seadornavirus VP3 protein; Members of this protein family are VP3 proteins in the ...
137-599
3.23e-13
seadornavirus VP3 protein; Members of this protein family are VP3 proteins in the seadornavirus group. Sequences show sequence similarity to methyltransferases.
The actual alignment was detected with superfamily member TIGR04232:
Pssm-ID: 211955 Cd Length: 731 Bit Score: 73.39 E-value: 3.23e-13
seadornavirus VP3 protein; Members of this protein family are VP3 proteins in the ...
137-599
3.23e-13
seadornavirus VP3 protein; Members of this protein family are VP3 proteins in the seadornavirus group. Sequences show sequence similarity to methyltransferases.
Pssm-ID: 211955 Cd Length: 731 Bit Score: 73.39 E-value: 3.23e-13
viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase; Cap-0 specific (nucleoside-2'-O-) ...
138-321
2.52e-06
viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase; Cap-0 specific (nucleoside-2'-O-)-methyltransferase (2'OMTase) catalyzes the methylation of Cap-0 (m7GpppNp) at the 2'-hydroxyl of the ribose of the first nucleotide, using S-adenosyl-L-methionine (AdoMet) as the methyl donor. This reaction is the fourth and last step in mRNA capping, the creation of the stabilizing five-prime cap (5' cap) on mRNA. Some dsDNA and dsRNA viruses, like the bluetongue virus (BTV), a member of the Reoviridae family, and Vaccinia virus, a member of the Poxviridae family, as well as some ss(+)RNA viruses, like Flaviviridae and Nidovirales, cap their mRNAs and encode their own 2'OMTase. In BTV, all four reactions are catalyzed by a single protein, VP4. In Vaccinia, the activity is located in the processing factor of the poly(A) polymerase, VP39.
Pssm-ID: 467730 Cd Length: 179 Bit Score: 48.59 E-value: 2.52e-06
seadornavirus VP3 protein; Members of this protein family are VP3 proteins in the ...
137-599
3.23e-13
seadornavirus VP3 protein; Members of this protein family are VP3 proteins in the seadornavirus group. Sequences show sequence similarity to methyltransferases.
Pssm-ID: 211955 Cd Length: 731 Bit Score: 73.39 E-value: 3.23e-13
viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase; Cap-0 specific (nucleoside-2'-O-) ...
138-321
2.52e-06
viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase; Cap-0 specific (nucleoside-2'-O-)-methyltransferase (2'OMTase) catalyzes the methylation of Cap-0 (m7GpppNp) at the 2'-hydroxyl of the ribose of the first nucleotide, using S-adenosyl-L-methionine (AdoMet) as the methyl donor. This reaction is the fourth and last step in mRNA capping, the creation of the stabilizing five-prime cap (5' cap) on mRNA. Some dsDNA and dsRNA viruses, like the bluetongue virus (BTV), a member of the Reoviridae family, and Vaccinia virus, a member of the Poxviridae family, as well as some ss(+)RNA viruses, like Flaviviridae and Nidovirales, cap their mRNAs and encode their own 2'OMTase. In BTV, all four reactions are catalyzed by a single protein, VP4. In Vaccinia, the activity is located in the processing factor of the poly(A) polymerase, VP39.
Pssm-ID: 467730 Cd Length: 179 Bit Score: 48.59 E-value: 2.52e-06
Cap-0 specific (nucleoside-2'-O-)-methyltransferase of mimiviridae and pithoviridae; Cap-0 ...
138-300
3.97e-04
Cap-0 specific (nucleoside-2'-O-)-methyltransferase of mimiviridae and pithoviridae; Cap-0 specific (nucleoside-2'-O-)-methyltransferase (2'OMTase) catalyzes the methylation of Cap-0 (m7GpppNp) at the 2'-hydroxyl of the ribose of the first nucleotide, using S-adenosyl-L-methionine (AdoMet) as the methyl donor. This reaction is the fourth and last step in mRNA capping, the creation of the stabilizing five-prime cap (5' cap) on mRNA. Mimiviridae and pithoviridae are part of the nucleocytoplasmic large dsDNA virus clade (NCLDV), and they cap their mRNAs. The 2'OMTase activity is located in the polyA polymerase regulatory subunit. This family also contains related proteins from a broad group of eukaryotes that include opisthokonts and protists.
Pssm-ID: 467735 Cd Length: 237 Bit Score: 42.62 E-value: 3.97e-04
Cap-0 specific (nucleoside-2'-O-)-methyltransferase of orbivirus; Cap-0 specific (nucleoside-2 ...
157-246
6.31e-04
Cap-0 specific (nucleoside-2'-O-)-methyltransferase of orbivirus; Cap-0 specific (nucleoside-2'-O-)-methyltransferase (2'OMTase) catalyzes the methylation of Cap-0 (m7GpppNp) at the 2'-hydroxyl of the ribose of the first nucleotide, using S-adenosyl-L-methionine (AdoMet) as the methyl donor. This reaction is the fourth and last step in mRNA capping, the creation of the stabilizing five-prime cap (5' cap) on mRNA. Orbiviruses, which comprise a family of dsRNA viruses, cap their mRNAs. The 2'OMTase activity is located in the multifunctional capping enzyme, VP4.
Pssm-ID: 467733 Cd Length: 211 Bit Score: 41.75 E-value: 6.31e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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