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Conserved domains on  [gi|2473355042|gb|WEZ22190|]
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peptide chain release factor 1 [Bacillus subtilis]

Protein Classification

PrfA family protein( domain architecture ID 11415460)

PrfA family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-355 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 713.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   1 MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEE 80
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  81 ISELQKETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE 160
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 161 IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMS 240
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 241 AVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRI 320
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2473355042 321 GLTIQKLDQILEGKLDEVVEALIVEDQASKLQQSE 355
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-355 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 713.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   1 MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEE 80
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  81 ISELQKETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE 160
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 161 IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMS 240
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 241 AVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRI 320
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2473355042 321 GLTIQKLDQILEGKLDEVVEALIVEDQASKLQQSE 355
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 1-355 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 684.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   1 MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEE 80
Cdd:PRK00591    4 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  81 ISELQKETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE 160
Cdd:PRK00591   84 LKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 161 IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMS 240
Cdd:PRK00591  164 VIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 241 AVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRI 320
Cdd:PRK00591  244 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRI 323

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2473355042 321 GLTIQKLDQILEGKLDEVVEALIVEDQASKLQQSE 355
Cdd:PRK00591  324 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALG 358
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-352 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 595.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   1 MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKlDAEMRDMVKEE 80
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEES-DPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  81 ISELQKETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE 160
Cdd:TIGR00019  84 LEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 161 IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMS 240
Cdd:TIGR00019 164 VIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 241 AVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRI 320
Cdd:TIGR00019 244 AVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRI 323

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2473355042 321 GLTIQKLDQILEGKLDEVVEALIVEDQASKLQ 352
Cdd:TIGR00019 324 NLTLYKLDEVLEGDLDELIEALIAEDQAQQLA 355
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 8-202 1.44e-111

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 322.80  E-value: 1.44e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   8 IEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEeklDAEMRDMVKEEISELQKE 87
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  88 TETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKEIIFMITG 167
Cdd:pfam03462  78 LEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2473355042 168 SGAYSKLKYENGAHRVQRVPETESGGRIHTSTATV 202
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
64-177 3.61e-54

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 173.80  E-value: 3.61e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   64 MLEEKLDAEMRDMVKEEISELQK-ETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQG 142
Cdd:smart00937   2 LLEEEEDDEMRELAEEELEELEAeLEEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKG 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2473355042  143 WKTEVMEANVTGTGGYKEIIFMITGSGAYSKLKYE 177
Cdd:smart00937  82 WKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-355 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 713.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   1 MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEE 80
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  81 ISELQKETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE 160
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 161 IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMS 240
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 241 AVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRI 320
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2473355042 321 GLTIQKLDQILEGKLDEVVEALIVEDQASKLQQSE 355
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 1-355 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 684.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   1 MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEE 80
Cdd:PRK00591    4 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  81 ISELQKETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE 160
Cdd:PRK00591   84 LKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 161 IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMS 240
Cdd:PRK00591  164 VIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 241 AVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRI 320
Cdd:PRK00591  244 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRI 323

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2473355042 321 GLTIQKLDQILEGKLDEVVEALIVEDQASKLQQSE 355
Cdd:PRK00591  324 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALG 358
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-352 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 595.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   1 MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKlDAEMRDMVKEE 80
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEILEES-DPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  81 ISELQKETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE 160
Cdd:TIGR00019  84 LEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 161 IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMS 240
Cdd:TIGR00019 164 VIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 241 AVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRI 320
Cdd:TIGR00019 244 AVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRI 323

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2473355042 321 GLTIQKLDQILEGKLDEVVEALIVEDQASKLQ 352
Cdd:TIGR00019 324 NLTLYKLDEVLEGDLDELIEALIAEDQAQQLA 355
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 8-202 1.44e-111

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 322.80  E-value: 1.44e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   8 IEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEeklDAEMRDMVKEEISELQKE 87
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  88 TETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKEIIFMITG 167
Cdd:pfam03462  78 LEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2473355042 168 SGAYSKLKYENGAHRVQRVPETESGGRIHTSTATV 202
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 58-341 2.23e-62

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 201.81  E-value: 2.23e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  58 LADAKAMLEEKLDAEMRDMVKEEISELQKETETLsERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRY 137
Cdd:PRK08787   16 LADAGELLDLAESEQDEDTALAVIADLDKYQAHV-EKLEFQRMFSGQMDGANAFVDIQAGAGGTEAQDWAEILLRMYLRW 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 138 AELQGWKTEVMEANVTGTGGYKEIIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEE-VEVDIH 216
Cdd:PRK08787   95 AESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDnIEIDIN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 217 EKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYD--QTRKS 294
Cdd:PRK08787  175 PADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRNAEKDalEATKS 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2473355042 295 AVGSGdrsERIRTYNFPQNRVTDHRIGLTIQKLDQILEGKLDEVVEA 341
Cdd:PRK08787  255 DIGWG---SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEA 298
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 21-341 8.99e-62

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 200.88  E-value: 8.99e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  21 DPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETEtlSERLKVLLI 100
Cdd:PRK07342    5 DPSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDNIELIAMGEEEGDKSIVEDAEKTIRDLKDEID--RRQIDALLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 101 PK-DPNDdknVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKEIIFMITGSGAYSKLKYENG 179
Cdd:PRK07342   83 GEaDAND---TYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 180 AHRVQRVPETESGGRIHTSTATVACLPEAEE-VEVDIHEKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDE 258
Cdd:PRK07342  160 VHRLVRISPYDSNARRHTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 259 KSQIKNKEKAMKVLRARIYD----KFQQEAQAEydQTRKSAVGSGdrsERIRTYNF-PQNRVTDHRIGLTIQKLDQILEG 333
Cdd:PRK07342  240 RSQHKNRAKAWSMLRARLYEeelkKREEATNAA--AASKTDIGWG---HQIRSYVLqPYQLVKDLRTGVESTNPQDVLDG 314


                  ....*...
gi 2473355042 334 KLDEVVEA 341
Cdd:PRK07342  315 DLNEFMEA 322
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 26-343 9.79e-61

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 198.03  E-value: 9.79e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  26 NDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETEtlseRLKVLLIPKDPN 105
Cdd:PRK06746    8 DDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMN----EYELQLLLSDPY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 106 DDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKEIIFMITGSGAYSKLKYENGAHRVQR 185
Cdd:PRK06746   84 DKNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 186 VPETESGGRIHTSTATVACLPE-AEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKN 264
Cdd:PRK06746  164 ISPFDSSGRRHTSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKN 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 265 KEKAMKVLRARIYDKFQQEAQAEYDQTR--KSAVGSGdrsERIRTYNF-PQNRVTDHRIGLTIQKLDQILEGKLDEVVEA 341
Cdd:PRK06746  244 REHAMKMLKAKLYQKKLEEQQAELDEIRgeQKEIGWG---SQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 320


                  ..
gi 2473355042 342 LI 343
Cdd:PRK06746  321 YL 322
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 209-319 7.77e-59

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 185.70  E-value: 7.77e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 209 EEVEVDIHEKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYdKFQQEAQAEY 288
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLY-ELEEEKEEEK 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2473355042 289 DQTRKSAVGSGDRSERIRTYNF-PQNRVTDHR 319
Cdd:pfam00472  80 KRRIKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 19-336 1.19e-56

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 187.32  E-value: 1.19e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  19 LSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKlDAEMRDMVKEEISELQKETETLseRLKVL 98
Cdd:PRK05589    1 MQEPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEE-DDEMKKEIISEVKNIKEEIDRF--KIETL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042  99 LipKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKEIIFMITGSGAYSKLKYEN 178
Cdd:PRK05589   78 L--SGEYDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 179 GAHRVQRVPETESGGRIHTSTATVACLPE-AEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQD 257
Cdd:PRK05589  156 GIHRLVRISPFNANGKRQTSFASVEVLPElTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQN 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 258 EKSQIKNKEKAMKVLRARIYDkFQQEAQAEYDQTRKSAVGSGDRSERIRTYNF-PQNRVTDHRIGLTIQKLDQILEGKLD 336
Cdd:PRK05589  236 ERSQHSNKETAMKMLKSKLVE-LKERAHKEKIEDLTGELKDMGWGSQIRSYVFhPYNLVKDHRTGVETSNVDSVMDGDID 314
PCRF smart00937
This domain is found in peptide chain release factors;
64-177 3.61e-54

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 173.80  E-value: 3.61e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   64 MLEEKLDAEMRDMVKEEISELQK-ETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQG 142
Cdd:smart00937   2 LLEEEEDDEMRELAEEELEELEAeLEEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKG 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2473355042  143 WKTEVMEANVTGTGGYKEIIFMITGSGAYSKLKYE 177
Cdd:smart00937  82 WKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 212-319 4.76e-31

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 114.46  E-value: 4.76e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 212 EVDIHEKDIRVDTFASSGPGGQSVNTTMSAVRLTH------------LPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDK 279
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2473355042 280 FQQEAQAEydQTRKSAVGSGDRSE--RIRtynfpqNRVTDHR 319
Cdd:COG1186   100 ELEPKERR--ATKPTRGSKKRRLWgkQIR------SMVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 214-308 3.12e-20

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 87.52  E-value: 3.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 214 DIHEKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIyDKFQQEAQAEYDQTRK 293
Cdd:TIGR03072 102 EATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRL-ADLQQEQAAALRAERR 180

                          90
                  ....*....|....*
gi 2473355042 294 SAVGSGDRSERIRTY 308
Cdd:TIGR03072 181 TAHHQIERGNPVRVF 195
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
205-276 4.73e-05

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 42.83  E-value: 4.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042 205 LPEAEevevdIHEKDIRvdtfaSSGPGGQSVNTTMSAVRL------THLPT-----------------GV-VVSCQDEKS 260
Cdd:PRK09256   10 IPENE-----LEWRFIR-----ASGPGGQNVNKVSTAVELrfdiaaSSLPEfykerllalaghritkdGViVIKAQEFRS 79

                          90
                  ....*....|....*.
gi 2473355042 261 QIKNKEKAMKVLRARI 276
Cdd:PRK09256   80 QERNREDALERLVALI 95
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 6-98 5.03e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 38.76  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2473355042   6 KSIEERYEKLNELLSD-PEVVNdpkKLREYSKEQSDIQETVDVYRqYRDASEQLADAKAMLEeKLDAEMRDMVkEEISEL 84
Cdd:PRK05771   39 ELSNERLRKLRSLLTKlSEALD---KLRSYLPKLNPLREEKKKVS-VKSLEELIKDVEEELE-KIEKEIKELE-EEISEL 112

                          90
                  ....*....|....
gi 2473355042  85 QKETETLSERLKVL 98
Cdd:PRK05771  113 ENEIKELEQEIERL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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