHNSCIGCHKEMAKAGKKtgpvgCAGCH 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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